Zilebesiran Clinical Trials (2026): 4 Studies for Hypertension & High Cardiovascular Risk
Hipa.ai Research · Source: ClinicalTrials.gov / AACT
Synced daily from ClinicalTrials.gov via AACT. Last sync: .
4 Zilebesiran clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 4 indications (including Hypertension & High Cardiovascular Risk) and 12,074 total planned enrollment. 1 Phase 3 Zilebesiran trial and 2 Phase 2 are listed. 1 Zilebesiran clinical trial is actively recruiting at 202 U.S. sites across 34 states. Most recent activity: NCT07181109 (Sep 2030).
Where to Participate: All Zilebesiran Trial Sites in the U.S. (202 sites across 34 states)
Every actively recruiting Zilebesirantrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.
| State | Facility | City | Trial | Map |
|---|---|---|---|---|
| AL | Clinical Trial Site | Birmingham35211 | NCT07181109 | Map |
| AL | Clinical Trial Site | Fairhope36532 | NCT07181109 | Map |
| AL | Clinical Trial Site | Foley36535 | NCT07181109 | Map |
| AL | Clinical Trial Site | Huntsville35805 | NCT07181109 | Map |
| AL | Clinical Trial Site | Sheffield35660 | NCT07181109 | Map |
| AZ | Clinical Trial Site | Chandler85224 | NCT07181109 | Map |
| AZ | Clinical Trial Site | Gilbert85296 | NCT07181109 | Map |
| AZ | Clinical Trial Site | Phoenix85015 | NCT07181109 | Map |
| AZ | Clinical Trial Site | Phoenix85020 | NCT07181109 | Map |
| AZ | Clinical Trial Site | Sun City West85375 | NCT07181109 | Map |
| AZ | Clinical Trial Site | Tucson85715 | NCT07181109 | Map |
| AZ | Clinical Trial Site | Tucson85741 | NCT07181109 | Map |
| AZ | Clinical Trial Site | Yuma85364 | NCT07181109 | Map |
| AR | Clinical Trial Site | Little Rock72204 | NCT07181109 | Map |
| AR | Clinical Trial Site | Little Rock72205 | NCT07181109 | Map |
| CA | Clinical Trial Site | Beverly Hills90211 | NCT07181109 | Map |
| CA | Clinical Trial Site | Chula Vista91910 | NCT07181109 | Map |
| CA | Clinical Trial Site | Covina91723 | NCT07181109 | Map |
| CA | Clinical Trial Site | Escondido92025 | NCT07181109 | Map |
| CA | Clinical Trial Site | Glendale91206 | NCT07181109 | Map |
| CA | Clinical Trial Site | Lancaster93534 | NCT07181109 | Map |
| CA | Clinical Trial Site | Long Beach90815 | NCT07181109 | Map |
| CA | Clinical Trial Site | Lynwood90262 | NCT07181109 | Map |
| CA | Clinical Trial Site | Newhall91321 | NCT07181109 | Map |
| CA | Clinical Trial Site | Northridge91325 | NCT07181109 | Map |
| CA | Clinical Trial Site | Pasadena91105 | NCT07181109 | Map |
| CA | Clinical Trial Site | San Diego92111 | NCT07181109 | Map |
| CA | Clinical Trial Site | San Dimas91773 | NCT07181109 | Map |
| CA | Clinical Trial Site | Tarzana91356 | NCT07181109 | Map |
| CA | Clinical Trial Site | Toluca Lake91602 | NCT07181109 | Map |
| CA | Clinical Trial Site | Tustin92780 | NCT07181109 | Map |
| CA | Clinical Trial Site | Vista92081 | NCT07181109 | Map |
| CA | Clinical Trial Site | Walnut Creek94598 | NCT07181109 | Map |
| CT | Clinical Trial Site | Bridgeport06610 | NCT07181109 | Map |
| FL | Clinical Trial Site | Boca Raton33434 | NCT07181109 | Map |
| FL | Clinical Trial Site | Brandon33511 | NCT07181109 | Map |
| FL | Clinical Trial Site | Fleming Island32003 | NCT07181109 | Map |
| FL | Clinical Trial Site | Fort Lauderdale33308 | NCT07181109 | Map |
| FL | Clinical Trial Site | Hialeah33012 | NCT07181109 | Map |
| FL | Clinical Trial Site | Hollywood33024 | NCT07181109 | Map |
| FL | Clinical Trial Site | Homestead33030 | NCT07181109 | Map |
| FL | Clinical Trial Site | Jacksonville32205 | NCT07181109 | Map |
| FL | Clinical Trial Site | Jacksonville32216 | NCT07181109 | Map |
| FL | Clinical Trial Site | Jensen Beach34957 | NCT07181109 | Map |
| FL | Clinical Trial Site | Leesburg34748 | NCT07181109 | Map |
| FL | Clinical Trial Site | Melbourne32934 | NCT07181109 | Map |
| FL | Clinical Trial Site | Miami33134 | NCT07181109 | Map |
| FL | Clinical Trial Site | Miami33135 | NCT07181109 | Map |
| FL | Clinical Trial Site | Miami33155 | NCT07181109 | Map |
| FL | Clinical Trial Site | Miami33186 | NCT07181109 | Map |
| FL | Clinical Trial Site | Orlando32825 | NCT07181109 | Map |
| FL | Clinical Trial Site | Palm Springs33406 | NCT07181109 | Map |
| FL | Clinical Trial Site | Tampa33615 | NCT07181109 | Map |
| FL | Clinical Trial Site | Wellington33449 | NCT07181109 | Map |
| GA | Clinical Trial Site | Atlanta30342 | NCT07181109 | Map |
| GA | Clinical Trial Site | Brunswick31520 | NCT07181109 | Map |
| GA | Clinical Trial Site | Columbus31901 | NCT07181109 | Map |
| GA | Clinical Trial Site | Columbus31904 | NCT07181109 | Map |
| GA | Clinical Trial Site | Conyers30012 | NCT07181109 | Map |
| GA | Clinical Trial Site | Conyers30094 | NCT07181109 | Map |
| GA | Clinical Trial Site | Fayetteville30214 | NCT07181109 | Map |
| GA | Clinical Trial Site | Johns Creek30024 | NCT07181109 | Map |
| GA | Clinical Trial Site | Lawrenceville30044 | NCT07181109 | Map |
| GA | Clinical Trial Site | Macon31201 | NCT07181109 | Map |
| IL | Clinical Trial Site | Chicago60640 | NCT07181109 | Map |
| IL | Clinical Trial Site | Hazel Crest60429 | NCT07181109 | Map |
| IL | Clinical Trial Site | Oak Brook60523 | NCT07181109 | Map |
| IL | Clinical Trial Site | Orland Park60462 | NCT07181109 | Map |
| IL | Clinical Trial Site | Springfield62701 | NCT07181109 | Map |
| IL | Clinical Trial Site | Tinley Park60477 | NCT07181109 | Map |
| IN | Clinical Trial Site | Avon46123 | NCT07181109 | Map |
| IN | Clinical Trial Site | Evansville47714 | NCT07181109 | Map |
| IN | Clinical Trial Site | Evansville47715 | NCT07181109 | Map |
| IN | Clinical Trial Site | Greenfield46140 | NCT07181109 | Map |
| IN | Clinical Trial Site | South Bend46617 | NCT07181109 | Map |
| IN | Clinical Trial Site | Valparaiso46383 | NCT07181109 | Map |
| KS | Clinical Trial Site | Hutchinson67502 | NCT07181109 | Map |
| KS | Clinical Trial Site | Topeka66606 | NCT07181109 | Map |
| KS | Clinical Trial Site | Wichita67214 | NCT07181109 | Map |
| KS | Clinical Trial Site | Wichita67218 | NCT07181109 | Map |
| KY | Clinical Trial Site | Bowling Green42101 | NCT07181109 | Map |
| KY | Clinical Trial Site | Lexington40503 | NCT07181109 | Map |
| KY | Clinical Trial Site | Versailles40383 | NCT07181109 | Map |
| LA | Clinical Trial Site | Hammond70403 | NCT07181109 | Map |
| LA | Clinical Trial Site | Lafayette70503 | NCT07181109 | Map |
| LA | Clinical Trial Site | Opelousas70570 | NCT07181109 | Map |
| LA | Clinical Trial Site | Shreveport71105 | NCT07181109 | Map |
| LA | Clinical Trial Site | Zachary70791 | NCT07181109 | Map |
| MD | Clinical Trial Site | Baltimore21229 | NCT07181109 | Map |
| MD | Clinical Trial Site | Beltsville20705 | NCT07181109 | Map |
| MD | Clinical Trial Site | Bowie20715 | NCT07181109 | Map |
| MD | Clinical Trial Site | Lanham20706 | NCT07181109 | Map |
| MD | Clinical Trial Site | Rockville20850 | NCT07181109 | Map |
| MI | Clinical Trial Site | Flint48504 | NCT07181109 | Map |
| MI | Clinical Trial Site | Shelby48315 | NCT07181109 | Map |
| MI | Clinical Trial Site | Southfield48075 | NCT07181109 | Map |
| MI | Clinical Trial Site | Troy48085 | NCT07181109 | Map |
| MI | Clinical Trial Site | Troy48098 | NCT07181109 | Map |
| MN | Clinical Trial Site | Richfield55423 | NCT07181109 | Map |
| MS | Clinical Trial Site | Jackson39216 | NCT07181109 | Map |
| MS | Clinical Trial Site | Olive Branch38654 | NCT07181109 | Map |
| MS | Clinical Trial Site | Port Gibson39150 | NCT07181109 | Map |
| MS | Clinical Trial Site | Ridgeland39157 | NCT07181109 | Map |
| MO | Clinical Trial Site | Kansas City64111 | NCT07181109 | Map |
| MO | Clinical Trial Site | Kansas City64151 | NCT07181109 | Map |
| MO | Clinical Trial Site | St Louis63136 | NCT07181109 | Map |
| NE | Clinical Trial Site | Fremont68025 | NCT07181109 | Map |
| NV | Clinical Trial Site | Las Vegas89121 | NCT07181109 | Map |
| NV | Clinical Trial Site | Las Vegas89148 | NCT07181109 | Map |
| NJ | Clinical Trial Site | Brick08724 | NCT07181109 | Map |
| NJ | Clinical Trial Site | Bridgewater08807 | NCT07181109 | Map |
| NJ | Clinical Trial Site | Flemington08822 | NCT07181109 | Map |
| NM | Clinical Trial Site | Albuquerque87106 | NCT07181109 | Map |
| NY | Clinical Trial Site | New Windsor12553 | NCT07181109 | Map |
| NY | Clinical Trial Site | North Massapequa11758 | NCT07181109 | Map |
| NY | Clinical Trial Site | Riverhead11901 | NCT07181109 | Map |
| NY | Clinical Trial Site | Rosedale11422 | NCT07181109 | Map |
| NY | Clinical Trial Site | The Bronx10461 | NCT07181109 | Map |
| NY | Clinical Trial Site | West Seneca14224 | NCT07181109 | Map |
| NY | Clinical Trial Site | Westfield14787 | NCT07181109 | Map |
| NC | Clinical Trial Site | Durham27704 | NCT07181109 | Map |
| NC | Clinical Trial Site | Greenville27834 | NCT07181109 | Map |
| NC | Clinical Trial Site | High Point27260 | NCT07181109 | Map |
| NC | Clinical Trial Site | Jacksonville28546 | NCT07181109 | Map |
| NC | Clinical Trial Site | Kings Mountain28086 | NCT07181109 | Map |
| NC | Clinical Trial Site | Monroe28112 | NCT07181109 | Map |
| NC | Clinical Trial Site | Statesville28625 | NCT07181109 | Map |
| ND | Clinical Trial Site | Fargo58104 | NCT07181109 | Map |
| OH | Clinical Trial Site | Beavercreek45431 | NCT07181109 | Map |
| OH | Clinical Trial Site | Cincinnati45212 | NCT07181109 | Map |
| OH | Clinical Trial Site | Cincinnati45219 | NCT07181109 | Map |
| OH | Clinical Trial Site | Columbus43213 | NCT07181109 | Map |
| OH | Clinical Trial Site | Dayton45409 | NCT07181109 | Map |
| OH | Clinical Trial Site | Lima45801 | NCT07181109 | Map |
| OH | Clinical Trial Site | Maumee43537 | NCT07181109 | Map |
| OH | Clinical Trial Site | Moraine45439 | NCT07181109 | Map |
| OK | Clinical Trial Site | Moore73160 | NCT07181109 | Map |
| OK | Clinical Trial Site | Norman73069 | NCT07181109 | Map |
| OK | Clinical Trial Site | Oklahoma City73120 | NCT07181109 | Map |
| PA | Clinical Trial Site | Camp Hill17701 | NCT07181109 | Map |
| PA | Clinical Trial Site | Horsham19044 | NCT07181109 | Map |
| PA | Clinical Trial Site | Linwood19061 | NCT07181109 | Map |
| PA | Clinical Trial Site | Media19063 | NCT07181109 | Map |
| PA | Clinical Trial Site | Uniontown15401 | NCT07181109 | Map |
| SC | Clinical Trial Site | Columbia29205 | NCT07181109 | Map |
| SC | Clinical Trial Site | Greenville29607 | NCT07181109 | Map |
| SC | Clinical Trial Site | Greer29650 | NCT07181109 | Map |
| TN | Clinical Trial Site | Chattanooga37412 | NCT07181109 | Map |
| TN | Clinical Trial Site | Knoxville37909 | NCT07181109 | Map |
| TN | Clinical Trial Site | Knoxville37923 | NCT07181109 | Map |
| TX | Clinical Trial Site | Allen75013 | NCT07181109 | Map |
| TX | Clinical Trial Site | Amarillo79106 | NCT07181109 | Map |
| TX | Clinical Trial Site | Amarillo79124 | NCT07181109 | Map |
| TX | Clinical Trial Site | Arlington76012 | NCT07181109 | Map |
| TX | Clinical Trial Site | Austin78735 | NCT07181109 | Map |
| TX | Clinical Trial Site | Austin78759 | NCT07181109 | Map |
| TX | Clinical Trial Site | Beaumont77702 | NCT07181109 | Map |
| TX | Clinical Trial Site | Carrollton75006 | NCT07181109 | Map |
| TX | Clinical Trial Site | Duncanville75137 | NCT07181109 | Map |
| TX | Clinical Trial Site | Euless76040 | NCT07181109 | Map |
| TX | Clinical Trial Site | Houston77002 | NCT07181109 | Map |
| TX | Clinical Trial Site | Houston77024 | NCT07181109 | Map |
| TX | Clinical Trial Site | Houston77025 | NCT07181109 | Map |
| TX | Clinical Trial Site | Houston77036 | NCT07181109 | Map |
| TX | Clinical Trial Site | Houston77043 | NCT07181109 | Map |
| TX | Clinical Trial Site | Houston77061 | NCT07181109 | Map |
| TX | Clinical Trial Site | Houston77070 | NCT07181109 | Map |
| TX | Clinical Trial Site | Houston77095 | NCT07181109 | Map |
| TX | Clinical Trial Site | Houston77429 | NCT07181109 | Map |
| TX | Clinical Trial Site | Humble77338 | NCT07181109 | Map |
| TX | Clinical Trial Site | Katy77450 | NCT07181109 | Map |
| TX | Clinical Trial Site | Laredo78041 | NCT07181109 | Map |
| TX | Clinical Trial Site | McAllen78503 | NCT07181109 | Map |
| TX | Clinical Trial Site | McKinney75071 | NCT07181109 | Map |
| TX | Clinical Trial Site | Mesquite75149 | NCT07181109 | Map |
| TX | Clinical Trial Site | Missouri City77459 | NCT07181109 | Map |
| TX | Clinical Trial Site | Paris75462 | NCT07181109 | Map |
| TX | Clinical Trial Site | Pasadena77504 | NCT07181109 | Map |
| TX | Clinical Trial Site | Plano75024 | NCT07181109 | Map |
| TX | Clinical Trial Site | Port Arthur77642 | NCT07181109 | Map |
| TX | Clinical Trial Site | San Antonio78220 | NCT07181109 | Map |
| TX | Clinical Trial Site | San Antonio78229 | NCT07181109 | Map |
| TX | Clinical Trial Site | San Antonio78231 | NCT07181109 | Map |
| TX | Clinical Trial Site | San Antonio78258 | NCT07181109 | Map |
| TX | Clinical Trial Site | Sherman75092 | NCT07181109 | Map |
| TX | Clinical Trial Site | Sugar Land77479 | NCT07181109 | Map |
| TX | Clinical Trial Site | Tomball77375 | NCT07181109 | Map |
| TX | Clinical Trial Site | Waco76712 | NCT07181109 | Map |
| UT | Clinical Trial Site | Bountiful84010 | NCT07181109 | Map |
| UT | Clinical Trial Site | Bountiful84025 | NCT07181109 | Map |
| UT | Clinical Trial Site | Layton84041 | NCT07181109 | Map |
| VA | Clinical Trial Site | Arlington22205 | NCT07181109 | Map |
| VA | Clinical Trial Site | Danville24541 | NCT07181109 | Map |
| VA | Clinical Trial Site | Falls Church22042 | NCT07181109 | Map |
| VA | Clinical Trial Site | Manassas20109 | NCT07181109 | Map |
| VA | Clinical Trial Site | Newport News23606 | NCT07181109 | Map |
| VA | Clinical Trial Site | Norfolk23502 | NCT07181109 | Map |
| VA | Clinical Trial Site | Richmond23219 | NCT07181109 | Map |
| VA | Clinical Trial Site | Suffolk23435 | NCT07181109 | Map |
| VA | Clinical Trial Site | Winchester22601 | NCT07181109 | Map |
| WA | Clinical Trial Site | Bellevue98007 | NCT07181109 | Map |
| WI | Clinical Trial Site | Kenosha53144 | NCT07181109 | Map |
Zilebesiran clinical trials at a glance: phase × recruitment status
| Phase | recruiting | completed | Total |
|---|---|---|---|
| P1/P2 | 1 | 1 | |
| P2 | 2 | 2 | |
| P3 | 1 | 1 |
Recruiting Zilebesiran clinical trials (1)
Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).
| NCT ID | Title | Phase | Indication | Enrollment | Started |
|---|---|---|---|---|---|
| NCT07181109 | ZENITHZilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease | P3 | High Risk Cardiovascular Disease | 11,000 | Sep 2025 |
Zilebesiran clinical trials by indication
High Risk Cardiovascular Disease (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07181109 | ZENITH | P3 | recruiting | Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease |
Mild to Moderate Hypertension (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06423352 | — | P1/P2 | completed | A Study to Evaluate Zilebesiran in Japanese Patients With Mild to Moderate Hypertension |
High Cardiovascular Risk (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06272487 | KARDIA-3 | P2 | completed | Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3) |
Hypertension (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05103332 | KARDIA-2 | P2 | completed | Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2) |
Zilebesiran pivotal trial highlights (Phase 2/3/4)
Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.
| Acronym | NCT | Phase | Status | Indication | Enrollment | PubMed |
|---|---|---|---|---|---|---|
| ZENITH | NCT07181109 | P3 | recruiting | High Risk Cardiovascular Disease | 11,000 | — |
| KARDIA-3 | NCT06272487 | P2 | completed | High Cardiovascular Risk | 375 | — |
| KARDIA-2 | NCT05103332 | P2 | completed | Hypertension | 663 | — |
All Zilebesiran trials (4)
Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.
| NCT ID | Acronym | Title | Phase | Status | Enrollment | Sponsor | Started |
|---|---|---|---|---|---|---|---|
| NCT07181109 | ZENITH | Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease | P3 | recruiting | 11,000 | Alnylam Pharmaceuticals | Sep 2025 |
| NCT06272487 | KARDIA-3 | Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3) | P2 | completed | 375 | Alnylam Pharmaceuticals | Feb 2024 |
| NCT06423352 | A Study to Evaluate Zilebesiran in Japanese Patients With Mild to Moderate Hypertension | P1/P2 | completed | 36 | Alnylam Pharmaceuticals | Jun 2024 | |
| NCT05103332 | KARDIA-2 | Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2) | P2 | completed | 663 | Alnylam Pharmaceuticals | Nov 2021 |
Zilebesiran clinical trials: frequently asked questions
- How many Zilebesiran clinical trials are there?
- 4 Zilebesiran clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 1 is actively recruiting participants. 3 are marked completed.
- Are Zilebesiran clinical trials recruiting in 2026?
- Yes — 1 Zilebesiran trial is actively recruiting in 2026, with 202 U.S. sites across 34 states. See the recruiting trials and the per-state site list further down this page.
- What conditions is Zilebesiran being studied for?
- Zilebesiran is being studied for Hypertension, High Cardiovascular Risk, High Risk Cardiovascular Disease, Mild to Moderate Hypertension. The trials are grouped by indication on this page.
- What phase is Zilebesiran in?
- Zilebesiran clinical trials span 1 Phase 3, 2 Phase 2. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
- Who sponsors Zilebesiran clinical trials?
- The lead sponsor across the most Zilebesiran trials is Alnylam Pharmaceuticals. Each trial row links to the full study detail page including sponsor information.
Sources and methodology
Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Zilebesiranas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.
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