Breast cancer Clinical Trials in Chicago, IL

As of June 2026, 53 paid clinical trials are recruiting for Breast cancer in Chicago, Illinois. Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

Related specialties in Chicago

Oncology· 709 Women's health· 129 Breast oncology· 92

Filter results

State

City

Facility

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

53 clinical trials for Breast cancer

·Clear filters·↓ Download CSV

First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer

for PIK3CA Mutation

24 locations incl. Tucson

Sponsor: Relay Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05216432·Phase 1·Recruiting

Apply to this trial

Evaluation of Talazoparib, a PARP Inhibitor, in Patients With Somatic BRCA Mutant Metastatic Breast Cancer: Genotyping Based Clinical Trial

for Breast Cancer

7 locations incl. San Francisco

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT03990896·Phase 2·Recruiting

Apply to this trial

ATEMPT 2.0: Adjuvant T-DM1 vs TH

for Breast Cancer

53 locations incl. San Francisco

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04893109·Phase 2·Recruiting

Apply to this trial

Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer

for Breast Cancer

7 locations incl. Washington D.C.

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04841148·Phase 2·Recruiting

Apply to this trial

Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

for Breast Cancer

15 locations incl. Stamford

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04468061·Phase 2·Recruiting

Apply to this trial

Atezolizumab + Sacituzumab Govitecan to Prevent Recurrence in TNBC (ASPRIA)

for Breast Cancer

Drug: Atezolizumab

7 locations incl. San Francisco

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04434040·Phase 2·Recruiting

Apply to this trial

A Multi-Modality Surveillance Program for Women at High Risk for Breast Cancer

for Breast Cancer

1 location in Chicago

Sponsor: University of Chicago

Sex: Female·Age: 25+·Accepts healthy volunteers

Code: NCT03729115·Recruiting

Apply to this trial

Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer

for Breast Cancer

451 locations incl. Fairbanks

Sponsor: Canadian Cancer Trials Group

Sex: Female·Age: 35+

Code: NCT03488693·Phase 3·Recruiting

Apply to this trial

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

for Cancer, Metastatic

67 locations incl. Birmingham

Sponsor: Massive Bio, Inc.

Sex: All·Age: All ages

Code: NCT03452774·Recruiting

Apply to this trial

MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles

for Breast Cancer

130 locations incl. Birmingham

Sponsor: Agendia

Sex: All·Age: 18+

Code: NCT03053193·Recruiting

Apply to this trial

Women Informed to Screen Depending on Measures of Risk (Wisdom Study)

for Breast Cancer Screening

11 locations incl. Birmingham

Sponsor: University of California, San Francisco

Sex: Female·Age: 30 - 74·Accepts healthy volunteers

Code: NCT02620852·Recruiting

Apply to this trial

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

for Breast Neoplasms

42 locations incl. Birmingham

Sponsor: QuantumLeap Healthcare Collaborative

Sex: All·Age: 18+

Code: NCT01042379·Phase 2·Recruiting

Apply to this trial

Collecting Tissue Samples for Future Research From Women Undergoing Surgery for Breast Cancer

for Breast Cancer

1 location in Chicago

Sponsor: Northwestern University

Sex: Female·Age: All ages

Code: NCT00898131·Recruiting

Apply to this trial