Pelareorep Clinical Trials (2026): 10 Studies for Recurrent Plasma Cell Myeloma & Anal Cancer Metastatic

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

10 Pelareorep clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 9 indications (including Recurrent Plasma Cell Myeloma & Anal Cancer Metastatic) and 449 total planned enrollment. 1 Pelareorep clinical trial is actively recruiting at 3 U.S. sites across 3 states. Most recent activity: NCT07446322 (Apr 2030).

Where to Participate: All Pelareorep Trial Sites in the U.S. (3 sites across 3 states)

Every actively recruiting Pelareoreptrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
ALCentral Alabama ResearchHomewood35209NCT07446322Map
NJSummit Health Cancer CenterFlorham Park07932NCT07446322Map
OHGabrail Cancer CenterCanton44718NCT07446322Map

Pelareorep clinical trials at a glance: phase × recruitment status

Phaserecruitingactive not recruitingcompletedterminatedTotal
Early P111
P133
P1/P222
P21214

Recruiting Pelareorep clinical trials (1)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT07446322FOLFIRI and Bevacizumab With or Without Pelareorep for Second-Line Treatment of Metastatic RAS-Mutated, Microsatellite-Stable Colorectal CancerP2Ras-mutated Metastatic Colorectal Cancer60Apr 2026

Pelareorep clinical trials by indication

Recurrent Plasma Cell Myeloma (2)

NCTAcronymPhaseStatusTitle
NCT05514990P1/P2active not recruitingBortezomib and Pembrolizumab With or Without Pelareorep for the Treatment of Relapsed or Refractory Multiple Myeloma, AMBUSH Trial
NCT03605719P1completedDexamethasone, Carfilzomib, & Nivolumab With Pelareorep for Relapsed/Refractory Multiple Myeloma

Ras-mutated Metastatic Colorectal Cancer (1)

NCTAcronymPhaseStatusTitle
NCT07446322P2recruitingFOLFIRI and Bevacizumab With or Without Pelareorep for Second-Line Treatment of Metastatic RAS-Mutated, Microsatellite-Stable Colorectal Cancer

Anal Cancer Metastatic (1)

NCTAcronymPhaseStatusTitle
NCT07280377GOBLETP1/P2active not recruitingA Study in Advanced or Metastatic Gastrointestinal Cancers Exploring Treatment Combinations With Pelareorep and Atezolizumab

Advanced or Metastatic Breast Cancer (1)

NCTAcronymPhaseStatusTitle
NCT05519059P1completedPelareorep and Paclitaxel Injection in Chinese Patients With Advanced or Metastatic Breast Cancer

Anatomic Stage IV Breast Cancer AJCC v8 (1)

NCTAcronymPhaseStatusTitle
NCT04445844P2active not recruitingINCMGA00012 and Pelareorep for the Treatment of Metastatic Triple Negative Breast Cancer, IRENE Study

Breast Cancer Metastatic (1)

NCTAcronymPhaseStatusTitle
NCT04215146P2active not recruitingA Study to Assess Overall Response Rate by Inducing an Inflammatory Phenotype in Metastatic BReast cAnCEr With the Oncolytic Reovirus PeLareorEp in CombinaTion With Anti-PD-L1 Avelumab and Paclitaxel - BRACELET-1 Study

Breast Cancer (1)

NCTAcronymPhaseStatusTitle
NCT04102618AWARE-1Early P1terminatedA Window-of-opportunity Study of Pelareorep in Early Breast Cancer

Anemia (1)

NCTAcronymPhaseStatusTitle
NCT02101944P1completedWild-Type Reovirus in Combination With Carfilzomib and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma

Recurrent Fallopian Tube Carcinoma (1)

NCTAcronymPhaseStatusTitle
NCT01199263P2completedPaclitaxel With or Without Viral Therapy in Treating Patients With Recurrent or Persistent Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer

Terminated and withdrawn Pelareorep trials (1)

Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.

All Pelareorep trials (10)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT07446322FOLFIRI and Bevacizumab With or Without Pelareorep for Second-Line Treatment of Metastatic RAS-Mutated, Microsatellite-Stable Colorectal CancerP2recruiting60Oncolytics BiotechApr 2026
NCT07280377GOBLETA Study in Advanced or Metastatic Gastrointestinal Cancers Exploring Treatment Combinations With Pelareorep and AtezolizumabP1/P2active not recruiting122Oncolytics BiotechOct 2021
NCT05514990Bortezomib and Pembrolizumab With or Without Pelareorep for the Treatment of Relapsed or Refractory Multiple Myeloma, AMBUSH TrialP1/P2active not recruiting10University of Southern CaliforniaOct 2022
NCT04445844INCMGA00012 and Pelareorep for the Treatment of Metastatic Triple Negative Breast Cancer, IRENE StudyP2active not recruiting25Mridula George, MDJul 2020
NCT04215146A Study to Assess Overall Response Rate by Inducing an Inflammatory Phenotype in Metastatic BReast cAnCEr With the Oncolytic Reovirus PeLareorEp in CombinaTion With Anti-PD-L1 Avelumab and Paclitaxel - BRACELET-1 StudyP2active not recruiting48Oncolytics BiotechJun 2020
NCT02101944Wild-Type Reovirus in Combination With Carfilzomib and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple MyelomaP1completed12National Cancer Institute (NCI)Dec 2014
NCT05519059Pelareorep and Paclitaxel Injection in Chinese Patients With Advanced or Metastatic Breast CancerP1completed15Adlai Nortye Biopharma Co., Ltd.Oct 2021
NCT03605719Dexamethasone, Carfilzomib, & Nivolumab With Pelareorep for Relapsed/Refractory Multiple MyelomaP1completed23Emory UniversityOct 2018
NCT04102618AWARE-1A Window-of-opportunity Study of Pelareorep in Early Breast CancerEarly P1terminated26Oncolytics BiotechMar 2019
NCT01199263Paclitaxel With or Without Viral Therapy in Treating Patients With Recurrent or Persistent Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal CancerP2completed108National Cancer Institute (NCI)Dec 2010

Pelareorep clinical trials: frequently asked questions

How many Pelareorep clinical trials are there?
10 Pelareorep clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 1 is actively recruiting participants. 4 are marked completed.
Are Pelareorep clinical trials recruiting in 2026?
Yes — 1 Pelareorep trial is actively recruiting in 2026, with 3 U.S. sites across 3 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Pelareorep being studied for?
Pelareorep is being studied for Recurrent Plasma Cell Myeloma, Anal Cancer Metastatic, Anatomic Stage IV Breast Cancer AJCC v8, Anemia, Breast Cancer and 18 more. The trials are grouped by indication on this page.
What phase is Pelareorep in?
Pelareorep clinical trials span 4 Phase 2, 3 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Pelareorep clinical trials?
The lead sponsor across the most Pelareorep trials is Oncolytics Biotech, with 5 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Pelareorepas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

Last refreshed .

Related pages on Hipa.ai: