Nemtabrutinib Clinical Trials (2026): 21 Studies for Chronic Lymphocytic Leukemia & Healthy

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

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21 Nemtabrutinib clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 13 indications (including Chronic Lymphocytic Leukemia & Healthy) and 3,453 total planned enrollment. 3 Phase 3 Nemtabrutinib trials and 7 Phase 2 are listed. 9 Nemtabrutinib clinical trials are actively recruiting at 59 U.S. sites across 24 states. Most recent activity: NCT05947851 (Jul 2035).

Where to Participate: All Nemtabrutinib Trial Sites in the U.S. (59 sites across 24 states)

Every actively recruiting Nemtabrutinibtrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
ALUSA Mitchell Cancer Institute ( Site 0014)Mobile36604NCT06136559Map
AZBanner MD Anderson Cancer Center ( Site 0059)Gilbert85234NCT06136559Map
AZBanner MD Anderson Cancer Center - University Medical Center Phoenix ( Site 0051)Phoenix85006NCT06136559Map
ARHighlands Oncology Group ( Site 2728)Springdale72762NCT04728893Map
ARHighlands Oncology Group ( Site 5405)Springdale72762NCT05947851Map
CAAlta Bates Summit Medical Center ( Site 0004)Berkeley94704NCT06136559Map
CACity of Hope Medical CenterDuarte91010NCT06572618Map
CAMoores Cancer Center ( Site 0003)La Jolla92093-0698NCT06136559Map
CAUniversity of California San Diego Moores Cancer Center ( Site 2717)La Jolla92093-0698NCT04728893Map
CAMemorialCare Health System - Long Beach Medical Center ( Site 5421)Long Beach90806NCT05947851Map
CACare Access - South Pasadena ( Site 0070)Pasadena91105NCT06136559Map
COColorado Blood Cancer Institute ( Site 2726)Denver80218NCT04728893Map
COSaint Joseph Hospital ( Site 0026)Denver80218NCT06136559Map
COLutheran Medical Center ( Site 0027)Golden80401NCT06136559Map
COIntermountain Health St. Mary's Regional Hospital ( Site 0025)Grand Junction81501NCT06136559Map
CTEastern CT Hematology & Oncology Associates ( Site 0033)Norwich06360NCT06136559Map
FLClermont Oncology Center ( Site 0046)Clermont34711NCT06136559Map
FLFlorida Cancer Specialists - South ( Site 7001)Fort Myers33901NCT06136559Map
FLClinical Pharmacology of Miami ( Site 0003)Miami33172NCT06442436Map
FLOrlando Clinical Research Center ( Site 0001)Orlando32809NCT06442436Map
FLMemorial Hospital West ( Site 5410)Pembroke Pines33028NCT05947851Map
FLFlorida Cancer Specialists - East ( Site 7002)West Palm Beach33401NCT06136559Map
INParkview Research Center at Parkview Regional Medical Center ( Site 0002)Fort Wayne46845NCT06136559Map
IAUniversity of Iowa Health Care. ( Site 0017)Waukee50263NCT06136559Map
IAUniversity of Iowa Health Care. ( Site 0057)Waukee50263NCT06136559Map
KYSaint Elizabeth Healthcare ( Site 0041)Edgewood41017NCT06136559Map
MICorewell Health-Lemmon Holton Cancer Pavilion ( Site 0011)Grand Rapids49503NCT06136559Map
MNRegions Hospital ( Site 0042)Saint Louis Park55416NCT06136559Map
MOMidAmerica Cancer Care, LLC ( Site 0043)Kansas City64132NCT06136559Map
MTIntermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana ( Site 0052)Billings59102NCT06136559Map
NJAstera Cancer Care ( Site 2732)East Brunswick08816NCT04728893Map
NJJohn Theurer Cancer Center at Hackensack University Medical Center ( Site 0016)Hackensack07601NCT06136559Map
NJJohn Theurer Cancer Center at Hackensack University Medical Center ( Site 2704)Hackensack07601NCT04728893Map
NYNew York Oncology Hematology, P.C. ( Site 0069)Albany12208NCT06136559Map
NYRoswell Park Cancer InstituteBuffalo14263NCT06863402Map
NYRoswell Park Cancer Institute ( Site 0023)Buffalo14263NCT06136559Map
NYRPCI Oncology, PC- Northtowns ( Site 0061)Williamsville14221NCT06136559Map
NCCarolina Oncology Specialists, PA ( Site 0054)Charlotte28207NCT06136559Map
NCSoutheastern Medical Oncology Center ( Site 0049)Goldsboro27534NCT06136559Map
OROregon Health and Science University ( Site 5425)Portland97239-3011NCT05947851Map
PAConsultants in Medical Oncology and Hematology (CMOH) ( Site 8002)Broomall19008NCT06136559Map
PACancer Care Associates Of York ( Site 0005)York17403NCT06136559Map
TNTennessee Oncology-Chattanooga ( Site 0045)Chattanooga37404NCT06136559Map
TNTennessee Oncology, PLLC - Elliston Place Plaza Medical Oncology & Hematology ( Site 0031)Nashville37203NCT06136559Map
TXTexas Oncology - Central/South Texas ( Site 8008)Austin78705NCT06136559Map
TXUT Southwestern-Harold C. Simmons Cancer Center ( Site 2730)Dallas75390NCT04728893Map
TXThe Center for Cancer and Blood Disorders ( Site 0032)Fort Worth76104NCT06136559Map
TXTexas Liver Institute ( Site 0002)San Antonio78215NCT06442436Map
TXTexas Oncology - San Antonio ( Site 8006)San Antonio78217NCT06136559Map
TXTexas Oncology - Northeast Texas ( Site 8012)Tyler75702NCT06136559Map
VAUniversity of Virginia Cancer Center ( Site 0040)Charlottesville22903NCT06136559Map
VAInova Schar Cancer Institute ( Site 0015)Fairfax22031NCT06136559Map
VAVirginia Commonwealth University (VCU) Medical Center ( Site 0030)Richmond23298NCT06136559Map
WAFred Hutch/University of Washington Cancer ConsortiumSeattle98109NCT07194980Map
WAMedical Oncology Associates (Summit Cancer Centers) ( Site 2710)Spokane99208NCT04728893Map
WAMedical Oncology Associates, PS ( Site 5406)Spokane99208NCT05947851Map
WAMedical Oncology Associates, PS (dba Summit Cancer Centers) ( Site 0010)Spokane99208NCT06136559Map
WISSM Health Dean Medical Group - South Madison Campus Health Research/Circuit Clinical ( Site 0048)Madison53715NCT06136559Map
WIUniversity Hospital and UW Health Clinics ( Site 0006)Madison53792NCT06136559Map

Nemtabrutinib clinical trials at a glance: phase × recruitment status

Phaserecruitingactive not recruitingcompletednot yet recruitingTotal
P111810
P1/P211
P24127
P3213

Recruiting Nemtabrutinib clinical trials (9)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT05947851VRA Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).P3Leukemia, Lymphocytic, Chronic, B-Cell735Aug 2023
NCT06136559MK-1026A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)P3Chronic Lymphocytic Leukemia1,200Dec 2023
NCT06863402Nemtabrutinib and Pembrolizumab for the Treatment of Richter Transformation, Diffuse Large B-cell Lymphoma SubtypeP2Richter Syndrome32Jun 2026
NCT07194980Nemtabrutinib and Lisocabtagene Maraleucel for the Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic LymphomaP2Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma20Jul 2026
NCT04728893MK-1026Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)P2Hematologic Malignancies490Apr 2021
NCT07583810Non-covalent BTK Inhibitor Nemtabrutinib in Combination With the CD20 Monoclonal Antibody Rituximab for the Treatment of Marginal Zone LymphomaP2Conjunctival Mucosa-Associated Lymphoid Tissue Lymphoma35Dec 2026
NCT07557056Nemtabrutinib and Venetoclax for the Treatment of Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic LymphomaP2Chronic Lymphocytic Leukemia25May 2026
NCT06572618Nemtabrutinib With Rituximab for the Treatment of Patients With Mantle Cell LymphomaP2Mantle Cell Lymphoma27Jan 2025
NCT06442436MK-1026-015A Study of Nemtabrutinib in Participants With Moderate Hepatic Impairment (MK-1026-015)P1Hepatic Impairment (HI)32Jul 2024

Nemtabrutinib clinical trials by indication

Healthy (6)

NCTAcronymPhaseStatusTitle
NCT07232589MK-1026-022P1completedA Study of the Effect of Diltiazem on the Plasma Levels of Nemtabrutinib (MK-1026-022)
NCT06772818MK-1026P1completedA Study to Evaluate the Effect of Food on Nemtabrutinib (MK-1026) in Healthy Participants (MK-1026-017)
NCT06625827MK-1026P1completedA Study of the Effect of Nemtabrutinib (MK-1026) on the Plasma Levels of Digoxin in Healthy Participants (MK-1026-012)
NCT06688045MK-1026-013P1completedA Study of the Effects of Itraconazole on the Plasma Levels of Nemtabrutinib (MK-1026-013)
NCT06772805MK-1026P1completedA Study to Evaluate the Effect of Food on Nemtabrutinib (MK-1026) in Healthy Participants (MK-1026-016)
NCT06698016MK-1026-014P1completedA Study of the Effect of Efavirenz on the Plasma Levels of Nemtabrutinib (MK-1026-014)

Chronic Lymphocytic Leukemia (4)

NCTAcronymPhaseStatusTitle
NCT06136559MK-1026P3recruitingA Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)
NCT05624554P3active not recruitingA Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-008, BELLWAVE-008)
NCT05458297MK-2140P2active not recruitingA Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)
NCT07557056P2not yet recruitingNemtabrutinib and Venetoclax for the Treatment of Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Conjunctival Mucosa-Associated Lymphoid Tissue Lymphoma (1)

NCTAcronymPhaseStatusTitle
NCT07583810P2not yet recruitingNon-covalent BTK Inhibitor Nemtabrutinib in Combination With the CD20 Monoclonal Antibody Rituximab for the Treatment of Marginal Zone Lymphoma

Richter Syndrome (1)

NCTAcronymPhaseStatusTitle
NCT06863402P2recruitingNemtabrutinib and Pembrolizumab for the Treatment of Richter Transformation, Diffuse Large B-cell Lymphoma Subtype

Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (1)

NCTAcronymPhaseStatusTitle
NCT07194980P2recruitingNemtabrutinib and Lisocabtagene Maraleucel for the Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Mantle Cell Lymphoma (1)

NCTAcronymPhaseStatusTitle
NCT06572618P2recruitingNemtabrutinib With Rituximab for the Treatment of Patients With Mantle Cell Lymphoma

Hepatic Impairment (HI) (1)

NCTAcronymPhaseStatusTitle
NCT06442436MK-1026-015P1recruitingA Study of Nemtabrutinib in Participants With Moderate Hepatic Impairment (MK-1026-015)

Hematological Malignancy (1)

NCTAcronymPhaseStatusTitle
NCT06586671MK-1026P1completedA Study to Compare Forms of Nemtabrutinib (MK-1026) in Healthy Adult Participants (MK-1026-007)

Leukemia, Lymphocytic, Chronic, B-Cell (1)

NCTAcronymPhaseStatusTitle
NCT05947851VRP3recruitingA Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).

Mature B-cell Neoplasms (1)

NCTAcronymPhaseStatusTitle
NCT05673460MK-1026-002P1completedA Clinical Study of Nemtabrutinib in Japanese Participants With Hematological Malignancies (MK-1026-002)

Hematological Malignancies (1)

NCTAcronymPhaseStatusTitle
NCT05347225MK-1026P1active not recruitingA Study of Nemtabrutinib (MK-1026) in China Participants With Relapsed or Refractory Hematologic Malignancies (MK-1026-005)

Hematologic Malignancies (1)

NCTAcronymPhaseStatusTitle
NCT04728893MK-1026P2recruitingEfficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

Lymphoma, B-Cell (1)

NCTAcronymPhaseStatusTitle
NCT03162536MK-1026P1/P2active not recruitingA Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)

Nemtabrutinib pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
VRNCT05947851P3recruitingLeukemia, Lymphocytic, Chronic, B-Cell735
MK-1026NCT06136559P3recruitingChronic Lymphocytic Leukemia1,200
MK-2140NCT05458297P2active not recruitingChronic Lymphocytic Leukemia189
MK-1026NCT04728893P2recruitingHematologic Malignancies490

All Nemtabrutinib trials (21)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT05947851VRA Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).P3recruiting735Merck Sharp & Dohme LLCAug 2023
NCT06136559MK-1026A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)P3recruiting1,200Merck Sharp & Dohme LLCDec 2023
NCT05624554A Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-008, BELLWAVE-008)P3active not recruiting300Merck Sharp & Dohme LLCMar 2023
NCT06863402Nemtabrutinib and Pembrolizumab for the Treatment of Richter Transformation, Diffuse Large B-cell Lymphoma SubtypeP2recruiting32Roswell Park Cancer InstituteJun 2026
NCT07194980Nemtabrutinib and Lisocabtagene Maraleucel for the Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic LymphomaP2recruiting20Fred Hutchinson Cancer CenterJul 2026
NCT05458297MK-2140A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)P2active not recruiting189Merck Sharp & Dohme LLCJul 2022
NCT04728893MK-1026Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)P2recruiting490Merck Sharp & Dohme LLCApr 2021
NCT05347225MK-1026A Study of Nemtabrutinib (MK-1026) in China Participants With Relapsed or Refractory Hematologic Malignancies (MK-1026-005)P1active not recruiting12Merck Sharp & Dohme LLCJun 2022
NCT07583810Non-covalent BTK Inhibitor Nemtabrutinib in Combination With the CD20 Monoclonal Antibody Rituximab for the Treatment of Marginal Zone LymphomaP2not yet recruiting35City of Hope Medical CenterDec 2026
NCT07557056Nemtabrutinib and Venetoclax for the Treatment of Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic LymphomaP2not yet recruiting25Jennifer WoyachMay 2026
NCT03162536MK-1026A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)P1/P2active not recruiting190ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)Jun 2017
NCT06572618Nemtabrutinib With Rituximab for the Treatment of Patients With Mantle Cell LymphomaP2recruiting27City of Hope Medical CenterJan 2025
NCT06442436MK-1026-015A Study of Nemtabrutinib in Participants With Moderate Hepatic Impairment (MK-1026-015)P1recruiting32Merck Sharp & Dohme LLCJul 2024
NCT07232589MK-1026-022A Study of the Effect of Diltiazem on the Plasma Levels of Nemtabrutinib (MK-1026-022)P1completed26Merck Sharp & Dohme LLCDec 2025
NCT05673460MK-1026-002A Clinical Study of Nemtabrutinib in Japanese Participants With Hematological Malignancies (MK-1026-002)P1completed7Merck Sharp & Dohme LLCFeb 2023
NCT06772818MK-1026A Study to Evaluate the Effect of Food on Nemtabrutinib (MK-1026) in Healthy Participants (MK-1026-017)P1completed20Merck Sharp & Dohme LLCOct 2023
NCT06625827MK-1026A Study of the Effect of Nemtabrutinib (MK-1026) on the Plasma Levels of Digoxin in Healthy Participants (MK-1026-012)P1completed24Merck Sharp & Dohme LLCNov 2023
NCT06688045MK-1026-013A Study of the Effects of Itraconazole on the Plasma Levels of Nemtabrutinib (MK-1026-013)P1completed15Merck Sharp & Dohme LLCOct 2023
NCT06772805MK-1026A Study to Evaluate the Effect of Food on Nemtabrutinib (MK-1026) in Healthy Participants (MK-1026-016)P1completed18Merck Sharp & Dohme LLCJul 2023
NCT06586671MK-1026A Study to Compare Forms of Nemtabrutinib (MK-1026) in Healthy Adult Participants (MK-1026-007)P1completed40Merck Sharp & Dohme LLCAug 2023
NCT06698016MK-1026-014A Study of the Effect of Efavirenz on the Plasma Levels of Nemtabrutinib (MK-1026-014)P1completed16Merck Sharp & Dohme LLCJul 2023

Nemtabrutinib clinical trials: frequently asked questions

How many Nemtabrutinib clinical trials are there?
21 Nemtabrutinib clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 7 are actively recruiting participants. 8 are marked completed.
Are Nemtabrutinib clinical trials recruiting in 2026?
Yes — 7 Nemtabrutinib trials are actively recruiting in 2026, with 59 U.S. sites across 24 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Nemtabrutinib being studied for?
Nemtabrutinib is being studied for Chronic Lymphocytic Leukemia, Healthy, Small Lymphocytic Lymphoma, Mantle Cell Lymphoma, Marginal Zone Lymphoma and 30 more. The trials are grouped by indication on this page.
What phase is Nemtabrutinib in?
Nemtabrutinib clinical trials span 3 Phase 3, 7 Phase 2, 10 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Nemtabrutinib clinical trials?
The lead sponsor across the most Nemtabrutinib trials is Merck Sharp & Dohme LLC, with 5 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Nemtabrutinibas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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