sigvotatug vedotin Clinical Trials (2026): 5 Studies for Carcinoma, Non-Small Cell Lung & Non-Small Cell Lung Cancer

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

5 sigvotatug vedotin clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 4 indications (including Carcinoma, Non-Small Cell Lung & Non-Small Cell Lung Cancer) and 2,650 total planned enrollment. 2 Phase 3 sigvotatug vedotin trials are listed. 3 sigvotatug vedotin clinical trials are actively recruiting at 178 U.S. sites across 25 states. Most recent activity: NCT07227298 (Aug 2033).

Where to Participate: All sigvotatug vedotin Trial Sites in the U.S. (178 sites across 25 states)

Every actively recruiting sigvotatug vedotintrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
AKAlaska Oncology and HematologyAnchorage99508NCT04389632Map
ARHighlands Oncology GroupFayetteville72703NCT04389632Map
ARHighlands Oncology Group, PAFayetteville72703NCT07227298Map
ARHighlands Oncology GroupRogers72758NCT04389632Map
ARHighlands Oncology Group, PARogers72758NCT07227298Map
ARHighlands Oncology GroupSpringdale72762NCT04389632Map
ARHighlands Oncology Group, PASpringdale72762NCT07227298Map
CAProvidence Medical FoundationAnaheim92805NCT04389632Map
CAProvidence Medical FoundationFullerton92835NCT04389632Map
CAProvidence Medical FoundationFullerton92835NCT07227298Map
CAProvidence St. Jude Medical CenterFullerton92835NCT06758401Map
CAProvidence St. Jude Medical CenterFullerton92835NCT07227298Map
CAProvidence St. Jude Medical Center - Virginia K. Crosson Cancer Center and Infusion CenterFullerton92835NCT07227298Map
CAProvidence St. Jude Medical Center Virginia K Crosson and Infusion CenterFullerton92835NCT04389632Map
CAProvidence St. Jude Medical Center Virginia K. Crosson Cancer Center and Infusion CenterFullerton92835NCT06758401Map
CASt. Jude Heritage Medical Group - Fullerton Plaza Multi-Specialty Clinic (Pulmonary Function Test)Fullerton92835NCT06758401Map
CARonald Reagan UCLA Medical CenterLos Angeles90095NCT04389632Map
CAThe Regents of the University of CaliforniaLos Angeles90095NCT04389632Map
CAUCLA Department of Medicine-Hematology/OncologyLos Angeles90095NCT04389632Map
CAUCLA Department of Medicine - Hematology & OncologySanta Monica90404NCT04389632Map
CORocky Mountain Cancer Centers, LLPDenver80218NCT07227298Map
COIntermountain Health Cancer Center Lutheran HospitalGolden80401NCT06758401Map
COCancer Centers of Colorado St. Mary's Regional HospitalGrand Junction81501NCT06758401Map
COIntermountain HealthGrand Junction81505NCT06758401Map
COIntermountain Health St. Mary's Regional HospitalGrand Junction81501NCT06758401Map
COIntermountain Health Lutheran HospitalWheat Ridge80401NCT06758401Map
DCWashington DC Veterans Affairs Medical CenterWashington D.C.20422NCT06758401Map
FLBRCR Medical Center Inc.Coral Springs33065NCT07227298Map
FLAmerican Oncology Partners, PA. a Florida professional service corporation, d/b/a Vista OncologyFort Myers33913NCT04389632Map
FLFlorida Cancer Specialists & Research Institute, LLCFort Myers33916NCT04389632Map
FLMemorial Cancer InstituteHollywood33021NCT04389632Map
FLMemorial Healthcare SystemHollywood33021NCT04389632Map
FLMid Florida Hematology and Oncology CenterOrange City32763NCT06758401Map
FLMid Florida Hematology and Oncology CenterOrange City32763NCT07227298Map
FLFlorida Cancer SpecialistsOrlando32827NCT04389632Map
FLOrlando Health Ambulatory Care CenterOrlando32806NCT07227298Map
FLOrlando Health Cancer InstituteOrlando32806NCT07227298Map
FLOrlando Health Orlando Regional Medical CenterOrlando32806NCT07227298Map
FLMemorial Cancer Institute at Memorial Hospital WestPembroke Pines33028NCT04389632Map
FLMemorial Hospital WestPembroke Pines33028NCT04389632Map
FLBRCR GlobalPlantation33322NCT06758401Map
FLBRCR Global - TamaracTamarac33321NCT07227298Map
ILIngalls Family Care CenterCalumet City60409NCT04389632Map
ILThe University Of ChicagoChicago60637NCT04389632Map
ILUChicago Medicine - River EastChicago60611NCT04389632Map
ILUniversity of Chicago Medical CenterChicago60637NCT04389632Map
ILEndeavor HealthElmhurst60126NCT06758401Map
ILUChicago Medicine at Ingalls - FlossmoorFlossmoor60422NCT04389632Map
ILUChicago Medicine Ingalls MemorialHarvey60426NCT04389632Map
ILHope and Healing Cancer ServicesHinsdale60521NCT06758401Map
ILEndeavor HealthNaperville60540NCT06758401Map
ILHope and Healing Cancer ServicesNew Lenox60451NCT06758401Map
ILUniversity of Chicago Comprehensive Cancer Center at Silver Cross HospitalNew Lenox60451NCT04389632Map
ILThe University of Chicago Medicine Center for Advanced Care Orland ParkOrland Park60462NCT04389632Map
ILSouthern Illinois University - Simmons Cancer InstituteSpringfield62702NCT04389632Map
ILSpringfield ClinicSpringfield62702NCT04389632Map
ILSpringfield Clinic Main CampusSpringfield62703NCT04389632Map
ILSpringfield Clinic Radiology - 800 BuildingSpringfield62702NCT04389632Map
ILSpringfield Clinic Radiology - Main CampusSpringfield62703NCT04389632Map
ILSpringfield Clinic Urgent Care PlusSpringfield62702NCT04389632Map
ILSpringfield Memorial HospitalSpringfield62781NCT04389632Map
ILUChicago Medicine at Ingalls - Tinley ParkTinley Park60477NCT04389632Map
INUChicago Medicine - Northwest IndianaCrown Point46307NCT04389632Map
INFort Wayne Medical Oncology and Hematology, IncFort Wayne46804NCT04389632Map
INCommunity Health Network Investigational Drug ServicesIndianapolis46250NCT04389632Map
INCommunity Health Network, IncIndianapolis46219NCT04389632Map
INCommunity Health Network, Inc.Indianapolis46227NCT04389632Map
INCommunity Health Network, Inc.Indianapolis46250NCT04389632Map
KSThe University of Kansas Cancer Center, Investigational Drug ServicesFairway66205NCT04389632Map
KSThe University of Kansas Clinical Research CenterFairway66205NCT04389632Map
KSThe University of Kansas HospitalKansas City66160NCT04389632Map
KSThe University of Kansas Medical Center Medical Office BuildingKansas City66160NCT04389632Map
KSUniversity of Kansas Hospital Cambridge North Tower AKansas City66160NCT04389632Map
KSUniversity of Kansas Medical Center Research InstituteKansas City66160NCT04389632Map
KSThe University of Kansas Cancer Center - Indian Creek CampusOverland Park66211NCT04389632Map
KSThe University of Kansas Cancer Center - WestwoodWestwood66205NCT04389632Map
KSUniversity of Kansas Cancer CenterWestwood66205NCT04389632Map
MEMaine Medical CenterPortland04102NCT06758401Map
MEMaineHealth Cancer Care - ScarboroughScarborough04074NCT06758401Map
MEMaineHealth Cancer Care and IV Therapy - South PortlandSouth Portland04106NCT06758401Map
MABeth Israel Deaconess Medical CenterBoston02215NCT04389632Map
MABeth Israel Deaconess Medical Center,East Campus Research PharmacyBoston02215NCT04389632Map
MABrigham & Women's HospitalBoston02115NCT04389632Map
MADana Farber Cancer InstituteBoston02215NCT04389632Map
MAMassachusetts General HospitalBoston02114NCT04389632Map
MADana-Farber Cancer Institute - Chestnut HillNewton02467NCT04389632Map
MNMinnesota Oncology Hematology, PABurnsville55337NCT06758401Map
MNAllina Health Cancer Institute - Mercy HospitalCoon Rapids55433NCT04389632Map
MNMinnesota Oncology Hematology PACoon Rapids55433NCT06758401Map
MNM Health Fairview Cancer Clinic-EdinaEdina55435NCT06758401Map
MNMinnesota Oncology Hematology PAEdina55435NCT06758401Map
MNMinnesota Oncology Hematology PAMaple Grove55369NCT06758401Map
MNM Health Fairview St. John's HospitalMaplewood55109NCT06758401Map
MNMinnesota Oncology Hematology PAMaplewood55109NCT06758401Map
MNAllina Health Cancer Institute - Abbott Northwestern HospitalMinneapolis55407NCT04389632Map
MNHennepin County Medical CenterMinneapolis55415NCT06758401Map
MNNorth Memorial Health Cancer CenterRobbinsdale55422NCT06758401Map
MNMetro Minnesota Community Oncology Research Consortium (MMCORC)Saint Louis Park55426NCT06758401Map
MNPark Nicollet Frauenshuh Cancer CenterSaint Louis Park55426NCT06758401Map
MNAllina Health Cancer InstituteSaint Paul55102NCT04389632Map
MNRegions HospitalSaint Paul55101NCT06758401Map
MNMinnesota Oncology Hematology, P.A. Cornerstone Medical Specialty CenterWoodbury55125NCT06758401Map
MSJackson Oncology Associates, PLLCJackson39202NCT06758401Map
MSJackson Oncology Associates, PLLCJackson39216NCT06758401Map
NEOncology Hematology West, PC dba Nebraska Cancer Specialists - FremontFremont68025NCT06758401Map
NEOncology Hematology West, PC dba Nebraska Cancer Specialists - Grand IslandGrand Island68803NCT06758401Map
NEOncology Hematology West, PC dba Nebraska Cancer Specialists - RegionalGrand Island68803NCT06758401Map
NECancer Partners of Nebraska - April Sampson Cancer CenterLincoln68516NCT06758401Map
NEOncology Hematology West P.C. dba Nebraska Cancer SpecialistsOmaha68130NCT06758401Map
NEOncology Hematology West P.C. dba Nebraska Cancer Specialists - MethodistOmaha68114NCT06758401Map
NEOncology Hematology West, PC dba Nebraska Cancer Specialists - BerganOmaha68124NCT06758401Map
NVComprehensive Cancer Centers of NevadaLas Vegas89169NCT04389632Map
NYNorth Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood SpecialistsBabylon11702NCT04389632Map
NYNorth Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood SpecialistsBrooklyn11210NCT04389632Map
NYNorth Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood SpecialistsNew Hyde Park11042NCT04389632Map
NYColumbia University Irving Medical CenterNew York10032NCT04389632Map
NYNorth Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood SpecialistsNew York10028NCT04389632Map
NYHematology Oncology Associates of RocklandNyack10960NCT06758401Map
NYNorth Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood SpecialistsPatchogue11772NCT04389632Map
NYNorth Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood SpecialistsPort Jefferson Station11776NCT04389632Map
NYNorth Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood SpecialistsRiverhead11901NCT04389632Map
NYNorth Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood SpecialistsShirley11967NCT04389632Map
NYMontefiore Medical Center- Montefiore Medical ParkThe Bronx10461NCT07227298Map
NYNorth Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood SpecialistsThe Bronx10469NCT04389632Map
NCCarolina Cancer Research CenterWilson27893NCT06758401Map
OHGabrail Cancer Center ResearchCanton44718NCT06758401Map
OKOU Health University of Oklahoma Medical CenterOklahoma City73104NCT04389632Map
OKStephenson Cancer Center (chemo location)Oklahoma City73104NCT04389632Map
OKUniversity of Oklahoma Health Science CenterOklahoma City73104NCT04389632Map
OROncology Associates of Oregon, P.C.Eugene97401NCT07227298Map
ORProvidence Cancer Institute Franz ClinicPortland97213NCT04389632Map
ORProvidence Oncology and Hematology Care Clinic - WestsidePortland97225NCT04389632Map
ORProvidence St. Vincent Medical CenterPortland97225NCT04389632Map
ORProvidence St. Vincent Medical Center- Investigational Drug ServicesPortland97225NCT04389632Map
SDSanford Cancer CenterSioux Falls57104NCT04389632Map
SDSanford USD Medical CenterSioux Falls57105NCT04389632Map
TNUS Oncology Research LLCNashville37203NCT04389632Map
TXThe University of Texas, MD Anderson Cancer Center - WoodlandsConroe77384NCT06758401Map
TXRenovatio Clinical - El PasoEl Paso79915NCT06758401Map
TXDallas Cancer SpecialistsGarland75042NCT07227298Map
TXLumi ResearchHouston77090NCT07227298Map
TXOncology Consultants, PAHouston77024NCT04389632Map
TXOncology Consultants, PA.Houston77030NCT04389632Map
TXSouthwest Oncology AssociatesHouston77030NCT07227298Map
TXThe University of Texas M.D. Anderson Cancer CenterHouston77030NCT04389632Map
TXThe University of Texas MD Anderson Cancer Center Clinical Research ImagingHouston77054NCT06758401Map
TXThe University of Texas MD Anderson Cancer Center Diagnostic ImagingHouston77030NCT06758401Map
TXThe University of Texas MD Anderson Cancer Center Investigational Pharmacy ServicesHouston77030NCT06758401Map
TXThe University of Texas, MD Anderson Cancer Center - West HoustonHouston77079NCT06758401Map
TXThe University of Texas, MD Anderson Cancer Center- Interventional RadiologyHouston77030NCT06758401Map
TXUniversity of Texas MD Anderson Cancer CenterHouston77030NCT06758401Map
TXUS Oncology Investigational Product Center (IPC)Irving75063NCT04389632Map
TXUS Oncology Investigational Products Center (IPC)Irving75063NCT07227298Map
TXCommunity Clinical TrialsKingwood77339NCT06758401Map
TXThe University of Texas, MD Anderson Cancer Center - League CityLeague City77573NCT06758401Map
TXThe University of Texas, MD Anderson Cancer Center - Sugar LandSugar Land77478NCT06758401Map
TXVoyage ClinicalSugar Land77479NCT07227298Map
TXRenovatio ClinicalThe Woodlands77380NCT06758401Map
TXWoodlands RadiologyThe Woodlands77381NCT06758401Map
TXUT Health East Texas Hope Cancer CenterTyler75708NCT04389632Map
TXUT Health East Texas HOPE Cancer CenterTyler75701NCT04389632Map
VAVirginia Cancer SpecialistsFairfax22031NCT04389632Map
VAMassey Cancer Center Clinical & Translational Research LabRichmond23298NCT07227298Map
VAVCU Health Stony PointRichmond23235NCT07227298Map
VAVCU Medical Center Gateway BuildingRichmond23219NCT07227298Map
VAVirginia Commonwealth UniversityRichmond23219NCT07227298Map
VAVirginia Commonwealth UniversityRichmond23298NCT07227298Map
VAVCU Health Community Memorial HospitalSouth Hill23970NCT07227298Map
VAVCU Health Tappahannock HospitalTappahannock22560NCT07227298Map
WASwedish Cancer Institute - Edmonds CampusEdmonds98026NCT04389632Map
WASwedish Cancer Institute Edmonds CampusEdmonds98026NCT04389632Map
WAAmerican Oncology Network Vista Oncology Division-East officeOlympia98506NCT04389632Map
WAAmerican Oncology Network Vista Oncology Division-East officeOlympia98506NCT06758401Map
WAAmerican Oncology Network Vista Oncology Division-West officeOlympia98502NCT04389632Map
WAAmerican Oncology Network Vista Oncology Division-West officeOlympia98502NCT06758401Map
WASwedish Cancer InstituteSeattle98104NCT04389632Map
WASwedish Medical CenterSeattle98122NCT04389632Map
WAExigent Research, LLCTacoma98405NCT04389632Map

sigvotatug vedotin clinical trials at a glance: phase × recruitment status

Phaserecruitingactive not recruitingcompletedTotal
P1112
P1/P211
P3112

Recruiting sigvotatug vedotin clinical trials (3)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT07227298Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced CancersP1/P2Advanced/Metastatic Non-Small Cell Lung Cancer162Jan 2026
NCT04389632A Study of Sigvotatug Vedotin in Advanced Solid TumorsP1Carcinoma, Non-Small Cell Lung1,006Jun 2020
NCT06758401Be6A Lung-02This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.P3Non-Small Cell Lung Cancer714Jul 2025

sigvotatug vedotin clinical trials by indication

Carcinoma, Non-Small Cell Lung (2)

NCTAcronymPhaseStatusTitle
NCT04389632P1recruitingA Study of Sigvotatug Vedotin in Advanced Solid Tumors
NCT06549816P1completedA Study of SGN-B6A in Chinese Participants With Advanced Solid Tumors

Advanced/Metastatic Non-Small Cell Lung Cancer (1)

NCTAcronymPhaseStatusTitle
NCT07227298P1/P2recruitingSymbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers

Non-Small Cell Lung Cancer (1)

NCTAcronymPhaseStatusTitle
NCT06758401Be6A Lung-02P3recruitingThis is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

Carcinoma, Non-Small-Cell Lung (1)

NCTAcronymPhaseStatusTitle
NCT06012435P3active not recruitingA Study of SGN-B6A Versus Docetaxel in Previously Treated Non-small Cell Lung Cancer

sigvotatug vedotin pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
Be6A Lung-02NCT06758401P3recruitingNon-Small Cell Lung Cancer714PMID 41388832

All sigvotatug vedotin trials (5)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT07227298Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced CancersP1/P2recruiting162PfizerJan 2026
NCT04389632A Study of Sigvotatug Vedotin in Advanced Solid TumorsP1recruiting1,006Seagen, a wholly owned subsidiary of PfizerJun 2020
NCT06758401Be6A Lung-02This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.P3recruiting714PfizerJul 2025
NCT06012435A Study of SGN-B6A Versus Docetaxel in Previously Treated Non-small Cell Lung CancerP3active not recruiting762Seagen, a wholly owned subsidiary of PfizerFeb 2024
NCT06549816A Study of SGN-B6A in Chinese Participants With Advanced Solid TumorsP1completed6Seagen, a wholly owned subsidiary of PfizerAug 2024

sigvotatug vedotin clinical trials: frequently asked questions

How many sigvotatug vedotin clinical trials are there?
5 sigvotatug vedotin clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 3 are actively recruiting participants. 1 is marked completed.
Are sigvotatug vedotin clinical trials recruiting in 2026?
Yes — 3 sigvotatug vedotin trials are actively recruiting in 2026, with 178 U.S. sites across 25 states. See the recruiting trials and the per-state site list further down this page.
What conditions is sigvotatug vedotin being studied for?
sigvotatug vedotin is being studied for Carcinoma, Non-Small Cell Lung, Non-Small Cell Lung Cancer, Esophageal Squamous Cell Carcinoma, Esophageal Adenocarcinoma, Carcinoma, Non-Small-Cell Lung and 12 more. The trials are grouped by indication on this page.
What phase is sigvotatug vedotin in?
sigvotatug vedotin clinical trials span 2 Phase 3, 2 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors sigvotatug vedotin clinical trials?
The lead sponsor across the most sigvotatug vedotin trials is Seagen, a wholly owned subsidiary of Pfizer, with 1 additional lead sponsor listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming sigvotatug vedotinas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

Last refreshed .

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