How many Tepotinib clinical trials are there?

27 Tepotinib clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 6 are actively recruiting participants. 12 are marked completed.

Are Tepotinib clinical trials recruiting in 2026?

Yes — 6 Tepotinib trials are actively recruiting in 2026, with 241 U.S. sites across 42 states. See the recruiting trials and the per-state site list further down this page.

What conditions is Tepotinib being studied for?

Tepotinib is being studied for Healthy, Non-small Cell Lung Cancer, Non Small Cell Lung Cancer, Carcinoma, Hepatocellular, Solid Tumor and 24 more. The trials are grouped by indication on this page.

What phase is Tepotinib in?

Tepotinib clinical trials span 1 Phase 3, 9 Phase 2, 11 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.

Who sponsors Tepotinib clinical trials?

The lead sponsor across the most Tepotinib trials is Merck KGaA, Darmstadt, Germany, with 13 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Tepotinib Clinical Trials (2026): 27 Studies for Healthy & Non-small Cell Lung Cancer

Creator: Hipa.ai Research
Published: 2026-05-20T23:45:41.373Z

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: June 12, 2026.

27 Tepotinib clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 16 indications (including Healthy & Non-small Cell Lung Cancer) and 3,559 total planned enrollment. 1 Phase 3 Tepotinib trial and 9 Phase 2 are listed. 6 Tepotinib clinical trials are actively recruiting at 241 U.S. sites across 42 states. Most recent activity: NCT06106802 (Sep 2029).

Where to Participate: All Tepotinib Trial Sites in the U.S. (241 sites across 42 states)

Every actively recruiting Tepotinibtrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

State	Facility	City	Trial	Map
AL	Gulf Health Hospitals Inc/Infirmary Cancer Care - Malbis	Daphne36526	NCT06031688	Map
AL	Thomas Hospital	Fairhope36532	NCT06031688	Map
AL	Mobile Infirmary Medical Center	Mobile36607	NCT06031688	Map
AL	Gulf Health Hospitals Inc/Infirmary Cancer Care - Saraland	Saraland36571	NCT06031688	Map
AR	NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro	Jonesboro72401	NCT06031688	Map
AR	University of Arkansas for Medical Sciences	Little Rock72205	NCT06031688	Map
CA	Sutter Auburn Faith Hospital	Auburn95602	NCT06031688	Map
CA	Alta Bates Summit Medical Center-Herrick Campus	Berkeley94704	NCT06031688	Map
CA	Tower Cancer Research Foundation	Beverly Hills90211	NCT06031688	Map
CA	Palo Alto Medical Foundation-Fremont	Fremont94538	NCT06031688	Map
CA	UC San Diego Moores Cancer Center	La Jolla92093	NCT06031688	Map
CA	Cedars-Sinai Medical Center	Los Angeles90048	NCT06031688	Map
CA	Memorial Medical Center	Modesto95355	NCT06031688	Map
CA	Eisenhower Medical Center	Rancho Mirage92270	NCT06031688	Map
CA	Sutter Roseville Medical Center	Roseville95661	NCT06031688	Map
CA	Sutter Medical Center Sacramento	Sacramento95816	NCT06031688	Map
CA	University of California Davis Comprehensive Cancer Center	Sacramento95817	NCT06031688	Map
CA	California Pacific Medical Center-Pacific Campus	San Francisco94115	NCT06031688	Map
CA	Kaiser Permanente-San Francisco	San Francisco94115	NCT06031688	Map
CA	Mills Health Center	San Mateo94401	NCT06031688	Map
CA	Palo Alto Medical Foundation-Santa Cruz	Santa Cruz95065	NCT06031688	Map
CA	Sutter Pacific Medical Foundation	Santa Rosa95403	NCT06031688	Map
CA	Palo Alto Medical Foundation-Sunnyvale	Sunnyvale94086	NCT06031688	Map
CA	Cedars-Sinai Cancer - Tarzana	Tarzana91356	NCT06031688	Map
CA	Torrance Memorial Physician Network - Cancer Care	Torrance90505	NCT06031688	Map
CA	Kaiser Permanente-Vallejo	Vallejo94589	NCT06031688	Map
CA	Sutter Solano Medical Center/Cancer Center	Vallejo94589	NCT06031688	Map
CO	UCHealth University of Colorado Hospital	Aurora80045	NCT06031688	Map
CO	Memorial Hospital North	Colorado Springs80920	NCT06031688	Map
CO	UCHealth Memorial Hospital Central	Colorado Springs80909	NCT06031688	Map
CO	Cancer Care and Hematology-Fort Collins	Fort Collins80528	NCT06031688	Map
CO	Poudre Valley Hospital	Fort Collins80524	NCT06031688	Map
CO	UCHealth Greeley Hospital	Greeley80631	NCT06031688	Map
CO	Medical Center of the Rockies	Loveland80538	NCT06031688	Map
CT	Smilow Cancer Hospital-Derby Care Center	Derby06418	NCT06031688	Map
CT	Smilow Cancer Hospital Care Center-Fairfield	Fairfield06824	NCT06031688	Map
CT	Smilow Cancer Hospital Care Center at Glastonbury	Glastonbury06033	NCT06031688	Map
CT	Smilow Cancer Hospital Care Center at Greenwich	Greenwich06830	NCT06031688	Map
CT	Smilow Cancer Hospital Care Center - Guilford	Guilford06437	NCT06031688	Map
CT	Smilow Cancer Hospital Care Center at Saint Francis	Hartford06105	NCT06031688	Map
CT	Yale University	New Haven06520	NCT06031688	Map
CT	Yale-New Haven Hospital North Haven Medical Center	North Haven06473	NCT06031688	Map
CT	Smilow Cancer Hospital Care Center at Long Ridge	Stamford06902	NCT06031688	Map
CT	Smilow Cancer Hospital-Torrington Care Center	Torrington06790	NCT06031688	Map
CT	Smilow Cancer Hospital Care Center-Trumbull	Trumbull06611	NCT06031688	Map
CT	Smilow Cancer Hospital-Waterbury Care Center	Waterbury06708	NCT06031688	Map
CT	Smilow Cancer Hospital Care Center - Waterford	Waterford06385	NCT06031688	Map
DE	Bayhealth Hospital Kent Campus	Dover19901	NCT06031688	Map
DE	Bayhealth Hospital Sussex Campus	Milford19963	NCT06031688	Map
DC	Kaiser Permanente-Capitol Hill Medical Center	Washington D.C.20002	NCT06031688	Map
FL	Moffitt Cancer Center	Tampa33612	NCT06031688	Map
GA	University Cancer and Blood Center LLC	Athens30607	NCT06031688	Map
GA	Northeast Georgia Medical Center-Gainesville	Gainesville30501	NCT06031688	Map
ID	Saint Alphonsus Cancer Care Center-Boise	Boise83706	NCT06031688	Map
ID	Saint Alphonsus Cancer Care Center-Caldwell	Caldwell83605	NCT06031688	Map
ID	Kootenai Health - Coeur d'Alene	Coeur d'Alene83814	NCT06031688	Map
ID	Saint Alphonsus Cancer Care Center-Nampa	Nampa83687	NCT06031688	Map
ID	Kootenai Clinic Cancer Services - Post Falls	Post Falls83854	NCT06031688	Map
ID	Kootenai Clinic Cancer Services - Sandpoint	Sandpoint83864	NCT06031688	Map
IL	Illinois CancerCare-Bloomington	Bloomington61704	NCT06031688	Map
IL	Illinois CancerCare-Canton	Canton61520	NCT06031688	Map
IL	Illinois CancerCare-Carthage	Carthage62321	NCT06031688	Map
IL	John H Stroger Jr Hospital of Cook County	Chicago60612	NCT06031688	Map
IL	Northwestern University	Chicago60611	NCT06031688	Map
IL	Carle at The Riverfront	Danville61832	NCT06031688	Map
IL	Cancer Care Specialists of Illinois - Decatur	Decatur62526	NCT06031688	Map
IL	Decatur Memorial Hospital	Decatur62526	NCT06031688	Map
IL	Northwestern Medicine Cancer Center Kishwaukee	DeKalb60115	NCT06031688	Map
IL	Illinois CancerCare-Dixon	Dixon61021	NCT06031688	Map
IL	Carle Physician Group-Effingham	Effingham62401	NCT06031688	Map
IL	Crossroads Cancer Center	Effingham62401	NCT06031688	Map
IL	Illinois CancerCare-Eureka	Eureka61530	NCT06031688	Map
IL	Illinois CancerCare-Galesburg	Galesburg61401	NCT06031688	Map
IL	Northwestern Medicine Cancer Center Delnor	Geneva60134	NCT06031688	Map
IL	Northwestern Medicine Glenview Outpatient Center	Glenview60026	NCT06031688	Map
IL	Northwestern Medicine Grayslake Outpatient Center	Grayslake60030	NCT06031688	Map
IL	Edward Hines Jr VA Hospital	Hines60141	NCT06031688	Map
IL	Illinois CancerCare-Kewanee Clinic	Kewanee61443	NCT06031688	Map
IL	Northwestern Medicine Lake Forest Hospital	Lake Forest60045	NCT06031688	Map
IL	Illinois CancerCare-Macomb	Macomb61455	NCT06031688	Map
IL	Carle Physician Group-Mattoon/Charleston	Mattoon61938	NCT06031688	Map
IL	Loyola University Medical Center	Maywood60153	NCT06031688	Map
IL	Cancer Care Center of O'Fallon	O'Fallon62269	NCT06031688	Map
IL	Northwestern Medicine Oak Brook	Oak Brook60523	NCT06031688	Map
IL	Northwestern Medicine Orland Park	Orland Park60462	NCT06031688	Map
IL	Illinois CancerCare-Ottawa Clinic	Ottawa61350	NCT06031688	Map
IL	Illinois CancerCare-Pekin	Pekin61554	NCT06031688	Map
IL	Illinois CancerCare-Peoria	Peoria61615	NCT06031688	Map
IL	Illinois CancerCare-Peru	Peru61354	NCT06031688	Map
IL	Illinois CancerCare-Princeton	Princeton61356	NCT06031688	Map
IL	Memorial Hospital East	Shiloh62269	NCT06031688	Map
IL	Southern Illinois University School of Medicine	Springfield62702	NCT06031688	Map
IL	Springfield Clinic	Springfield62702	NCT06031688	Map
IL	Springfield Memorial Hospital	Springfield62781	NCT06031688	Map
IL	Carle Cancer Center	Urbana61801	NCT06031688	Map
IL	Northwestern Medicine Cancer Center Warrenville	Warrenville60555	NCT06031688	Map
IL	Illinois CancerCare - Washington	Washington61571	NCT06031688	Map
IN	Indiana University/Melvin and Bren Simon Cancer Center	Indianapolis46202	NCT06031688	Map
IA	Mary Greeley Medical Center	Ames50010	NCT06031688	Map
IA	McFarland Clinic - Ames	Ames50010	NCT06031688	Map
IA	UI Health Care Mission Cancer and Blood - Ankeny Clinic	Ankeny50023	NCT06031688	Map
IA	UI Health Care Mission Cancer and Blood - West Des Moines Clinic	Clive50325	NCT06031688	Map
IA	Iowa Methodist Medical Center	Des Moines50309	NCT06031688	Map
IA	UI Health Care Mission Cancer and Blood - Des Moines Clinic	Des Moines50309	NCT06031688	Map
IA	UI Health Care Mission Cancer and Blood - Laurel Clinic	Des Moines50314	NCT06031688	Map
IA	McFarland Clinic - Trinity Cancer Center	Fort Dodge50501	NCT06031688	Map
IA	McFarland Clinic - Marshalltown	Marshalltown50158	NCT06031688	Map
IA	UI Health Care Mission Cancer and Blood - Waukee Clinic	Waukee50263	NCT06031688	Map
KS	University of Kansas Clinical Research Center	Fairway66205	NCT06031688	Map
KS	HaysMed	Hays67601	NCT06031688	Map
KS	University of Kansas Cancer Center	Kansas City66160	NCT06031688	Map
KS	Lawrence Memorial Hospital	Lawrence66044	NCT06031688	Map
KS	The University of Kansas Cancer Center - Olathe	Olathe66061	NCT06031688	Map
KS	University of Kansas Cancer Center-Overland Park	Overland Park66210	NCT06031688	Map
KS	University of Kansas Hospital-Indian Creek Campus	Overland Park66211	NCT06031688	Map
KS	Salina Regional Health Center	Salina67401	NCT06031688	Map
KS	University of Kansas Health System Saint Francis Campus	Topeka66606	NCT06031688	Map
KS	University of Kansas Hospital-Westwood Cancer Center	Westwood66205	NCT06031688	Map
KY	University of Kentucky/Markey Cancer Center	Lexington40536	NCT06031688	Map
ME	Lafayette Family Cancer Center-EMMC	Brewer04412	NCT06031688	Map
MD	Kaiser Permanente-Woodlawn Medical Center	Baltimore21244	NCT06031688	Map
MD	Kaiser Permanente-Gaithersburg Medical Center	Gaithersburg20879	NCT06031688	Map
MD	Kaiser Permanente - Largo Medical Center	Largo20774	NCT06031688	Map
MD	Kaiser Permanente Lutherville - Timonium Medical Center	Lutherville21093	NCT06031688	Map
MA	UMass Memorial Medical Center - University Campus	Worcester01655	NCT06031688	Map
MI	Trinity Health Saint Joseph Mercy Hospital Ann Arbor	Ann Arbor48106	NCT06031688	Map
MI	Trinity Health IHA Medical Group Hematology Oncology - Brighton	Brighton48114	NCT06031688	Map
MI	Trinity Health Medical Center - Brighton	Brighton48114	NCT06031688	Map
MI	Trinity Health IHA Medical Group Hematology Oncology - Canton	Canton48188	NCT06031688	Map
MI	Trinity Health Medical Center - Canton	Canton48188	NCT06031688	Map
MI	Chelsea Hospital	Chelsea48118	NCT06031688	Map
MI	Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital	Chelsea48118	NCT06031688	Map
MI	Cancer Hematology Centers - Flint	Flint48503	NCT06031688	Map
MI	Genesys Hurley Cancer Institute	Flint48503	NCT06031688	Map
MI	Hurley Medical Center	Flint48503	NCT06031688	Map
MI	University of Michigan Health - Sparrow Lansing	Lansing48912	NCT06031688	Map
MI	Trinity Health Saint Mary Mercy Livonia Hospital	Livonia48154	NCT06031688	Map
MI	Trinity Health Saint Joseph Mercy Oakland Hospital	Pontiac48341	NCT06031688	Map
MI	MyMichigan Medical Center Saginaw	Saginaw48601	NCT06031688	Map
MI	MyMichigan Medical Center Tawas	Tawas City48764	NCT06031688	Map
MI	Huron Gastroenterology PC	Ypsilanti48106	NCT06031688	Map
MI	Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus	Ypsilanti48197	NCT06031688	Map
MN	Sanford Joe Lueken Cancer Center	Bemidji56601	NCT06031688	Map
MN	Essentia Health - Deer River Clinic	Deer River56636	NCT06031688	Map
MN	Essentia Health Cancer Center	Duluth55805	NCT06031688	Map
MN	Essentia Health Hibbing Clinic	Hibbing55746	NCT06031688	Map
MN	Essentia Health Sandstone	Sandstone55072	NCT06031688	Map
MN	Essentia Health Virginia Clinic	Virginia55792	NCT06031688	Map
MS	Baptist Memorial Hospital and Cancer Center-Golden Triangle	Columbus39705	NCT06031688	Map
MS	Baptist Cancer Center-Grenada	Grenada38901	NCT06031688	Map
MS	Baptist Memorial Hospital and Cancer Center-Union County	New Albany38652	NCT06031688	Map
MS	Baptist Memorial Hospital and Cancer Center-Oxford	Oxford38655	NCT06031688	Map
MS	Baptist Memorial Hospital and Cancer Center-Desoto	Southhaven38671	NCT06031688	Map
MO	Saint Francis Medical Center	Cape Girardeau63703	NCT06031688	Map
MO	Siteman Cancer Center at Saint Peters Hospital	City of Saint Peters63376	NCT06031688	Map
MO	Siteman Cancer Center at West County Hospital	Creve Coeur63141	NCT06031688	Map
MO	University Health Truman Medical Center	Kansas City64108	NCT06031688	Map
MO	University of Kansas Cancer Center - Briarcliff	Kansas City64116	NCT06031688	Map
MO	University of Kansas Cancer Center - North	Kansas City64154	NCT06031688	Map
MO	University of Kansas Cancer Center - Lee's Summit	Lee's Summit64064	NCT06031688	Map
MO	Mercy Hospital South	St Louis63128	NCT06031688	Map
MO	Siteman Cancer Center at Christian Hospital	St Louis63136	NCT06031688	Map
MO	Siteman Cancer Center-South County	St Louis63129	NCT06031688	Map
MO	Washington University School of Medicine	St Louis63110	NCT06031688	Map
MT	Community Hospital of Anaconda	Anaconda59711	NCT06031688	Map
MT	Billings Clinic Cancer Center	Billings59101	NCT06031688	Map
MT	Bozeman Health Deaconess Hospital	Bozeman59715	NCT06031688	Map
MT	Benefis Sletten Cancer Institute	Great Falls59405	NCT06031688	Map
MT	Logan Health Medical Center	Kalispell59901	NCT06031688	Map
MT	Community Medical Center	Missoula59804	NCT06031688	Map
NV	OptumCare Cancer Care at Charleston	Las Vegas89102	NCT06031688	Map
NV	OptumCare Cancer Care at Fort Apache	Las Vegas89183	NCT06031688	Map
NH	New Hampshire Oncology Hematology PA-Concord	Concord03301	NCT06031688	Map
NH	Solinsky Center for Cancer Care	Manchester03103	NCT06031688	Map
NJ	Memorial Sloan Kettering Basking Ridge	Basking Ridge07920	NCT06031688	Map
NJ	Memorial Sloan Kettering Monmouth	Middletown07748	NCT06031688	Map
NJ	Memorial Sloan Kettering Bergen	Montvale07645	NCT06031688	Map
NJ	Virtua Samson Cancer Center	Moorestown08057	NCT06031688	Map
NJ	Virtua Voorhees	Voorhees Township08043	NCT06031688	Map
NY	Memorial Sloan Kettering Commack	Commack11725	NCT06031688	Map
NY	Memorial Sloan Kettering Westchester	Harrison10604	NCT06031688	Map
NY	Memorial Sloan Kettering Cancer Center	New York10065	NCT06031688	Map
NY	University of Rochester	Rochester14642	NCT06031688	Map
NY	Memorial Sloan Kettering Nassau	Uniondale11553	NCT06031688	Map
NC	FirstHealth of the Carolinas-Moore Regional Hospital	Pinehurst28374	NCT06031688	Map
ND	Sanford Bismarck Medical Center	Bismarck58501	NCT06031688	Map
ND	Sanford Broadway Medical Center	Fargo58122	NCT06031688	Map
ND	Sanford Roger Maris Cancer Center	Fargo58122	NCT06031688	Map
OH	Aultman Health Foundation	Canton44710	NCT06031688	Map
OH	Miami Valley Hospital South	Centerville45459	NCT06031688	Map
OH	Ohio State University Comprehensive Cancer Center	Columbus43210	NCT06031688	Map
OH	Miami Valley Hospital	Dayton45409	NCT06031688	Map
OH	Miami Valley Hospital North	Dayton45415	NCT06031688	Map
OH	Premier Blood and Cancer Center	Dayton45409	NCT06031688	Map
OH	Atrium Medical Center-Middletown Regional Hospital	Franklin45005-1066	NCT06031688	Map
OH	Miami Valley Cancer Care and Infusion	Greenville45331	NCT06031688	Map
OH	ProMedica Flower Hospital	Sylvania43560	NCT06031688	Map
OH	Upper Valley Medical Center	Troy45373	NCT06031688	Map
OK	Cancer Centers of Southwest Oklahoma Research	Lawton73505	NCT06031688	Map
OK	University of Oklahoma Health Sciences Center	Oklahoma City73104	NCT06031688	Map
OR	Providence Newberg Medical Center	Newberg97132	NCT06031688	Map
OR	Saint Alphonsus Cancer Care Center-Ontario	Ontario97914	NCT06031688	Map
OR	Providence Willamette Falls Medical Center	Oregon City97045	NCT06031688	Map
OR	Kaiser Permanente Northwest	Portland97227	NCT06031688	Map
OR	Oregon Health and Science University	Portland97239	NCT06031688	Map
OR	Providence Portland Medical Center	Portland97213	NCT06031688	Map
OR	Providence Saint Vincent Medical Center	Portland97225	NCT06031688	Map
PA	WellSpan Medical Oncology and Hematology	Chambersburg17201	NCT06031688	Map
PA	Geisinger Medical Center	Danville17822	NCT06031688	Map
PA	Geisinger Cancer Center Dickson City	Dickson City18519	NCT06031688	Map
PA	Ephrata Cancer Center	Ephrata17522	NCT06031688	Map
PA	Adams Cancer Center	Gettysburg17325	NCT06031688	Map
PA	Sechler Family Cancer Center	Lebanon17042	NCT06031688	Map
PA	Geisinger Medical Oncology-Lewisburg	Lewisburg17837	NCT06031688	Map
PA	Community Medical Center	Scranton18510	NCT06031688	Map
PA	Geisinger Wyoming Valley/Henry Cancer Center	Wilkes-Barre18711	NCT06031688	Map
PA	Cancer Care Associates of York	York17403	NCT06031688	Map
PA	WellSpan Health-York Cancer Center	York17403	NCT06031688	Map
PA	WellSpan Health-York Hospital	York17403	NCT06031688	Map
SC	AnMed Health Cancer Center	Anderson29621	NCT06031688	Map
SD	Sanford Cancer Center Oncology Clinic	Sioux Falls57104	NCT06031688	Map
SD	Sanford USD Medical Center - Sioux Falls	Sioux Falls57117-5134	NCT06031688	Map
TN	Baptist Memorial Hospital and Cancer Center-Collierville	Collierville38017	NCT06031688	Map
TN	Baptist Memorial Hospital and Cancer Center-Memphis	Memphis38120	NCT06031688	Map
TX	The Don and Sybil Harrington Cancer Center	Amarillo79106	NCT06031688	Map
UT	Huntsman Cancer Institute/University of Utah	Salt Lake City84112	NCT06031688	Map
VA	Kaiser Permanente Tysons Corner Medical Center	McLean22102	NCT06031688	Map
VA	Kaiser Permanente-Caton Hill Medical Center	Woodbridge22192	NCT06031688	Map
WA	Swedish Cancer Institute-Edmonds	Edmonds98026	NCT06031688	Map
WA	Swedish Cancer Institute-Issaquah	Issaquah98029	NCT06031688	Map
WA	Swedish Medical Center-First Hill	Seattle98122	NCT06031688	Map
WV	Edwards Comprehensive Cancer Center	Huntington25701	NCT06031688	Map
WV	West Virginia University Healthcare	Morgantown26506	NCT06031688	Map
WI	Duluth Clinic Ashland	Ashland54806	NCT06031688	Map
WI	Marshfield Medical Center-EC Cancer Center	Eau Claire54701	NCT06031688	Map
WI	Gundersen Lutheran Medical Center	La Crosse54601	NCT06031688	Map
WI	Marshfield Medical Center-Marshfield	Marshfield54449	NCT06031688	Map
WI	Marshfield Medical Center - Minocqua	Minocqua54548	NCT06031688	Map
WI	Marshfield Medical Center-Rice Lake	Rice Lake54868	NCT06031688	Map
WI	Marshfield Medical Center-River Region at Stevens Point	Stevens Point54482	NCT06031688	Map
WI	Marshfield Medical Center - Weston	Weston54476	NCT06031688	Map

Tepotinib clinical trials at a glance: phase × recruitment status

Phase	recruiting	active not recruiting	completed	terminated	withdrawn	unknown	Total
P1		1	9		1		11
P1/P2	1	1	3	1			6
P2	4	2		1		2	9
P3	1						1

Recruiting Tepotinib clinical trials (6)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT ID	Title	Phase	Indication	Enrollment	Started
NCT06106802	Lazertinib & Tepotinib for EGFR Mutant NSCLC in MET Overexpressed or Amplified Who Progressed After Lazertinib Treatment	P2	Non-Small Cell Lung Cancer Metastatic	47	Jun 2024
NCT06908993	COMETTepotinib vs Standard Treatment in Patients With Advanced MET Exon 14 Mutated Non-Small Cell Lung Cancer Previously Treated	P3	Advanced Non Small Cell Lung Cancer	133	Dec 2025
NCT06031688	Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)	P2	Recurrent Lung Non-Small Cell Carcinoma	56	Aug 2024
NCT02925234	DRUPThe Drug Rediscovery Protocol (DRUP Trial)	P2	Cancer	1,550	Aug 2016
NCT05159245	FINPROVEThe Finnish National Study to Facilitate Patient Access to Targeted Anti-cancer Drugs	P2	Advanced Cancer	250	Dec 2021
NCT05439993	Tepotinib Plus Paclitaxel in MET Amplified or MET Exon 14 Alterated Gastric and GEJ Carcinoma	P1/P2	Gastric Cancer	42	Mar 2022

Tepotinib clinical trials by indication

Healthy (8)

NCT	Acronym	Phase	Status	Title
NCT05203822	—	P1	completed	Tepotinib Drug-Drug Interaction Study With Itraconazole in Healthy Participants
NCT05213481	—	P1	completed	Tepotinib Drug-Drug Interaction Study With Carbamazepine in Healthy Participants
NCT04204902	—	P1	completed	Bioequivalence of 5 Tablets of 100 mg Versus 2 Tablets of 250 mg TF3 of Tepotinib
NCT03629223	—	P1	completed	Bioequivalence of TF3 and TF2 and Effect of Food on the PK of Tepotinib
NCT03628339	—	P1	completed	Effect of Tepotinib on PK of CYP3A Substrate Midazolam
NCT03492437	—	P1	completed	Effect of Tepotinib on the PK of the P-gp Substrate Dabigatran Etexilate
NCT03531762	—	P1	completed	Effect of a Proton Pump Inhibitor on the PK of Tepotinib
NCT03021642	—	P1	completed	Relative Bioavailability of Two Tepotinib Film-Coated Tablet Formulations in Healthy Volunteers

Non-small Cell Lung Cancer (3)

NCT	Acronym	Phase	Status	Title
NCT06083857	—	P1/P2	active not recruiting	PhI/II Study of Amivantamab and Tepotinib Combo in MET-altered Non-small Cell Lung Cancer
NCT03940703	INSIGHT 2	P2	active not recruiting	A Study of Tepotinib Plus Osimertinib in Osimertinib Relapsed MET Amplified NSCLC (INSIGHT 2)
NCT01982955	INSIGHT	P1/P2	completed	Tepotinib With Gefitinib in Participants With Locally Advanced or Metastatic NSCLC (INSIGHT)

Advanced Cancer (2)

NCT	Acronym	Phase	Status	Title
NCT05782361	POTENT	P1	active not recruiting	POTENT - Tepotinib in Combination With Pembrolizumab in NSCLC
NCT05159245	FINPROVE	P2	recruiting	The Finnish National Study to Facilitate Patient Access to Targeted Anti-cancer Drugs

Carcinoma, Hepatocellular (2)

NCT	Acronym	Phase	Status	Title
NCT01988493	—	P1/P2	completed	Efficacy, Safety, and Pharmacokinetic of MSC2156119J in Asian Participants With Hepatocellular Carcinoma
NCT02115373	—	P1/P2	completed	c-Met Second-Line Hepatocellular Carcinoma

Advanced Non Small Cell Lung Cancer (1)

NCT	Acronym	Phase	Status	Title
NCT06908993	COMET	P3	recruiting	Tepotinib vs Standard Treatment in Patients With Advanced MET Exon 14 Mutated Non-Small Cell Lung Cancer Previously Treated

Recurrent Lung Non-Small Cell Carcinoma (1)

NCT	Acronym	Phase	Status	Title
NCT06031688	—	P2	recruiting	Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

Non-Small Cell Lung Cancer Metastatic (1)

NCT	Acronym	Phase	Status	Title
NCT06106802	—	P2	recruiting	Lazertinib & Tepotinib for EGFR Mutant NSCLC in MET Overexpressed or Amplified Who Progressed After Lazertinib Treatment

Brain Tumor (1)

NCT	Acronym	Phase	Status	Title
NCT05120960	—	P1	withdrawn	A Phase 1a/1b Study to Determine the Recommended Phase 2 Dose, of Tepotinib in Participants With MET Alterations and Brain Tumors

Advanced Non-Small Cell Lung Cancer With MET Mutations (1)

NCT	Acronym	Phase	Status	Title
NCT04739358	—	P1/P2	terminated	CNS Dose Escalation/Expansion of Tepotinib in MET-driven NSCLC

Gastric Cancer (1)

NCT	Acronym	Phase	Status	Title
NCT05439993	—	P1/P2	recruiting	Tepotinib Plus Paclitaxel in MET Amplified or MET Exon 14 Alterated Gastric and GEJ Carcinoma

Colorectal Neoplasms (1)

NCT	Acronym	Phase	Status	Title
NCT04515394	PERSPECTIVE	P2	terminated	Study of Tepotinib Combined With Cetuximab in Participants With Left-Sided RAS/BRAF Wild Type Metastatic Colorectal Cancer (PERSPECTIVE)

Breast Cancer (1)

NCT	Acronym	Phase	Status	Title
NCT04591431	ROME	P2	unknown	The Rome Trial From Histology to Target: the Road to Personalize Target Therapy and Immunotherapy

Solid Tumor (1)

NCT	Acronym	Phase	Status	Title
NCT04647838	—	P2	unknown	Tepotinib in Solid Tumors Harboring MET Alterations

Hepatic Impairment (1)

NCT	Acronym	Phase	Status	Title
NCT03546608	—	P1	completed	Tepotinib Hepatic Impairment Trial

Advanced (Stage IIIB/IV) Non-small Cell Lung Cancer (NSCLC) With MET Exon 14 (METex14) Skipping Alterations or MET Amplification (1)

NCT	Acronym	Phase	Status	Title
NCT02864992	VISION	P2	active not recruiting	Tepotinib Phase II in NSCLC Harboring MET Alterations (VISION)

Cancer (1)

NCT	Acronym	Phase	Status	Title
NCT02925234	DRUP	P2	recruiting	The Drug Rediscovery Protocol (DRUP Trial)

Tepotinib pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

Acronym	NCT	Phase	Status	Indication	Enrollment	PubMed
COMET	NCT06908993	P3	recruiting	Advanced Non Small Cell Lung Cancer	133	—
DRUP	NCT02925234	P2	recruiting	Cancer	1,550	PMID 37424386
FINPROVE	NCT05159245	P2	recruiting	Advanced Cancer	250	—
INSIGHT 2	NCT03940703	P2	active not recruiting	Non-small Cell Lung Cancer	140	PMID 39089305
VISION	NCT02864992	P2	active not recruiting	Advanced (Stage IIIB/IV) Non-small Cell Lung Cancer (NSCLC) With MET Exon 14 (METex14) Skipping Alterations or MET Amplification	337	PMID 32469185
ROME	NCT04591431	P2	unknown	Breast Cancer	400	PMID 41963505
PERSPECTIVE	NCT04515394	P2	terminated	Colorectal Neoplasms	3	—

Terminated and withdrawn Tepotinib trials (3)

Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.

NCT05120960withdrawnA Phase 1a/1b Study to Determine the Recommended Phase 2 Dose, of Tepotinib in Participants With MET Alterations and Brain Tumors
NCT04739358terminatedCNS Dose Escalation/Expansion of Tepotinib in MET-driven NSCLC
NCT04515394terminatedStudy of Tepotinib Combined With Cetuximab in Participants With Left-Sided RAS/BRAF Wild Type Metastatic Colorectal Cancer (PERSPECTIVE)

All Tepotinib trials (27)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT ID	Acronym	Title	Phase	Status	Enrollment	Sponsor	Started
NCT06106802		Lazertinib & Tepotinib for EGFR Mutant NSCLC in MET Overexpressed or Amplified Who Progressed After Lazertinib Treatment	P2	recruiting	47	Samsung Medical Center	Jun 2024
NCT05782361	POTENT	POTENT - Tepotinib in Combination With Pembrolizumab in NSCLC	P1	active not recruiting	19	Institute of Cancer Research, United Kingdom	May 2023
NCT06908993	COMET	Tepotinib vs Standard Treatment in Patients With Advanced MET Exon 14 Mutated Non-Small Cell Lung Cancer Previously Treated	P3	recruiting	133	Intergroupe Francophone de Cancerologie Thoracique	Dec 2025
NCT06031688		Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)	P2	recruiting	56	SWOG Cancer Research Network	Aug 2024
NCT06083857		PhI/II Study of Amivantamab and Tepotinib Combo in MET-altered Non-small Cell Lung Cancer	P1/P2	active not recruiting	3	M.D. Anderson Cancer Center	Jun 2024
NCT02925234	DRUP	The Drug Rediscovery Protocol (DRUP Trial)	P2	recruiting	1,550	The Netherlands Cancer Institute	Aug 2016
NCT05159245	FINPROVE	The Finnish National Study to Facilitate Patient Access to Targeted Anti-cancer Drugs	P2	recruiting	250	Helsinki University Central Hospital	Dec 2021
NCT05439993		Tepotinib Plus Paclitaxel in MET Amplified or MET Exon 14 Alterated Gastric and GEJ Carcinoma	P1/P2	recruiting	42	Hallym University Medical Center	Mar 2022
NCT03940703	INSIGHT 2	A Study of Tepotinib Plus Osimertinib in Osimertinib Relapsed MET Amplified NSCLC (INSIGHT 2)	P2	active not recruiting	140	EMD Serono Research & Development Institute, Inc.	Sep 2019
NCT02864992	VISION	Tepotinib Phase II in NSCLC Harboring MET Alterations (VISION)	P2	active not recruiting	337	EMD Serono Research & Development Institute, Inc.	Sep 2016
NCT04591431	ROME	The Rome Trial From Histology to Target: the Road to Personalize Target Therapy and Immunotherapy	P2	unknown	400	Fondazione per la Medicina Personalizzata	Oct 2020
NCT04647838		Tepotinib in Solid Tumors Harboring MET Alterations	P2	unknown	100	Chungbuk National University Hospital	Jan 2020
NCT05120960		A Phase 1a/1b Study to Determine the Recommended Phase 2 Dose, of Tepotinib in Participants With MET Alterations and Brain Tumors	P1	withdrawn	0	M.D. Anderson Cancer Center	Feb 2023
NCT04739358		CNS Dose Escalation/Expansion of Tepotinib in MET-driven NSCLC	P1/P2	terminated	2	Criterium, Inc.	May 2022
NCT05203822		Tepotinib Drug-Drug Interaction Study With Itraconazole in Healthy Participants	P1	completed	18	Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany	Jan 2022
NCT05213481		Tepotinib Drug-Drug Interaction Study With Carbamazepine in Healthy Participants	P1	completed	18	Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany	Dec 2021
NCT04515394	PERSPECTIVE	Study of Tepotinib Combined With Cetuximab in Participants With Left-Sided RAS/BRAF Wild Type Metastatic Colorectal Cancer (PERSPECTIVE)	P2	terminated	3	EMD Serono Research & Development Institute, Inc.	Jan 2021
NCT01982955	INSIGHT	Tepotinib With Gefitinib in Participants With Locally Advanced or Metastatic NSCLC (INSIGHT)	P1/P2	completed	88	Merck KGaA, Darmstadt, Germany	Dec 2013
NCT01988493		Efficacy, Safety, and Pharmacokinetic of MSC2156119J in Asian Participants With Hepatocellular Carcinoma	P1/P2	completed	117	Merck KGaA, Darmstadt, Germany	Jan 2014
NCT04204902		Bioequivalence of 5 Tablets of 100 mg Versus 2 Tablets of 250 mg TF3 of Tepotinib	P1	completed	18	Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany	Oct 2019
NCT03546608		Tepotinib Hepatic Impairment Trial	P1	completed	18	EMD Serono Research & Development Institute, Inc.	Jun 2018
NCT03629223		Bioequivalence of TF3 and TF2 and Effect of Food on the PK of Tepotinib	P1	completed	66	Merck KGaA, Darmstadt, Germany	Aug 2018
NCT03628339		Effect of Tepotinib on PK of CYP3A Substrate Midazolam	P1	completed	12	Merck KGaA, Darmstadt, Germany	Aug 2018
NCT03492437		Effect of Tepotinib on the PK of the P-gp Substrate Dabigatran Etexilate	P1	completed	20	Merck KGaA, Darmstadt, Germany	May 2018
NCT03531762		Effect of a Proton Pump Inhibitor on the PK of Tepotinib	P1	completed	12	Merck KGaA, Darmstadt, Germany	May 2018
NCT02115373		c-Met Second-Line Hepatocellular Carcinoma	P1/P2	completed	66	Merck KGaA, Darmstadt, Germany	May 2014
NCT03021642		Relative Bioavailability of Two Tepotinib Film-Coated Tablet Formulations in Healthy Volunteers	P1	completed	24	Merck KGaA, Darmstadt, Germany	Jan 2016

Tepotinib clinical trials: frequently asked questions

How many Tepotinib clinical trials are there?: 27 Tepotinib clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 6 are actively recruiting participants. 12 are marked completed.
Are Tepotinib clinical trials recruiting in 2026?: Yes — 6 Tepotinib trials are actively recruiting in 2026, with 241 U.S. sites across 42 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Tepotinib being studied for?: Tepotinib is being studied for Healthy, Non-small Cell Lung Cancer, Non Small Cell Lung Cancer, Carcinoma, Hepatocellular, Solid Tumor and 24 more. The trials are grouped by indication on this page.
What phase is Tepotinib in?: Tepotinib clinical trials span 1 Phase 3, 9 Phase 2, 11 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Tepotinib clinical trials?: The lead sponsor across the most Tepotinib trials is Merck KGaA, Darmstadt, Germany, with 13 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Tepotinibas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

Last refreshed June 12, 2026.

Related pages on Hipa.ai:

Tepotinib overview Tepotinib evidence & publications