Ziltivekimab Clinical Trials (2026): 11 Studies for Inflammation & Cardiovascular Risk
Hipa.ai Research · Source: ClinicalTrials.gov / AACT
Synced daily from ClinicalTrials.gov via AACT. Last sync: .
11 Ziltivekimab clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 9 indications (including Inflammation & Cardiovascular Risk) and 23,775 total planned enrollment. 7 Phase 3 Ziltivekimab trials and 2 Phase 2 are listed. 6 Ziltivekimab clinical trials are actively recruiting at 134 U.S. sites across 35 states. Most recent activity: NCT07301034 (Feb 2029).
Where to Participate: All Ziltivekimab Trial Sites in the U.S. (134 sites across 35 states)
Every actively recruiting Ziltivekimabtrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.
| State | Facility | City | Trial | Map |
|---|---|---|---|---|
| AL | Advanced Cardiovascular, LLC | Alexander City35010 | NCT05636176 | Map |
| AL | Eastern Shore Rsrch Inst, LLC | Fairhope36532 | NCT05636176 | Map |
| AL | Heart Center Rsrch_Hunstville | Huntsville35801 | NCT05636176 | Map |
| CA | InvivoCure -2 | Alhambra91801 | NCT05636176 | Map |
| CA | National Heart Institute Cal | Beverly Hills90211 | NCT05636176 | Map |
| CA | Valley Clinical Trials | Covina91723 | NCT05636176 | Map |
| CA | Purushotham & Akther Kotha MD, inc. | La Mesa91942 | NCT05636176 | Map |
| CA | VA Loma Linda Hlthcr Sys | Loma Linda92357 | NCT05636176 | Map |
| CA | Biopharma Clinical Research Services, LLC | Los Angeles90035 | NCT05636176 | Map |
| CA | VA Greater Los Angeles Hlthcare System | Los Angeles90073 | NCT05636176 | Map |
| CA | VAGrtrLosAngelesHlthcareSystem | Los Angeles90073 | NCT05636176 | Map |
| CA | Valley Clinical Trials, Inc. | Northridge91325 | NCT05636176 | Map |
| CA | Valley Clinical Trials, Inc. | Northridge91325 | NCT06200207 | Map |
| CA | San Diego Cardiac Center | San Diego92123 | NCT05636176 | Map |
| CA | North America Research Institute | San Dimas91773 | NCT05636176 | Map |
| CA | Manshadi Heart Institute | Stockton95204 | NCT05636176 | Map |
| CA | Lundquist Inst-Biomed Innovtn | Torrance90502 | NCT05636176 | Map |
| CA | InvivoCure | Van Nuys91405 | NCT05636176 | Map |
| CO | Rocky Mountain Regional VAMC | Aurora80045 | NCT05636176 | Map |
| CT | Bridgeport Hospital | Bridgeport06610 | NCT05636176 | Map |
| CT | Cardiology Associates of Fairfield County | Stamford06905 | NCT05636176 | Map |
| FL | Pioneer Clinical Studies-Coral Gables | Coral Gables33134 | NCT05636176 | Map |
| FL | Nature Coast Clin Rsrch_Crystal River | Crystal River34429 | NCT05636176 | Map |
| FL | New Generation of Medical Research | Hialeah33016 | NCT05636176 | Map |
| FL | Memorial Region Hosp_Hollywood | Hollywood33021 | NCT05636176 | Map |
| FL | Baptist Health Research Institute | Jacksonville32258 | NCT05636176 | Map |
| FL | Jacksonville Ctr for Clin Res | Jacksonville32216 | NCT05636176 | Map |
| FL | Clearwater Cardiovascular Consultants | Largo33777 | NCT06200207 | Map |
| FL | Baptist Health South Florida | Miami33173 | NCT05636176 | Map |
| FL | Pioneer Clinical Studies-Coral Gables | Miami33176 | NCT05636176 | Map |
| FL | NCH Research Institute | Naples34102 | NCT05636176 | Map |
| FL | Amavita Research Services, LLC | North Miami Beach33169 | NCT05636176 | Map |
| FL | Ocala Cardiovascular Research | Ocala34471 | NCT05636176 | Map |
| FL | Ormond Beach Clinical Research | Ormond Beach32174 | NCT05636176 | Map |
| FL | St Johns Ctr Clin Rsch-St. Aug | Saint Augustine32086 | NCT05636176 | Map |
| FL | Cardio Partners Clin Res Inst | Wellington33449 | NCT05636176 | Map |
| FL | Winter Haven Hospital | Winter Haven33881 | NCT05636176 | Map |
| FL | Winter Haven Hospital | Winter Haven33881 | NCT06118281 | Map |
| FL | Guardian Research Org LLC | Winter Park32792 | NCT05636176 | Map |
| GA | Emory University School of Medicine_Atlanta | Atlanta30322 | NCT05636176 | Map |
| GA | Morehouse School of Medicine | Atlanta30310 | NCT05636176 | Map |
| GA | NSC Research, Inc | Johns Creek30024 | NCT05636176 | Map |
| GA | GA Arrhythmia Cons & Rsch Inst | Macon31201 | NCT05636176 | Map |
| ID | St. Luke's Idaho Cardiology Associates | Meridian83642 | NCT05636176 | Map |
| IL | Chicago Medical Research LLC | Hazel Crest60429 | NCT05636176 | Map |
| IL | Midwest Cardiovascular Institute | Naperville60540 | NCT05636176 | Map |
| IL | Methodist Medical Center of Illinois | Peoria61636 | NCT05636176 | Map |
| IL | OSF HealthCare_Cardiovasc Inst | Peoria61614 | NCT05636176 | Map |
| IN | Midwest Cardiovascu Rsrch Foundation | Elkhart46514 | NCT05636176 | Map |
| IN | Asha Clinical Rsch-Munster, LLC | Hammond46324 | NCT05636176 | Map |
| IN | Franciscan Network-IN Heart PHY | Indianapolis46237 | NCT05636176 | Map |
| IN | Cardiovascular Rsrch of NW_IN | Munster46321 | NCT05636176 | Map |
| IN | Reid Physician Associates | Richmond47374 | NCT05636176 | Map |
| IA | University Of Iowa Hospitals and Clinics | Iowa City52242 | NCT05636176 | Map |
| KS | Midwest Heart & Vasc Spec | Overland Park66211 | NCT05636176 | Map |
| KY | Baptist Health Hardin | Elizabethtown42701 | NCT05636176 | Map |
| KY | Baptist Health Louisville | Louisville40207 | NCT05636176 | Map |
| LA | LOUISIANA HEART Center | Bogalusa70427 | NCT05636176 | Map |
| LA | Heart Clinic of Hammond | Hammond70403 | NCT05636176 | Map |
| LA | University Medical Center New Orleans | New Orleans70112 | NCT05636176 | Map |
| MD | Ascension Saint Agnes Heart Ca | Baltimore21229 | NCT05636176 | Map |
| MD | Johns Hopkins University_Baltimore | Baltimore21287 | NCT05636176 | Map |
| MD | Capitol Cardiology Assoc_Lanham | Lanham20706 | NCT05636176 | Map |
| MD | MD Medical Research | Oxon Hill20745 | NCT05636176 | Map |
| MA | Pentucket Medical Associates | Haverhill01830 | NCT05636176 | Map |
| MI | Detroit Med Center-Wayne State | Detroit48201 | NCT05636176 | Map |
| MI | Trinity Health Michigan Heart | Ypsilanti48197 | NCT05636176 | Map |
| MN | Fairview Health Services | Maplewood55109 | NCT05636176 | Map |
| MN | Minneapolis VA Health Care Sys | Minneapolis55417 | NCT05636176 | Map |
| MS | Cardiolg Assoc Rsch LLC_Tupelo | Tupelo38801 | NCT06118281 | Map |
| MO | Kansas City VA Medical Center | Kansas City64128 | NCT06200207 | Map |
| MO | St Louis Heart & Vascular, P.C. | St Louis63136 | NCT05636176 | Map |
| NE | Univ. of Nebraska Medical Center_Omaha | Omaha68198 | NCT05636176 | Map |
| NV | Palm Research Center Inc. | Las Vegas89128 | NCT05636176 | Map |
| NJ | NJ Heart | Linden07036 | NCT05636176 | Map |
| NJ | Barnabas Health | Livingston07039 | NCT05636176 | Map |
| NJ | Inspira Health | Mullica Hill08062 | NCT05636176 | Map |
| NJ | Saint Michael's Med Ctr NJ | Newark07102 | NCT05636176 | Map |
| NY | Capital Cardiology Associates_Albany | Albany12211 | NCT05636176 | Map |
| NY | Mount Sinai Hosp at NYC | New York10019 | NCT05636176 | Map |
| NY | Mount Sinai Hosp at NYC | New York10029 | NCT05636176 | Map |
| NY | NY Presbyt Hosp-W Cornell Med | New York10021 | NCT05636176 | Map |
| NY | Laurelton Heart Specialist PC | Rosedale11422 | NCT05636176 | Map |
| NY | Saratoga Clinical Research | Saratoga Springs12866 | NCT05636176 | Map |
| NY | Stony Brook University Hospital | Stony Brook11794 | NCT05636176 | Map |
| NY | Chear Center LLC | The Bronx10455 | NCT05636176 | Map |
| NY | Jacobi Medical Center | The Bronx10461 | NCT06118281 | Map |
| NC | Duke University | Durham27710 | NCT05636176 | Map |
| NC | Medication Mgmnt, LLC_Grnsboro | Greensboro27405 | NCT05636176 | Map |
| NC | Carteret Medical Group | Morehead City28557 | NCT05636176 | Map |
| NC | UNC Rex Healthcare | Raleigh27607 | NCT05636176 | Map |
| ND | Trinity Medical Group | Minot58701 | NCT06118281 | Map |
| OH | Aultman Hospital | Canton44710 | NCT05636176 | Map |
| OH | K&R Research Llc | Marion43302 | NCT05636176 | Map |
| OH | Rama Research LLC | Marion43302 | NCT05636176 | Map |
| OK | South Oklahoma Heart Research, LLC | Oklahoma City73135 | NCT05636176 | Map |
| PA | Capital Area Research LLC | Camp Hill17011 | NCT05636176 | Map |
| PA | Penn State Hlth Holy Spirit Med Ctr | Camp Hill17011 | NCT05636176 | Map |
| PA | Chambersburg Hospital | Chambersburg17201 | NCT06118281 | Map |
| PA | Geisinger Medical Center | Danville17822 | NCT05636176 | Map |
| PA | Thomas Jefferson University_Philadelphia | Philadelphia19114 | NCT05636176 | Map |
| PA | Penn State Health-Berks Cardiology | Wyomissing19610 | NCT05636176 | Map |
| SD | Monument Health Clinical Rsrch | Rapid City57701 | NCT05636176 | Map |
| SD | Sanford Health_Sioux Falls | Sioux Falls57117 | NCT05636176 | Map |
| TN | Apex Research Foundation, LLC | Jackson38301 | NCT05636176 | Map |
| TN | The Jackson Clinic, PA | Jackson38305 | NCT05636176 | Map |
| TN | Tennova HC Turkey Creek MC | Knoxville37934 | NCT05636176 | Map |
| TX | Heart MD_Allen TX | Allen75013 | NCT05636176 | Map |
| TX | PharmaTex Research | Amarillo79106 | NCT06200207 | Map |
| TX | PharmaTex Research, LLC | Amarillo79106 | NCT05636176 | Map |
| TX | Austin Heart | Austin78756 | NCT05636176 | Map |
| TX | UTD SW Medical Center-Dallas | Dallas75390 | NCT05636176 | Map |
| TX | Dallas Heart and Vascular | Duncanville75137 | NCT05636176 | Map |
| TX | David Turbay, MD, PLLC | El Paso79905 | NCT05636176 | Map |
| TX | Biopharma Informatic_Houston | Houston77025 | NCT05636176 | Map |
| TX | Card Specialists of Willowbrook | Houston77070 | NCT05636176 | Map |
| TX | Houston Methodist Hospital | Houston77030-2703 | NCT05636176 | Map |
| TX | Texas Institute of Cardiology PA | McKinney75071 | NCT05636176 | Map |
| TX | Clinical Advancement Center | San Antonio78212 | NCT05636176 | Map |
| TX | Methodist Healthcare System of San Antonio | San Antonio78229 | NCT06118281 | Map |
| TX | Sherman Clinical Research | Sherman75092 | NCT05636176 | Map |
| VT | University of Vermont Med Ctr | Burlington05401 | NCT05636176 | Map |
| VT | University of Vermont Medical Center | Burlington05401 | NCT05636176 | Map |
| VA | University of Virginia | Charlottesville22908 | NCT05636176 | Map |
| VA | James River Cardiology | Chesterfield23832 | NCT05636176 | Map |
| VA | Carient Heart and Vascular | Manassas20109 | NCT05636176 | Map |
| VA | Sentara Health Research Center | Norfolk23507 | NCT05636176 | Map |
| VA | York Clinical Research LLC | Norfolk23504 | NCT05636176 | Map |
| VA | VA Medical Center_Salem | Salem24153-6404 | NCT05636176 | Map |
| VA | Selma Medical Associates | Winchester22601-3834 | NCT05636176 | Map |
| VA | Valley Health Link | Winchester22601 | NCT05636176 | Map |
| WA | Swedish Medical Center_Seattle | Seattle98122-5789 | NCT05636176 | Map |
| WA | Providence Med Research Ctr | Spokane99204 | NCT05636176 | Map |
| WI | William S Middleton Mem VA Hosp | Madison53705 | NCT05636176 | Map |
Ziltivekimab clinical trials at a glance: phase × recruitment status
| Phase | recruiting | active not recruiting | completed | Total |
|---|---|---|---|---|
| P1 | 2 | 2 | ||
| P2 | 2 | 2 | ||
| P3 | 6 | 1 | 7 |
Recruiting Ziltivekimab clinical trials (6)
Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).
| NCT ID | Title | Phase | Indication | Enrollment | Started |
|---|---|---|---|---|---|
| NCT07301034 | ZEPHYRA Research Study to Look at the Effect of Ziltivekimab on Plaque in the Blood Vessels of the Heart, Compared to Placebo, in People With a Heart Attack | P3 | Myocardial Infarction | 332 | Dec 2025 |
| NCT07276282 | ZEPHYREffects of Ziltivekimab on Coronary Atherosclerotic Burden in Patients With Acute Myocardial Infarction | P3 | Coronary Artery Disease | 332 | Dec 2025 |
| NCT05636176 | HERMESA Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation | P3 | Heart Failure | 5,600 | May 2023 |
| NCT06200207 | ATHENAA Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation | P3 | Heart Failure | 680 | Apr 2024 |
| NCT06118281 | ARTEMISARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack | P3 | Cardiovascular Risk | 10,000 | Jun 2024 |
| NCT06263244 | SPIDERSpecifying the Anti-inflammatory Effects of Ziltivekimab | P3 | Atherosclerosis | 40 | May 2024 |
Ziltivekimab clinical trials by indication
Cardiovascular Risk (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06118281 | ARTEMIS | P3 | recruiting | ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack |
| NCT05021835 | ZEUS | P3 | active not recruiting | ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation |
Heart Failure (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05636176 | HERMES | P3 | recruiting | A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation |
| NCT06200207 | ATHENA | P3 | recruiting | A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation |
Coronary Artery Disease (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07276282 | ZEPHYR | P3 | recruiting | Effects of Ziltivekimab on Coronary Atherosclerotic Burden in Patients With Acute Myocardial Infarction |
Myocardial Infarction (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07301034 | ZEPHYR | P3 | recruiting | A Research Study to Look at the Effect of Ziltivekimab on Plaque in the Blood Vessels of the Heart, Compared to Placebo, in People With a Heart Attack |
Atherosclerosis (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06263244 | SPIDER | P3 | recruiting | Specifying the Anti-inflammatory Effects of Ziltivekimab |
Healthy Participants (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05721989 | — | P1 | completed | A Research Study Looking Into Blood Levels of Three Different Formulations of the Study Medicine Ziltivekimab |
Chronic Kidney Disease and Systemic Inflammation (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05379829 | — | P1 | completed | A Research Study of How the Medicine Ziltivekimab Works in the Body of Chinese Men and Women With Kidney Disease and Inflammation |
Chronic Kidney Disease (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT04626505 | RESCUE-2 | P2 | completed | Trial to Evaluate Reduction in Inflammation in Patients With Advanced Chronic Renal Disease Utilizing Antibody Mediated IL-6 Inhibition in Japan. |
Chronic Kidney Diseases (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT03926117 | RESCUE | P2 | completed | Trial to Evaluate Reduction in Inflammation in Patients With Advanced Chronic Renal Disease Utilizing Antibody Mediated IL-6 Inhibition |
Ziltivekimab pivotal trial highlights (Phase 2/3/4)
Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.
| Acronym | NCT | Phase | Status | Indication | Enrollment | PubMed |
|---|---|---|---|---|---|---|
| ZEPHYR | NCT07301034 | P3 | recruiting | Myocardial Infarction | 332 | — |
| ZEPHYR | NCT07276282 | P3 | recruiting | Coronary Artery Disease | 332 | — |
| HERMES | NCT05636176 | P3 | recruiting | Heart Failure | 5,600 | — |
| ATHENA | NCT06200207 | P3 | recruiting | Heart Failure | 680 | — |
| ARTEMIS | NCT06118281 | P3 | recruiting | Cardiovascular Risk | 10,000 | — |
| SPIDER | NCT06263244 | P3 | recruiting | Atherosclerosis | 40 | — |
| ZEUS | NCT05021835 | P3 | active not recruiting | Cardiovascular Risk | 6,200 | PMID 40318255 |
| RESCUE-2 | NCT04626505 | P2 | completed | Chronic Kidney Disease | 36 | PMID 37211246 |
| RESCUE | NCT03926117 | P2 | completed | Chronic Kidney Diseases | 264 | PMID 35212585 |
All Ziltivekimab trials (11)
Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.
| NCT ID | Acronym | Title | Phase | Status | Enrollment | Sponsor | Started |
|---|---|---|---|---|---|---|---|
| NCT07301034 | ZEPHYR | A Research Study to Look at the Effect of Ziltivekimab on Plaque in the Blood Vessels of the Heart, Compared to Placebo, in People With a Heart Attack | P3 | recruiting | 332 | Novo Nordisk A/S | Dec 2025 |
| NCT07276282 | ZEPHYR | Effects of Ziltivekimab on Coronary Atherosclerotic Burden in Patients With Acute Myocardial Infarction | P3 | recruiting | 332 | ECRI bv | Dec 2025 |
| NCT05636176 | HERMES | A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation | P3 | recruiting | 5,600 | Novo Nordisk A/S | May 2023 |
| NCT06200207 | ATHENA | A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation | P3 | recruiting | 680 | Novo Nordisk A/S | Apr 2024 |
| NCT06118281 | ARTEMIS | ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack | P3 | recruiting | 10,000 | Novo Nordisk A/S | Jun 2024 |
| NCT06263244 | SPIDER | Specifying the Anti-inflammatory Effects of Ziltivekimab | P3 | recruiting | 40 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | May 2024 |
| NCT05021835 | ZEUS | ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation | P3 | active not recruiting | 6,200 | Novo Nordisk A/S | Aug 2021 |
| NCT05379829 | A Research Study of How the Medicine Ziltivekimab Works in the Body of Chinese Men and Women With Kidney Disease and Inflammation | P1 | completed | 24 | Novo Nordisk A/S | May 2022 | |
| NCT05721989 | A Research Study Looking Into Blood Levels of Three Different Formulations of the Study Medicine Ziltivekimab | P1 | completed | 267 | Novo Nordisk A/S | Feb 2023 | |
| NCT04626505 | RESCUE-2 | Trial to Evaluate Reduction in Inflammation in Patients With Advanced Chronic Renal Disease Utilizing Antibody Mediated IL-6 Inhibition in Japan. | P2 | completed | 36 | Novo Nordisk A/S | Oct 2020 |
| NCT03926117 | RESCUE | Trial to Evaluate Reduction in Inflammation in Patients With Advanced Chronic Renal Disease Utilizing Antibody Mediated IL-6 Inhibition | P2 | completed | 264 | Novo Nordisk A/S | Jun 2019 |
Ziltivekimab clinical trials: frequently asked questions
- How many Ziltivekimab clinical trials are there?
- 11 Ziltivekimab clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 6 are actively recruiting participants. 4 are marked completed.
- Are Ziltivekimab clinical trials recruiting in 2026?
- Yes — 6 Ziltivekimab trials are actively recruiting in 2026, with 134 U.S. sites across 35 states. See the recruiting trials and the per-state site list further down this page.
- What conditions is Ziltivekimab being studied for?
- Ziltivekimab is being studied for Inflammation, Cardiovascular Risk, Heart Failure, Chronic Kidney Disease, Acute Myocardial Infarction (AMI) and 8 more. The trials are grouped by indication on this page.
- What phase is Ziltivekimab in?
- Ziltivekimab clinical trials span 7 Phase 3, 2 Phase 2, 2 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
- Who sponsors Ziltivekimab clinical trials?
- The lead sponsor across the most Ziltivekimab trials is Novo Nordisk A/S, with 2 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.
Sources and methodology
Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Ziltivekimabas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.
Last refreshed .
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