patiromer Clinical Trials (2026): 25 Studies for Hyperkalemia & Hypertension

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

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25 patiromer clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 12 indications (including Hyperkalemia & Hypertension) and 3,345 total planned enrollment. 5 Phase 3 patiromer trials and 9 Phase 2, 10 Phase 4 are listed. 3 patiromer clinical trials are actively recruiting at 11 U.S. sites across 9 states. Most recent activity: NCT05766839 (Dec 2030).

Where to Participate: All patiromer Trial Sites in the U.S. (11 sites across 9 states)

Every actively recruiting patiromertrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
COChildren's Hospital ColoradoAurora80045NCT05766839Map
FLMiller School of Medicine, University of MiamiMiami33124NCT05766839Map
FLArnold Palmer Hospital for ChildrenOrlando32806NCT05766839Map
GAAugusta University - Children's Hospital of GeorgiaAugusta30912NCT05766839Map
ILUniversity of Illinois College of MedicinePeoria61605NCT05766839Map
MABoston Children's HospitalBoston02115NCT05766839Map
MOChildren's Mercy Hospitals and ClinicsKansas City64108NCT05766839Map
NCDuke University HospitalDurham27710NCT05766839Map
NCDuke University Hospital & Medical CenterDurham27710NCT05766839Map
PAThe Children's Hospital of PhiladelphiaPhiladelphia19104NCT05766839Map
TNVanderbilt Children's Hospital NeurologyNashville37232NCT05766839Map

patiromer clinical trials at a glance: phase × recruitment status

PhaserecruitingcompletedterminatedTotal
P21629
P3145
P416310
N/A11

Recruiting patiromer clinical trials (3)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT05766839Patiromer for Treatment of Hyperkalaemia in Children Under 12 Years of AgeP2Hyperkalemia32Apr 2025
NCT06256991PROMISEPotassium Correction for RAAS Optimization in Chronic Kidney DiseaseP4Chronic Kidney Diseases44Apr 2024
NCT06858280PRINCEPatiromer and Diet/hrQoL in Chronic DialysisP3Hyperkalaemia40Jul 2025

patiromer clinical trials by indication

Hyperkalemia (13)

NCTAcronymPhaseStatusTitle
NCT05766839P2recruitingPatiromer for Treatment of Hyperkalaemia in Children Under 12 Years of Age
NCT05136664Patiromer JADEP3completedTrial Evaluating the Efficacy and Safety of Patiromer in Chinese Subjects
NCT04443608PLATINUMP4terminatedPatiromer Utility as an Adjunct Treatment in Patients Needing Urgent Hyperkalemia Management
NCT03781089P4completedPatiromer Efficacy to Reduce Episodic Hyperkalemia in End Stage Renal Disease Patients
NCT05029310TACPATP4completedEffects of Patiromer on Pharmacokinetics of Immunosuppresive Drugs in Renal Transplant Recipients
NCT03888066DIAMONDP3completedPatiromer for the Management of Hyperkalemia in Subjects Receiving RAASi Medications for the Treatment of Heart Failure (DIAMOND)
NCT03087058EMERALDP2terminatedPharmacodynamic & Safety of Patiromer in Children & Adolescents (2-<18 Yrs) With Chronic Kidney Disease and Hyperkalemia
NCT03799926P2completedExploratory Study of ZG-801 for the Treatment of Hyperkalemia
+ 5 more, see All trials below.

Chronic Kidney Diseases (2)

NCTAcronymPhaseStatusTitle
NCT06256991PROMISEP4recruitingPotassium Correction for RAAS Optimization in Chronic Kidney Disease
NCT03183778P4completedUse of Patiromer to Transition Chronic Kidney Disease Patients With Hyperkalemia to a Plant-rich Diet.

Hyperkalaemia (1)

NCTAcronymPhaseStatusTitle
NCT06858280PRINCEP3recruitingPatiromer and Diet/hrQoL in Chronic Dialysis

Acute Hyperkalemia (1)

NCTAcronymPhaseStatusTitle
NCT04585542KBindERP4terminatedComparison of Potassium Binders in the ER

Heart Failure,Congestive (1)

NCTAcronymPhaseStatusTitle
NCT04142788RELIEHFP4terminatedRELieving Increasing oEdema Due to Heart Failure

End Stage Renal Failure on Dialysis (1)

NCTAcronymPhaseStatusTitle
NCT03740048TWOPLUS-HDP3completedA Pilot Trial of Twice-weekly Versus Thrice-weekly Hemodialysis in Patients With Incident End-stage Kidney Disease

ESRD (1)

NCTAcronymPhaseStatusTitle
NCT03326583P2completedThe Effects of Patiromer on Serum Potassium Level and Gut Microbiome of ESRD Patients With Hyperkalemia

Acute Decompensated Heart Failure (1)

NCTAcronymPhaseStatusTitle
NCT02823626N/AcompletedHigh-dose Aldosterone Antagonist for Acute Decompensated Heart Failure

Kidney Failure, Chronic (1)

NCTAcronymPhaseStatusTitle
NCT02933450REDUCEP4completedRelypsa For ED Acute Hyperkalemia Control and Reduction (REDUCE)

Chronic Kidney Disease (CKD) (1)

NCTAcronymPhaseStatusTitle
NCT01810939OPALP3completedA Two-Part, Single-Blind, Phase 3 Study Evaluating the Efficacy and Safety of Patiromer for the Treatment of Hyperkalemia (OPAL)

Chronic Kidney Disease (1)

NCTAcronymPhaseStatusTitle
NCT01371747AMETHYST-DNP2completedPatiromer in the Treatment of Hyperkalemia in Patients With Hypertension and Diabetic Nephropathy (AMETHYST-DN)

Heart Failure (1)

NCTAcronymPhaseStatusTitle
NCT01130597P2completedEvaluation of Patiromer Titration in Heart Failure Patients With Chronic Kidney Disease

patiromer pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
PROMISENCT06256991P4recruitingChronic Kidney Diseases44
KBindERNCT04585542P4terminatedAcute Hyperkalemia37PMID 37016309
PLATINUMNCT04443608P4terminatedHyperkalemia115PMID 41730555
TACPATNCT05029310P4completedHyperkalemia13
RELIEHFNCT04142788P4terminatedHeart Failure,Congestive19
REDUCENCT02933450P4completedKidney Failure, Chronic43
TOURMALINENCT02694744P4completedHyperkalemia114PMID 32588430
PRINCENCT06858280P3recruitingHyperkalaemia40
Patiromer JADENCT05136664P3completedHyperkalemia262
TWOPLUS-HDNCT03740048P3completedEnd Stage Renal Failure on Dialysis51PMID 33165001
DIAMONDNCT03888066P3completedHyperkalemia1,195PMID 39340493
OPALNCT01810939P3completedChronic Kidney Disease (CKD)243
EMERALDNCT03087058P2terminatedHyperkalemia23
AMBERNCT03071263P2completedHyperkalemia295PMID 31533906
AMETHYST-DNNCT01371747P2completedChronic Kidney Disease324PMID 29767459
PEARL-HFNCT00868439P2completedHyperkalemia120PMID 21208974

Terminated and withdrawn patiromer trials (5)

Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.

All patiromer trials (25)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT05766839Patiromer for Treatment of Hyperkalaemia in Children Under 12 Years of AgeP2recruiting32Vifor Pharma, Inc.Apr 2025
NCT06256991PROMISEPotassium Correction for RAAS Optimization in Chronic Kidney DiseaseP4recruiting44University Medical Center GroningenApr 2024
NCT06858280PRINCEPatiromer and Diet/hrQoL in Chronic DialysisP3recruiting40Mario Negri Institute for Pharmacological ResearchJul 2025
NCT05136664Patiromer JADETrial Evaluating the Efficacy and Safety of Patiromer in Chinese SubjectsP3completed262Vifor Fresenius Medical Care Renal PharmaFeb 2022
NCT04585542KBindERComparison of Potassium Binders in the ERP4terminated37University of California, IrvineOct 2020
NCT04443608PLATINUMPatiromer Utility as an Adjunct Treatment in Patients Needing Urgent Hyperkalemia ManagementP4terminated115Comprehensive Research AssociatesOct 2020
NCT03781089Patiromer Efficacy to Reduce Episodic Hyperkalemia in End Stage Renal Disease PatientsP4completed36Duke UniversityJun 2019
NCT05029310TACPATEffects of Patiromer on Pharmacokinetics of Immunosuppresive Drugs in Renal Transplant RecipientsP4completed13Oslo University HospitalSep 2021
NCT04142788RELIEHFRELieving Increasing oEdema Due to Heart FailureP4terminated19NHS Greater Glasgow and ClydeAug 2020
NCT03740048TWOPLUS-HDA Pilot Trial of Twice-weekly Versus Thrice-weekly Hemodialysis in Patients With Incident End-stage Kidney DiseaseP3completed51Wake Forest University Health SciencesJun 2019
NCT03888066DIAMONDPatiromer for the Management of Hyperkalemia in Subjects Receiving RAASi Medications for the Treatment of Heart Failure (DIAMOND)P3completed1,195Vifor Pharma, Inc.Apr 2019
NCT03087058EMERALDPharmacodynamic & Safety of Patiromer in Children & Adolescents (2-<18 Yrs) With Chronic Kidney Disease and HyperkalemiaP2terminated23Vifor Pharma, Inc.Jul 2017
NCT03799926Exploratory Study of ZG-801 for the Treatment of HyperkalemiaP2completed184Zeria PharmaceuticalFeb 2019
NCT03326583The Effects of Patiromer on Serum Potassium Level and Gut Microbiome of ESRD Patients With HyperkalemiaP2completed27Dominic RajNov 2017
NCT03229265Pharmacokinetic Study of Tacrolimus and Mycophenolate Mofetil in Kidney Transplant Recipients With Hyperkalemia Receiving PatiromerP4completed8The Rogosin InstituteAug 2017
NCT03183778Use of Patiromer to Transition Chronic Kidney Disease Patients With Hyperkalemia to a Plant-rich Diet.P4completed3NYU Langone HealthMar 2018
NCT03071263AMBERSpironolactone With Patiromer in the Treatment of Resistant Hypertension in Chronic Kidney DiseaseP2completed295Relypsa, Inc.Jan 2017
NCT02823626High-dose Aldosterone Antagonist for Acute Decompensated Heart Failurecompleted48The University of Texas Health Science Center at San AntonioSep 2016
NCT02933450REDUCERelypsa For ED Acute Hyperkalemia Control and Reduction (REDUCE)P4completed43Baylor College of MedicineAug 2016
NCT02694744TOURMALINEPatiromer With or Without Food for the Treatment of HyperkalemiaP4completed114Relypsa, Inc.Feb 2016
NCT01810939OPALA Two-Part, Single-Blind, Phase 3 Study Evaluating the Efficacy and Safety of Patiromer for the Treatment of Hyperkalemia (OPAL)P3completed243Relypsa, Inc.Feb 2013
NCT01371747AMETHYST-DNPatiromer in the Treatment of Hyperkalemia in Patients With Hypertension and Diabetic Nephropathy (AMETHYST-DN)P2completed324Relypsa, Inc.Jun 2011
NCT01130597Evaluation of Patiromer Titration in Heart Failure Patients With Chronic Kidney DiseaseP2completed63Relypsa, Inc.May 2010
NCT00868439PEARL-HFEvaluation of Patiromer in Heart Failure PatientsP2completed120Relypsa, Inc.Apr 2009
NCT02033317An Open-Label, Multiple Dose Study to Evaluate the Pharmacology, Safety, and Tolerability of Patiromer in Participants on HemodialysisP2terminated6Relypsa, Inc.Aug 2008

patiromer clinical trials: frequently asked questions

How many patiromer clinical trials are there?
25 patiromer clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 3 are actively recruiting participants. 17 are marked completed.
Are patiromer clinical trials recruiting in 2026?
Yes — 3 patiromer trials are actively recruiting in 2026, with 11 U.S. sites across 9 states. See the recruiting trials and the per-state site list further down this page.
What conditions is patiromer being studied for?
patiromer is being studied for Hyperkalemia, Hypertension, Chronic Kidney Diseases, Kidney Transplant, End Stage Renal Disease and 16 more. The trials are grouped by indication on this page.
What phase is patiromer in?
patiromer clinical trials span 10 Phase 4, 5 Phase 3, 9 Phase 2. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors patiromer clinical trials?
The lead sponsor across the most patiromer trials is Relypsa, Inc., with 16 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming patiromeras an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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