How many Pelacarsen clinical trials are there?

10 Pelacarsen clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 4 are actively recruiting participants. 3 are marked completed.

Are Pelacarsen clinical trials recruiting in 2026?

Yes — 4 Pelacarsen trials are actively recruiting in 2026, with 262 U.S. sites across 36 states. See the recruiting trials and the per-state site list further down this page.

What conditions is Pelacarsen being studied for?

Pelacarsen is being studied for Acute Coronary Syndrome, Aortic Stenosis, Atherosclerotic Cardiovascular Disease, Atherosclerotic Cardiovascular Disease (ASCVD), Atherosclerotic Cardiovascular Disease, ASCVD and 8 more. The trials are grouped by indication on this page.

What phase is Pelacarsen in?

Pelacarsen clinical trials span 5 Phase 3, 1 Phase 2, 2 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.

Who sponsors Pelacarsen clinical trials?

The lead sponsor across the most Pelacarsen trials is Novartis Pharmaceuticals, with 2 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Pelacarsen Clinical Trials (2026): 10 Studies for Acute Coronary Syndrome & Aortic Stenosis

Creator: Hipa.ai Research
Published: 2026-04-21T18:14:32.591Z

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: June 16, 2026.

10 Pelacarsen clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 10 indications (including Acute Coronary Syndrome & Aortic Stenosis) and 7,279 total planned enrollment. 5 Phase 3 Pelacarsen trials and 1 Phase 2 are listed. 4 Pelacarsen clinical trials are actively recruiting at 262 U.S. sites across 36 states. Most recent activity: NCT06875973 (Dec 2030).

Where to Participate: All Pelacarsen Trial Sites in the U.S. (262 sites across 36 states)

Every actively recruiting Pelacarsentrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

State	Facility	City	Trial	Map
AL	SEC Clinical Research LLC	Andalusia36420	NCT07517263	Map
AL	Parkway Medical Center	Birmingham35215	NCT06813911	Map
AL	Parkway Medical Center	Birmingham35215	NCT06875973	Map
AL	Heart Center Research Llc	Huntsville35801	NCT05646381	Map
AL	Heart Center Research Llc	Huntsville35801	NCT07517263	Map
AL	Mobile Heart Specialists	Mobile36608	NCT07517263	Map
AZ	Mercy Gilbert Medical Center	Gilbert85297	NCT07517263	Map
AZ	Clinical Research Inst of Arizona	Sun City West85375	NCT06813911	Map
AZ	Clinical Research Inst of Arizona	Sun City West85375	NCT07517263	Map
AZ	Eclipse Clinical Research	Tucson85745	NCT07517263	Map
AR	Cardiology and Medicine Clinic PA	Little Rock72204	NCT06875973	Map
AR	Cardiology and Medicine Clinic PA	Little Rock72204	NCT07517263	Map
CA	Cardiovascular Res Found	Beverly Hills90210	NCT05646381	Map
CA	Cardiovascular Res Found	Beverly Hills90210	NCT07517263	Map
CA	National Heart Institute	Beverly Hills90211	NCT05646381	Map
CA	National Heart Institute	Beverly Hills90211	NCT06813911	Map
CA	National Heart Institute	Beverly Hills90211	NCT06875973	Map
CA	National Heart Institute	Beverly Hills90211	NCT07517263	Map
CA	Hope Clinical Research	Canoga Park91303	NCT06875973	Map
CA	Flourish Clinical Resrch Covin	Covina91723	NCT05646381	Map
CA	Valley Clinical Trials Inc	Covina91723	NCT06875973	Map
CA	Valley Clinical Trials Inc	Covina91723	NCT07517263	Map
CA	NICRs Research Center	Garden Grove92844	NCT06875973	Map
CA	University of Calif Irvine Med Cntr	Irvine92660	NCT06875973	Map
CA	University of Calif Irvine Med Cntr	Irvine92660	NCT07517263	Map
CA	Long Beach Clinical Trials	Long Beach90806	NCT06875973	Map
CA	Angel City Research Inc	Los Angeles90026	NCT06875973	Map
CA	Keck Medical Center USC	Los Angeles90033	NCT07517263	Map
CA	California Medical Research Associates Inc	Northridge91324	NCT06875973	Map
CA	Valley Clinical Trials	Northridge91325	NCT05646381	Map
CA	Valley Clinical Trials	Northridge91325	NCT07517263	Map
CA	Stanford University Medical Center	Palo Alto94304	NCT05646381	Map
CA	Stanford University Medical Center	Palo Alto94304	NCT07517263	Map
CA	University Of California San Diego	San Diego92103-8415	NCT05646381	Map
CA	UC San Francisco Medical Center	San Francisco94143	NCT05646381	Map
CA	UCSF	San Francisco94115	NCT07517263	Map
CA	Helping Hands Medical Associates INC	Santa Ana92704	NCT07517263	Map
CA	Stanford Health Care	Stanford94305	NCT06875973	Map
CA	Manshadi Heart Institute	Stockton95204	NCT07517263	Map
CA	Interv Cardiology Med Grp	West Hills91307	NCT06813911	Map
CA	Interv Cardiology Med Grp	West Hills91307	NCT07517263	Map
CO	Univ Of Color Anschutz Med Center	Aurora80045	NCT07517263	Map
CT	Bridgeport Hospital	Bridgeport06610	NCT07517263	Map
CT	Hartford Hospital	Hartford06102	NCT07517263	Map
CT	Chase Medical Research LLC	Waterbury06708	NCT07517263	Map
FL	Excel Medical Clinical Trials LLC	Boca Raton33434	NCT06813911	Map
FL	Excel Medical Clinical Trials LLC	Boca Raton33434	NCT07517263	Map
FL	Nova Clinical Research LLC	Bradenton34209	NCT05646381	Map
FL	Bay Area Cardiology Assoc	Brandon33511	NCT07517263	Map
FL	C and A Clinical Trials	Cape Coral33990	NCT06875973	Map
FL	Proactive Clinical Research	Fort Lauderdale33308	NCT06875973	Map
FL	National Research Institute	Hialeah33013	NCT06875973	Map
FL	Sister Life Research Inc	Hialeah33013	NCT06875973	Map
FL	Zenith Clinical Research	Hollywood33021	NCT06875973	Map
FL	Jacksonville Center for Clinical	Jacksonville32216	NCT06813911	Map
FL	Jacksonville Center for Clinical Research	Jacksonville32216	NCT07517263	Map
FL	K2 Medical Research LLC	Maitland32751	NCT06813911	Map
FL	A&A Research Group Inc	Miami33186	NCT06875973	Map
FL	Baptist Health South	Miami33173	NCT06813911	Map
FL	Baptist Health South	Miami33173	NCT06875973	Map
FL	Columbus Clinical Services LLC	Miami33125	NCT06875973	Map
FL	Flourish Res Acq LLC North Miami	Miami33138	NCT05646381	Map
FL	Infinite Clinical Research	Miami33133	NCT06875973	Map
FL	International Research Associates LLC	Miami33156	NCT06875973	Map
FL	University of Miami Hospital	Miami33136	NCT06813911	Map
FL	Inpatient Research Clinical LLC	Miami Lakes33014	NCT05646381	Map
FL	Inpatient Research Clinical LLC	Miami Lakes33014	NCT06813911	Map
FL	Inpatient Research Clinical LLC	Miami Lakes33014	NCT06813911	Map
FL	Inpatient Research Clinical LLC	Miami Lakes33014	NCT06875973	Map
FL	Inpatient Research Clinical LLC	Miami Lakes33014	NCT06875973	Map
FL	FXM Clin Res Miramar LLC	Miramar33027	NCT06813911	Map
FL	Advanced Research for Health Improvement LLC	Naples34102	NCT07517263	Map
FL	Ocala Cardiovascular Research	Ocala34471	NCT06813911	Map
FL	CTMD Research	Palm Springs33406	NCT06875973	Map
FL	DBC Research USA	Pembroke Pines33029	NCT06875973	Map
FL	SEC Clinical Research	Pensacola32503	NCT06813911	Map
FL	Peace River Cardiovascular Center	Port Charlotte33952	NCT06813911	Map
FL	Peace River Cardiovascular Center	Port Charlotte33952	NCT07517263	Map
FL	Progressive Medical Research	Port Orange32127	NCT07517263	Map
FL	East Coast Inst for Research LLC	Saint Augustine32086	NCT07517263	Map
FL	James A Haley Veterans Hospital	Tampa33612	NCT06875973	Map
FL	New Tampa Health	Tampa33603	NCT06875973	Map
FL	University Of South Florida	Tampa33612	NCT06813911	Map
FL	Cardiology Partners Clinical Research Institute	Wellington33449	NCT06875973	Map
FL	Cardiology Partners Clinical Research Institute	Wellington33449	NCT07517263	Map
FL	FC Site Partners Miami	Winter Park32789	NCT06813911	Map
FL	Flourish Research	Winter Park32789	NCT06875973	Map
GA	Emory University	Atlanta30322	NCT07517263	Map
GA	Morehouse School Of Medicine	Atlanta30310	NCT06875973	Map
GA	Piedmont Heart Institute	Atlanta30309	NCT07517263	Map
GA	Cardiovascular Consultants of S GA	Thomasville31792	NCT07517263	Map
GA	Atlanta Heart Specialists LLC	Tucker30084	NCT06875973	Map
IL	Chicago Clinical Research Inst	Chicago60607	NCT06875973	Map
IL	Rush University Medical Center	Chicago60612	NCT07517263	Map
IL	Advocate Lutheran General Childrens Hospital	Park Ridge60068	NCT06813911	Map
IN	Krannert Institute of Cardiology	Indianapolis46202 4800	NCT07517263	Map
IN	American Health Network Research Dept	Muncie47304	NCT06813911	Map
IN	American Health Network Research Dept	Muncie47304	NCT06813911	Map
IA	Uni Of Iowa Hospitals And Clinics	Iowa City52242	NCT07517263	Map
KS	University of Kansas Hospital	Kansas City66160	NCT07517263	Map
KS	Midwest Heart and Vascular Spec	Overland Park66211	NCT05646381	Map
KS	Cotton O Neil Clinical Res Center	Topeka66606	NCT07517263	Map
LA	Cardiovascular Associates Research	Covington70433	NCT06813911	Map
LA	Cardiovascular Associates Research	Covington70433	NCT06875973	Map
LA	Cardiovascular Associates Research	Covington70433	NCT07517263	Map
LA	Louisiana Heart Center Research	Covington70433	NCT07517263	Map
LA	Louisiana Heart Center Research	Covington70433	NCT07517263	Map
LA	CV Institute of the South	Houma70360	NCT07517263	Map
LA	Horizon Research Grp	Lafayette70501	NCT07517263	Map
LA	Omega Clinical Research	Metairie70006	NCT06813911	Map
LA	Omega Clinical Research	Metairie70006	NCT06875973	Map
LA	Omega Clinical Research	Metairie70006	NCT07517263	Map
LA	Tulane Center for Clinical Research	New Orleans70112	NCT07517263	Map
LA	CV Ins of the South	Opelousas70570	NCT06875973	Map
LA	CV Ins of the South	Opelousas70570	NCT07517263	Map
LA	Grace Research Llc	Shreveport71105	NCT07517263	Map
LA	Louisiana Heart Center Research	Slidell70458	NCT07517263	Map
LA	Monroe Research Llc	West Monroe71291	NCT06875973	Map
LA	Southern Clinical Research	Zachary70791	NCT07517263	Map
ME	Maine Health Cardiology	Scarborough04074	NCT07517263	Map
MD	Ascension Saint Agnes Heart Care	Baltimore21229	NCT06875973	Map
MD	Johns Hopkins Univ School of Med	Baltimore21287	NCT06875973	Map
MD	Johns Hopkins Univ School of Med	Baltimore21287	NCT07517263	Map
MD	Sinai Ct for Throm Res and Drug Dev	Baltimore21209	NCT06875973	Map
MD	Sinai Ct for Throm Res and Drug Dev	Baltimore21209	NCT07517263	Map
MD	Metropolitan Cardiovascular Consultants Llc	Beltsville20705	NCT06875973	Map
MD	Flourish Research Bowie	Bowie20715	NCT06813911	Map
MD	Johns Hopkins University	Columbia21044	NCT06875973	Map
MD	Johns Hopkins University	Columbia21044	NCT07517263	Map
MD	Anderson Medical Research	Ft. Washington20744	NCT06813911	Map
MD	Anderson Medical Research	Ft. Washington20744	NCT07517263	Map
MD	Capitol Cardiology Associates	Lanham20706	NCT06875973	Map
MD	MD Medical Research	Oxon Hill20745	NCT06875973	Map
MD	Adventist HealthCare Shady Grove Medical Center	Rockville20850	NCT07517263	Map
MA	Brigham and Womens Hosp Harvard Med School	Boston02115	NCT05646381	Map
MA	Brigham and Womens Hosp Harvard Med School	Boston02115	NCT05646381	Map
MA	Brigham and Womens Hosp Harvard Med School	Boston02115	NCT07517263	Map
MA	Massachusetts General Hospital	Boston02114	NCT05646381	Map
MA	Massachusetts General Hospital	Boston02114	NCT05646381	Map
MA	MGH	Boston02114 2696	NCT07517263	Map
MA	Tufts Medical Center	Boston02111	NCT05646381	Map
MI	Henry Ford Hospital	Detroit48202	NCT05646381	Map
MI	Henry Ford Hospital	Detroit48202	NCT05646381	Map
MI	Henry Ford Hospital	Detroit48202	NCT06813911	Map
MI	Henry Ford Hospital	Detroit48202	NCT06875973	Map
MI	Henry Ford Hospital	Detroit48202	NCT07517263	Map
MI	Wayne State University	Detroit48201	NCT07517263	Map
MI	AA Medical Research Center	Flint48504	NCT05646381	Map
MI	AA Medical Research Center	Flint48504	NCT07517263	Map
MI	Aa Mrc Llc	Flint48504	NCT06813911	Map
MI	Aa Mrc Mhs	Flint48503	NCT06875973	Map
MI	Western Michigan University	Kalamazoo49008	NCT07517263	Map
MI	MyMichigan Medical Center Midland	Midland48670	NCT06813911	Map
MI	McLaren Ctr Research Innovation	Petoskey49770	NCT07517263	Map
MI	William Beaumont Hospital	Royal Oak48073-4192	NCT05646381	Map
MI	Central Michigan University	Saginaw48601	NCT07517263	Map
MI	Metro Health Univ of MI Health	Wyoming49519	NCT07517263	Map
MN	Saint Johns Hospital	Maplewood55109	NCT07517263	Map
MN	Minneapolis Heart Institute	Minneapolis55407	NCT07517263	Map
MN	University Of Minnesota	Minneapolis55455	NCT05646381	Map
MN	University Of Minnesota	Minneapolis55455	NCT07517263	Map
MS	Belzoni Clinical Research	Belzoni39038	NCT07517263	Map
MS	Elite Clinical Research	Jackson39202	NCT06875973	Map
MS	Stern Cardiovascular Foundation Inc	Southaven38671	NCT06875973	Map
MS	Stern Cardiovascular Foundation Inc	Southaven38671	NCT07517263	Map
MO	StudyMetrix Research	City of Saint Peters63303	NCT07517263	Map
MO	Washington Univ School Of Medicine	St Louis63110	NCT07517263	Map
NE	Quality Clinical Research	Omaha68114	NCT07517263	Map
NV	Las Vegas Endocrinology	Henderson89074	NCT06875973	Map
NV	AB Clinical Trials	Las Vegas89119	NCT06813911	Map
NV	AB Clinical Trials	Las Vegas89119	NCT06875973	Map
NV	Clinical Research of South Nevada	Las Vegas89121	NCT06875973	Map
NH	Dartmouth Hitchcock Medical Center	Lebanon03756	NCT07517263	Map
NJ	Robert Wood Johnson Medical School	New Brunswick08901	NCT06875973	Map
NJ	The Valley Hospital	Ridgewood07450	NCT07517263	Map
NJ	Overlook Medical Center	Summit07901	NCT05646381	Map
NJ	Overlook Medical Center	Summit07901	NCT06813911	Map
NJ	Overlook Medical Center	Summit07901	NCT06875973	Map
NJ	Overlook Medical Center	Summit07901	NCT07517263	Map
NY	Capital Cardiology Associates	Albany12211	NCT05646381	Map
NY	Northwell Health	Manhasset11030	NCT07517263	Map
NY	Icahn School of Med at Mt Sinai	New York10029	NCT05646381	Map
NY	Icahn School of Med at Mt Sinai	New York10029	NCT07517263	Map
NY	Lenox Hill Hospital	New York43210	NCT07517263	Map
NY	Weill Cornell Medical Center	New York10021	NCT07517263	Map
NY	Jamaica Hospital Medical Center	Richmond Hill11418	NCT06875973	Map
NY	Northwell Health Physician Peconic	Riverhead11901	NCT07517263	Map
NY	Strong Memorial Hospital	Rochester14642	NCT05646381	Map
NC	Novant Health Heart Vas Inst	Charlotte28204	NCT07517263	Map
NC	Medication Management LLC	Greensboro27405	NCT07517263	Map
NC	Monroe Biomedical Research	Monroe28112	NCT06875973	Map
NC	Accellacare US Inc	Raleigh27609	NCT07517263	Map
NC	Alliance Medical Ministry	Raleigh27610	NCT06875973	Map
NC	Wake Forest University Baptist Medical Center	Winston-Salem27157	NCT05646381	Map
NC	Wake Forest University Baptist Medical Center	Winston-Salem27157	NCT06813911	Map
NC	Wake Forest University Baptist Medical Center	Winston-Salem27157	NCT07517263	Map
NC	Wake Forest University Baptist Medical Center	Winston-Salem27157	NCT07517263	Map
OH	Aultman Hospital	Canton44710	NCT07517263	Map
OH	Lindner Ctr At The Christ Hosp	Cincinnati45219	NCT05646381	Map
OH	Lindner Ctr At The Christ Hosp	Cincinnati45219	NCT07517263	Map
OH	Cleveland Clinic Foundation	Cleveland44195	NCT07517263	Map
OH	Ohio State University	Columbus43210	NCT07517263	Map
OH	NexGen Research	Lima45801	NCT06875973	Map
OH	Rama Research LLC	Marion43302	NCT07517263	Map
OR	The Corvallis Clinic P C	Corvallis97330	NCT06813911	Map
PA	Care Access Research	Easton18045	NCT06875973	Map
PA	Lancaster General Health	Lancaster17603	NCT07517263	Map
PA	TCV Clinical Studies	Linwood19061	NCT06875973	Map
PA	Perelman School of Medicine	Philadelphia19104	NCT05646381	Map
PA	Perelman School of Medicine	Philadelphia19104	NCT07517263	Map
PA	Cardiology Consultants of Philadelphia	Yardley19067	NCT07517263	Map
SD	Monument Health Clinical Research	Rapid City57701	NCT07517263	Map
TN	The Stern Cardiovascular Foundation	Germantown38138	NCT07517263	Map
TN	Apex Cardiology Research Associates of Jackson	Jackson38301	NCT06875973	Map
TN	Apex Cardiology Research Associates of Jackson	Jackson38301	NCT07517263	Map
TN	Vanderbilt Univ Medi Cen	Nashville37232	NCT07517263	Map
TN	Cardiovascular Res of Knoxville LLC	Powell37849	NCT07517263	Map
TN	Novartis Investigative Site	Tullahoma37388	NCT06813911	Map
TX	Plano Primary Care Clinic	Allen75002-3688	NCT06875973	Map
TX	Pharma Tex Research	Amarillo79106	NCT06875973	Map
TX	PharmaTex Research LLC	Amarillo79106	NCT06813911	Map
TX	North Texas Endocrine Center	Dallas75231	NCT07517263	Map
TX	Soltero Cardiovascular Research Center	Dallas75226	NCT07517263	Map
TX	SW Family Medicine Associates	Dallas75235	NCT06875973	Map
TX	SW Family Medicine Associates	Dallas75235	NCT07517263	Map
TX	David Turbay MD PLLC	El Paso79905	NCT06875973	Map
TX	Angiocardiac Care of Texas PA	Houston77025	NCT06875973	Map
TX	Baylor College Of Medicine	Houston77030	NCT07517263	Map
TX	Dallas Heart and Vascular Consultants PA	Houston77084	NCT06875973	Map
TX	Dallas Heart and Vascular Consultants PA	Houston77084	NCT06875973	Map
TX	Kelsey Seybold Research Foundation	Houston77030	NCT06813911	Map
TX	Orion Medical	Houston77034	NCT05646381	Map
TX	Epic Clinical Research	Lewisville75057	NCT06875973	Map
TX	The Heart Institute of East Texas	Lufkin75904	NCT06875973	Map
TX	Grace Research	Marshall75670	NCT07517263	Map
TX	Discovery Clinical Trials	Pflugerville78660-3015	NCT06875973	Map
TX	University of Texas Health Science Ctr	San Antonio78229-3900	NCT06875973	Map
TX	Northwest Houston Clinical Research PLLC	Tomball77375	NCT06813911	Map
TX	Northwest Houston Clinical Research PLLC	Tomball77375	NCT07517263	Map
UT	Progressive Clinical Research	Bountiful84010	NCT07517263	Map
UT	Intermountain Medical Center	Murray84107	NCT06813911	Map
UT	Intermountain Medical Center	Murray84107	NCT07517263	Map
UT	The University of Utah	Salt Lake City84132-0001	NCT07517263	Map
VA	Javara Research	Alexandria22311	NCT06875973	Map
VA	Javara Research	Alexandria22311	NCT06875973	Map
VA	Javara Research	Alexandria22311	NCT06875973	Map
VA	Javara Research	Alexandria22311	NCT06875973	Map
VA	Inova Fairfax Hospital	Falls Church22042	NCT07517263	Map
VA	Virginia Heart	Falls Church22042	NCT05646381	Map
VA	Virginia Heart	Falls Church22042	NCT06813911	Map
VA	Virginia Heart	Falls Church22042	NCT06875973	Map
VA	Virginia Heart	Falls Church22042	NCT07517263	Map
VA	Heart Care Associates P C	Hopewell23860	NCT06875973	Map
VA	Carient Heart and Vascular	Manassas20109	NCT05646381	Map
VA	Carient Heart and Vascular	Manassas20109	NCT07517263	Map
VA	Dominion Medical Associates	Richmond23219	NCT07517263	Map
VA	Vcu Health	Richmond23298	NCT06875973	Map
WA	Harborview Medical Center	Seattle98104	NCT07517263	Map
WA	Swedish Medical Center-Cardiovascular Research	Seattle98122	NCT07517263	Map
WA	Univ of Washington Medical Center	Seattle98195	NCT07517263	Map
WA	University of Washington	Seattle98195	NCT06875973	Map
WV	West Virginia University Hospital	Morgantown26506	NCT07517263	Map

Pelacarsen clinical trials at a glance: phase × recruitment status

Phase	recruiting	active not recruiting	completed	withdrawn	available	Total
P1			2			2
P2	1					1
P3	3	1	1			5
N/A				1	1	2

Recruiting Pelacarsen clinical trials (4)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT ID	Title	Phase	Indication	Enrollment	Started
NCT06875973	Pelacarsen Roll-over Extension Program	P3	Atherosclerotic Cardiovascular Disease	599	May 2025
NCT05646381	TQJ230A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis	P2	Aortic Stenosis	502	Mar 2024
NCT07517263	OLEAn Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)	P3	Cardiovascular Disease and Lipoprotein(a)	5,700	May 2026
NCT06813911	ADD-VANTAGELp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD	P3	Atherosclerotic Cardiovascular Disease (ASCVD)	340	Apr 2025

Pelacarsen clinical trials by indication

Cardiovascular Disease and Lipoprotein(a) (1)

NCT	Acronym	Phase	Status	Title
NCT07517263	OLE	P3	recruiting	An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)

Atherosclerotic Cardiovascular Disease (1)

NCT	Acronym	Phase	Status	Title
NCT06875973	—	P3	recruiting	Pelacarsen Roll-over Extension Program

Atherosclerotic Cardiovascular Disease (ASCVD) (1)

NCT	Acronym	Phase	Status	Title
NCT06813911	ADD-VANTAGE	P3	recruiting	Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD

Aortic Stenosis (1)

NCT	Acronym	Phase	Status	Title
NCT05646381	TQJ230	P2	recruiting	A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis

Hyperlipoproteinemia (a) (1)

NCT	Acronym	Phase	Status	Title
NCT05900141	OLE	P3	active not recruiting	An Open Label Extension (OLE) Study to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)

Hyperlipoproteinemia(a) (1)

NCT	Acronym	Phase	Status	Title
NCT05305664	TQJ230	P3	completed	A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Rate of Weekly Lipoprotein Apheresis Sessions in Patients With Hyperlipoproteinemia(a) and Established Cardiovascular Disease in Germany

Hepatic Impairment (1)

NCT	Acronym	Phase	Status	Title
NCT05026996	TQJ230	P1	completed	Study to Assess the Pharmacokinetics of Pelacarsen (TQJ230) in Participants With Mild Hepatic Impairment Compared to Matched Healthy Participants

Acute Coronary Syndrome (1)

NCT	Acronym	Phase	Status	Title
NCT04993664	PEMILA	N/A	withdrawn	Influence of Pelacarsen on Patients After Myocardial Infarction With High Lp(a) Values (PEMILA)

Healthy Participants (1)

NCT	Acronym	Phase	Status	Title
NCT05337878	ISIS 681257	P1	completed	A Study to Assess Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Pelacarsen (ISIS 681257) in Healthy Japanese Participants

Atherosclerotic Cardiovascular Disease, ASCVD (1)

NCT	Acronym	Phase	Status	Title
NCT07000695	—	N/A	available	Managed Access Programs for TQJ230, Pelacarsen

Pelacarsen pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

Acronym	NCT	Phase	Status	Indication	Enrollment	PubMed
OLE	NCT07517263	P3	recruiting	Cardiovascular Disease and Lipoprotein(a)	5,700	—
OLE	NCT05900141	P3	active not recruiting	Hyperlipoproteinemia (a)	41	—
ADD-VANTAGE	NCT06813911	P3	recruiting	Atherosclerotic Cardiovascular Disease (ASCVD)	340	—
TQJ230	NCT05305664	P3	completed	Hyperlipoproteinemia(a)	51	—
TQJ230	NCT05646381	P2	recruiting	Aortic Stenosis	502	—

Terminated and withdrawn Pelacarsen trials (1)

Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.

NCT04993664withdrawnInfluence of Pelacarsen on Patients After Myocardial Infarction With High Lp(a) Values (PEMILA)

All Pelacarsen trials (10)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT ID	Acronym	Title	Phase	Status	Enrollment	Sponsor	Started
NCT06875973		Pelacarsen Roll-over Extension Program	P3	recruiting	599	Novartis Pharmaceuticals	May 2025
NCT05646381	TQJ230	A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis	P2	recruiting	502	Novartis Pharmaceuticals	Mar 2024
NCT07517263	OLE	An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)	P3	recruiting	5,700	Novartis Pharmaceuticals	May 2026
NCT05900141	OLE	An Open Label Extension (OLE) Study to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)	P3	active not recruiting	41	Novartis Pharmaceuticals	Sep 2023
NCT06813911	ADD-VANTAGE	Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD	P3	recruiting	340	Novartis Pharmaceuticals	Apr 2025
NCT07000695		Managed Access Programs for TQJ230, Pelacarsen	—	available	0	Novartis Pharmaceuticals	—
NCT05305664	TQJ230	A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Rate of Weekly Lipoprotein Apheresis Sessions in Patients With Hyperlipoproteinemia(a) and Established Cardiovascular Disease in Germany	P3	completed	51	Novartis Pharmaceuticals	Aug 2022
NCT05026996	TQJ230	Study to Assess the Pharmacokinetics of Pelacarsen (TQJ230) in Participants With Mild Hepatic Impairment Compared to Matched Healthy Participants	P1	completed	17	Novartis Pharmaceuticals	Nov 2021
NCT04993664	PEMILA	Influence of Pelacarsen on Patients After Myocardial Infarction With High Lp(a) Values (PEMILA)	N/A	withdrawn	0	University Medical Centre Ljubljana	Oct 2021
NCT05337878	ISIS 681257	A Study to Assess Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Pelacarsen (ISIS 681257) in Healthy Japanese Participants	P1	completed	29	Ionis Pharmaceuticals, Inc.	Oct 2018

Pelacarsen clinical trials: frequently asked questions

How many Pelacarsen clinical trials are there?: 10 Pelacarsen clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 4 are actively recruiting participants. 3 are marked completed.
Are Pelacarsen clinical trials recruiting in 2026?: Yes — 4 Pelacarsen trials are actively recruiting in 2026, with 262 U.S. sites across 36 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Pelacarsen being studied for?: Pelacarsen is being studied for Acute Coronary Syndrome, Aortic Stenosis, Atherosclerotic Cardiovascular Disease, Atherosclerotic Cardiovascular Disease (ASCVD), Atherosclerotic Cardiovascular Disease, ASCVD and 8 more. The trials are grouped by indication on this page.
What phase is Pelacarsen in?: Pelacarsen clinical trials span 5 Phase 3, 1 Phase 2, 2 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Pelacarsen clinical trials?: The lead sponsor across the most Pelacarsen trials is Novartis Pharmaceuticals, with 2 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Pelacarsenas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

Last refreshed June 16, 2026.

Related pages on Hipa.ai:

Pelacarsen overview