Tebentafusp Clinical Trials (2026): 14 Studies for Metastatic Uveal Melanoma & Uveal Melanoma

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

14 Tebentafusp clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 10 indications (including Metastatic Uveal Melanoma & Uveal Melanoma) and 2,696 total planned enrollment. 2 Phase 3 Tebentafusp trials and 7 Phase 2 are listed. 10 Tebentafusp clinical trials are actively recruiting at 47 U.S. sites across 24 states. Most recent activity: NCT06246149 (Nov 2032).

Where to Participate: All Tebentafusp Trial Sites in the U.S. (47 sites across 24 states)

Every actively recruiting Tebentafusptrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
ALUniversity of AlabamaBirmingham35294NCT05785754Map
AZMayo ClinicPhoenix85054NCT05785754Map
AZMayo Clinic ArizonaPhoenix85054NCT05549297Map
AZHonorHealthScottsdale85258NCT05785754Map
CAUniversity of Southern California - Norris Cancer CenterLos Angeles90033NCT06942442Map
COUniversity of ColoradoAurora80045NCT05785754Map
COUniversity of Colorado Cancer CenterAurora80045NCT06070012Map
COSarah Cannon Research Institute Denver HealthoneDenver80218NCT05785754Map
CTYale Cancer CenterNew Haven06519NCT05785754Map
DCGeorgetown University Medical CenterWashington D.C.20007NCT06070012Map
FLMayo ClinicJacksonville32224NCT05785754Map
FLMayo Clinic FloridaJacksonville32224NCT05549297Map
FLUniversity of MiamiMiami33136NCT05785754Map
FLUniversity of MiamiMiami33136NCT06627244Map
FLOrlando Health Cancer InstituteOrlando32806NCT05549297Map
FLMoffitt Cancer CenterTampa33612NCT07276386Map
GAWinship Cancer Institute of Emory UniversityAtlanta30322NCT05549297Map
KSUniversity of Kansas Cancer Center - WestwoodWestwood66205NCT05549297Map
KYSt Elizabeth Healthcare (St Elizabeth MedicalEdgewood41017NCT05549297Map
KYSt Elizabeth Healthcare (St Elizabeth Medical Center)Edgewood41017NCT05549297Map
MDJohn Hopkins Sidney Kimmel Comprehensive Cancer CenterBaltimore21231NCT05785754Map
MABeth Israel Deaconess Medical Center (BIDMC)Boston02215NCT05549297Map
MADana Farber Cancer InstituteBoston02215NCT05549297Map
MAMassachusetts General HospitalBoston02114NCT05549297Map
MNUniversity of Minnesota Medical CenterMinneapolis55455NCT05549297Map
MNMayo ClinicRochester55905NCT05785754Map
MNMayo Clinic MinnesotaRochester55905NCT05549297Map
MOWashington University School of MedicineSt Louis63110NCT05549297Map
NJRutgers Cancer Institute of New JerseyNew Brunswick08901NCT05549297Map
NYNorthwell Health Cancer Institute - Zuckerberg Cancer CenterLake Success11042NCT05549297Map
NYMemorial Sloan Kettering Cancer CenterNew York10068NCT05549297Map
NYMemorial Sloan Kettering Cancer CenterNew York10065NCT06942442Map
NYMonteFioreThe Bronx10461NCT05785754Map
OHOhio State UniversityColumbus43210NCT05785754Map
OHThe Ohio State University Comprehensive Cancer CenterColumbus43210NCT05549297Map
OKOU Health Stephenson Cancer CenterOklahoma City73104NCT05549297Map
PASidney Kimmel Cancer Center at Thomas Jefferson UniversityPhiladelphia19107NCT06414590Map
PAThomas Jefferson UniversityPhiladelphia19107NCT06626516Map
PAThomas Jefferson University Medical Oncology ClinicPhiladelphia19107NCT05549297Map
PAUPMC Hillman Cancer CenterPittsburgh15232NCT05549297Map
PAUPMC Hillman Cancer CenterPittsburgh15232NCT06070012Map
SCGibbs Cancer Center and Research InstituteSpartanburg29303NCT05549297Map
TNUniversity of Tennessee Medical CenterKnoxville37920NCT05549297Map
TNSCRI Oncology PartnersNashville37203NCT05785754Map
TXHouston Methodist Hospital/Houston Methodist Cancer CenterHouston77030NCT05549297Map
UTUniversity of Utah Huntsman Cancer InstituteSalt Lake City84112NCT05549297Map
WAFred Hutchinson Cancer CenterSeattle98109NCT05549297Map

Tebentafusp clinical trials at a glance: phase × recruitment status

Phaserecruitingactive not recruitingwithdrawnavailableTotal
P111
P1/P21113
P2617
P322
N/A11

Recruiting Tebentafusp clinical trials (10)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT06246149ATOMAdjuvant Tebentafusp in High Risk Ocular MelanomaP3Uveal Melanoma290Nov 2024
NCT06626516Tebentafusp-tebn With LDT in Metastatic UMP1/P2Metastatic Uveal Melanoma109Oct 2025
NCT06414590Neoadjuvant Tebentafusp for Uveal MelanomaP2Locally Advanced Unresectable Uveal Melanoma19Sep 2025
NCT06627244Study of Tebentafusp and Radioembolization in the Treatment of Metastatic Uveal MelanomaP2Metastatic Uveal Melanoma30Feb 2025
NCT07276386Phase 2 Combination of Melphalan/HDS Via PHP + Tebentafusp in Treating Metastatic Uveal MelanomaP2Metastatic Uveal Melanoma18Dec 2025
NCT06942442A Phase II Trial of Tebentafusp in HLA-A*02:01 Positive Patients With Advanced Clear Cell SarcomaP2HLA-A*0201 Positive Cells Present47Oct 2025
NCT06070012Tebentafusp in HLA-A*0201 Positive Previously Untreated Metastatic Uveal MelanomaP2Uveal Melanoma44Aug 2025
NCT05549297TEBE-AMTebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)P3Advanced Melanoma540Dec 2022
NCT07057596NEO-TBNeoadjuvant Tebentafusp in Patients With Metastatic Uveal MelanomaP2Mestastatic Uveal Melanoma19Jul 2025
NCT05785754DCSZ11 as a Monotherapy and in Combination in Patients With Advanced or Metastatic Solid TumorsP1Advanced or Metastatic Solid Tumors320Jun 2023

Tebentafusp clinical trials by indication

Metastatic Uveal Melanoma (3)

NCTAcronymPhaseStatusTitle
NCT06626516P1/P2recruitingTebentafusp-tebn With LDT in Metastatic UM
NCT06627244P2recruitingStudy of Tebentafusp and Radioembolization in the Treatment of Metastatic Uveal Melanoma
NCT07276386P2recruitingPhase 2 Combination of Melphalan/HDS Via PHP + Tebentafusp in Treating Metastatic Uveal Melanoma

Uveal Melanoma (3)

NCTAcronymPhaseStatusTitle
NCT06246149ATOMP3recruitingAdjuvant Tebentafusp in High Risk Ocular Melanoma
NCT06070012P2recruitingTebentafusp in HLA-A*0201 Positive Previously Untreated Metastatic Uveal Melanoma
NCT04960891Non ApplicableN/AavailableA Cohort IND Expanded Access Program for Supporting Patient Access to Tebentafusp

HLA-A*0201 Positive Cells Present (1)

NCTAcronymPhaseStatusTitle
NCT06942442P2recruitingA Phase II Trial of Tebentafusp in HLA-A*02:01 Positive Patients With Advanced Clear Cell Sarcoma

Locally Advanced Unresectable Uveal Melanoma (1)

NCTAcronymPhaseStatusTitle
NCT06414590P2recruitingNeoadjuvant Tebentafusp for Uveal Melanoma

Mestastatic Uveal Melanoma (1)

NCTAcronymPhaseStatusTitle
NCT07057596NEO-TBP2recruitingNeoadjuvant Tebentafusp in Patients With Metastatic Uveal Melanoma

Advanced or Metastatic Solid Tumors (1)

NCTAcronymPhaseStatusTitle
NCT05785754P1recruitingDCSZ11 as a Monotherapy and in Combination in Patients With Advanced or Metastatic Solid Tumors

Advanced Melanoma (1)

NCTAcronymPhaseStatusTitle
NCT05549297TEBE-AMP3recruitingTebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)

Melanoma (Skin) (1)

NCTAcronymPhaseStatusTitle
NCT05315258TebeMRDP2active not recruitingTebentafusp in Molecular Relapsed Disease (MRD) Melanoma

Select Advanced Solid Tumors (1)

NCTAcronymPhaseStatusTitle
NCT04262466P1/P2active not recruitingSafety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors

Malignant Melanoma (1)

NCTAcronymPhaseStatusTitle
NCT02535078P1/P2withdrawnPhase 1b/2 Study of the Combination of IMCgp100 With Durvalumab and/or Tremelimumab in Advanced Cutaneous Melanoma

Tebentafusp pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
ATOMNCT06246149P3recruitingUveal Melanoma290
TEBE-AMNCT05549297P3recruitingAdvanced Melanoma540
NEO-TBNCT07057596P2recruitingMestastatic Uveal Melanoma19
TebeMRDNCT05315258P2active not recruitingMelanoma (Skin)850

Terminated and withdrawn Tebentafusp trials (1)

Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.

All Tebentafusp trials (14)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT06246149ATOMAdjuvant Tebentafusp in High Risk Ocular MelanomaP3recruiting290European Organisation for Research and Treatment of Cancer - EORTCNov 2024
NCT06626516Tebentafusp-tebn With LDT in Metastatic UMP1/P2recruiting109Thomas Jefferson UniversityOct 2025
NCT06414590Neoadjuvant Tebentafusp for Uveal MelanomaP2recruiting19Thomas Jefferson UniversitySep 2025
NCT06627244Study of Tebentafusp and Radioembolization in the Treatment of Metastatic Uveal MelanomaP2recruiting30University of MiamiFeb 2025
NCT07276386Phase 2 Combination of Melphalan/HDS Via PHP + Tebentafusp in Treating Metastatic Uveal MelanomaP2recruiting18H. Lee Moffitt Cancer Center and Research InstituteDec 2025
NCT06942442A Phase II Trial of Tebentafusp in HLA-A*02:01 Positive Patients With Advanced Clear Cell SarcomaP2recruiting47Sarcoma Alliance for Research through CollaborationOct 2025
NCT06070012Tebentafusp in HLA-A*0201 Positive Previously Untreated Metastatic Uveal MelanomaP2recruiting44Diwakar DavarAug 2025
NCT05549297TEBE-AMTebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)P3recruiting540Immunocore LtdDec 2022
NCT07057596NEO-TBNeoadjuvant Tebentafusp in Patients With Metastatic Uveal MelanomaP2recruiting19Grupo Español Multidisciplinar de MelanomaJul 2025
NCT04262466Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint InhibitorsP1/P2active not recruiting410Immunocore LtdFeb 2020
NCT05315258TebeMRDTebentafusp in Molecular Relapsed Disease (MRD) MelanomaP2active not recruiting850University of OxfordJul 2022
NCT05785754DCSZ11 as a Monotherapy and in Combination in Patients With Advanced or Metastatic Solid TumorsP1recruiting320DynamiCure BiotechnologyJun 2023
NCT02535078Phase 1b/2 Study of the Combination of IMCgp100 With Durvalumab and/or Tremelimumab in Advanced Cutaneous MelanomaP1/P2withdrawn0Immunocore LtdNov 2015
NCT04960891Non ApplicableA Cohort IND Expanded Access Program for Supporting Patient Access to Tebentafuspavailable0Immunocore Ltd

Tebentafusp clinical trials: frequently asked questions

How many Tebentafusp clinical trials are there?
14 Tebentafusp clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 10 are actively recruiting participants.
Are Tebentafusp clinical trials recruiting in 2026?
Yes — 10 Tebentafusp trials are actively recruiting in 2026, with 47 U.S. sites across 24 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Tebentafusp being studied for?
Tebentafusp is being studied for Metastatic Uveal Melanoma, Uveal Melanoma, Clear Cell Sarcoma (CCS), HLA-A*0201 Positive Cells Present, Locally Advanced Unresectable Uveal Melanoma and 8 more. The trials are grouped by indication on this page.
What phase is Tebentafusp in?
Tebentafusp clinical trials span 2 Phase 3, 7 Phase 2, 1 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Tebentafusp clinical trials?
The lead sponsor across the most Tebentafusp trials is Immunocore Ltd, with 9 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Tebentafuspas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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