Paid Clinical Trials in Illinois

Illinois has 2,971 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,971 clinical trials

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Trial of Ixazomib for Kaposi Sarcoma

for Kaposi Sarcoma

11 locations incl. San Diego

Sponsor: AIDS Malignancy Consortium

Sex: All·Age: 18+

Code: NCT04305691·Phase 2·Recruiting

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Safety, PK, and Preliminary Efficacy of MBRC-101 in Advanced Refractory Solid Tumors

for Cancer

17 locations incl. San Francisco

Sponsor: MBrace Therapeutics

Sex: All·Age: 18+

Code: NCT06014658·Phase 1, Phase 2·Recruiting

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Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

for Heart Failure

31 locations incl. Birmingham

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 40 - 85

Code: NCT06122779·Phase 2·Recruiting

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Study of Mental Health and Relationships

for Mental Health

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 9 - 16·Accepts healthy volunteers

Code: NCT06534827·Recruiting

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Performance and Safety of a Digital Tool for Unsupervised Self-assessment of NMOSD

for Neuromyelitis Optica

10 locations incl. Los Angeles

Sponsor: Ad scientiam

Sex: All·Age: 18+

Code: NCT05566769·Recruiting

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Pilot Testing of a Structural Racism Intervention for Immigrant Latinx Families

for Stress, Psychological

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 14 - 17·Accepts healthy volunteers

Code: NCT05991739·Recruiting

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Open-Label Extension of EDG-5506 in Participants With Becker Muscular Dystrophy

for Becker Muscular Dystrophy

24 locations incl. Little Rock

Sponsor: Edgewise Therapeutics, Inc.

Sex: Male·Age: All ages

Code: NCT06066580·Phase 2·Enrolling By Invitation

Paclitaxel Coated Balloon for the Treatment of Chronic bEnigN sTricture- Bowel

for Bowel

33 locations incl. Scottsdale

Sponsor: GIE Medical

Sex: All·Age: 22+

Code: NCT05561127·Phase 3·Recruiting

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Study of ISB 2001 in Relapsed/Refractory Multiple Myeloma (TRIgnite-1)

for Relapsed/Refractory Multiple Myeloma

10 locations incl. Palo Alto

Sponsor: Ichnos Sciences SA

Sex: All·Age: 18+

Code: NCT05862012·Phase 1·Recruiting

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MindWalk Intervention for Older South Asian Caregivers of People With Cognitive Disabilities (CD)

for Stress, Psychological

8 locations incl. Bolingbrook

Sponsor: University of Illinois at Chicago

Sex: All·Age: 45+

Code: NCT06002919·Recruiting

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Fontan Udenafil Exercise Longitudinal Assessment Trial - 2

for Single Ventricle Heart Disease

37 locations incl. Phoenix

Sponsor: Mezzion Pharma Co. Ltd

Sex: All·Age: 12 - 18

Code: NCT05918211·Phase 3·Recruiting

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Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)

for Progressive Pulmonary Fibrosis

71 locations incl. Birmingham

Sponsor: United Therapeutics

Sex: All·Age: 18+

Code: NCT05943535·Phase 3·Recruiting

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Resilience in East Asian Immigrants for Advance Care Planning Discussions

for Neoplasms

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 80

Code: NCT06035549·Recruiting

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Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future

for LVAD

7 locations incl. San Francisco

Sponsor: International Consortium of Circulatory Assist Clinicians

Sex: All·Age: 18 - 100

Code: NCT06039176·Recruiting

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A Phase 1 Clinical Study of NXP900 in Subjects With Advanced Cancers

for Advanced Solid Tumor

Drug: NXP900

10 locations incl. Phoenix

Sponsor: Nuvectis Pharma, Inc.

Sex: All·Age: 18+

Code: NCT05873686·Phase 1·Recruiting

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Study to Evaluate the Efficacy, Safety, and Tolerability of Efzofitimod in Patients With Systemic Sclerosis (SSc)-Related Interstitial Lung Disease (ILD) (SSc-ILD)

for Interstitial Lung Disease

15 locations incl. Los Angeles

Sponsor: aTyr Pharma, Inc.

Sex: All·Age: 18+

Code: NCT05892614·Phase 2·Recruiting

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Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients

for Non-Small Cell Lung Cancer

Drug: Ivonescimab

76 locations incl. Phoenix

Sponsor: Summit Therapeutics

Sex: All·Age: 18+

Code: NCT05899608·Phase 3·Recruiting

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SIBYL: obServation of Therapy Response With lIquid BiopsY evaLuation

for Non-small Cell Lung Cancer

1 location in Skokie

Sponsor: Guardant Health, Inc.

Sex: All·Age: 18+

Code: NCT05935384·Recruiting

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Nectero EAST System Clinical Study

for Abdominal Aortic Aneurysm

37 locations incl. Scottsdale

Sponsor: Nectero Medical, Inc.

Sex: All·Age: 21 - 85

Code: NCT06001918·Phase 2, Phase 3·Recruiting

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Long-Term Safety and Efficacy of Tegoprubart in Kidney Transplant Recipients

for Kidney Transplant Rejection

26 locations incl. Los Angeles

Sponsor: Eledon Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT06126380·Phase 2·Enrolling By Invitation

Indocyanine Green (ICG) Guided Sentinel Lymph Node Mapping for Pediatric Visceral Solid Tumors

for Solid Tumor

3 locations incl. Chicago

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: Up to 20

Code: NCT05645523·EARLY_Phase 1·Recruiting

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SELUTION 4 De Novo Small Vessel IDE Trial

for Coronary Artery Disease

43 locations incl. Jonesboro

Sponsor: M.A. Med Alliance S.A.

Sex: All·Age: 18+

Code: NCT05946629·Recruiting

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Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma

for Mantle Cell Lymphoma

237 locations incl. Little Rock

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 60+

Code: NCT05976763·Phase 3·Recruiting

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An Observational Extension Study for Adult Patients Treated in Study R5459-RT-1944 Who Receive a Kidney Transplant

for Chronic Kidney Disease (CKD)

9 locations incl. Los Angeles

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18 - 70

Code: NCT05106387·Recruiting

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Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

for Metastatic Colorectal Carcinoma

60 locations incl. Birmingham

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT05863195·Phase 3·Recruiting

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AlloMend Acellular Dermal Matrix Allograft in Pre-Pectoral Breast Reconstruction

for Pre-Pectoral Breast Reconstruction Following Single or Double Mastectomy

1 location in Joliet

Sponsor: AlloSource

Sex: Female·Age: 18+

Code: NCT06512259·Recruiting

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Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

for Breast Cancer

1208 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: Female·Age: 18 - 60

Code: NCT05879926·Phase 3·Recruiting

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The Impact of a Race-Based Stress Reduction Intervention

for Racism

1 location in Maywood

Sponsor: Loyola University

Sex: Female·Age: 50 - 75

Code: NCT05902741·Recruiting

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A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

for Advanced Solid Tumor

14 locations incl. Los Angeles

Sponsor: Volastra Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05902988·Phase 1, Phase 2·Recruiting

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A Study of the Efficacy and Safety of Adjuvant Autogene Cevumeran Plus Atezolizumab and mFOLFIRINOX Versus mFOLFIRINOX Alone in Participants With Resected PDAC

for Adenocarcinoma, Pancreatic Ductal

Drug: Atezolizumab

32 locations incl. Los Angeles

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT05968326·Phase 2·Recruiting

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A Study of Enzalutamide, Enzalutamide in Combination With Mifepristone, or Chemotherapy in People With Metastatic Breast Cancer

for Metastatic Breast Cancer

12 locations incl. Birmingham

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06099769·Phase 2·Recruiting

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Alternate Day Fasting After Surgery for Patients Undergoing Chemotherapy

for Ovary Cancer

1 location in Chicago

Sponsor: Northwestern University

Sex: Female·Age: 18+

Code: NCT05990426·Recruiting

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Assessment of a Minimally Invasive Collection Device for Molecular Analysis of Esophageal Samples

for Barrett Esophagus

5 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 90

Code: NCT06071845·Recruiting

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Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors

for Hodgkin Lymphoma

428 locations incl. Anchorage

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT06002828·Recruiting

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Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment

for Plasma Cell Myeloma

397 locations incl. Anchorage

Sponsor: SWOG Cancer Research Network

Sex: All·Age: All ages

Code: NCT05561387·Phase 3·Recruiting

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A Study to Evaluate the Safety and Effectiveness of Upadacitinib Tablets in Adult and Adolescent Participants With Severe Alopecia Areata

for Alopecia Areata

Drug: Upadacitinib

77 locations incl. Birmingham

Sponsor: AbbVie

Sex: All·Age: 12 - 63

Code: NCT06012240·Phase 3·Recruiting

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AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia

for Community-acquired Pneumonia

6 locations incl. Chicago

Sponsor: University of Manitoba

Sex: All·Age: 18+

Code: NCT05848713·Phase 3·Recruiting

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A Study to Test How Effective Belumosudil Tablets Are for Treating Adult Participants With Chronic Lung Allograft Dysfunction

for Lung Transplant Rejection

32 locations incl. Birmingham

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT06082037·Phase 3·Recruiting

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Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, The ERASur Study

for Metastatic Colorectal Adenocarcinoma

184 locations incl. Kingman

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05673148·Phase 3·Recruiting

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The Gut Microbiome and Serum Metabolites As a Biological Mechanism Underlying Pain in Kidney Transplantation

for Kidney Transplant Symptoms

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT06206486·Recruiting

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