Zilebesiran Clinical Trials (2026): 4 Studies for Hypertension & High Cardiovascular Risk

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

4 Zilebesiran clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 4 indications (including Hypertension & High Cardiovascular Risk) and 12,074 total planned enrollment. 1 Phase 3 Zilebesiran trial and 2 Phase 2 are listed. 1 Zilebesiran clinical trial is actively recruiting at 202 U.S. sites across 34 states. Most recent activity: NCT07181109 (Sep 2030).

Where to Participate: All Zilebesiran Trial Sites in the U.S. (202 sites across 34 states)

Every actively recruiting Zilebesirantrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
ALClinical Trial SiteBirmingham35211NCT07181109Map
ALClinical Trial SiteFairhope36532NCT07181109Map
ALClinical Trial SiteFoley36535NCT07181109Map
ALClinical Trial SiteHuntsville35805NCT07181109Map
ALClinical Trial SiteSheffield35660NCT07181109Map
AZClinical Trial SiteChandler85224NCT07181109Map
AZClinical Trial SiteGilbert85296NCT07181109Map
AZClinical Trial SitePhoenix85015NCT07181109Map
AZClinical Trial SitePhoenix85020NCT07181109Map
AZClinical Trial SiteSun City West85375NCT07181109Map
AZClinical Trial SiteTucson85715NCT07181109Map
AZClinical Trial SiteTucson85741NCT07181109Map
AZClinical Trial SiteYuma85364NCT07181109Map
ARClinical Trial SiteLittle Rock72204NCT07181109Map
ARClinical Trial SiteLittle Rock72205NCT07181109Map
CAClinical Trial SiteBeverly Hills90211NCT07181109Map
CAClinical Trial SiteChula Vista91910NCT07181109Map
CAClinical Trial SiteCovina91723NCT07181109Map
CAClinical Trial SiteEscondido92025NCT07181109Map
CAClinical Trial SiteGlendale91206NCT07181109Map
CAClinical Trial SiteLancaster93534NCT07181109Map
CAClinical Trial SiteLong Beach90815NCT07181109Map
CAClinical Trial SiteLynwood90262NCT07181109Map
CAClinical Trial SiteNewhall91321NCT07181109Map
CAClinical Trial SiteNorthridge91325NCT07181109Map
CAClinical Trial SitePasadena91105NCT07181109Map
CAClinical Trial SiteSan Diego92111NCT07181109Map
CAClinical Trial SiteSan Dimas91773NCT07181109Map
CAClinical Trial SiteTarzana91356NCT07181109Map
CAClinical Trial SiteToluca Lake91602NCT07181109Map
CAClinical Trial SiteTustin92780NCT07181109Map
CAClinical Trial SiteVista92081NCT07181109Map
CAClinical Trial SiteWalnut Creek94598NCT07181109Map
CTClinical Trial SiteBridgeport06610NCT07181109Map
FLClinical Trial SiteBoca Raton33434NCT07181109Map
FLClinical Trial SiteBrandon33511NCT07181109Map
FLClinical Trial SiteFleming Island32003NCT07181109Map
FLClinical Trial SiteFort Lauderdale33308NCT07181109Map
FLClinical Trial SiteHialeah33012NCT07181109Map
FLClinical Trial SiteHollywood33024NCT07181109Map
FLClinical Trial SiteHomestead33030NCT07181109Map
FLClinical Trial SiteJacksonville32205NCT07181109Map
FLClinical Trial SiteJacksonville32216NCT07181109Map
FLClinical Trial SiteJensen Beach34957NCT07181109Map
FLClinical Trial SiteLeesburg34748NCT07181109Map
FLClinical Trial SiteMelbourne32934NCT07181109Map
FLClinical Trial SiteMiami33134NCT07181109Map
FLClinical Trial SiteMiami33135NCT07181109Map
FLClinical Trial SiteMiami33155NCT07181109Map
FLClinical Trial SiteMiami33186NCT07181109Map
FLClinical Trial SiteOrlando32825NCT07181109Map
FLClinical Trial SitePalm Springs33406NCT07181109Map
FLClinical Trial SiteTampa33615NCT07181109Map
FLClinical Trial SiteWellington33449NCT07181109Map
GAClinical Trial SiteAtlanta30342NCT07181109Map
GAClinical Trial SiteBrunswick31520NCT07181109Map
GAClinical Trial SiteColumbus31901NCT07181109Map
GAClinical Trial SiteColumbus31904NCT07181109Map
GAClinical Trial SiteConyers30012NCT07181109Map
GAClinical Trial SiteConyers30094NCT07181109Map
GAClinical Trial SiteFayetteville30214NCT07181109Map
GAClinical Trial SiteJohns Creek30024NCT07181109Map
GAClinical Trial SiteLawrenceville30044NCT07181109Map
GAClinical Trial SiteMacon31201NCT07181109Map
ILClinical Trial SiteChicago60640NCT07181109Map
ILClinical Trial SiteHazel Crest60429NCT07181109Map
ILClinical Trial SiteOak Brook60523NCT07181109Map
ILClinical Trial SiteOrland Park60462NCT07181109Map
ILClinical Trial SiteSpringfield62701NCT07181109Map
ILClinical Trial SiteTinley Park60477NCT07181109Map
INClinical Trial SiteAvon46123NCT07181109Map
INClinical Trial SiteEvansville47714NCT07181109Map
INClinical Trial SiteEvansville47715NCT07181109Map
INClinical Trial SiteGreenfield46140NCT07181109Map
INClinical Trial SiteSouth Bend46617NCT07181109Map
INClinical Trial SiteValparaiso46383NCT07181109Map
KSClinical Trial SiteHutchinson67502NCT07181109Map
KSClinical Trial SiteTopeka66606NCT07181109Map
KSClinical Trial SiteWichita67214NCT07181109Map
KSClinical Trial SiteWichita67218NCT07181109Map
KYClinical Trial SiteBowling Green42101NCT07181109Map
KYClinical Trial SiteLexington40503NCT07181109Map
KYClinical Trial SiteVersailles40383NCT07181109Map
LAClinical Trial SiteHammond70403NCT07181109Map
LAClinical Trial SiteLafayette70503NCT07181109Map
LAClinical Trial SiteOpelousas70570NCT07181109Map
LAClinical Trial SiteShreveport71105NCT07181109Map
LAClinical Trial SiteZachary70791NCT07181109Map
MDClinical Trial SiteBaltimore21229NCT07181109Map
MDClinical Trial SiteBeltsville20705NCT07181109Map
MDClinical Trial SiteBowie20715NCT07181109Map
MDClinical Trial SiteLanham20706NCT07181109Map
MDClinical Trial SiteRockville20850NCT07181109Map
MIClinical Trial SiteFlint48504NCT07181109Map
MIClinical Trial SiteShelby48315NCT07181109Map
MIClinical Trial SiteSouthfield48075NCT07181109Map
MIClinical Trial SiteTroy48085NCT07181109Map
MIClinical Trial SiteTroy48098NCT07181109Map
MNClinical Trial SiteRichfield55423NCT07181109Map
MSClinical Trial SiteJackson39216NCT07181109Map
MSClinical Trial SiteOlive Branch38654NCT07181109Map
MSClinical Trial SitePort Gibson39150NCT07181109Map
MSClinical Trial SiteRidgeland39157NCT07181109Map
MOClinical Trial SiteKansas City64111NCT07181109Map
MOClinical Trial SiteKansas City64151NCT07181109Map
MOClinical Trial SiteSt Louis63136NCT07181109Map
NEClinical Trial SiteFremont68025NCT07181109Map
NVClinical Trial SiteLas Vegas89121NCT07181109Map
NVClinical Trial SiteLas Vegas89148NCT07181109Map
NJClinical Trial SiteBrick08724NCT07181109Map
NJClinical Trial SiteBridgewater08807NCT07181109Map
NJClinical Trial SiteFlemington08822NCT07181109Map
NMClinical Trial SiteAlbuquerque87106NCT07181109Map
NYClinical Trial SiteNew Windsor12553NCT07181109Map
NYClinical Trial SiteNorth Massapequa11758NCT07181109Map
NYClinical Trial SiteRiverhead11901NCT07181109Map
NYClinical Trial SiteRosedale11422NCT07181109Map
NYClinical Trial SiteThe Bronx10461NCT07181109Map
NYClinical Trial SiteWest Seneca14224NCT07181109Map
NYClinical Trial SiteWestfield14787NCT07181109Map
NCClinical Trial SiteDurham27704NCT07181109Map
NCClinical Trial SiteGreenville27834NCT07181109Map
NCClinical Trial SiteHigh Point27260NCT07181109Map
NCClinical Trial SiteJacksonville28546NCT07181109Map
NCClinical Trial SiteKings Mountain28086NCT07181109Map
NCClinical Trial SiteMonroe28112NCT07181109Map
NCClinical Trial SiteStatesville28625NCT07181109Map
NDClinical Trial SiteFargo58104NCT07181109Map
OHClinical Trial SiteBeavercreek45431NCT07181109Map
OHClinical Trial SiteCincinnati45212NCT07181109Map
OHClinical Trial SiteCincinnati45219NCT07181109Map
OHClinical Trial SiteColumbus43213NCT07181109Map
OHClinical Trial SiteDayton45409NCT07181109Map
OHClinical Trial SiteLima45801NCT07181109Map
OHClinical Trial SiteMaumee43537NCT07181109Map
OHClinical Trial SiteMoraine45439NCT07181109Map
OKClinical Trial SiteMoore73160NCT07181109Map
OKClinical Trial SiteNorman73069NCT07181109Map
OKClinical Trial SiteOklahoma City73120NCT07181109Map
PAClinical Trial SiteCamp Hill17701NCT07181109Map
PAClinical Trial SiteHorsham19044NCT07181109Map
PAClinical Trial SiteLinwood19061NCT07181109Map
PAClinical Trial SiteMedia19063NCT07181109Map
PAClinical Trial SiteUniontown15401NCT07181109Map
SCClinical Trial SiteColumbia29205NCT07181109Map
SCClinical Trial SiteGreenville29607NCT07181109Map
SCClinical Trial SiteGreer29650NCT07181109Map
TNClinical Trial SiteChattanooga37412NCT07181109Map
TNClinical Trial SiteKnoxville37909NCT07181109Map
TNClinical Trial SiteKnoxville37923NCT07181109Map
TXClinical Trial SiteAllen75013NCT07181109Map
TXClinical Trial SiteAmarillo79106NCT07181109Map
TXClinical Trial SiteAmarillo79124NCT07181109Map
TXClinical Trial SiteArlington76012NCT07181109Map
TXClinical Trial SiteAustin78735NCT07181109Map
TXClinical Trial SiteAustin78759NCT07181109Map
TXClinical Trial SiteBeaumont77702NCT07181109Map
TXClinical Trial SiteCarrollton75006NCT07181109Map
TXClinical Trial SiteDuncanville75137NCT07181109Map
TXClinical Trial SiteEuless76040NCT07181109Map
TXClinical Trial SiteHouston77002NCT07181109Map
TXClinical Trial SiteHouston77024NCT07181109Map
TXClinical Trial SiteHouston77025NCT07181109Map
TXClinical Trial SiteHouston77036NCT07181109Map
TXClinical Trial SiteHouston77043NCT07181109Map
TXClinical Trial SiteHouston77061NCT07181109Map
TXClinical Trial SiteHouston77070NCT07181109Map
TXClinical Trial SiteHouston77095NCT07181109Map
TXClinical Trial SiteHouston77429NCT07181109Map
TXClinical Trial SiteHumble77338NCT07181109Map
TXClinical Trial SiteKaty77450NCT07181109Map
TXClinical Trial SiteLaredo78041NCT07181109Map
TXClinical Trial SiteMcAllen78503NCT07181109Map
TXClinical Trial SiteMcKinney75071NCT07181109Map
TXClinical Trial SiteMesquite75149NCT07181109Map
TXClinical Trial SiteMissouri City77459NCT07181109Map
TXClinical Trial SiteParis75462NCT07181109Map
TXClinical Trial SitePasadena77504NCT07181109Map
TXClinical Trial SitePlano75024NCT07181109Map
TXClinical Trial SitePort Arthur77642NCT07181109Map
TXClinical Trial SiteSan Antonio78220NCT07181109Map
TXClinical Trial SiteSan Antonio78229NCT07181109Map
TXClinical Trial SiteSan Antonio78231NCT07181109Map
TXClinical Trial SiteSan Antonio78258NCT07181109Map
TXClinical Trial SiteSherman75092NCT07181109Map
TXClinical Trial SiteSugar Land77479NCT07181109Map
TXClinical Trial SiteTomball77375NCT07181109Map
TXClinical Trial SiteWaco76712NCT07181109Map
UTClinical Trial SiteBountiful84010NCT07181109Map
UTClinical Trial SiteBountiful84025NCT07181109Map
UTClinical Trial SiteLayton84041NCT07181109Map
VAClinical Trial SiteArlington22205NCT07181109Map
VAClinical Trial SiteDanville24541NCT07181109Map
VAClinical Trial SiteFalls Church22042NCT07181109Map
VAClinical Trial SiteManassas20109NCT07181109Map
VAClinical Trial SiteNewport News23606NCT07181109Map
VAClinical Trial SiteNorfolk23502NCT07181109Map
VAClinical Trial SiteRichmond23219NCT07181109Map
VAClinical Trial SiteSuffolk23435NCT07181109Map
VAClinical Trial SiteWinchester22601NCT07181109Map
WAClinical Trial SiteBellevue98007NCT07181109Map
WIClinical Trial SiteKenosha53144NCT07181109Map

Zilebesiran clinical trials at a glance: phase × recruitment status

PhaserecruitingcompletedTotal
P1/P211
P222
P311

Recruiting Zilebesiran clinical trials (1)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT07181109ZENITHZilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular DiseaseP3High Risk Cardiovascular Disease11,000Sep 2025

Zilebesiran clinical trials by indication

High Risk Cardiovascular Disease (1)

NCTAcronymPhaseStatusTitle
NCT07181109ZENITHP3recruitingZilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

Mild to Moderate Hypertension (1)

NCTAcronymPhaseStatusTitle
NCT06423352P1/P2completedA Study to Evaluate Zilebesiran in Japanese Patients With Mild to Moderate Hypertension

High Cardiovascular Risk (1)

NCTAcronymPhaseStatusTitle
NCT06272487KARDIA-3P2completedZilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)

Hypertension (1)

NCTAcronymPhaseStatusTitle
NCT05103332KARDIA-2P2completedZilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)

Zilebesiran pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
ZENITHNCT07181109P3recruitingHigh Risk Cardiovascular Disease11,000
KARDIA-3NCT06272487P2completedHigh Cardiovascular Risk375
KARDIA-2NCT05103332P2completedHypertension663

All Zilebesiran trials (4)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT07181109ZENITHZilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular DiseaseP3recruiting11,000Alnylam PharmaceuticalsSep 2025
NCT06272487KARDIA-3Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)P2completed375Alnylam PharmaceuticalsFeb 2024
NCT06423352A Study to Evaluate Zilebesiran in Japanese Patients With Mild to Moderate HypertensionP1/P2completed36Alnylam PharmaceuticalsJun 2024
NCT05103332KARDIA-2Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)P2completed663Alnylam PharmaceuticalsNov 2021

Zilebesiran clinical trials: frequently asked questions

How many Zilebesiran clinical trials are there?
4 Zilebesiran clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 1 is actively recruiting participants. 3 are marked completed.
Are Zilebesiran clinical trials recruiting in 2026?
Yes — 1 Zilebesiran trial is actively recruiting in 2026, with 202 U.S. sites across 34 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Zilebesiran being studied for?
Zilebesiran is being studied for Hypertension, High Cardiovascular Risk, High Risk Cardiovascular Disease, Mild to Moderate Hypertension. The trials are grouped by indication on this page.
What phase is Zilebesiran in?
Zilebesiran clinical trials span 1 Phase 3, 2 Phase 2. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Zilebesiran clinical trials?
The lead sponsor across the most Zilebesiran trials is Alnylam Pharmaceuticals. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Zilebesiranas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

Last refreshed .

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