Seltorexant Clinical Trials (2026): 14 Studies for Depressive Disorder, Major & Healthy

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

14 Seltorexant clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 5 indications (including Depressive Disorder, Major & Healthy) and 2,983 total planned enrollment. 4 Phase 3 Seltorexant trials and 1 Phase 2 are listed. 1 Seltorexant clinical trial is actively recruiting at 45 U.S. sites across 18 states. Most recent activity: NCT06559306 (Dec 2026).

Where to Participate: All Seltorexant Trial Sites in the U.S. (45 sites across 18 states)

Every actively recruiting Seltorexanttrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
ALUniversity of Alabama at BirminghamBirmingham35294NCT06559306Map
AZUniversity of ArizonaTucson85724NCT06559306Map
ARSanRo Clinical Research Group LLC WCG Clinical NetworkBryant72022NCT06559306Map
CAPAMOJA Clinical Institute LLCAnaheim92801NCT06559306Map
CAAxiom ResearchColton92324NCT06559306Map
CAExcell Research IncOceanside92056NCT06559306Map
CAAnderson Clinical ResearchRedlands92374NCT06559306Map
CALumos Clinical Research Center LLCSan Jose95124NCT06559306Map
COMountain View Clinical ResearchDenver80209NCT06559306Map
CTUConn Health CenterFarmington06030NCT06559306Map
FLClinical Research of BrandonBrandon33511NCT06559306Map
FLAGA Clinical TrialsHialeah33012NCT06559306Map
FLReliable Clinical ResearchHialeah33012NCT06559306Map
FLAdvanced Research Institute of MiamiHomestead33033NCT06559306Map
FLClinical NeuroScience Solutions IncJacksonville32256NCT06559306Map
FLMiami Dade Medical Research InstituteMiami33176NCT06559306Map
FLNuovida Research CenterMiami33186NCT06559306Map
FLPharmax Research Clinic IncMiami33126NCT06559306Map
FLNova Psychiatry INCOrlando32803NCT06559306Map
FLInterventional Psychiatry of Tampa BayTampa33629NCT06559306Map
FLPsych Me Medical Research IncTampa33614NCT06559306Map
FLHealth Synergy Clinical ResearchWest Palm Beach33407NCT06559306Map
GAAdvanced Discovery ResearchAtlanta30318NCT06559306Map
GAiResearch Atlanta LLCDecatur30030NCT06559306Map
GAAccelerated Clinical Research Group LLCSnellville30078NCT06559306Map
ILNorthwestern UniversityChicago60611NCT06559306Map
ILUniversity of Chicago Medical CenterChicago60637NCT06559306Map
ILBaber Research GroupNaperville60563NCT06559306Map
MAAdams Clinical LLCWatertown02472NCT06559306Map
MNMankato ClinicMankato56001NCT06559306Map
NYIntegrative Clinical Trials LLCBrooklyn11229NCT06559306Map
NYSPRI Clinical Trials, LLCBrooklyn11235NCT06559306Map
NYBioscience Research LLCMount Kisco10549NCT06559306Map
NYFieve Clinical Research IncNew York10017NCT06559306Map
OHPatient Priority Clinical Sites LLCCincinnati45215NCT06559306Map
OHThe Ohio State UniversityColumbus43210NCT06559306Map
OKConrad Clinical ResearchEdmond73013NCT06559306Map
PAUniversity of PennsylvaniaPhiladelphia19104NCT06559306Map
SCClinical Trials of South CarolinaCharleston29406NCT06559306Map
TXHouston Clinical Trials LLCBellaire77401NCT06559306Map
TXNorth Texas Clinical TrialsFort Worth76104NCT06559306Map
TXBaylor College of MedicineHouston77030NCT06559306Map
TXDM Clinical ResearchHouston77081NCT06559306Map
TXR and H Clinical ResearchStafford77477NCT06559306Map
WACore Clinical ResearchEverett98201NCT06559306Map

Seltorexant clinical trials at a glance: phase × recruitment status

PhaserecruitingcompletedterminatedTotal
P1819
P211
P31214

Recruiting Seltorexant clinical trials (1)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT06559306Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia SymptomsP3Depressive Disorder, Major752Jul 2024

Seltorexant clinical trials by indication

Depressive Disorder, Major (6)

NCTAcronymPhaseStatusTitle
NCT06559306P3recruitingPhase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
NCT04533529P3completedA Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant and Long-term Safety Extension Treatment With Seltorexant
NCT04951609SSRIP1terminatedA Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adolescents With Major Depressive Disorder Who Have an Inadequate Response to Selective Serotonin Reuptake Inhibitor (SSRI) and Psychotherapy
NCT04513912P3completedA Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy
NCT04451187P1completedA Study of Oral Seltorexant as an add-on Medication to an Antidepressant on On-road Driving Performance in Participants With Major Depressive Disorder
NCT04532749P3terminatedA Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy

Healthy (5)

NCTAcronymPhaseStatusTitle
NCT05236868P1completedA Study of JNJ-42847922 (Seltorexant) in Healthy Participants
NCT04553042P1completedA Study of Seltorexant in Healthy Participants
NCT03682380JNJ-42847922P1completedA Study of Seltorexant (JNJ-42847922) After Single-Dose Administration in Healthy Participants
NCT03494907P1completedA Study to Evaluate the Effects of Single-dose Seltorexant on Electrocardiogram Intervals in Healthy Adult Participants
NCT03438461JNJ-42847922P1completedA Study to Evaluate the Relative Oral Bioavailability of Seltorexant (JNJ-42847922) After Administration of 3 Different Formulations in Healthy Participants Under Fasted and Semi-fasted Conditions

Alzheimer Disease (1)

NCTAcronymPhaseStatusTitle
NCT05307692P2completedA Study of Seltorexant in Participants With Probable Alzheimer's Disease

Healthy Non-dependent, Recreational Sedative Users (1)

NCTAcronymPhaseStatusTitle
NCT05106153P1completedA Study to Determine the Abuse Potential of Seltorexant Compared to Suvorexant and Zolpidem

Sleep Apnea, Obstructive (1)

NCTAcronymPhaseStatusTitle
NCT03796026P1completedA Study to Assess the Effect of Seltorexant Compared to Placebo on Respiration During Sleep in Adult Participants With Obstructive Sleep Apnea

Terminated and withdrawn Seltorexant trials (2)

Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.

All Seltorexant trials (14)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT06559306Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia SymptomsP3recruiting752Janssen Research & Development, LLCJul 2024
NCT04533529A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant and Long-term Safety Extension Treatment With SeltorexantP3completed588Janssen Research & Development, LLCSep 2020
NCT04951609SSRIA Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adolescents With Major Depressive Disorder Who Have an Inadequate Response to Selective Serotonin Reuptake Inhibitor (SSRI) and PsychotherapyP1terminated31Janssen Research & Development, LLCSep 2021
NCT05307692A Study of Seltorexant in Participants With Probable Alzheimer's DiseaseP2completed88Janssen Research & Development, LLCMay 2022
NCT04513912A Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant TherapyP3completed757Janssen Research & Development, LLCSep 2020
NCT05106153A Study to Determine the Abuse Potential of Seltorexant Compared to Suvorexant and ZolpidemP1completed127Janssen Research & Development, LLCDec 2021
NCT04451187A Study of Oral Seltorexant as an add-on Medication to an Antidepressant on On-road Driving Performance in Participants With Major Depressive DisorderP1completed63Janssen Research & Development, LLCJul 2020
NCT04532749A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant TherapyP3terminated212Janssen Research & Development, LLCSep 2020
NCT05236868A Study of JNJ-42847922 (Seltorexant) in Healthy ParticipantsP1completed10Janssen Research & Development, LLCFeb 2022
NCT04553042A Study of Seltorexant in Healthy ParticipantsP1completed69Janssen Research & Development, LLCSep 2020
NCT03682380JNJ-42847922A Study of Seltorexant (JNJ-42847922) After Single-Dose Administration in Healthy ParticipantsP1completed151Janssen Research & Development, LLCOct 2018
NCT03796026A Study to Assess the Effect of Seltorexant Compared to Placebo on Respiration During Sleep in Adult Participants With Obstructive Sleep ApneaP1completed34Janssen Research & Development, LLCJan 2019
NCT03494907A Study to Evaluate the Effects of Single-dose Seltorexant on Electrocardiogram Intervals in Healthy Adult ParticipantsP1completed52Janssen Research & Development, LLCApr 2018
NCT03438461JNJ-42847922A Study to Evaluate the Relative Oral Bioavailability of Seltorexant (JNJ-42847922) After Administration of 3 Different Formulations in Healthy Participants Under Fasted and Semi-fasted ConditionsP1completed49Janssen Research & Development, LLCFeb 2018

Seltorexant clinical trials: frequently asked questions

How many Seltorexant clinical trials are there?
14 Seltorexant clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 1 is actively recruiting participants. 11 are marked completed.
Are Seltorexant clinical trials recruiting in 2026?
Yes — 1 Seltorexant trial is actively recruiting in 2026, with 45 U.S. sites across 18 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Seltorexant being studied for?
Seltorexant is being studied for Depressive Disorder, Major, Healthy, Abuse Potential, Alzheimer Disease, Healthy Non-dependent, Recreational Sedative Users and 1 more. The trials are grouped by indication on this page.
What phase is Seltorexant in?
Seltorexant clinical trials span 4 Phase 3, 1 Phase 2, 9 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Seltorexant clinical trials?
The lead sponsor across the most Seltorexant trials is Janssen Research & Development, LLC. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Seltorexantas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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