Mazdutide Clinical Trials (2026): 6 Studies for Type 2 Diabetes & Dementia, Mild

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

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6 Mazdutide clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 6 indications (including Type 2 Diabetes & Dementia, Mild) and 2,358 total planned enrollment. 2 Phase 3 Mazdutide trials and 1 Phase 2 are listed. 5 Mazdutide clinical trials are actively recruiting. Most recent activity: NCT07135141 (Sep 2029).

Mazdutide clinical trials at a glance: phase × recruitment status

Phaserecruitingactive not recruitingnot yet recruitingTotal
P1/P211
P211
P3112
N/A112

Recruiting Mazdutide clinical trials (5)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT07135141SMARTMazdutide as Adjuvant Therapy Following Sleeve Gastrectomy in Severe ObesityN/ASevere Obesity256Sep 2025
NCT07083154GLP-1/GCG Dual Agonist in Type 2 Diabetes With Early Dementia (LIGHT-COG Study)P3Dementia, Mild420Sep 2025
NCT07517042ASCEND-1ASCEND-1: Lifestyle Intervention Plus Mazdutide for Weight ManagementN/AObesity420Apr 2026
NCT07417306SGLT2A Study of HDM1005 in Participants With T2DM Not Controlled With Metformin Alone or in Combination With a Sodium-Glucose Cotransporter 2 (SGLT2) InhibitorP3Type 2 Diabetes912Mar 2026
NCT06519656Efficacy of Mazdutide for Treating PCOSP1/P2Polycystic Ovary Syndrome50Oct 2024

Mazdutide clinical trials by indication

Obesity (1)

NCTAcronymPhaseStatusTitle
NCT07517042ASCEND-1N/ArecruitingASCEND-1: Lifestyle Intervention Plus Mazdutide for Weight Management

Type 2 Diabetes (1)

NCTAcronymPhaseStatusTitle
NCT07417306SGLT2P3not yet recruitingA Study of HDM1005 in Participants With T2DM Not Controlled With Metformin Alone or in Combination With a Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor

Severe Obesity (1)

NCTAcronymPhaseStatusTitle
NCT07135141SMARTN/Anot yet recruitingMazdutide as Adjuvant Therapy Following Sleeve Gastrectomy in Severe Obesity

Dementia, Mild (1)

NCTAcronymPhaseStatusTitle
NCT07083154P3recruitingGLP-1/GCG Dual Agonist in Type 2 Diabetes With Early Dementia (LIGHT-COG Study)

Alcohol Use Disorder (1)

NCTAcronymPhaseStatusTitle
NCT06817356P2active not recruitingA Study to Evaluate Mazdutide Compared With Placebo in Participants With Alcohol Use Disorder

Polycystic Ovary Syndrome (1)

NCTAcronymPhaseStatusTitle
NCT06519656P1/P2recruitingEfficacy of Mazdutide for Treating PCOS

Mazdutide pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
SGLT2NCT07417306P3not yet recruitingType 2 Diabetes912

All Mazdutide trials (6)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT07135141SMARTMazdutide as Adjuvant Therapy Following Sleeve Gastrectomy in Severe ObesityN/Anot yet recruiting256Beijing Friendship HospitalSep 2025
NCT07083154GLP-1/GCG Dual Agonist in Type 2 Diabetes With Early Dementia (LIGHT-COG Study)P3recruiting420The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolSep 2025
NCT07517042ASCEND-1ASCEND-1: Lifestyle Intervention Plus Mazdutide for Weight ManagementN/Arecruiting420Shanghai Zhongshan HospitalApr 2026
NCT07417306SGLT2A Study of HDM1005 in Participants With T2DM Not Controlled With Metformin Alone or in Combination With a Sodium-Glucose Cotransporter 2 (SGLT2) InhibitorP3not yet recruiting912Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.Mar 2026
NCT06817356A Study to Evaluate Mazdutide Compared With Placebo in Participants With Alcohol Use DisorderP2active not recruiting300Eli Lilly and CompanyFeb 2025
NCT06519656Efficacy of Mazdutide for Treating PCOSP1/P2recruiting50Shanghai Zhongshan HospitalOct 2024

Mazdutide clinical trials: frequently asked questions

How many Mazdutide clinical trials are there?
6 Mazdutide clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 3 are actively recruiting participants.
Are Mazdutide clinical trials recruiting in 2026?
Yes — 3 Mazdutide trials are actively recruiting in 2026. See the recruiting trials and the per-state site list further down this page.
What conditions is Mazdutide being studied for?
Mazdutide is being studied for Type 2 Diabetes, Dementia, Mild, Mild Cognitive Impairment, Obesity, Polycystic Ovary Syndrome and 3 more. The trials are grouped by indication on this page.
What phase is Mazdutide in?
Mazdutide clinical trials span 2 Phase 3, 1 Phase 2. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Mazdutide clinical trials?
The lead sponsor across the most Mazdutide trials is Shanghai Zhongshan Hospital, with 4 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Mazdutideas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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