Plozasiran Clinical Trials (2026): 8 Studies for Severe Hypertriglyceridemia & Familial Chylomicronemia

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

8 Plozasiran clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 4 indications (including Severe Hypertriglyceridemia & Familial Chylomicronemia) and 3,482 total planned enrollment. 7 Phase 3 Plozasiran trials are listed. 2 Plozasiran clinical trials are actively recruiting at 92 U.S. sites across 23 states. Most recent activity: NCT06880770 (Jun 2029).

Where to Participate: All Plozasiran Trial Sites in the U.S. (92 sites across 23 states)

Every actively recruiting Plozasirantrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
CAResearch Site 21Bakersfield93311NCT06822790Map
CAResearch Site 9Beverly Hills90211NCT06822790Map
CAResearch Site 11Canoga Park91303NCT06822790Map
CAResearch Site 40Garden Grove92844NCT06822790Map
CAResearch Site 235Huntington Beach92648NCT06822790Map
CAResearch Site 236Lake Forest92630NCT06822790Map
CAResearch Site 39Lincoln95648NCT06822790Map
CAResearch SiteLos Angeles90027NCT06880770Map
CAResearch Site 34Oxnard93030NCT06822790Map
CAResearch Site 229Palm Springs92262NCT06822790Map
CAResearch Site 275Redding96001NCT06822790Map
CAClinical Research Site 4Santa Clarita91321NCT06880770Map
CTResearch SiteNew Haven06519NCT06880770Map
FLResearch Site 155Fort Lauderdale33308NCT06822790Map
FLResearch Site 14Hialeah33016NCT06822790Map
FLResearch Site 154Miami33144NCT06822790Map
FLResearch Site 1Miami Lakes33014NCT06822790Map
FLResearch Site 162Mt. Dora32757NCT06822790Map
FLResearch Site 42Mt. Dora32757NCT06822790Map
FLResearch Site 38North Miami33162NCT06822790Map
FLResearch Site 159Orlando32825NCT06822790Map
FLResearch Site 41Orlando32825NCT06822790Map
FLResearch Site 16Tamarac33321NCT06822790Map
FLResearch Site 18Tampa33614NCT06822790Map
GAResearch Site 237Lawrenceville30044NCT06822790Map
ILResearch Site 17Park Ridge60068NCT06822790Map
ILClinical Research Site 6Springfield62702NCT06880770Map
INResearch Site 167Elkhart46514-2487NCT06822790Map
INResearch Site 43Elkhart46514NCT06822790Map
INResearch SiteIndianapolis46202NCT06880770Map
INResearch Site 157Indianapolis46290NCT06822790Map
KSResearch SiteKansas City66160NCT06880770Map
KSResearch Site 28Overland Park66211NCT06822790Map
KSResearch Site 23Topeka66606NCT06822790Map
MDResearch Site 12Annapolis21401NCT06822790Map
MDResearch Site 166Baltimore21229NCT06822790Map
MDResearch Site 44Baltimore21229NCT06822790Map
MIResearch SiteAnn Arbor48109NCT06880770Map
MIResearch Site 30Flint48532NCT06822790Map
MSResearch Site 33Jackson39202NCT06822790Map
MSResearch Site 32Olive Branch38654NCT06822790Map
MOResearch Site 2Jefferson City65109NCT06822790Map
MOResearch SiteSt Louis63110NCT06880770Map
MOResearch Site 232St Louis63136NCT06822790Map
NEResearch Site 29Fremont68025NCT06822790Map
NEClinical Research Site 5North Platte69101NCT06880770Map
NEResearch Site 3Omaha68144NCT06822790Map
NJResearch Site 165Summit07901NCT06822790Map
NJResearch Site 77Summit07901NCT06822790Map
NYResearch Site 156Long Island City11106NCT06822790Map
NYResearch Site 72Long Island City11106NCT06822790Map
NYResearch Site 228New York10029NCT06822790Map
NYResearch Site 233New York10016NCT06822790Map
NYResearch Site 273Riverhead12401NCT06822790Map
NCResearch Site 37Asheboro27203NCT06822790Map
NCClinical Research Site 3Greensboro27401NCT06880770Map
NCResearch Site 36Morehead City28557NCT06822790Map
NCResearch SiteWilmington28412NCT06880770Map
NCResearch Site 169Wilmington28401NCT06822790Map
OHResearch Site 22Beavercreek45431NCT06822790Map
OHResearch Site 234Columbus43214NCT06822790Map
OKResearch Site 164Norman73072NCT06822790Map
OKResearch Site 76Norman73072NCT06822790Map
OKResearch Site 31Oklahoma City73112NCT06822790Map
PAResearch Site 26Horsham19044NCT06822790Map
PAResearch Site 8Newport17074NCT06822790Map
PAClinical Research Site 7Philadelphia19107NCT06880770Map
PAResearch Site 231Philadelphia19104NCT06822790Map
PAResearch SitePittsburgh15213NCT06880770Map
SCResearch Site 238Fort Mill29707NCT06822790Map
TXResearch Site 27El Paso19044NCT06822790Map
TXResearch Site 160Fort Worth76132NCT06822790Map
TXResearch Site 158Houston77061NCT06822790Map
TXResearch Site 163Houston77090NCT06822790Map
TXResearch Site 24Houston77095NCT06822790Map
TXResearch Site 272Houston77030NCT06822790Map
TXResearch Site 73Houston77061NCT06822790Map
TXResearch Site 75Houston77090NCT06822790Map
TXClinical Research Site 1Mesquite75149NCT06880770Map
TXResearch Site 230Missouri City77459NCT06822790Map
TXResearch Site 161Plano75093NCT06822790Map
TXResearch Site 74Plano75093NCT06822790Map
TXClinical Research Site 2San Antonio78233NCT06880770Map
TXResearch Site 168San Antonio78230NCT06822790Map
TXResearch Site 13Sugar Land77479NCT06822790Map
TXResearch Site 170Tomball77375NCT06822790Map
TXResearch Site 25Victoria77901NCT06822790Map
UTResearch Site 15Bountiful84010NCT06822790Map
UTResearch Site 35St. George84790NCT06822790Map
VAResearch Site 10Manassas20110NCT06822790Map
WAResearch SiteSeattle98109NCT06880770Map
WAResearch Site 274Seattle98109NCT06822790Map

Plozasiran clinical trials at a glance: phase × recruitment status

Phaserecruitingactive not recruitingcompletedavailableTotal
P32327
N/A11

Recruiting Plozasiran clinical trials (2)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT06880770SHASTA-5Study of Plozasiran in Adults With Severe Hypertriglyceridemia at Risk of Acute PancreatitisP3Severe Hypertriglyceridemia288Apr 2025
NCT06822790SHASTA-10Long-Term Safety and Efficacy of Plozasiran in Adults With HypertriglyceridemiaP3Hypertriglyceridemia869Apr 2025

Plozasiran clinical trials by indication

Severe Hypertriglyceridemia (3)

NCTAcronymPhaseStatusTitle
NCT06880770SHASTA-5P3recruitingStudy of Plozasiran in Adults With Severe Hypertriglyceridemia at Risk of Acute Pancreatitis
NCT06347016SHASTA-4P3active not recruitingStudy of Plozasiran in Adults With Severe Hypertriglyceridemia
NCT06347003SHASTA-3P3active not recruitingStudy of Plozasiran (ARO-APOC3) in Adults With Severe Hypertriglyceridemia

Hypertriglyceridemia (2)

NCTAcronymPhaseStatusTitle
NCT06822790SHASTA-10P3recruitingLong-Term Safety and Efficacy of Plozasiran in Adults With Hypertriglyceridemia
NCT06347133MUIR-3P3active not recruitingPhase 3 Study of Plozasiran in Adults With Hypertriglyceridemia

Familial Chylomicronemia (2)

NCTAcronymPhaseStatusTitle
NCT05089084PALISADEP3completedStudy of ARO-APOC3 (Plozasiran) in Adults With Familial Chylomicronemia Syndrome (FCS)
NCT06796426SHTGN/AavailableTreatment Protocol of Plozasiran in Adults With High-Risk Severe Hypertriglyceridemia (SHTG) and in Adults and Adolescents With FCS

Familial Chylomicronemia Syndrome (1)

NCTAcronymPhaseStatusTitle
NCT05902598P3completedA Phase 3 Study of ARO-APOC3 / VSA001 / SAR449124 (Plozasiran) in Chinese Adults With Familial Chylomicronemia Syndrome

Plozasiran pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
SHASTA-5NCT06880770P3recruitingSevere Hypertriglyceridemia288
SHASTA-10NCT06822790P3recruitingHypertriglyceridemia869
SHASTA-4NCT06347016P3active not recruitingSevere Hypertriglyceridemia311
SHASTA-3NCT06347003P3active not recruitingSevere Hypertriglyceridemia446
MUIR-3NCT06347133P3active not recruitingHypertriglyceridemia1,456
PALISADENCT05089084P3completedFamilial Chylomicronemia75

All Plozasiran trials (8)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT06880770SHASTA-5Study of Plozasiran in Adults With Severe Hypertriglyceridemia at Risk of Acute PancreatitisP3recruiting288Arrowhead PharmaceuticalsApr 2025
NCT06822790SHASTA-10Long-Term Safety and Efficacy of Plozasiran in Adults With HypertriglyceridemiaP3recruiting869Arrowhead PharmaceuticalsApr 2025
NCT06347016SHASTA-4Study of Plozasiran in Adults With Severe HypertriglyceridemiaP3active not recruiting311Arrowhead PharmaceuticalsJul 2024
NCT06347003SHASTA-3Study of Plozasiran (ARO-APOC3) in Adults With Severe HypertriglyceridemiaP3active not recruiting446Arrowhead PharmaceuticalsJul 2024
NCT06347133MUIR-3Phase 3 Study of Plozasiran in Adults With HypertriglyceridemiaP3active not recruiting1,456Arrowhead PharmaceuticalsMay 2024
NCT05089084PALISADEStudy of ARO-APOC3 (Plozasiran) in Adults With Familial Chylomicronemia Syndrome (FCS)P3completed75Arrowhead PharmaceuticalsDec 2021
NCT05902598A Phase 3 Study of ARO-APOC3 / VSA001 / SAR449124 (Plozasiran) in Chinese Adults With Familial Chylomicronemia SyndromeP3completed37Visirna Therapeutics HK LimitedJul 2023
NCT06796426SHTGTreatment Protocol of Plozasiran in Adults With High-Risk Severe Hypertriglyceridemia (SHTG) and in Adults and Adolescents With FCSavailable0Arrowhead Pharmaceuticals

Plozasiran clinical trials: frequently asked questions

How many Plozasiran clinical trials are there?
8 Plozasiran clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 2 are actively recruiting participants. 2 are marked completed.
Are Plozasiran clinical trials recruiting in 2026?
Yes — 2 Plozasiran trials are actively recruiting in 2026, with 92 U.S. sites across 23 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Plozasiran being studied for?
Plozasiran is being studied for Severe Hypertriglyceridemia, Familial Chylomicronemia, Hypertriglyceridemia, Familial Chylomicronemia Syndrome, High Risk Severe Hypertriglyceridemia (SHTG). The trials are grouped by indication on this page.
What phase is Plozasiran in?
Plozasiran clinical trials span 7 Phase 3. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Plozasiran clinical trials?
The lead sponsor across the most Plozasiran trials is Arrowhead Pharmaceuticals, with 1 additional lead sponsor listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Plozasiranas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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