Breast cancer Clinical Trials in Houston, TX

As of June 2026, 113 paid clinical trials are recruiting for Breast cancer in Houston, Texas. Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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Oncology· 1,692 Women's health· 260 Breast oncology· 184

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113 clinical trials for Breast cancer

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Finding the Best Tamoxifen Dose for Breast Cancer Risk Reduction in Premenopausal Women, RENAISSANCE Trial

for Breast Atypical Ductal Hyperplasia

11 locations incl. Tucson

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18 - 55

Code: NCT06184750·Phase 2·Recruiting

Apply to this trial

A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

for Breast Cancer

165 locations incl. Daphne

Sponsor: Stemline Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06492616·Phase 3·Recruiting

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A Phase I/II, Dose Finding and Optimization Study of [177Lu]Lu-NeoB in Combination With Capecitabine in Patients With GRPR+, ER+, HER2- Metastatic Breast Cancer After Progression on Previous Endocrine Therapy in Combination With a CDK4/6 Inhibitor.

for Breast Cancer

5 locations incl. Los Angeles

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT06247995·Phase 1, Phase 2·Recruiting

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Safety/Efficacy Study of CID-078 in Patients With Advanced Solid Tumor Malignancies

for Advanced Solid Tumor

10 locations incl. Sarasota

Sponsor: Circle Pharma

Sex: All·Age: 12+

Code: NCT06577987·Phase 1·Recruiting

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Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of BTX-9341 in Advanced and/or Metastatic Breast Cancer

for Breast Cancer

6 locations incl. Rochester

Sponsor: Biotheryx, Inc.

Sex: All·Age: 18+

Code: NCT06515470·Phase 1·Recruiting

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Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

for Biliary Tract Cancer

6 locations incl. Denver

Sponsor: ModeX Therapeutics, An OPKO Health Company

Sex: All·Age: 18+

Code: NCT06239194·Phase 1, Phase 2·Recruiting

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EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)

for Breast Cancer

53 locations incl. Anchorage

Sponsor: Exact Sciences Corporation

Sex: All·Age: 18+

Code: NCT06401421·Recruiting

Apply to this trial

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

for Advanced or Metastatic Solid Tumors

14 locations incl. Phoenix

Sponsor: 858 Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06395519·Phase 1, Phase 2·Recruiting

Apply to this trial

BostonGene and Exigent Genomic INsight Study

for Breast Cancer

7 locations incl. Rogers

Sponsor: BostonGene

Sex: All·Age: 18+

Code: NCT06272864·Recruiting

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A Study of MGC026 in Participants With Advanced Solid Tumors

for Advanced Solid Tumor

7 locations incl. Los Angeles

Sponsor: MacroGenics

Sex: All·Age: 18+

Code: NCT06242470·Phase 1·Recruiting

Apply to this trial

Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors

for Breast Cancer

673 locations incl. Anchorage

Sponsor: NRG Oncology

Sex: All·Age: 18 - 100

Code: NCT05896189·Recruiting

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A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

for Advanced Solid Tumor

13 locations incl. Duarte

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06172478·Phase 2·Recruiting

Apply to this trial

Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

for Endometrial Cancer

17 locations incl. Birmingham

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT06293898·Phase 1·Recruiting

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Surveillance MRI Registry for Patients Who Had Breast Cancer With Dense Breast Tissue

for Breast Cancer

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT06127797·Recruiting

Apply to this trial

A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer

for Breast Cancer

Drug: Durvalumab

64 locations incl. Daphne

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06103864·Phase 3·Recruiting

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OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer

for Breast Cancer

Drug: Palazestrant

47 locations incl. Tucson

Sponsor: Olema Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06016738·Phase 3·Recruiting

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[177Lu]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanced Breast Cancer

for Breast Cancer

Drug: Ribociclib

6 locations incl. Los Angeles

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT05870579·Phase 1·Recruiting

Apply to this trial

ARTIDIS Nanomechanical Generated Measurements for Early Breast Lesions

for Breast Cancer

3 locations incl. Dallas

Sponsor: ARTIDIS AG

Sex: All·Age: 18+

Code: NCT06085833·Recruiting

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Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

for Breast Cancer

1208 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: Female·Age: 18 - 60

Code: NCT05879926·Phase 3·Recruiting

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Opioid-Sparing Effects of Nurse-Delivered Hypnosis During Breast Cancer Surgery

for Breast Cancer

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT05766891·Phase 2, Phase 3·Recruiting

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Temporal Immunologic Changes With Hypofractionated Radiation-Induced DNA Damage in Breast Cancer

for Breast Carcinoma

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT05406232·Recruiting

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Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

for Non Small Cell Lung Cancer

24 locations incl. Beverly Hills

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT05983432·Phase 1·Recruiting

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A Study of NT-175 in Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

for Non-small Cell Lung Cancer

18 locations incl. Gilbert

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05877599·Phase 1·Recruiting

Apply to this trial

TRUDI: TDXD+Durva in HER2+/Low IBC

for Invasive Breast Cancer

3 locations incl. Boston

Sponsor: Filipa Lynce, MD

Sex: Female·Age: 18+

Code: NCT05795101·Phase 2·Recruiting

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Correlation of Clinical Response to Pathologic Response in Patients With Early Breast Cancer

for Breast Cancer

2 locations incl. Houston

Sponsor: Baylor Breast Care Center

Sex: All·Age: 18+

Code: NCT05020860·Phase 2·Recruiting

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First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

for Breast Cancer

28 locations incl. Los Angeles

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT05768139·Phase 1, Phase 2·Recruiting

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Trial Of PreoperAtive Radiation (TOPAz): A Randomized Trial Comparing Hypofractionated Versus Conventionally Fractionated Preoperative Radiation Followed by Mastectomy With Immediate Autologous Breast Reconstruction With Integrated Nanomechanical Biomarker Evaluation

for Breast Cancer

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT05774678·Phase 3·Recruiting

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Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

for Breast Cancer

15 locations incl. Orlando

Sponsor: Incyclix Bio

Sex: All·Age: 18+

Code: NCT05735080·Phase 1, Phase 2·Recruiting

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Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts

for Breast Cancer

10 locations incl. Birmingham

Sponsor: American College of Radiology

Sex: Female·Age: 45 - 74·Accepts healthy volunteers

Code: NCT05625659·Recruiting

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(Z)-Endoxifen for the Treatment of Premenopausal Women With ER+/HER2- Breast Cancer

for Breast Neoplasms

15 locations incl. Phoenix

Sponsor: Atossa Therapeutics, Inc.

Sex: Female·Age: 18+

Code: NCT05607004·Phase 2·Recruiting

Apply to this trial

Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Participants With Metastatic Breast Cancer

for Breast Cancer

45 locations incl. Dothan

Sponsor: Stemline Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05563220·Phase 1, Phase 2·Recruiting

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The C-MERIT Screening Cohort: Contrast-enhanced Mammography for Breast Cancer Screening and Risk Assessment in Women With Dense Breasts

for Breast Cancer

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 30 - 75

Code: NCT05667532·Recruiting

Apply to this trial

Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics

for Breast Cancer

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05694559·Recruiting

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Identifying Underserved Individuals inTexas With Hereditary Cancer Risk Using Mobile Mammography Units and Telegenetics.

for Ovarian Cancer

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT05649072·Recruiting

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A Pilot Study to Assess the Clinical Utility of PYLARIFY PET-CT for Detecting Metastasis in Pancreatic Cancer, Hepatocellular Carcinoma and Breast Cancer

for Pancreatic Cancer

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT05394259·Phase 1·Recruiting

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Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

for Breast Neoplasms

11 locations incl. Fullerton

Sponsor: Stemline Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05386108·Phase 1, Phase 2·Recruiting

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Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer

for Metastatic Breast Cancer

Drug: Palazestrant

14 locations incl. Gilbert

Sponsor: Olema Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05508906·Phase 1·Recruiting

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Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

for Acute Lymphoblastic Leukemia

746 locations incl. Anchorage

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 40 - 75·Accepts healthy volunteers

Code: NCT05334069·Recruiting

Apply to this trial

A Study of XMT-1660 in Participants With Solid Tumors

for Triple Negative Breast Cancer

26 locations incl. Phoenix

Sponsor: Mersana Therapeutics

Sex: All·Age: 18+

Code: NCT05377996·Phase 1·Recruiting

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Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects

for Breast Cancer

51 locations incl. Mobile

Sponsor: Greenwich LifeSciences, Inc.

Sex: All·Age: 18 - 100

Code: NCT05232916·Phase 3·Recruiting

Apply to this trial