Odronextamab Clinical Trials (2026): 16 Studies for Follicular Lymphoma (FL) & Refractory Diffuse Large B-Cell Lymphoma

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

16 Odronextamab clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 14 indications (including Follicular Lymphoma (FL) & Refractory Diffuse Large B-Cell Lymphoma) and 4,491 total planned enrollment. 5 Phase 3 Odronextamab trials and 4 Phase 2 are listed. 10 Odronextamab clinical trials are actively recruiting at 53 U.S. sites across 21 states. Most recent activity: NCT05991388 (May 2033).

Where to Participate: All Odronextamab Trial Sites in the U.S. (53 sites across 21 states)

Every actively recruiting Odronextamabtrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
AZUniversity of Arizona Cancer CenterTucson85724NCT06091254Map
CACity of HopeDuarte91010NCT05685173Map
CACity of Hope Medical CenterDuarte91010NCT06735664Map
CADavid Geffen School of Medicine at UCLALos Angeles90095NCT06091254Map
CADavid Geffen School of Medicine at UCLALos Angeles90095NCT06091865Map
CADavid Geffen School of Medicine at UCLALos Angeles90095NCT06149286Map
CAUniversity of California Irvine Medical CenterOrange92868NCT06091865Map
CAUniversity of California (UC) DavisSacramento95817NCT06091865Map
CAUniversity of California Davis Comprehensive Cancer CenterSacramento95817NCT06854159Map
CAUniversity of California Los Angeles (UCLA) Medical CenterSanta Monica90404NCT05685173Map
FLBoca Raton Clinical Research (BRCR) GlobalPlantation33322NCT06149286Map
INIndiana University and Comprehensive Cancer CenterIndianapolis46202NCT06149286Map
INIndiana University Melvin and Bren Simon Comprehensive Cancer CenterIndianapolis46202NCT06091865Map
INSt Vincent Ascension at Peyton Manning Childrens HospitalIndianapolis46260NCT06091865Map
INInvestigative Clinical Research of IndianaNoblesville46062NCT06091254Map
INInvestigative Clinical Research of IndianaNoblesville46062NCT06091865Map
KYUniversity of KentuckyLexington40536NCT06091865Map
KYNorton Cancer InstituteLouisville40207NCT05685173Map
MDUniversity of Maryland Greenebaum Comprehensive Cancer CenterBaltimore21201NCT06091865Map
MABeth Israel Deaconess Medical CenterBoston02215NCT06091254Map
MABeth Israel Deaconess Medical CenterBoston02215NCT06091865Map
MABeth Israel Deaconess Medical CenterBoston02215NCT07128641Map
MAHarvard Medical School - Beth Israel Deaconess Medical CenterBoston02215NCT05685173Map
MAMassachusetts General HospitalBoston02114NCT05685173Map
MIHenry Ford Health SystemDetroit48202NCT06091865Map
MIKarmanos Cancer InstituteDetroit48201NCT06091254Map
MICancer and Hematology Centers of Western MichiganGrand Rapids49503NCT06091865Map
MNMayo ClinicRochester55905NCT06975787Map
MSHattiesburg ClinicHattiesburg39401NCT06149286Map
NHDartmouth Cancer CenterLebanon03756NCT06149286Map
NJRutgers Cancer Institute of New JerseyNew Brunswick08901NCT05685173Map
NJRutgers Cancer Institute of New JerseyNew Brunswick08901NCT06091865Map
NYIcahn School of Medicine at Mount SinaiNew York10029NCT05685173Map
NYIcahn School of Medicine at Mt SinaiNew York10029NCT06091254Map
NYNYU Langone Health Perlmutter Cancer CenterNew York10016NCT05685173Map
NYStony Brook University HospitalStony Brook11794NCT06091254Map
NYStony Brook University HospitalStony Brook11794NCT06091865Map
NYStony Brook University HospitalStony Brook11794NCT06149286Map
NCUniversity of North CarolinaChapel Hill27514NCT06091254Map
NCLevine Cancer InstituteCharlotte28207NCT06091254Map
NCDuke University Medical CenterDurham27710NCT06091865Map
NCEast Carolina UniversityGreenville27834NCT06091865Map
OHUniversity Hospitals Cleveland Medical CenterCleveland44106NCT06091254Map
OHUniversity Hospitals Cleveland Medical CenterCleveland44106NCT06091865Map
TNVanderbilt University Medical CenterNashville37232NCT06091254Map
TXUT SouthwesternDallas75390NCT05685173Map
TXBaylor College of MedicineHouston77030NCT06975787Map
TXCenter for Oncology and Blood DisordersHouston77030NCT06091254Map
UTCommunity Cancer Trials of UtahOgden84405NCT06091865Map
UTHuntsman Cancer Institute - Oncology DivisionSalt Lake City84112NCT06091254Map
VAUniversity of VirginiaCharlottesville22908NCT06091254Map
WAFred Hutch/University of Washington Cancer ConsortiumSeattle98109NCT06784726Map
WIProhealth Care IncWaukesha53188NCT06149286Map

Odronextamab clinical trials at a glance: phase × recruitment status

Phaserecruitingactive not recruitingcompletedavailableTotal
P1325
P2314
P2/P311
P3325
N/A11

Recruiting Odronextamab clinical trials (10)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT05991388Glo-BNHLA Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-cell Non-Hodgkin LymphomaP2/P3B-cell Non Hodgkin Lymphoma210May 2024
NCT06784726Odronextamab for Relapsed and Refractory Large B-cell Lymphomas Before CAR-TP2Recurrent Diffuse Large B-Cell Lymphoma27Sep 2025
NCT05685173ATHENA-1A Trial to Study if REGN5837 in Combination With Odronextamab is Safe for Adult Participants With Aggressive B-cell Non-Hodgkin LymphomasP1B-cell Non-Hodgkins Lymphoma (B-NHL)107Apr 2023
NCT06091254OLYMPIA-1A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Previously Untreated Follicular LymphomaP3Follicular Lymphoma (FL)822Dec 2023
NCT06091865OLYMPIA-3A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell LymphomaP3Diffuse Large B-cell Lymphoma (DLBCL)904Dec 2023
NCT06975787Dose Escalation Study With Bispecific Antibodies in Adult Participants With Lupus NephritisP1Lupus Nephritis (LN)90Dec 2025
NCT06854159Odronextamab for the Treatment of Relapsed and Refractory Diffuse Large B-cell Lymphoma Before and After Chimeric Antigen Receptor T-cell TherapyP2Recurrent Diffuse Large B-Cell Lymphoma34Aug 2025
NCT06149286OLYMPIA-5A Trial to Find Out if Odronextamab Combined With Lenalidomide is Safe and Works Better Than Rituximab Combined With Lenalidomide in Adult Participants With Follicular Lymphoma and Marginal Zone LymphomaP3Relapsed/Refractory Follicular Lymphoma470Dec 2023
NCT07128641Odronextamab in Low Tumor Volume Advanced FLP2Follicular Lymphoma35Sep 2025
NCT06735664Zanubrutinib in Combination With Odronextamab for the Treatment of Patients With Richter's TransformationP1Recurrent Transformed Chronic Lymphocytic Leukemia23Aug 2025

Odronextamab clinical trials by indication

Recurrent Diffuse Large B-Cell Lymphoma (2)

NCTAcronymPhaseStatusTitle
NCT06784726P2recruitingOdronextamab for Relapsed and Refractory Large B-cell Lymphomas Before CAR-T
NCT06854159P2recruitingOdronextamab for the Treatment of Relapsed and Refractory Diffuse Large B-cell Lymphoma Before and After Chimeric Antigen Receptor T-cell Therapy

Follicular Lymphoma (FL) (2)

NCTAcronymPhaseStatusTitle
NCT06091254OLYMPIA-1P3recruitingA Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Previously Untreated Follicular Lymphoma
NCT06097364OLYMPIA-2P3active not recruitingA Trial to Learn if Odronextamab Combined With Chemotherapy is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Chemotherapy for Adult Participants With Follicular Lymphoma

Lupus Nephritis (LN) (1)

NCTAcronymPhaseStatusTitle
NCT06975787P1recruitingDose Escalation Study With Bispecific Antibodies in Adult Participants With Lupus Nephritis

Follicular Lymphoma (1)

NCTAcronymPhaseStatusTitle
NCT07128641P2recruitingOdronextamab in Low Tumor Volume Advanced FL

Recurrent Transformed Chronic Lymphocytic Leukemia (1)

NCTAcronymPhaseStatusTitle
NCT06735664P1recruitingZanubrutinib in Combination With Odronextamab for the Treatment of Patients With Richter's Transformation

B-cell Non Hodgkin Lymphoma (1)

NCTAcronymPhaseStatusTitle
NCT05991388Glo-BNHLP2/P3recruitingA Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-cell Non-Hodgkin Lymphoma

B-Cell Non-Hodgkin Lymphoma (B-NHL) (1)

NCTAcronymPhaseStatusTitle
NCT06230224OLYMPIA-4P3active not recruitingA Trial to Learn How Effective and Safe Odronextamab is Compared to Standard of Care for Adult Participants With Previously Treated Aggressive B-cell Non-Hodgkin Lymphoma

Relapsed/Refractory Follicular Lymphoma (1)

NCTAcronymPhaseStatusTitle
NCT06149286OLYMPIA-5P3recruitingA Trial to Find Out if Odronextamab Combined With Lenalidomide is Safe and Works Better Than Rituximab Combined With Lenalidomide in Adult Participants With Follicular Lymphoma and Marginal Zone Lymphoma

Diffuse Large B-cell Lymphoma (DLBCL) (1)

NCTAcronymPhaseStatusTitle
NCT06091865OLYMPIA-3P3recruitingA Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell Lymphoma

B-cell Non-Hodgkins Lymphoma (B-NHL) (1)

NCTAcronymPhaseStatusTitle
NCT05685173ATHENA-1P1recruitingA Trial to Study if REGN5837 in Combination With Odronextamab is Safe for Adult Participants With Aggressive B-cell Non-Hodgkin Lymphomas

B-cell Non-Hodgkin Lymphoma (B-NHL) (1)

NCTAcronymPhaseStatusTitle
NCT03888105ELM-2P2active not recruitingA Study to Assess the Anti-Tumor Activity and Safety of Odronextamab in Adult Patients With B-cell Non-Hodgkin Lymphoma Who Have Been Previously Treated With Other Cancer Therapies

Relapsed/Refractory Aggressive B-Cell Lymphoma (1)

NCTAcronymPhaseStatusTitle
NCT02651662CLIO-1P1completedA Study to Learn How Safe and Tolerable Odronextamab and Cemiplimab Are in Adult Patients With B-cell Malignancies

Non-Hodgkin Lymphoma (1)

NCTAcronymPhaseStatusTitle
NCT02290951ELM-1P1completedStudy to Investigate the Safety and Tolerability of Odronextamab in Patients With CD20+ B-Cell Malignancies

Relapsed or Refractory (R/R) Follicular Lymphoma (FL) (1)

NCTAcronymPhaseStatusTitle
NCT05619367CUN/AavailableA Compassionate Use (CU) Program of Odronextamab

Odronextamab pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
OLYMPIA-1NCT06091254P3recruitingFollicular Lymphoma (FL)822
OLYMPIA-3NCT06091865P3recruitingDiffuse Large B-cell Lymphoma (DLBCL)904
OLYMPIA-2NCT06097364P3active not recruitingFollicular Lymphoma (FL)733
OLYMPIA-4NCT06230224P3active not recruitingB-Cell Non-Hodgkin Lymphoma (B-NHL)216
OLYMPIA-5NCT06149286P3recruitingRelapsed/Refractory Follicular Lymphoma470
ELM-2NCT03888105P2active not recruitingB-cell Non-Hodgkin Lymphoma (B-NHL)515

All Odronextamab trials (16)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT05991388Glo-BNHLA Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-cell Non-Hodgkin LymphomaP2/P3recruiting210University of BirminghamMay 2024
NCT06784726Odronextamab for Relapsed and Refractory Large B-cell Lymphomas Before CAR-TP2recruiting27University of WashingtonSep 2025
NCT05685173ATHENA-1A Trial to Study if REGN5837 in Combination With Odronextamab is Safe for Adult Participants With Aggressive B-cell Non-Hodgkin LymphomasP1recruiting107Regeneron PharmaceuticalsApr 2023
NCT06091254OLYMPIA-1A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Previously Untreated Follicular LymphomaP3recruiting822Regeneron PharmaceuticalsDec 2023
NCT06091865OLYMPIA-3A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell LymphomaP3recruiting904Regeneron PharmaceuticalsDec 2023
NCT06975787Dose Escalation Study With Bispecific Antibodies in Adult Participants With Lupus NephritisP1recruiting90Regeneron PharmaceuticalsDec 2025
NCT06097364OLYMPIA-2A Trial to Learn if Odronextamab Combined With Chemotherapy is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Chemotherapy for Adult Participants With Follicular LymphomaP3active not recruiting733Regeneron PharmaceuticalsNov 2023
NCT06230224OLYMPIA-4A Trial to Learn How Effective and Safe Odronextamab is Compared to Standard of Care for Adult Participants With Previously Treated Aggressive B-cell Non-Hodgkin LymphomaP3active not recruiting216Regeneron PharmaceuticalsFeb 2024
NCT06854159Odronextamab for the Treatment of Relapsed and Refractory Diffuse Large B-cell Lymphoma Before and After Chimeric Antigen Receptor T-cell TherapyP2recruiting34Joseph TuscanoAug 2025
NCT06149286OLYMPIA-5A Trial to Find Out if Odronextamab Combined With Lenalidomide is Safe and Works Better Than Rituximab Combined With Lenalidomide in Adult Participants With Follicular Lymphoma and Marginal Zone LymphomaP3recruiting470Regeneron PharmaceuticalsDec 2023
NCT03888105ELM-2A Study to Assess the Anti-Tumor Activity and Safety of Odronextamab in Adult Patients With B-cell Non-Hodgkin Lymphoma Who Have Been Previously Treated With Other Cancer TherapiesP2active not recruiting515Regeneron PharmaceuticalsNov 2019
NCT07128641Odronextamab in Low Tumor Volume Advanced FLP2recruiting35Gottfried von Keudell, MD PhDSep 2025
NCT06735664Zanubrutinib in Combination With Odronextamab for the Treatment of Patients With Richter's TransformationP1recruiting23City of Hope Medical CenterAug 2025
NCT02651662CLIO-1A Study to Learn How Safe and Tolerable Odronextamab and Cemiplimab Are in Adult Patients With B-cell MalignanciesP1completed105Regeneron PharmaceuticalsJan 2016
NCT02290951ELM-1Study to Investigate the Safety and Tolerability of Odronextamab in Patients With CD20+ B-Cell MalignanciesP1completed200Regeneron PharmaceuticalsJan 2015
NCT05619367CUA Compassionate Use (CU) Program of Odronextamabavailable0Regeneron Pharmaceuticals

Odronextamab clinical trials: frequently asked questions

How many Odronextamab clinical trials are there?
16 Odronextamab clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 10 are actively recruiting participants. 2 are marked completed.
Are Odronextamab clinical trials recruiting in 2026?
Yes — 10 Odronextamab trials are actively recruiting in 2026, with 53 U.S. sites across 21 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Odronextamab being studied for?
Odronextamab is being studied for Follicular Lymphoma (FL), Refractory Diffuse Large B-Cell Lymphoma, Recurrent Diffuse Large B-Cell Lymphoma, B-cell Non-Hodgkins Lymphoma (B-NHL), B-cell Non Hodgkin Lymphoma and 31 more. The trials are grouped by indication on this page.
What phase is Odronextamab in?
Odronextamab clinical trials span 5 Phase 3, 4 Phase 2, 5 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Odronextamab clinical trials?
The lead sponsor across the most Odronextamab trials is Regeneron Pharmaceuticals, with 5 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Odronextamabas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

Last refreshed .

Related pages on Hipa.ai: