Palazestrant Clinical Trials (2026): 5 Studies for Metastatic Breast Cancer & Breast Cancer

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

5 Palazestrant clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 3 indications (including Metastatic Breast Cancer & Breast Cancer) and 1,940 total planned enrollment. 2 Phase 3 Palazestrant trials are listed. 4 Palazestrant clinical trials are actively recruiting at 71 U.S. sites across 27 states. Most recent activity: NCT07085767 (Jan 2032).

Where to Participate: All Palazestrant Trial Sites in the U.S. (71 sites across 27 states)

Every actively recruiting Palazestranttrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
AZBanner MD Anderson Cancer CenterGilbert85234NCT05508906Map
AZClinical Trial SiteTucson85719NCT06016738Map
CAClinical Trial SiteLos Alamitos90720NCT06016738Map
CAClinical Trial SiteLos Angeles90027NCT06016738Map
CAUniversity of California San Francisco HealthSan Francisco94158NCT05508906Map
CAClinical Trial SiteWhittier90602NCT06016738Map
COClinical Trial SiteAurora80045NCT06016738Map
COUniversity of Colorado Cancer CenterAurora80045NCT05508906Map
COClinical Trial SiteDenver80218NCT06016738Map
COClinical Trial SiteDenver80220NCT07085767Map
COClinical Trial SiteGolden80401NCT06016738Map
CTClinical Trial SiteDanbury06810NCT06016738Map
DEClinical Trial SiteNewark19713NCT06016738Map
FLClinical Trial SiteMargate33063NCT06016738Map
FLAdvent Health Hematology and OncologyOrlando32804NCT05508906Map
FLClinical Trial SiteOrlando32804NCT06016738Map
FLClinical Trial SitePlantation33324NCT06016738Map
FLFlorida Cancer SpecialistsSarasota34232NCT06784193Map
FLClinical Trial SiteTamarac33321NCT06016738Map
GAClinical Trial SiteAtlanta30322NCT06016738Map
ILClinical Trial SiteChicago60616-2315NCT06016738Map
ILClinical Trial SiteChicago60637NCT06016738Map
ILClinical Trial SitePeoria61615NCT07085767Map
ILClinical Trial SiteUrbana61801NCT06016738Map
IAUniversity of IowaIowa City52242NCT05508906Map
LAClinical Trial SiteNew Orleans70112NCT06016738Map
LAUniversity Medical Center - New OrleansNew Orleans70112NCT06784193Map
MEClinical Trial SiteScarborough04074NCT07085767Map
MDClinical Trial SiteBaltimore21201NCT06016738Map
MAClinical Trial SiteBoston02111NCT06016738Map
MADana Farber Cancer InstituteBoston02215NCT05508906Map
MADana-Farber Cancer InstituteBoston02215NCT06784193Map
MIClinical Trial SiteDetroit48202NCT06016738Map
MIHenry Ford HealthDetroit48126NCT05508906Map
MISTART - MidwestGrand Rapids49546NCT06784193Map
MNClinical Trial SiteMinneapolis55404NCT07085767Map
MNRegents of the University of MinnesotaMinneapolis55455NCT05508906Map
MNClinical Trial SiteSaint Louis Park55426NCT06016738Map
MNClinical Trial SiteWoodbury55125NCT06016738Map
MOClinical Trial SiteKansas City64132NCT07085767Map
MOWashington University, School of MedicineSt Louis63110NCT05508906Map
NEClinical Trial SiteLincoln68516NCT06016738Map
NMClinical Trial SiteFarmington87401NCT06016738Map
NMClinical Trial SiteSanta Fe87505NCT07085767Map
NYClinical Trial SiteNew York10032NCT06016738Map
NYIchan School of Medicine at Mount SinaiNew York10029NCT05508906Map
NCAtrium Health Levine Cancer InstituteCharlotte28204NCT05508906Map
OHClinical Trial SiteColumbus43219NCT07085767Map
OHClinical Trial SiteDayton45415NCT06016738Map
ORClinical Trial SitePortland97239NCT06016738Map
PAClinical Trial SiteSayre18840NCT06016738Map
PAClinical Trial SiteSayre18840NCT07085767Map
TNClinical Trial SiteNashville37203NCT06016738Map
TNClinical Trial SiteNashville37208NCT06016738Map
TNClinical Trial SiteNashville37232NCT06016738Map
TNHenry-Joyce Cancer Clinic, The Vanderbilt ClinicNashville37232NCT05508906Map
TNSCRI Oncology PartnersNashville37203NCT06784193Map
TNClinical Trial SiteTennessee City37203NCT07085767Map
TXClinical Trial SiteDallas75246NCT06016738Map
TXClinical Trial SiteDallas75390NCT06016738Map
TXClinical Trial SiteDenton76201NCT07085767Map
TXClinical Trial SiteEl Paso79902NCT07085767Map
TXClinical Trial SiteHouston77054NCT06016738Map
TXClinical Trial SiteHouston77024NCT07085767Map
TXMD Anderson Cancer CenterHouston77030NCT05508906Map
TXSTART - San AntonioSan Antonio78229NCT06784193Map
TXClinical Trial SiteWebster77598NCT06016738Map
UTClinical Trial SiteOgden84405NCT06016738Map
UTSTART - Mountain RegionWest Valley City84119NCT06784193Map
WAClinical Trial SiteSpokane99208NCT06016738Map
WANorthwest Medical SpecialtiesTacoma98405NCT05508906Map

Palazestrant clinical trials at a glance: phase × recruitment status

Phaserecruitingactive not recruitingTotal
P1213
P322

Recruiting Palazestrant clinical trials (4)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT07085767OPERA-02Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast CancerP3Breast Cancer1,000Nov 2025
NCT05508906Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast CancerP1Metastatic Breast Cancer190Aug 2022
NCT06016738OPERA-01OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast CancerP3Breast Cancer510Nov 2023
NCT06784193Phase 1 Study of OP-3136 in Advanced or Metastatic Solid TumorsP1Advanced or Metastatic ER+ HER2- Breast Cancer (mBC)180Dec 2024

Palazestrant clinical trials by indication

Breast Cancer (3)

NCTAcronymPhaseStatusTitle
NCT07085767OPERA-02P3recruitingPalazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer
NCT06016738OPERA-01P3recruitingOP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer
NCT05266105P1active not recruitingA Phase 1 Study of Oral OP-1250 in Combination With Palbociclib in HR+/HER2- Breast Cancer Patients

Advanced or Metastatic ER+ HER2- Breast Cancer (mBC) (1)

NCTAcronymPhaseStatusTitle
NCT06784193P1recruitingPhase 1 Study of OP-3136 in Advanced or Metastatic Solid Tumors

Metastatic Breast Cancer (1)

NCTAcronymPhaseStatusTitle
NCT05508906P1recruitingPhase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer

Palazestrant pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
OPERA-02NCT07085767P3recruitingBreast Cancer1,000
OPERA-01NCT06016738P3recruitingBreast Cancer510PMID 41461598

All Palazestrant trials (5)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT07085767OPERA-02Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast CancerP3recruiting1,000Olema Pharmaceuticals, Inc.Nov 2025
NCT05508906Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast CancerP1recruiting190Olema Pharmaceuticals, Inc.Aug 2022
NCT06016738OPERA-01OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast CancerP3recruiting510Olema Pharmaceuticals, Inc.Nov 2023
NCT06784193Phase 1 Study of OP-3136 in Advanced or Metastatic Solid TumorsP1recruiting180Olema Pharmaceuticals, Inc.Dec 2024
NCT05266105A Phase 1 Study of Oral OP-1250 in Combination With Palbociclib in HR+/HER2- Breast Cancer PatientsP1active not recruiting60Olema Pharmaceuticals, Inc.Dec 2021

Palazestrant clinical trials: frequently asked questions

How many Palazestrant clinical trials are there?
5 Palazestrant clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 4 are actively recruiting participants.
Are Palazestrant clinical trials recruiting in 2026?
Yes — 4 Palazestrant trials are actively recruiting in 2026, with 71 U.S. sites across 27 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Palazestrant being studied for?
Palazestrant is being studied for Metastatic Breast Cancer, Breast Cancer, ER Positive Breast Cancer, HER2 Negative Breast Carcinoma, Locally Advanced Breast Cancer and 8 more. The trials are grouped by indication on this page.
What phase is Palazestrant in?
Palazestrant clinical trials span 2 Phase 3, 3 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Palazestrant clinical trials?
The lead sponsor across the most Palazestrant trials is Olema Pharmaceuticals, Inc.. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Palazestrantas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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