Vorasidenib Clinical Trials (2026): 18 Studies for Glioma & Low Grade Glioma of Brain

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

18 Vorasidenib clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 15 indications (including Glioma & Low Grade Glioma of Brain) and 1,899 total planned enrollment. 4 Phase 3 Vorasidenib trials and 1 Phase 2 are listed. 9 Vorasidenib clinical trials are actively recruiting at 4 U.S. sites across 4 states. Most recent activity: NCT07215910 (Jan 2040).

Where to Participate: All Vorasidenib Trial Sites in the U.S. (4 sites across 4 states)

Every actively recruiting Vorasidenibtrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
AZArizona Clinical TrialsChandler85225NCT07250633Map
FLOrlando Clinical Research CenterOrlando32809NCT07250633Map
NCDuke University Medical CenterDurham27710NCT05609994Map
TXAmerican Research CorporationSan Antonio78215NCT07250633Map

Vorasidenib clinical trials at a glance: phase × recruitment status

Phaserecruitingactive not recruitingcompletednot yet recruitingapproved for marketingTotal
P12147
P1/P211
P211
P31214
N/A2215

Recruiting Vorasidenib clinical trials (9)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT07215910Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain CancerP3Astrocytoma, IDH-Mutant, Grade 3408Oct 2025
NCT06809322VIGORVorasidenib Maintenance for IDH Mutant AstrocytomaP3IDH-mutant Grade 2 or 3 Astrocytoma468Jan 2026
NCT07286292Vorasidenib Study in Pediatric Participants With Grade 2 Astrocytoma or Oligodendroglioma With an IDH1 or IDH2 MutationP2Grade 2 Astrocytoma or Oligodendroglioma With an IDH1 or IDH2 Mutation10Mar 2026
NCT07240662VIOLETAVorasidenib in CNS WHO Grade 2 IDH-mutant Diffuse GliomaGlioma150Dec 2025
NCT05609994ViCToRyViCToRy: Vorasidenib in Combination With Tumor Specific Peptide Vaccine for Recurrent IDH1 Mutant Lower Grade GliomasP1Low Grade Glioma of Brain48Jul 2025
NCT07469735VANGUARDVorasidenib Guided by AGX PET in Recurrent/Low-grade GliomaN/AGlioma10Apr 2026
NCT07547163LGG PRO'sPatient Voice in the Treatment of Low-grade Gliomas: Use of Patient-reported Outcomes, Vorasidenib and Radiotherapy ComparedGlioma90Apr 2025
NCT06969352VICTORIAA Multicentre, Retrospective-prospective Real-world Study: to Evaluate the Effectiveness and Safety of Vorasidenib in Patients With Isocitrate Dehydrogenase IDH1/2 Mutant Grade 2 Astrocytoma or Oligodendroglioma (VICTORIA Study)Gliomas60Jun 2025
NCT07250633Pharmacokinetic Study of Vorasidenib in Severe Hepatically Impaired and Matched-Control ParticipantsP1Severe Hepatic Impairment20Apr 2026

Vorasidenib clinical trials by indication

Glioma (4)

NCTAcronymPhaseStatusTitle
NCT07240662VIOLETAN/ArecruitingVorasidenib in CNS WHO Grade 2 IDH-mutant Diffuse Glioma
NCT07469735VANGUARDN/Anot yet recruitingVorasidenib Guided by AGX PET in Recurrent/Low-grade Glioma
NCT07547163LGG PRO'sN/ArecruitingPatient Voice in the Treatment of Low-grade Gliomas: Use of Patient-reported Outcomes, Vorasidenib and Radiotherapy Compared
NCT05592743N/Aapproved for marketingVorasidenib Expanded Access Program

Severe Hepatic Impairment (1)

NCTAcronymPhaseStatusTitle
NCT07250633P1recruitingPharmacokinetic Study of Vorasidenib in Severe Hepatically Impaired and Matched-Control Participants

Grade 2 Astrocytoma or Oligodendroglioma With an IDH1 or IDH2 Mutation (1)

NCTAcronymPhaseStatusTitle
NCT07286292P2not yet recruitingVorasidenib Study in Pediatric Participants With Grade 2 Astrocytoma or Oligodendroglioma With an IDH1 or IDH2 Mutation

IDH-mutant Grade 2 or 3 Astrocytoma (1)

NCTAcronymPhaseStatusTitle
NCT06809322VIGORP3recruitingVorasidenib Maintenance for IDH Mutant Astrocytoma

Healthy Adult Female Participants (1)

NCTAcronymPhaseStatusTitle
NCT07235774P1completedA Drug-drug Interaction Study of Vorasidenib and a Combined Oral Contraceptive in Healthy Female Participants

Astrocytoma, IDH-Mutant, Grade 3 (1)

NCTAcronymPhaseStatusTitle
NCT07215910P3not yet recruitingTesting Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer

Healthy Adult Participants (1)

NCTAcronymPhaseStatusTitle
NCT07235748P1completedDrug-drug Interaction Study of Vorasidenib With Bupropion, Repaglinide, Flurbiprofen, Omeprazole, Midazolam, and Rosuvastatin in Healthy Adult Participants

Low Grade Glioma of Brain (1)

NCTAcronymPhaseStatusTitle
NCT05609994ViCToRyP1recruitingViCToRy: Vorasidenib in Combination With Tumor Specific Peptide Vaccine for Recurrent IDH1 Mutant Lower Grade Gliomas

Gliomas (1)

NCTAcronymPhaseStatusTitle
NCT06969352VICTORIAN/Anot yet recruitingA Multicentre, Retrospective-prospective Real-world Study: to Evaluate the Effectiveness and Safety of Vorasidenib in Patients With Isocitrate Dehydrogenase IDH1/2 Mutant Grade 2 Astrocytoma or Oligodendroglioma (VICTORIA Study)

IDH1-mutant Glioma (1)

NCTAcronymPhaseStatusTitle
NCT06478212TMZP1/P2active not recruitingVorasidenib in Combination With Temozolomide (TMZ) in IDH-mutant Glioma

Residual or Recurrent Grade 2 IDH Mutant Glioma (1)

NCTAcronymPhaseStatusTitle
NCT06780930P3active not recruitingPhase 3 Study of Vorasidenib (S095032/AG-881) in Asian Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 orIDH2 Mutation

Healthy Subjects (1)

NCTAcronymPhaseStatusTitle
NCT05843708P1completedA Phase 1, Open-Label Study to Evaluate the Effect of a Low-Fat Meal and Multiple Doses of Ciprofloxacin on the Pharmacokinetics of Vorasidenib in Healthy Subjects

Hepatic Impairment (1)

NCTAcronymPhaseStatusTitle
NCT05674474P1completedA Study of Vorasidenib in Participants With Moderate or Mild Hepatic Impairment and Matched Participants With Normal Hepatic Function

Astrocytoma (1)

NCTAcronymPhaseStatusTitle
NCT05484622P1active not recruitingStudy of Vorasidenib and Pembrolizumab Combination in Recurrent or Progressive IDH-1 Mutant Glioma

Grade 2 Glioma (1)

NCTAcronymPhaseStatusTitle
NCT04164901AG-881P3active not recruitingStudy of Vorasidenib (AG-881) in Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (INDIGO)

Vorasidenib pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
VIGORNCT06809322P3recruitingIDH-mutant Grade 2 or 3 Astrocytoma468
AG-881NCT04164901P3active not recruitingGrade 2 Glioma331PMID 37272516

All Vorasidenib trials (18)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT07215910Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain CancerP3not yet recruiting408Alliance for Clinical Trials in OncologyOct 2025
NCT06809322VIGORVorasidenib Maintenance for IDH Mutant AstrocytomaP3recruiting468European Organisation for Research and Treatment of Cancer - EORTCJan 2026
NCT07286292Vorasidenib Study in Pediatric Participants With Grade 2 Astrocytoma or Oligodendroglioma With an IDH1 or IDH2 MutationP2not yet recruiting10Institut de Recherches Internationales Servier (I.R.I.S.)Mar 2026
NCT07240662VIOLETAVorasidenib in CNS WHO Grade 2 IDH-mutant Diffuse Gliomarecruiting150iOMEDICO AGDec 2025
NCT06780930Phase 3 Study of Vorasidenib (S095032/AG-881) in Asian Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 orIDH2 MutationP3active not recruiting57ServierOct 2024
NCT05609994ViCToRyViCToRy: Vorasidenib in Combination With Tumor Specific Peptide Vaccine for Recurrent IDH1 Mutant Lower Grade GliomasP1recruiting48Katy Peters, MD, PhDJul 2025
NCT06478212TMZVorasidenib in Combination With Temozolomide (TMZ) in IDH-mutant GliomaP1/P2active not recruiting51Institut de Recherches Internationales ServierJan 2025
NCT04164901AG-881Study of Vorasidenib (AG-881) in Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (INDIGO)P3active not recruiting331Institut de Recherches Internationales ServierJan 2020
NCT07469735VANGUARDVorasidenib Guided by AGX PET in Recurrent/Low-grade GliomaN/Anot yet recruiting10Huashan HospitalApr 2026
NCT07547163LGG PRO'sPatient Voice in the Treatment of Low-grade Gliomas: Use of Patient-reported Outcomes, Vorasidenib and Radiotherapy Comparedrecruiting90Fondazione I.R.C.C.S. Istituto Neurologico Carlo BestaApr 2025
NCT05484622Study of Vorasidenib and Pembrolizumab Combination in Recurrent or Progressive IDH-1 Mutant GliomaP1active not recruiting60Institut de Recherches Internationales ServierJan 2023
NCT06969352VICTORIAA Multicentre, Retrospective-prospective Real-world Study: to Evaluate the Effectiveness and Safety of Vorasidenib in Patients With Isocitrate Dehydrogenase IDH1/2 Mutant Grade 2 Astrocytoma or Oligodendroglioma (VICTORIA Study)not yet recruiting60Servier (Tianjin) Pharmaceutical Co. LTD.Jun 2025
NCT07250633Pharmacokinetic Study of Vorasidenib in Severe Hepatically Impaired and Matched-Control ParticipantsP1recruiting20Institut de Recherches Internationales Servier (I.R.I.S.)Apr 2026
NCT07235774A Drug-drug Interaction Study of Vorasidenib and a Combined Oral Contraceptive in Healthy Female ParticipantsP1completed28Institut de Recherches Internationales Servier (I.R.I.S.)Nov 2025
NCT07235748Drug-drug Interaction Study of Vorasidenib With Bupropion, Repaglinide, Flurbiprofen, Omeprazole, Midazolam, and Rosuvastatin in Healthy Adult ParticipantsP1completed28Institut de Recherches Internationales Servier (I.R.I.S.)Oct 2025
NCT05843708A Phase 1, Open-Label Study to Evaluate the Effect of a Low-Fat Meal and Multiple Doses of Ciprofloxacin on the Pharmacokinetics of Vorasidenib in Healthy SubjectsP1completed64Servier Bio-Innovation LLCApr 2023
NCT05674474A Study of Vorasidenib in Participants With Moderate or Mild Hepatic Impairment and Matched Participants With Normal Hepatic FunctionP1completed16Institut de Recherches Internationales ServierMar 2023
NCT05592743Vorasidenib Expanded Access Programapproved for marketing0Servier

Vorasidenib clinical trials: frequently asked questions

How many Vorasidenib clinical trials are there?
18 Vorasidenib clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 5 are actively recruiting participants. 4 are marked completed.
Are Vorasidenib clinical trials recruiting in 2026?
Yes — 5 Vorasidenib trials are actively recruiting in 2026, with 4 U.S. sites across 4 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Vorasidenib being studied for?
Vorasidenib is being studied for Glioma, Low Grade Glioma of Brain, Diffuse Glioma, Disease Attributes, Glioma of Brain and 30 more. The trials are grouped by indication on this page.
What phase is Vorasidenib in?
Vorasidenib clinical trials span 4 Phase 3, 1 Phase 2, 7 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Vorasidenib clinical trials?
The lead sponsor across the most Vorasidenib trials is Institut de Recherches Internationales Servier, with 10 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Vorasidenibas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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