Sparsentan Clinical Trials (2026): 11 Studies for Focal Segmental Glomerulosclerosis & Immunoglobulin A Nephropathy

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

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11 Sparsentan clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 7 indications (including Focal Segmental Glomerulosclerosis & Immunoglobulin A Nephropathy) and 1,194 total planned enrollment. 2 Phase 3 Sparsentan trials and 5 Phase 2, 1 Phase 4 are listed. 5 Sparsentan clinical trials are actively recruiting at 26 U.S. sites across 16 states. Most recent activity: NCT07555301 (Dec 2029).

Where to Participate: All Sparsentan Trial Sites in the U.S. (26 sites across 16 states)

Every actively recruiting Sparsentantrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
ALUniversity of Alabama at BirminghamBirmingham35294NCT07219121Map
CACedars-Sinai Medical CenterLos Angeles90048NCT05003986Map
DENemours Children's HospitalWilmington19803NCT05003986Map
FLNicklaus Children's HospitalMiami33155NCT05003986Map
FLUniversity of Miami, Leonard M. Miller School of MedicineMiami33136NCT05003986Map
MIC.S. Mott Children's HospitalAnn Arbor48109-5008NCT05003986Map
MNUniversity of Minnesota, Masonic Children's HospitalMinneapolis55454NCT05003986Map
MOChildren's Mercy Hospitals and ClinicsKansas City64108NCT05003986Map
NJHackensack University Medical CenterHackensack07601NCT05003986Map
NJJersey Shore University Medical CenterNeptune City07753NCT05003986Map
NYCohen Children's Medical CenterNew Hyde Park11042NCT05003986Map
NYCornell Medical CenterNew York10065NCT07219121Map
NCUniversity of North Carolina at Chapel HillChapel Hill27599NCT05003986Map
NCDuke Molecular Physiology InstituteDurham22710NCT05003986Map
NCUniversity of North Carolina Chapel HillMorrisville27560NCT07219121Map
OHNationwide Children's HospitalColumbus43205NCT05003986Map
OHOhio State UniversityColumbus43210NCT07219121Map
OKUniversity of Oklahoma Health Sciences Center (OUHSC)Oklahoma City73104NCT05003986Map
PAChildren's Hospital of PhiladelphiaPhiladelphia19104NCT05003986Map
PAUniversity of Pittsburgh Medical CenterPittsburgh15213NCT07219121Map
TXDallas Nephrology AssociatesDallas75204NCT07219121Map
TXUniversity of TexasGalveston27599NCT07219121Map
TXTexas Children's HospitalHouston77030NCT05003986Map
WASeattle Children's HospitalSeattle98105NCT05003986Map
WAUniversity of WashingtonSeattle98195NCT07219121Map
WIUniversity of WisconsinMadison53705NCT07219121Map

Sparsentan clinical trials at a glance: phase × recruitment status

Phaserecruitingactive not recruitingcompletednot yet recruitingTotal
P1112
P22125
P3112
P411
N/A11

Recruiting Sparsentan clinical trials (5)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT07555301SWIANClinical Experience With Sparsentan in Switzerland in IgA NephropathyIgA Nephropathy (IgAN)50Jun 2026
NCT07224776Sparsentan for the Treatment of VEGF Signaling Pathway Inhibitor-Associated ProteinuriaP1Proteinuric Renal Disease20Jun 2026
NCT04663204SPARTANA Study of the Safety and Activity of Sparsentan for the Treatment of Patients With Immunoglobulin A NephropathyP2Immunoglobulin A Nephropathy24Dec 2020
NCT07219121SPARXSparsentan in Posttransplant Immunoglobulin A Nephropathy or Focal Segmental GlomerulosclerosisP4Proteinuria20Oct 2025
NCT05003986EPPIKStudy of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular DiseasesP2Focal Segmental Glomerulosclerosis67Aug 2021

Sparsentan clinical trials by indication

Immunoglobulin A Nephropathy (3)

NCTAcronymPhaseStatusTitle
NCT04663204SPARTANP2recruitingA Study of the Safety and Activity of Sparsentan for the Treatment of Patients With Immunoglobulin A Nephropathy
NCT03762850PROTECTP3active not recruitingA Study of the Effect and Safety of Sparsentan in the Treatment of Patients With IgA Nephropathy
NCT05856760SPARTACUSP2completedA Study to Investigate Safety and Effect of Sparsentan in Combination With SGLT2 Inhibition in Participants With IgAN

Focal Segmental Glomerulosclerosis (3)

NCTAcronymPhaseStatusTitle
NCT05003986EPPIKP2recruitingStudy of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases
NCT03493685DUPLEXP3completedStudy of Sparsentan in Patients With Primary Focal Segmental Glomerulosclerosis (FSGS)
NCT01613118DUETP2completedRandomized, Double-Blind, Safety and Efficacy Study of RE-021 (Sparsentan) in Focal Segmental Glomerulosclerosis

IgA Nephropathy (IgAN) (1)

NCTAcronymPhaseStatusTitle
NCT07555301SWIANN/Anot yet recruitingClinical Experience With Sparsentan in Switzerland in IgA Nephropathy

Proteinuric Renal Disease (1)

NCTAcronymPhaseStatusTitle
NCT07224776P1not yet recruitingSparsentan for the Treatment of VEGF Signaling Pathway Inhibitor-Associated Proteinuria

Proteinuria (1)

NCTAcronymPhaseStatusTitle
NCT07219121SPARXP4recruitingSparsentan in Posttransplant Immunoglobulin A Nephropathy or Focal Segmental Glomerulosclerosis

ANCA Associated Vasculitis (1)

NCTAcronymPhaseStatusTitle
NCT05630612SPARVASCP2active not recruitingETA and AT1 Antagonism in ANCA-vasculitis (SPARVASC)

Healthy Subjects (1)

NCTAcronymPhaseStatusTitle
NCT05562362P1completedStudy to Evaluate the Pharmacokinetics of Oral Sparsentan Suspension

Sparsentan pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
SPARXNCT07219121P4recruitingProteinuria20
PROTECTNCT03762850P3active not recruitingImmunoglobulin A Nephropathy406PMID 38299639
DUPLEXNCT03493685P3completedFocal Segmental Glomerulosclerosis371PMID 41433094
SPARTANNCT04663204P2recruitingImmunoglobulin A Nephropathy24
SPARVASCNCT05630612P2active not recruitingANCA Associated Vasculitis32PMID 35998848
EPPIKNCT05003986P2recruitingFocal Segmental Glomerulosclerosis67PMID 40938675
SPARTACUSNCT05856760P2completedImmunoglobulin A Nephropathy48
DUETNCT01613118P2completedFocal Segmental Glomerulosclerosis109PMID 30361325

All Sparsentan trials (11)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT07555301SWIANClinical Experience With Sparsentan in Switzerland in IgA Nephropathynot yet recruiting50Waid City Hospital, ZurichJun 2026
NCT07224776Sparsentan for the Treatment of VEGF Signaling Pathway Inhibitor-Associated ProteinuriaP1not yet recruiting20Brigham and Women's HospitalJun 2026
NCT04663204SPARTANA Study of the Safety and Activity of Sparsentan for the Treatment of Patients With Immunoglobulin A NephropathyP2recruiting24University of LeicesterDec 2020
NCT05630612SPARVASCETA and AT1 Antagonism in ANCA-vasculitis (SPARVASC)P2active not recruiting32University of EdinburghDec 2022
NCT07219121SPARXSparsentan in Posttransplant Immunoglobulin A Nephropathy or Focal Segmental GlomerulosclerosisP4recruiting20Travere Therapeutics, Inc.Oct 2025
NCT05003986EPPIKStudy of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular DiseasesP2recruiting67Travere Therapeutics, Inc.Aug 2021
NCT03762850PROTECTA Study of the Effect and Safety of Sparsentan in the Treatment of Patients With IgA NephropathyP3active not recruiting406Travere Therapeutics, Inc.Dec 2018
NCT03493685DUPLEXStudy of Sparsentan in Patients With Primary Focal Segmental Glomerulosclerosis (FSGS)P3completed371Travere Therapeutics, Inc.Apr 2018
NCT05856760SPARTACUSA Study to Investigate Safety and Effect of Sparsentan in Combination With SGLT2 Inhibition in Participants With IgANP2completed48Travere Therapeutics, Inc.May 2023
NCT01613118DUETRandomized, Double-Blind, Safety and Efficacy Study of RE-021 (Sparsentan) in Focal Segmental GlomerulosclerosisP2completed109Travere Therapeutics, Inc.Mar 2014
NCT05562362Study to Evaluate the Pharmacokinetics of Oral Sparsentan SuspensionP1completed47Travere Therapeutics, Inc.Jun 2020

Sparsentan clinical trials: frequently asked questions

How many Sparsentan clinical trials are there?
11 Sparsentan clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 3 are actively recruiting participants. 4 are marked completed.
Are Sparsentan clinical trials recruiting in 2026?
Yes — 3 Sparsentan trials are actively recruiting in 2026, with 26 U.S. sites across 16 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Sparsentan being studied for?
Sparsentan is being studied for Focal Segmental Glomerulosclerosis, Immunoglobulin A Nephropathy, Proteinuria, Kidney Diseases, Glomerulonephritis and 15 more. The trials are grouped by indication on this page.
What phase is Sparsentan in?
Sparsentan clinical trials span 1 Phase 4, 2 Phase 3, 5 Phase 2, 2 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Sparsentan clinical trials?
The lead sponsor across the most Sparsentan trials is Travere Therapeutics, Inc., with 4 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Sparsentanas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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