Paid Clinical Trials in Chicago, IL

As of June 2026, 2,235 paid clinical trials are recruiting in Chicago, Illinois. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,235 clinical trials

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Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement

for Pain Management

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: Female·Age: 18+

Code: NCT07487246·Phase 2·Not Yet Recruiting

PACU Discharge Readiness

for Patient Discharge

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT07588542·Not Yet Recruiting

Trial in HPV Prevention for the U.S. Vietnamese Community

for HPV-related Cancers

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07637630·Recruiting

Apply to this trial

Geriatric Assessment and Technology Evaluation in Prostate Cancer

for Prostate Cancer

1 location in Chicago

Sponsor: University of Chicago

Sex: Male·Age: 18 Minutes+

Code: NCT06215508·Recruiting

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Horizon Two: HR NDMM (MMRC-100)

for High Risk Newly Diagnosed Multiple Myeloma

7 locations incl. Atlanta

Sponsor: Multiple Myeloma Research Consortium

Sex: All·Age: 18+

Code: NCT07053436·Phase 2·Recruiting

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Correlation Between an Impedance Cardiography Test for Decompensation and the Development of Left Ventricular Replacement Fibrosis

for Aortic Stenosis

1 location in Chicago

Sponsor: Dermed Diagnostics, Inc.

Sex: All·Age: 18+

Code: NCT07230964·Recruiting

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Study of Oral Food Challenge Biomarkers (SAFER)

for Allergy

10 locations incl. Little Rock

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 12 Months - 17

Code: NCT07279467·Not Yet Recruiting

A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)

for Lung Neoplasm Malignant

2 locations incl. Clermont

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07286149·Phase 1, Phase 2·Recruiting

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52-week Open Label Safety-Tolerability Study

for Schizophrenia

23 locations incl. Chandler

Sponsor: LB Pharmaceuticals Inc.

Sex: All·Age: 18 - 65

Code: NCT07369154·Phase 3·Not Yet Recruiting

Study to Evaluate the Efficacy and Safety of BMN 333 Versus Vosoritide in Children With Achondroplasia

for Achondroplasia

Drug: Vosoritide

5 locations incl. Oakland

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: 2 - 17

Code: NCT07441876·Phase 2, Phase 3·Recruiting

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Watchful Waiting Versus Immediate Repair for Occult Contralateral Inguinal Hernias.

for Inguinal Hernia Bilateral

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07461558·Recruiting

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Combatting HIV Or Other STIs Early (CHOOSE)

for HIV

6 locations incl. San Francisco

Sponsor: Westat

Sex: Male·Age: 13 - 24·Accepts healthy volunteers

Code: NCT07510048·Phase 2·Not Yet Recruiting

Effects of Delay in Hearing Assistive Technology

for Audio Processing Delay

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07533071·Not Yet Recruiting

EEG Dynamics in Lennox-Gastaut Syndrome Patients Undergoing Fenfluramine Treatment

for Lennox Gastaut Syndrome (LGS)

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 2 - 35

Code: NCT07555171·Enrolling By Invitation

BOND: Direct Breastfeeding to Enhance Maternal and Infant Health in Congenital Heart Disease

for Congenital Heart Disease (CHD)

8 locations incl. Phoenix

Sponsor: Carelon Research

Sex: All·Age: 18+

Code: NCT07582848·Not Yet Recruiting

Prenatally-initiated Psychological Intervention for Mothers of Infants With Congenital Heart Disease (CHD)

for Congenital Heart Disease (CHD)

17 locations incl. Phoenix

Sponsor: Carelon Research

Sex: All·Age: 18+

Code: NCT07582861·Not Yet Recruiting

Selenium Supplementation in Moderate-Severely Active Ulcerative Colitis Patients Treated With Advanced Therapies

for Ulcerative Colitis (UC)

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 85

Code: NCT07427017·Phase 2·Recruiting

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Breakthrough - T1DM and Chronic Kidney Disease

for Diabete Type 1

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 70

Code: NCT07592000·Phase 1, Phase 2·Recruiting

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A Study to Learn About Salanersen's (BIIB115) Effects on Movement and Its Safety When Given Before Symptoms Appear in Babies With Genetically Diagnosed Spinal Muscular Atrophy (SMA)

for Muscular Atrophy, Spinal

3 locations incl. Chicago

Sponsor: Biogen

Sex: All·Age: 0 Days - 42 Days

Code: NCT07221669·Phase 3·Recruiting

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U.S. Prospective Evaluation of EPIONE Device for Percutaneous MSK Procedures

for Bone Tumor

3 locations incl. San Diego

Sponsor: Precision IO Group

Sex: All·Age: 22+

Code: NCT07325578·Recruiting

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A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer

for Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction , or Esophageal Adenocarcinoma

Drug: PF-08634404

57 locations incl. Aurora

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07392892·Phase 2, Phase 3·Recruiting

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ROAM OA: Functional and Patient Reported Outcomes Wearing a Knee Brace for Unicompartmental OA

for Knee Osteoarthritis

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 40 - 85

Code: NCT07224958·Recruiting

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Comparing Efficiency and Stone-Free Rates Mini PCNL vs Flex URS

for Kidney Stones

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07072598·Recruiting

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Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

for Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

51 locations incl. Tucson

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07195734·Phase 2·Recruiting

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PREcision MEDicine In Achalasia (PREMEDIA)

for Type I Achalasia

13 locations incl. Scottsdale

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07293650·Phase 3·Recruiting

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Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression

for Post Operative Delirium

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07610655·Recruiting

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A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma

for Glioblastoma Multiforme of Brain

3 locations incl. Tampa

Sponsor: Tetragon Biosciences Ltd

Sex: All·Age: 18+

Code: NCT07464925·Phase 1·Recruiting

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A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes

for Diabetes Mellitus, Type 2

Drug: NNC0662-0419

23 locations incl. Lancaster

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18 - 75

Code: NCT07415954·Phase 2·Recruiting

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Randomized Study on Transoral Outlet Reduction and Lifestyle Changes for Weight Regain After Gastric Bypass

for Weight Regain

9 locations incl. Irvine

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT07015424·Recruiting

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N-803 in Patients With Progressive Synovial Sarcoma and Myxoid/Round Cell Liposarcoma Previously Treated With Adoptive Cellular Therapy

for Myxoid Liposarcoma

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 80

Code: NCT07261657·EARLY_Phase 1·Recruiting

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PREACTIVE: Preconditioning Exercise Intervention to Improve Symptoms and Quality of Life in Comorbid Atrial Fibrillation and HFpEF

for Atrial Fibrillation (AF)

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 60 - 99

Code: NCT07324772·Not Yet Recruiting

Choice and Autonomy in Learning Mindfulness for Pediatric Residents

for Program Engagement

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07542769·Recruiting

Apply to this trial

Pharmacokinetic and Early Efficacy of OPT101 in Patients With Type 1 Diabetes Mellitus

for Type I Diabetes

5 locations incl. Birmingham

Sponsor: Op-T LLC

Sex: All·Age: 18 - 50

Code: NCT06964087·Phase 2·Recruiting

Apply to this trial

Menopausal HT for Women Living With HIV (HoT)

for HIV Infection

23 locations incl. Birmingham

Sponsor: Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

Sex: Female·Age: 40 - 60

Code: NCT06856174·Phase 4·Recruiting

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A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

for Solid Tumors

Drug: INCB161734

68 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07522073·Phase 3·Recruiting

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Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using the SGLT2 Inhibitors, Empagliflozin

for Sickle Cell Anemia (HbSS, or HbSβ-thalassemia0)

Drug: Empagliflozin

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 60

Code: NCT07175051·Phase 2·Recruiting

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A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively

for Schizophrenia

Drug: KarXT

19 locations incl. Anaheim

Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Sex: All·Age: 5 - 17

Code: NCT07424404·Phase 3·Recruiting

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An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)

for Post Traumatic Stress Disorder

26 locations incl. Little Rock

Sponsor: Transcend Therapeutics

Sex: All·Age: 18+

Code: NCT07456696·Phase 3·Recruiting

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Second Line Endovascular Treatment in Acute DVT

for Deep Venous Thrombosis

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18 - 75

Code: NCT06486181·Phase 4·Not Yet Recruiting

Evaluating The Efficacy Of Combined Cognitive Processing Therapy and Stellate Ganglion Blocks for PTSD

for PTSD

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT06570213·EARLY_Phase 1·Recruiting

Apply to this trial