How many Tenapanor clinical trials are there?

17 Tenapanor clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 4 are actively recruiting participants. 11 are marked completed.

Are Tenapanor clinical trials recruiting in 2026?

Yes — 4 Tenapanor trials are actively recruiting in 2026, with 111 U.S. sites across 34 states. See the recruiting trials and the per-state site list further down this page.

What conditions is Tenapanor being studied for?

Tenapanor is being studied for Hyperphosphatemia, Constipation Predominant Irritable Bowel Syndrome, Irritable Bowel Syndrome With Constipation (IBS-C), Cystic Fibrosis, End Stage Renal Disease and 9 more. The trials are grouped by indication on this page.

What phase is Tenapanor in?

Tenapanor clinical trials span 4 Phase 4, 9 Phase 3, 2 Phase 2, 1 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.

Who sponsors Tenapanor clinical trials?

The lead sponsor across the most Tenapanor trials is Ardelyx, with 4 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Tenapanor Clinical Trials (2026): 17 Studies for Hyperphosphatemia & Constipation Predominant Irritable Bowel Syndrome

Creator: Hipa.ai Research
Published: 2026-04-20T19:04:25.445Z

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: June 12, 2026.

17 Tenapanor clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 10 indications (including Hyperphosphatemia & Constipation Predominant Irritable Bowel Syndrome) and 5,240 total planned enrollment. 9 Phase 3 Tenapanor trials and 2 Phase 2, 4 Phase 4 are listed. 4 Tenapanor clinical trials are actively recruiting at 111 U.S. sites across 34 states. Most recent activity: NCT05905926 (Oct 2031).

Where to Participate: All Tenapanor Trial Sites in the U.S. (111 sites across 34 states)

Every actively recruiting Tenapanortrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

State	Facility	City	Trial	Map
AL	G & L Research, LLC	Foley36535	NCT07382167	Map
AL	The Center for Clinical Trials	Saraland36571	NCT07382167	Map
AZ	Arizona Liver Health - Chandler	Chandler85225	NCT07382167	Map
AZ	Elite Clinical Studies	Phoenix85018	NCT07382167	Map
AZ	Clinical Research Institute of Arizona, LLC	Sun City West85375	NCT07382167	Map
AZ	Del Sol Research Management, LLC	Tucson85715	NCT07382167	Map
AR	Arkansas Gastroenterology - North Little Rock	North Little Rock72117	NCT07382167	Map
CA	Hope Clinical Research - Canoga Park	Canoga Park91303	NCT07382167	Map
CA	Erick H. Alayo Medical Corporation	Chula Vista91910	NCT07382167	Map
CA	GW Research Inc.	Chula Vista91010	NCT07382167	Map
CA	310 Clinical Research	Inglewood90301	NCT07382167	Map
CA	Om Research LLC	Lancaster93534	NCT07382167	Map
CA	Clinical Trials Research	Lincoln95648	NCT07382167	Map
CA	Acclaim Clinical Research	San Diego92120	NCT07382167	Map
CA	San Jose Gastroenterology	San Jose95128	NCT07382167	Map
CA	Paragon Rx Clinical, Inc. - Santa Ana	Santa Ana92703	NCT07382167	Map
CO	Advanced Research Institute - Denver	Denver80218	NCT07382167	Map
CO	Rocky Mountain Gastroenterology (RMG) - Littleton	Lakewood80228	NCT07382167	Map
CO	Tekton Research - Longmont, CO	Longmont80501	NCT07382167	Map
FL	Proactive Clinical Research	Fort Lauderdale33308	NCT07382167	Map
FL	IMIC, Inc	Miami33176	NCT07382167	Map
FL	Valencia Medical and Research Center	Miami33174	NCT07382167	Map
FL	Waterway Research	Miami33155	NCT07382167	Map
FL	Harmony Clinical Research, Inc - North Miami Beach	Miami Beach33162	NCT07382167	Map
FL	Suncoast Clinical Research, Inc. - New Port Richey	New Port Richey34652	NCT07382167	Map
FL	Sensible Healthcare, LLC	Ocoee34761	NCT07382167	Map
FL	Harmony Clinical Research - Orlando	Orange City32763	NCT07382167	Map
FL	Suncoast Clinical Research, Inc. - Palm Harbor	Palm Harbor34684	NCT07382167	Map
FL	Clinical Research Center of Florida	Pompano Beach33060	NCT07382167	Map
GA	Agile Clinical Research Trials, LLC	Atlanta30328	NCT07382167	Map
GA	DelRicht Clinical Research - Atlanta	Atlanta30329	NCT07382167	Map
GA	Gastrointestinal Specialists of Georgia PC	Marietta30060	NCT07382167	Map
GA	North Georgia Clinical Research	Woodstock30189	NCT07382167	Map
ID	Elite Clinical Trials-Idaho	Blackfoot83221	NCT07382167	Map
ID	Treasure Valley Medical Research	Boise83706	NCT07382167	Map
IL	GI Alliance - Glenview, IL	Glenview60026	NCT07382167	Map
IL	Clinical Investigation Specialists, Inc	Gurnee60031	NCT07382167	Map
IL	Southwest Gastroenterology	Oak Lawn60453	NCT07382167	Map
IL	Evanston Premier Healthcare Research LLC	Skokie60077	NCT07382167	Map
IN	DelRicht Clinical Research - Indianapolis	Indianapolis46202	NCT07382167	Map
IA	Cedar Valley Digestive Health Center	Waterloo50701	NCT06460038	Map
KS	DelRicht Clinical Research - Overland Park	Overland Park66209	NCT07382167	Map
KS	Tekton Research - Wichita, KS	Wichita67218	NCT07382167	Map
KY	DelRicht Clinical Research - Louisville	Louisville40205	NCT07382167	Map
LA	Tandem Clinical Research GI - Houma	Houma70363	NCT07382167	Map
LA	DelRicht Clinical Research - Covington	Mandeville70471	NCT07382167	Map
LA	Tandem Clinical Research	Marrero70072	NCT07382167	Map
LA	DelRicht Clinical Research - New Orleans	New Orleans70115	NCT07382167	Map
LA	DelRicht Clinical Research - Prairieville	Prairieville70769	NCT07382167	Map
LA	Delta Research Partners of West Monroe, LLC	West Monroe71291	NCT07382167	Map
MD	Woodholme Gastroenterology	Glen Burnie21061	NCT07382167	Map
MA	Massachusetts General Hospital	Boston02114	NCT06810167	Map
MA	Elixia SISU BHR - Sprinfield	Springfield01103	NCT07382167	Map
MA	Bay State Clinical Trials	Watertown02472	NCT07382167	Map
MI	University of Michigan Health System	Ann Arbor48109	NCT07382167	Map
MS	DelRicht Clinical Research - Gulfport	Gulfport39503	NCT07382167	Map
MO	Kansas City Research Institute	Kansas City64131	NCT07382167	Map
MO	DelRicht Clinical Research - Springfield	Springfield65807	NCT07382167	Map
MO	St. Charles Clinical Research	St Louis63141	NCT07382167	Map
MO	DelRicht Clinical Research - Town and Country	Town and Country63017	NCT07382167	Map
MT	Gastrointestinal Associates LLP	Columbia Falls65201	NCT07382167	Map
NV	Digestive Disease Specialists	Las Vegas89128	NCT07382167	Map
NV	Excel Clinical Research	Las Vegas89109	NCT07382167	Map
NV	Jubilee Clinical Research, Inc.	Las Vegas89106	NCT07382167	Map
NV	Advanced Research Institute - Reno	Reno89511	NCT07382167	Map
NJ	Allied Health Clinical Research Organization, LLC (AHCRO) - Jackson	Jackson08724	NCT07382167	Map
NJ	Allied Digestive Health - Jersey Shore Gastroenterology - Point Commons	Somers Point08244	NCT07382167	Map
NM	Albuquerque Clinical Trials (ACT)	Albuquerque87102	NCT07382167	Map
NY	NY Scientific	Brooklyn11235	NCT07382167	Map
NY	Drug Trials America	Hartsdale10530	NCT07382167	Map
NC	Accellacare of Cary	Cary27518	NCT07382167	Map
NC	Delricht Clinical Research - Badmus	Charlotte28210	NCT07382167	Map
NC	Coastal Research Institute, LLC	Fayetteville28304	NCT07382167	Map
NC	Peters Medical Research	High Point27260	NCT07382167	Map
NC	Lucas Research - Diabetes & Endocrinology Consultants, PC	Morehead City28557	NCT07382167	Map
NC	Accellacare of Raleigh	Raleigh27609	NCT07382167	Map
NC	Accellacare of Rocky Mount	Rocky Mount27804	NCT07382167	Map
NC	Accellacare of Salisbury	Salisbury28144	NCT07382167	Map
NC	Accellacare of Piedmont HealthCare	Statesville28625	NCT07382167	Map
NC	Accellacare of Winston-Salem, Triad Neurological Associates	Winston-Salem27103	NCT07382167	Map
ND	Lillestol Research, LLC	Fargo58104	NCT07382167	Map
OH	Cleveland Clinic	Cleveland44195	NCT07382167	Map
OH	Centricity Research Columbus Ohio Multispecialty	Columbus43213	NCT07382167	Map
OH	Remington Davis, Inc.	Columbus43215	NCT07382167	Map
OH	Hometown Urgent Care and Research - Huber Heights	Huber Heights45424	NCT07382167	Map
OH	Great Lakes Gastroenterology Research	Mentor44060	NCT07382167	Map
OK	DelRicht Clinical Research - Tulsa	Tulsa74133	NCT07382167	Map
OK	Tekton Research - Yukon, OK	Yukon73099	NCT07382167	Map
OR	Advanced Research Institute - Portland	Tigard97223	NCT07382167	Map
SC	DelRicht Clinical Research - Charleston	Charleston29407	NCT07382167	Map
SC	Coastal Carolina Research Center	North Charleston29405	NCT07382167	Map
TN	Accellacare of Bristol	Bristol37620	NCT07382167	Map
TN	DelRicht Clinical Research - Nashville	Hendersonville37075	NCT07382167	Map
TN	Accellacare of Knoxville	Knoxville37938	NCT07382167	Map
TN	New Phase Research & Development - Knoxville	Knoxville37909	NCT07382167	Map
TN	Clinical Neuroscience Solutions, Inc - Memphis	Memphis38119	NCT07382167	Map
TN	Quality Medical Research, PLLC	Nashville37211	NCT07382167	Map
TX	Zenos Clinical Research	Dallas75230	NCT07382167	Map
TX	EPIC Medical Research	DeSoto75115	NCT07382167	Map
TX	3A Research	El Paso79925	NCT07382167	Map
TX	North Hills Medical Research Inc. (North Hills Family Medicine)	North Richland Hills76180	NCT07382167	Map
TX	LinQ Research, LLC	Pearland77584	NCT07382167	Map
TX	DelRicht Clinical Research - McKinney	Prosper75078	NCT07382167	Map
TX	Sun Research Institute	San Antonio78215	NCT07382167	Map
TX	Texas Gastro Consultants	Tomball77375	NCT07382167	Map
UT	Advanced Research Institute - Ogden	Ogden84405	NCT07382167	Map
UT	Wasatch Clinical Research, LLC	Salt Lake City84107	NCT07382167	Map
UT	Advanced Research Institute - Sandy	Sandy City84092	NCT07382167	Map
VA	Charlottesville Medical Research Center, LLC	Charlottesville22911	NCT07382167	Map
VA	Health Research of Hampton Roads, Inc. - Newport News	Newport News23606	NCT07382167	Map
VA	DelRicht Clinical Research - Vienn	Vienna22182	NCT07382167	Map

Tenapanor clinical trials at a glance: phase × recruitment status

Phase	recruiting	active not recruiting	enrolling by invitation	completed	Total
P1				1	1
P2	1	1			2
P2/P3				1	1
P3	2	1	1	5	9
P4				4	4

Recruiting Tenapanor clinical trials (4)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT ID	Title	Phase	Indication	Enrollment	Started
NCT05905926	Safety Study of Tenapanor for the Treatment of Pediatric Patients (6 to Less Than 18 Years Old) With IBS-C	P3	Irritable Bowel Syndrome With Constipation (IBS-C)	150	Feb 2023
NCT06810167	Assessing Tenapanor as a Treatment of CF-related Constipation.	P3	Cystic Fibrosis	25	Jun 2025
NCT07382167	A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults	P3	Chronic Idiopathic Constipation (CIC)	692	Jan 2026
NCT06460038	Tenapanor in Synucleinopathy-Related Constipation	P2	Synucleinopathy	30	Jan 2025

Tenapanor clinical trials by indication

Hyperphosphatemia (4)

NCT	Acronym	Phase	Status	Title
NCT03988920	NORMALIZE	P4	completed	A Long-Term Study of Tenapanor Alone or in Combination With Sevelamer in Patients With CKD on Dialysis and HP
NCT03427125	—	P3	completed	A Phase 3 Study of Tenapanor to Treat Hyperphosphatemia in ESRD Patients on Dialysis
NCT03824587	—	P2/P3	completed	Study to Evaluate the Efficacy of Tenapanor as Adjunctive Therapy to Phosphate Binder Therapy
NCT02675998	ESRD-HD	P3	completed	An 8-Week Study to Evaluate Tenapanor in the Treatment of Hyperphosphatemia in End-Stage Renal Disease Patients on Hemodialysis (ESRD-HD)

Irritable Bowel Syndrome With Constipation (IBS-C) (3)

NCT	Acronym	Phase	Status	Title
NCT05905926	—	P3	enrolling by invitation	Safety Study of Tenapanor for the Treatment of Pediatric Patients (6 to Less Than 18 Years Old) With IBS-C
NCT05643534	—	P3	active not recruiting	Study to Assess Safety and Efficacy of Tenapanor for Treatment of IBS-C in Pediatric Patients 12 to Less Than 18 Years
NCT06553547	—	P2	active not recruiting	4-Week, Multi-center Dose-Ranging Study for the IBS-C in Pts. 6 to <12 Yrs

Constipation Predominant Irritable Bowel Syndrome (3)

NCT	Acronym	Phase	Status	Title
NCT02727751	T3MPO-3	P3	completed	A Long-Term Safety Study of Tenapanor for the Treatment of IBS-C
NCT02686138	T3MPO-2	P3	completed	A 26-Week Study to Evaluate the Efficacy and Safety of Tenapanor in IBS-C
NCT02621892	T3MPO-1	P3	completed	A 12-Week Study With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Tenapanor for the Treatment of IBS-C

Chronic Idiopathic Constipation (CIC) (1)

NCT	Acronym	Phase	Status	Title
NCT07382167	—	P3	recruiting	A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults

Cystic Fibrosis (1)

NCT	Acronym	Phase	Status	Title
NCT06810167	—	P3	recruiting	Assessing Tenapanor as a Treatment of CF-related Constipation.

Synucleinopathy (1)

NCT	Acronym	Phase	Status	Title
NCT06460038	—	P2	recruiting	Tenapanor in Synucleinopathy-Related Constipation

Hyperoxaluria (1)

NCT	Acronym	Phase	Status	Title
NCT06481150	—	P4	completed	A Novel Approach for Reducing Hyperoxaluria and Kidney Stone Risk.

IBS (1)

NCT	Acronym	Phase	Status	Title
NCT05995899	—	P4	completed	Effect of Tenapanor on the Metagenomics and Metabolomics of Patients With Irritable Bowel Syndrome With Constipation

Lactation (1)

NCT	Acronym	Phase	Status	Title
NCT06203444	—	P1	completed	An Open-label Study to Evaluate the Pharmacokinetics of Oral Tenapanor in Breast Milk of Lactating Females

Chronic Kidney Disease Requiring Chronic Dialysis (1)

NCT	Acronym	Phase	Status	Title
NCT04549597	OPTIMIZE	P4	completed	Study to Evaluate the Use of Tenapanor as Core Therapy in the Treatment of Hyperphosphatemia

Tenapanor pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

Acronym	NCT	Phase	Status	Indication	Enrollment	PubMed
OPTIMIZE	NCT04549597	P4	completed	Chronic Kidney Disease Requiring Chronic Dialysis	333	—
NORMALIZE	NCT03988920	P4	completed	Hyperphosphatemia	172	—
ESRD-HD	NCT02675998	P3	completed	Hyperphosphatemia	219	—
T3MPO-3	NCT02727751	P3	completed	Constipation Predominant Irritable Bowel Syndrome	312	—
T3MPO-2	NCT02686138	P3	completed	Constipation Predominant Irritable Bowel Syndrome	593	—
T3MPO-1	NCT02621892	P3	completed	Constipation Predominant Irritable Bowel Syndrome	606	—

All Tenapanor trials (17)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT ID	Acronym	Title	Phase	Status	Enrollment	Sponsor	Started
NCT05905926		Safety Study of Tenapanor for the Treatment of Pediatric Patients (6 to Less Than 18 Years Old) With IBS-C	P3	enrolling by invitation	150	Ardelyx	Feb 2023
NCT06810167		Assessing Tenapanor as a Treatment of CF-related Constipation.	P3	recruiting	25	Massachusetts General Hospital	Jun 2025
NCT07382167		A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults	P3	recruiting	692	Ardelyx	Jan 2026
NCT06460038		Tenapanor in Synucleinopathy-Related Constipation	P2	recruiting	30	Cedar Valley Digestive Health Center	Jan 2025
NCT05643534		Study to Assess Safety and Efficacy of Tenapanor for Treatment of IBS-C in Pediatric Patients 12 to Less Than 18 Years	P3	active not recruiting	180	Ardelyx	Nov 2022
NCT06553547		4-Week, Multi-center Dose-Ranging Study for the IBS-C in Pts. 6 to <12 Yrs	P2	active not recruiting	72	Ardelyx	Jul 2024
NCT05995899		Effect of Tenapanor on the Metagenomics and Metabolomics of Patients With Irritable Bowel Syndrome With Constipation	P4	completed	36	Kyle Staller, MD, MPH	Feb 2024
NCT06481150		A Novel Approach for Reducing Hyperoxaluria and Kidney Stone Risk.	P4	completed	18	University of Texas Southwestern Medical Center	Jul 2024
NCT06203444		An Open-label Study to Evaluate the Pharmacokinetics of Oral Tenapanor in Breast Milk of Lactating Females	P1	completed	7	Ardelyx	Nov 2023
NCT04549597	OPTIMIZE	Study to Evaluate the Use of Tenapanor as Core Therapy in the Treatment of Hyperphosphatemia	P4	completed	333	Ardelyx	Nov 2020
NCT03988920	NORMALIZE	A Long-Term Study of Tenapanor Alone or in Combination With Sevelamer in Patients With CKD on Dialysis and HP	P4	completed	172	Ardelyx	Jun 2019
NCT03427125		A Phase 3 Study of Tenapanor to Treat Hyperphosphatemia in ESRD Patients on Dialysis	P3	completed	1,559	Ardelyx	Jan 2018
NCT03824587		Study to Evaluate the Efficacy of Tenapanor as Adjunctive Therapy to Phosphate Binder Therapy	P2/P3	completed	236	Ardelyx	Feb 2019
NCT02675998	ESRD-HD	An 8-Week Study to Evaluate Tenapanor in the Treatment of Hyperphosphatemia in End-Stage Renal Disease Patients on Hemodialysis (ESRD-HD)	P3	completed	219	Ardelyx	Jan 2016
NCT02727751	T3MPO-3	A Long-Term Safety Study of Tenapanor for the Treatment of IBS-C	P3	completed	312	Ardelyx	Mar 2016
NCT02686138	T3MPO-2	A 26-Week Study to Evaluate the Efficacy and Safety of Tenapanor in IBS-C	P3	completed	593	Ardelyx	Dec 2015
NCT02621892	T3MPO-1	A 12-Week Study With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Tenapanor for the Treatment of IBS-C	P3	completed	606	Ardelyx	Oct 2015

Tenapanor clinical trials: frequently asked questions

How many Tenapanor clinical trials are there?: 17 Tenapanor clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 4 are actively recruiting participants. 11 are marked completed.
Are Tenapanor clinical trials recruiting in 2026?: Yes — 4 Tenapanor trials are actively recruiting in 2026, with 111 U.S. sites across 34 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Tenapanor being studied for?: Tenapanor is being studied for Hyperphosphatemia, Constipation Predominant Irritable Bowel Syndrome, Irritable Bowel Syndrome With Constipation (IBS-C), Cystic Fibrosis, End Stage Renal Disease and 9 more. The trials are grouped by indication on this page.
What phase is Tenapanor in?: Tenapanor clinical trials span 4 Phase 4, 9 Phase 3, 2 Phase 2, 1 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Tenapanor clinical trials?: The lead sponsor across the most Tenapanor trials is Ardelyx, with 4 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Tenapanoras an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

Last refreshed June 12, 2026.

Related pages on Hipa.ai:

Tenapanor overview