Seltorexant Clinical Trials (2026): 14 Studies for Depressive Disorder, Major & Healthy
Hipa.ai Research · Source: ClinicalTrials.gov / AACT
Synced daily from ClinicalTrials.gov via AACT. Last sync: .
14 Seltorexant clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 5 indications (including Depressive Disorder, Major & Healthy) and 2,983 total planned enrollment. 4 Phase 3 Seltorexant trials and 1 Phase 2 are listed. 1 Seltorexant clinical trial is actively recruiting at 45 U.S. sites across 18 states. Most recent activity: NCT06559306 (Dec 2026).
Where to Participate: All Seltorexant Trial Sites in the U.S. (45 sites across 18 states)
Every actively recruiting Seltorexanttrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.
| State | Facility | City | Trial | Map |
|---|---|---|---|---|
| AL | University of Alabama at Birmingham | Birmingham35294 | NCT06559306 | Map |
| AZ | University of Arizona | Tucson85724 | NCT06559306 | Map |
| AR | SanRo Clinical Research Group LLC WCG Clinical Network | Bryant72022 | NCT06559306 | Map |
| CA | PAMOJA Clinical Institute LLC | Anaheim92801 | NCT06559306 | Map |
| CA | Axiom Research | Colton92324 | NCT06559306 | Map |
| CA | Excell Research Inc | Oceanside92056 | NCT06559306 | Map |
| CA | Anderson Clinical Research | Redlands92374 | NCT06559306 | Map |
| CA | Lumos Clinical Research Center LLC | San Jose95124 | NCT06559306 | Map |
| CO | Mountain View Clinical Research | Denver80209 | NCT06559306 | Map |
| CT | UConn Health Center | Farmington06030 | NCT06559306 | Map |
| FL | Clinical Research of Brandon | Brandon33511 | NCT06559306 | Map |
| FL | AGA Clinical Trials | Hialeah33012 | NCT06559306 | Map |
| FL | Reliable Clinical Research | Hialeah33012 | NCT06559306 | Map |
| FL | Advanced Research Institute of Miami | Homestead33033 | NCT06559306 | Map |
| FL | Clinical NeuroScience Solutions Inc | Jacksonville32256 | NCT06559306 | Map |
| FL | Miami Dade Medical Research Institute | Miami33176 | NCT06559306 | Map |
| FL | Nuovida Research Center | Miami33186 | NCT06559306 | Map |
| FL | Pharmax Research Clinic Inc | Miami33126 | NCT06559306 | Map |
| FL | Nova Psychiatry INC | Orlando32803 | NCT06559306 | Map |
| FL | Interventional Psychiatry of Tampa Bay | Tampa33629 | NCT06559306 | Map |
| FL | Psych Me Medical Research Inc | Tampa33614 | NCT06559306 | Map |
| FL | Health Synergy Clinical Research | West Palm Beach33407 | NCT06559306 | Map |
| GA | Advanced Discovery Research | Atlanta30318 | NCT06559306 | Map |
| GA | iResearch Atlanta LLC | Decatur30030 | NCT06559306 | Map |
| GA | Accelerated Clinical Research Group LLC | Snellville30078 | NCT06559306 | Map |
| IL | Northwestern University | Chicago60611 | NCT06559306 | Map |
| IL | University of Chicago Medical Center | Chicago60637 | NCT06559306 | Map |
| IL | Baber Research Group | Naperville60563 | NCT06559306 | Map |
| MA | Adams Clinical LLC | Watertown02472 | NCT06559306 | Map |
| MN | Mankato Clinic | Mankato56001 | NCT06559306 | Map |
| NY | Integrative Clinical Trials LLC | Brooklyn11229 | NCT06559306 | Map |
| NY | SPRI Clinical Trials, LLC | Brooklyn11235 | NCT06559306 | Map |
| NY | Bioscience Research LLC | Mount Kisco10549 | NCT06559306 | Map |
| NY | Fieve Clinical Research Inc | New York10017 | NCT06559306 | Map |
| OH | Patient Priority Clinical Sites LLC | Cincinnati45215 | NCT06559306 | Map |
| OH | The Ohio State University | Columbus43210 | NCT06559306 | Map |
| OK | Conrad Clinical Research | Edmond73013 | NCT06559306 | Map |
| PA | University of Pennsylvania | Philadelphia19104 | NCT06559306 | Map |
| SC | Clinical Trials of South Carolina | Charleston29406 | NCT06559306 | Map |
| TX | Houston Clinical Trials LLC | Bellaire77401 | NCT06559306 | Map |
| TX | North Texas Clinical Trials | Fort Worth76104 | NCT06559306 | Map |
| TX | Baylor College of Medicine | Houston77030 | NCT06559306 | Map |
| TX | DM Clinical Research | Houston77081 | NCT06559306 | Map |
| TX | R and H Clinical Research | Stafford77477 | NCT06559306 | Map |
| WA | Core Clinical Research | Everett98201 | NCT06559306 | Map |
Seltorexant clinical trials at a glance: phase × recruitment status
| Phase | recruiting | completed | terminated | Total |
|---|---|---|---|---|
| P1 | 8 | 1 | 9 | |
| P2 | 1 | 1 | ||
| P3 | 1 | 2 | 1 | 4 |
Recruiting Seltorexant clinical trials (1)
Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).
| NCT ID | Title | Phase | Indication | Enrollment | Started |
|---|---|---|---|---|---|
| NCT06559306 | Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms | P3 | Depressive Disorder, Major | 752 | Jul 2024 |
Seltorexant clinical trials by indication
Depressive Disorder, Major (6)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06559306 | — | P3 | recruiting | Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms |
| NCT04533529 | — | P3 | completed | A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant and Long-term Safety Extension Treatment With Seltorexant |
| NCT04951609 | SSRI | P1 | terminated | A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adolescents With Major Depressive Disorder Who Have an Inadequate Response to Selective Serotonin Reuptake Inhibitor (SSRI) and Psychotherapy |
| NCT04513912 | — | P3 | completed | A Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy |
| NCT04451187 | — | P1 | completed | A Study of Oral Seltorexant as an add-on Medication to an Antidepressant on On-road Driving Performance in Participants With Major Depressive Disorder |
| NCT04532749 | — | P3 | terminated | A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy |
Healthy (5)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05236868 | — | P1 | completed | A Study of JNJ-42847922 (Seltorexant) in Healthy Participants |
| NCT04553042 | — | P1 | completed | A Study of Seltorexant in Healthy Participants |
| NCT03682380 | JNJ-42847922 | P1 | completed | A Study of Seltorexant (JNJ-42847922) After Single-Dose Administration in Healthy Participants |
| NCT03494907 | — | P1 | completed | A Study to Evaluate the Effects of Single-dose Seltorexant on Electrocardiogram Intervals in Healthy Adult Participants |
| NCT03438461 | JNJ-42847922 | P1 | completed | A Study to Evaluate the Relative Oral Bioavailability of Seltorexant (JNJ-42847922) After Administration of 3 Different Formulations in Healthy Participants Under Fasted and Semi-fasted Conditions |
Alzheimer Disease (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05307692 | — | P2 | completed | A Study of Seltorexant in Participants With Probable Alzheimer's Disease |
Healthy Non-dependent, Recreational Sedative Users (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05106153 | — | P1 | completed | A Study to Determine the Abuse Potential of Seltorexant Compared to Suvorexant and Zolpidem |
Sleep Apnea, Obstructive (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT03796026 | — | P1 | completed | A Study to Assess the Effect of Seltorexant Compared to Placebo on Respiration During Sleep in Adult Participants With Obstructive Sleep Apnea |
Terminated and withdrawn Seltorexant trials (2)
Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.
- NCT04951609terminatedA Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adolescents With Major Depressive Disorder Who Have an Inadequate Response to Selective Serotonin Reuptake Inhibitor (SSRI) and Psychotherapy
- NCT04532749terminatedA Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy
All Seltorexant trials (14)
Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.
| NCT ID | Acronym | Title | Phase | Status | Enrollment | Sponsor | Started |
|---|---|---|---|---|---|---|---|
| NCT06559306 | Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms | P3 | recruiting | 752 | Janssen Research & Development, LLC | Jul 2024 | |
| NCT04533529 | A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant and Long-term Safety Extension Treatment With Seltorexant | P3 | completed | 588 | Janssen Research & Development, LLC | Sep 2020 | |
| NCT04951609 | SSRI | A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adolescents With Major Depressive Disorder Who Have an Inadequate Response to Selective Serotonin Reuptake Inhibitor (SSRI) and Psychotherapy | P1 | terminated | 31 | Janssen Research & Development, LLC | Sep 2021 |
| NCT05307692 | A Study of Seltorexant in Participants With Probable Alzheimer's Disease | P2 | completed | 88 | Janssen Research & Development, LLC | May 2022 | |
| NCT04513912 | A Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy | P3 | completed | 757 | Janssen Research & Development, LLC | Sep 2020 | |
| NCT05106153 | A Study to Determine the Abuse Potential of Seltorexant Compared to Suvorexant and Zolpidem | P1 | completed | 127 | Janssen Research & Development, LLC | Dec 2021 | |
| NCT04451187 | A Study of Oral Seltorexant as an add-on Medication to an Antidepressant on On-road Driving Performance in Participants With Major Depressive Disorder | P1 | completed | 63 | Janssen Research & Development, LLC | Jul 2020 | |
| NCT04532749 | A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy | P3 | terminated | 212 | Janssen Research & Development, LLC | Sep 2020 | |
| NCT05236868 | A Study of JNJ-42847922 (Seltorexant) in Healthy Participants | P1 | completed | 10 | Janssen Research & Development, LLC | Feb 2022 | |
| NCT04553042 | A Study of Seltorexant in Healthy Participants | P1 | completed | 69 | Janssen Research & Development, LLC | Sep 2020 | |
| NCT03682380 | JNJ-42847922 | A Study of Seltorexant (JNJ-42847922) After Single-Dose Administration in Healthy Participants | P1 | completed | 151 | Janssen Research & Development, LLC | Oct 2018 |
| NCT03796026 | A Study to Assess the Effect of Seltorexant Compared to Placebo on Respiration During Sleep in Adult Participants With Obstructive Sleep Apnea | P1 | completed | 34 | Janssen Research & Development, LLC | Jan 2019 | |
| NCT03494907 | A Study to Evaluate the Effects of Single-dose Seltorexant on Electrocardiogram Intervals in Healthy Adult Participants | P1 | completed | 52 | Janssen Research & Development, LLC | Apr 2018 | |
| NCT03438461 | JNJ-42847922 | A Study to Evaluate the Relative Oral Bioavailability of Seltorexant (JNJ-42847922) After Administration of 3 Different Formulations in Healthy Participants Under Fasted and Semi-fasted Conditions | P1 | completed | 49 | Janssen Research & Development, LLC | Feb 2018 |
Seltorexant clinical trials: frequently asked questions
- How many Seltorexant clinical trials are there?
- 14 Seltorexant clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 1 is actively recruiting participants. 11 are marked completed.
- Are Seltorexant clinical trials recruiting in 2026?
- Yes — 1 Seltorexant trial is actively recruiting in 2026, with 45 U.S. sites across 18 states. See the recruiting trials and the per-state site list further down this page.
- What conditions is Seltorexant being studied for?
- Seltorexant is being studied for Depressive Disorder, Major, Healthy, Abuse Potential, Alzheimer Disease, Healthy Non-dependent, Recreational Sedative Users and 1 more. The trials are grouped by indication on this page.
- What phase is Seltorexant in?
- Seltorexant clinical trials span 4 Phase 3, 1 Phase 2, 9 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
- Who sponsors Seltorexant clinical trials?
- The lead sponsor across the most Seltorexant trials is Janssen Research & Development, LLC. Each trial row links to the full study detail page including sponsor information.
Sources and methodology
Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Seltorexantas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.
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