Mavacamten Clinical Trials (2026): 36 Studies for Obstructive Hypertrophic Cardiomyopathy & Hypertrophic Cardiomyopathy
Hipa.ai Research · Source: ClinicalTrials.gov / AACT
Synced daily from ClinicalTrials.gov via AACT. Last sync: .
36 Mavacamten clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 15 indications (including Obstructive Hypertrophic Cardiomyopathy & Hypertrophic Cardiomyopathy) and 7,263 total planned enrollment. 6 Phase 3 Mavacamten trials and 3 Phase 2, 3 Phase 4 are listed. 11 Mavacamten clinical trials are actively recruiting at 65 U.S. sites across 32 states. Most recent activity: NCT06253221 (Mar 2031).
Where to Participate: All Mavacamten Trial Sites in the U.S. (65 sites across 32 states)
Every actively recruiting Mavacamtentrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.
| State | Facility | City | Trial | Map |
|---|---|---|---|---|
| AK | Alaska Heart Institute | Anchorage99508 | NCT05489705 | Map |
| AZ | Pima Heart and Vascular | Tucson85704 | NCT05489705 | Map |
| AR | UAMS | Little Rock72205-7199 | NCT05489705 | Map |
| CA | UC San Diego School of Medicine | La Jolla92037 | NCT05489705 | Map |
| CA | Keck School of Medicine of USC-Usc | Los Angeles90033 | NCT05489705 | Map |
| CA | Stanford Health Care Hospital & Clinics | Palo Alto94304 | NCT05489705 | Map |
| CA | University Of California San Francisco Medical Center | San Francisco94117 | NCT05489705 | Map |
| CO | UC Denver, AMC | Aurora48377 | NCT05489705 | Map |
| CT | Hartford HealthCare | Hartford06106 | NCT05489705 | Map |
| DC | MedStar Washington Hospital Center | Washington D.C.20010 | NCT05489705 | Map |
| FL | Uf Health Jacksonville | Jacksonville32209 | NCT05489705 | Map |
| HI | University of Hawaii Cancer Center | Honolulu96813 | NCT05489705 | Map |
| IL | University of Chicago Dept of Medicine | Chicago60637 | NCT05489705 | Map |
| IN | Franciscan Physician Network-Indiana Heart Physicians | Indianapolis46237 | NCT05489705 | Map |
| IN | Indiana. University | Indianapolis46202 | NCT05489705 | Map |
| IA | University of Iowa Hospitals & Clinics | Iowa City52242 | NCT05489705 | Map |
| KS | University Of Kansas Medical Center & Medical Pavilion | Kansas City66160 | NCT05489705 | Map |
| MD | MedStar Health Research Institute | Baltimore21218 | NCT05489705 | Map |
| MD | University Of Maryland, Ihv | Baltimore21201 | NCT05489705 | Map |
| MA | Analysis Group Inc. | Boston02199 | NCT06551129 | Map |
| MA | Harvard (Massachusetts General Hospital) | Boston02114 | NCT05489705 | Map |
| MA | Harvard Medical School - Brigham and Women's Hospital (BWH) | Boston02215 | NCT05489705 | Map |
| MI | Spectrum Health Medical Group | Grand Rapids49525 | NCT05489705 | Map |
| MI | Henry Ford Health System | West Bloomfield48322 | NCT05489705 | Map |
| MN | Minneapolis Heart Institute Foundation | Minneapolis55407 | NCT05489705 | Map |
| MS | Cardiology Associates Research, Llc | Tupelo38801 | NCT05489705 | Map |
| MO | St. Luke's Mid-America Heart Institute | Kansas City64111 | NCT05489705 | Map |
| MO | Washington University | St Louis63110 | NCT05489705 | Map |
| NE | CHI Health Reseach Center | Omaha68124 | NCT05489705 | Map |
| NJ | Hackensack University Medical Center | Hackensack07601 | NCT05489705 | Map |
| NJ | Morristown Medical Center | Morristown07960 | NCT05489705 | Map |
| NY | Bassett Medical Center | Cooperstown13326 | NCT05489705 | Map |
| NY | Northwell Health | Manhasset11030 | NCT05489705 | Map |
| NY | Mount Sinai Hospital | New York10029 | NCT05489705 | Map |
| NY | Mount Sinai West | New York10019 | NCT05489705 | Map |
| NY | Saint Francis Hospital | Roslyn11576 | NCT05489705 | Map |
| NY | WMCHealth Advanced Physician Services | Valhalla10595 | NCT05489705 | Map |
| NC | Focus Clinical Research | Charlotte28207 | NCT05489705 | Map |
| NC | Duke University Health System | Durham27710 | NCT05489705 | Map |
| NC | The Mavacamten Pregnancy Surveillance Program, PPD Inc | Wilmington28401-3331 | NCT05939700 | Map |
| OH | Christ Hospital Health Network | Cincinnati45219 | NCT05489705 | Map |
| OH | Cleveland Clinic | Cleveland44195 | NCT05489705 | Map |
| OH | University Hospitals Cleveland Medical Center | Cleveland44106 | NCT05489705 | Map |
| PA | St. Luke's University Health Network | Bethlehem18015 | NCT05489705 | Map |
| PA | Lancaster General Hospital | Lancaster17603 | NCT05489705 | Map |
| PA | AHN Allegheny General Hospital | Pittsburgh15212 | NCT05489705 | Map |
| PA | University Of Pittsburgh | Pittsburgh15213 | NCT05489705 | Map |
| PA | Geisinger Health System | Wilkes-Barre18711 | NCT05489705 | Map |
| SC | Prisma Health - Upstate | Greenville29605 | NCT05489705 | Map |
| TN | Saint Thomas Health | Nashville37205-2018 | NCT05489705 | Map |
| TN | Tristar Centennial Medical Ctr | Nashville37203 | NCT05489705 | Map |
| TX | Baylor Scott & White Research Institute | Dallas75246 | NCT05489705 | Map |
| TX | North Texas Cardiology Center | Dallas75208 | NCT05489705 | Map |
| TX | BI Research Center | Houston77084 | NCT05489705 | Map |
| TX | The Methodist Hospital, Methodist Cancer Cencer | Houston77030 | NCT05489705 | Map |
| TX | Baylor Scott & White The Heart Hospital Plano | Plano75093 | NCT05489705 | Map |
| TX | Baylor Scott & White Medical Centre - Temple | Temple76508 | NCT05489705 | Map |
| VA | The Rector and Visitors of the Univ of Virginia | Charlottesville22908 | NCT05489705 | Map |
| VA | University of Virginia | Charlottesville22908 | NCT06023186 | Map |
| VA | VCU Medical Center | Richmond23298 | NCT05489705 | Map |
| VA | Carilion Clinic; Virginia Tech-Carilion School of Medicine | Roanoke24014 | NCT05489705 | Map |
| WA | Virginia Mason Medical Center | Seattle98101 | NCT05489705 | Map |
| WV | WVU Hospitals | Morgantown26506 | NCT05489705 | Map |
| WI | University Of Wisconsin - Madison | Madison53792 | NCT05489705 | Map |
| WI | Medical College of Wisconsin, Inc (PI Address) | Milwaukee53226 | NCT05489705 | Map |
Mavacamten clinical trials at a glance: phase × recruitment status
| Phase | recruiting | active not recruiting | completed | not yet recruiting | Total |
|---|---|---|---|---|---|
| P1 | 6 | 6 | |||
| P2 | 3 | 3 | |||
| P2/P3 | 1 | 1 | |||
| P3 | 1 | 5 | 6 | ||
| P4 | 2 | 1 | 3 | ||
| N/A | 9 | 3 | 4 | 1 | 17 |
Recruiting Mavacamten clinical trials (11)
Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).
| NCT ID | Title | Phase | Indication | Enrollment | Started |
|---|---|---|---|---|---|
| NCT07383025 | Mavacamten Post-marketing Surveillance in Patients With Obstructive Hypertrophic Cardiomyopathy in Japan | — | Obstructive Hypertrophic Cardiomyopathy (oHCM) | 200 | May 2025 |
| NCT05489705 | DISCOVER-HCMA Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM) | — | Obstructive Hypertrophic Cardiomyopathy | 1,700 | Aug 2022 |
| NCT07120776 | PEACHPositron Emission Tomography to Assess the Effect of Camzyos on Ischaemia in HOCM: PEACH Trial | N/A | Hypertrophic Obstructive Cardiomyopathy \(HOCM\) | 75 | Mar 2026 |
| NCT07361289 | SOAR-HCMA Study to Assess the Real-World Effectiveness of Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy in China | — | Hypertrophic Cardiomyopathy | 500 | Jan 2026 |
| NCT07150299 | oHCMMyocardial Perfusion Changes Following Optimal Medical Treatment in Symptomatic Hypertrophic Cardiomyopathy | — | Hypertrophic Obstructive Cardiomyopathy \(HOCM\) | 20 | Sep 2025 |
| NCT06551129 | COMPASS-HCMReal-world Patient Reported Outcomes Among Patients Treated With Camzyos | — | Obstructive Hypertrophic Cardiomyopathy | 118 | May 2024 |
| NCT05939700 | Mavacamten Pregnancy Surveillance Program | — | Breastfeeding | 20 | Nov 2023 |
| NCT07103655 | BRAVE-HCMThe Therapeutic Value of Mavacamten in Hypertrophic Cardiomyopathy With Mid-to-Apical Left Ventricular Obstruction | P4 | Hypertrophic Cardiomyopathy (HCM) | 132 | Jan 2026 |
| NCT06146660 | A Study to Assess the Safety of Mavacamten in Korean Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy | — | Obstructive Hypertrophic Cardiomyopathy | 600 | Jul 2024 |
| NCT06023186 | MavaPETEffect of Mavacamten Treatment on Coronary Flow Reserve in oHCM | — | Obstructive Hypertrophic Cardiomyopathy | 20 | Nov 2023 |
| NCT06856265 | Efficacy of Mavacamten Combined With Radiofrequency Ablation in Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy | N/A | Obstructive Hypertrophic Cardiomyopathy | 40 | Feb 2025 |
Mavacamten clinical trials by indication
Obstructive Hypertrophic Cardiomyopathy (7)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05489705 | DISCOVER-HCM | N/A | recruiting | A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM) |
| NCT06551129 | COMPASS-HCM | N/A | recruiting | Real-world Patient Reported Outcomes Among Patients Treated With Camzyos |
| NCT06146660 | — | N/A | recruiting | A Study to Assess the Safety of Mavacamten in Korean Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy |
| NCT06023186 | MavaPET | N/A | recruiting | Effect of Mavacamten Treatment on Coronary Flow Reserve in oHCM |
| NCT06856265 | — | N/A | not yet recruiting | Efficacy of Mavacamten Combined With Radiofrequency Ablation in Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy |
| NCT05174416 | — | P3 | completed | A Study to Evaluate the Efficacy and Safety of Mavacamten in Chinese Adults With Symptomatic Obstructive HCM |
| NCT03470545 | EXPLORER-HCM | P3 | completed | Clinical Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy |
Hypertrophic Cardiomyopathy (5)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07361289 | SOAR-HCM | N/A | recruiting | A Study to Assess the Real-World Effectiveness of Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy in China |
| NCT03723655 | — | P2/P3 | completed | A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM |
| NCT06549608 | — | N/A | completed | A Retrospective Cohort Study of Mavacamten Patient Support Program in Canada |
| NCT03496168 | PIONEER-OLE | P2 | completed | Extension Study of Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Previously Enrolled in PIONEER |
| NCT05135871 | — | P1 | completed | Study Evaluating the Pharmacokinetics of Mavacamten in Healthy Adult Chinese Subjects |
Obstructive Hypertrophic Cardiomyopathy (oHCM) (4)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07383025 | — | N/A | recruiting | Mavacamten Post-marketing Surveillance in Patients With Obstructive Hypertrophic Cardiomyopathy in Japan |
| NCT07107373 | — | N/A | active not recruiting | A Study to Assess the Treatment of Obstructive Hypertrophic Cardiomyopathy (oHCM) With Mavacamten in the US |
| NCT07168655 | — | N/A | completed | Mavacamten in Obstructive Hypertrophic Cardiomyopathy |
| NCT06338202 | MAVEN | N/A | completed | Real-World Effectiveness of Mavacamten in Canada |
Healthy Participants (4)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05719805 | — | P1 | completed | A Study to Evaluate the Effects of Mavacamten in Healthy Participants |
| NCT05658146 | — | P1 | completed | A Study to Assess the Effects on the Single-Dose Drug Levels of Mavacamten in Healthy Participants |
| NCT05320094 | — | P1 | completed | A Study to Evaluate the Effect of Activated Charcoal With Sorbitol on the Single-dose of Mavacamten in Healthy Participants |
| NCT05362045 | — | P1 | completed | A Study to Evaluate the Effects on the Single-Dose Drug Levels of Mavacamten in Healthy Participants |
Hypertrophic Cardiomyopathy (HCM) (3)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07103655 | BRAVE-HCM | P4 | not yet recruiting | The Therapeutic Value of Mavacamten in Hypertrophic Cardiomyopathy With Mid-to-Apical Left Ventricular Obstruction |
| NCT06372457 | COLLIGO-HCM | N/A | active not recruiting | COLLIGO-HCM: A Multinational Observational Study of the Real-World Effectiveness of Mavacamten Among Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM) |
| NCT07529938 | MAVA-HCM | N/A | completed | Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy |
Cardiomyopathy, Hypertrophic (3)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06253221 | — | P3 | active not recruiting | A Study to Evaluate Mavacamten in Adolescents With Symptomatic Obstructive Hypertrophic Cardiomyopathy |
| NCT06112743 | MEMENTO | P4 | active not recruiting | A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy |
| NCT05582395 | ODYSSEY-HCM | P3 | completed | A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy |
Hypertrophic Obstructive Cardiomyopathy \(HOCM\) (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07120776 | PEACH | N/A | recruiting | Positron Emission Tomography to Assess the Effect of Camzyos on Ischaemia in HOCM: PEACH Trial |
| NCT07150299 | oHCM | N/A | recruiting | Myocardial Perfusion Changes Following Optimal Medical Treatment in Symptomatic Hypertrophic Cardiomyopathy |
Symptomatic Obstructive Hypertrophic Cardiomyopathy (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07004972 | ROVER | P4 | active not recruiting | A Study of Mavacamten in Adults With Obstructive Hypertrophic Cardiomyopathy in India (ROVER) |
HCM - Hypertrophic Cardiomyopathy (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06947590 | — | N/A | active not recruiting | Efficacy of Mavacamten in Patients With Symptomatic Latent Obstructive Hypertrophic Cardiomyopathy |
Healthy Volunteers (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06211179 | — | P1 | completed | A Study to Assess the Relative Bioavailability of 5 mg Mavacamten Opened Capsule Administered Via Nasogastric Tube Compared to Intact Oral 5 mg Mavacamten in Healthy Participants |
Breastfeeding (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05939700 | — | N/A | recruiting | Mavacamten Pregnancy Surveillance Program |
Cardiomyopathy, Hypertrophic Obstructive (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05414175 | HORIZON-HCM | P3 | completed | A Study of Mavacamten in Obstructive Hypertrophic Cardiomyopathy |
Heart Failure With Preserved Ejection Fraction (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT04766892 | EMBARK-HFpEF | P2 | completed | A Study of Mavacamten in Participants With HFpEF and Elevation of NT-proBNP With or Without Elevation of cTnT |
HOCM, Hypertrophic Obstructive Cardiomyopathy (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT04349072 | VALOR-HCM | P3 | completed | A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive HCM Who Are Eligible for Septal Reduction Therapy |
Non-obstructive Hypertrophic Cardiomyopathy (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT03442764 | MAVERICK-HCM | P2 | completed | A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM) |
Mavacamten pivotal trial highlights (Phase 2/3/4)
Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.
| Acronym | NCT | Phase | Status | Indication | Enrollment | PubMed |
|---|---|---|---|---|---|---|
| ROVER | NCT07004972 | P4 | active not recruiting | Symptomatic Obstructive Hypertrophic Cardiomyopathy | 50 | — |
| BRAVE-HCM | NCT07103655 | P4 | not yet recruiting | Hypertrophic Cardiomyopathy (HCM) | 132 | — |
| MEMENTO | NCT06112743 | P4 | active not recruiting | Cardiomyopathy, Hypertrophic | 63 | — |
| HORIZON-HCM | NCT05414175 | P3 | completed | Cardiomyopathy, Hypertrophic Obstructive | 38 | — |
| ODYSSEY-HCM | NCT05582395 | P3 | completed | Cardiomyopathy, Hypertrophic | 580 | — |
| VALOR-HCM | NCT04349072 | P3 | completed | HOCM, Hypertrophic Obstructive Cardiomyopathy | 112 | — |
| EXPLORER-HCM | NCT03470545 | P3 | completed | Obstructive Hypertrophic Cardiomyopathy | 251 | — |
| EMBARK-HFpEF | NCT04766892 | P2 | completed | Heart Failure With Preserved Ejection Fraction | 30 | — |
| PIONEER-OLE | NCT03496168 | P2 | completed | Hypertrophic Cardiomyopathy | 13 | — |
| MAVERICK-HCM | NCT03442764 | P2 | completed | Non-obstructive Hypertrophic Cardiomyopathy | 59 | — |
All Mavacamten trials (36)
Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.
| NCT ID | Acronym | Title | Phase | Status | Enrollment | Sponsor | Started |
|---|---|---|---|---|---|---|---|
| NCT06253221 | A Study to Evaluate Mavacamten in Adolescents With Symptomatic Obstructive Hypertrophic Cardiomyopathy | P3 | active not recruiting | 44 | Bristol-Myers Squibb | Apr 2024 | |
| NCT07383025 | Mavacamten Post-marketing Surveillance in Patients With Obstructive Hypertrophic Cardiomyopathy in Japan | — | recruiting | 200 | Bristol-Myers Squibb | May 2025 | |
| NCT05489705 | DISCOVER-HCM | A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM) | — | recruiting | 1,700 | Bristol-Myers Squibb | Aug 2022 |
| NCT07120776 | PEACH | Positron Emission Tomography to Assess the Effect of Camzyos on Ischaemia in HOCM: PEACH Trial | N/A | recruiting | 75 | University of Manchester | Mar 2026 |
| NCT07361289 | SOAR-HCM | A Study to Assess the Real-World Effectiveness of Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy in China | — | recruiting | 500 | Bristol-Myers Squibb | Jan 2026 |
| NCT07004972 | ROVER | A Study of Mavacamten in Adults With Obstructive Hypertrophic Cardiomyopathy in India (ROVER) | P4 | active not recruiting | 50 | Bristol-Myers Squibb | Sep 2025 |
| NCT07150299 | oHCM | Myocardial Perfusion Changes Following Optimal Medical Treatment in Symptomatic Hypertrophic Cardiomyopathy | — | recruiting | 20 | Medical University of Vienna | Sep 2025 |
| NCT06551129 | COMPASS-HCM | Real-world Patient Reported Outcomes Among Patients Treated With Camzyos | — | recruiting | 118 | Bristol-Myers Squibb | May 2024 |
| NCT05939700 | Mavacamten Pregnancy Surveillance Program | — | recruiting | 20 | Bristol-Myers Squibb | Nov 2023 | |
| NCT07103655 | BRAVE-HCM | The Therapeutic Value of Mavacamten in Hypertrophic Cardiomyopathy With Mid-to-Apical Left Ventricular Obstruction | P4 | not yet recruiting | 132 | Second Affiliated Hospital, School of Medicine, Zhejiang University | Jan 2026 |
| NCT06146660 | A Study to Assess the Safety of Mavacamten in Korean Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy | — | recruiting | 600 | Bristol-Myers Squibb | Jul 2024 | |
| NCT06023186 | MavaPET | Effect of Mavacamten Treatment on Coronary Flow Reserve in oHCM | — | recruiting | 20 | Michael Ayers | Nov 2023 |
| NCT06112743 | MEMENTO | A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy | P4 | active not recruiting | 63 | Bristol-Myers Squibb | Jan 2024 |
| NCT06372457 | COLLIGO-HCM | COLLIGO-HCM: A Multinational Observational Study of the Real-World Effectiveness of Mavacamten Among Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM) | — | active not recruiting | 331 | Bristol-Myers Squibb | Dec 2023 |
| NCT06947590 | Efficacy of Mavacamten in Patients With Symptomatic Latent Obstructive Hypertrophic Cardiomyopathy | N/A | active not recruiting | 78 | Xu Liu | Apr 2025 | |
| NCT03723655 | A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM | P2/P3 | completed | 314 | Bristol-Myers Squibb | Sep 2018 | |
| NCT07107373 | A Study to Assess the Treatment of Obstructive Hypertrophic Cardiomyopathy (oHCM) With Mavacamten in the US | — | active not recruiting | 150 | Bristol-Myers Squibb | Dec 2023 | |
| NCT05414175 | HORIZON-HCM | A Study of Mavacamten in Obstructive Hypertrophic Cardiomyopathy | P3 | completed | 38 | Bristol-Myers Squibb | Aug 2022 |
| NCT06856265 | Efficacy of Mavacamten Combined With Radiofrequency Ablation in Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy | N/A | not yet recruiting | 40 | Shanghai Chest Hospital | Feb 2025 | |
| NCT05582395 | ODYSSEY-HCM | A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy | P3 | completed | 580 | Bristol-Myers Squibb | Dec 2022 |
| NCT07529938 | MAVA-HCM | Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy | — | completed | 222 | Chinese Academy of Medical Sciences, Fuwai Hospital | Jan 2024 |
| NCT06549608 | A Retrospective Cohort Study of Mavacamten Patient Support Program in Canada | — | completed | 683 | Bristol-Myers Squibb | Apr 2024 | |
| NCT07168655 | Mavacamten in Obstructive Hypertrophic Cardiomyopathy | — | completed | 163 | Bristol-Myers Squibb | Feb 2023 | |
| NCT06338202 | MAVEN | Real-World Effectiveness of Mavacamten in Canada | — | completed | 115 | Bristol-Myers Squibb | Jun 2024 |
| NCT05174416 | A Study to Evaluate the Efficacy and Safety of Mavacamten in Chinese Adults With Symptomatic Obstructive HCM | P3 | completed | 81 | LianBio LLC | Jan 2022 | |
| NCT06211179 | A Study to Assess the Relative Bioavailability of 5 mg Mavacamten Opened Capsule Administered Via Nasogastric Tube Compared to Intact Oral 5 mg Mavacamten in Healthy Participants | P1 | completed | 34 | Bristol-Myers Squibb | Jan 2024 | |
| NCT04349072 | VALOR-HCM | A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive HCM Who Are Eligible for Septal Reduction Therapy | P3 | completed | 112 | Bristol-Myers Squibb | Jul 2020 |
| NCT04766892 | EMBARK-HFpEF | A Study of Mavacamten in Participants With HFpEF and Elevation of NT-proBNP With or Without Elevation of cTnT | P2 | completed | 30 | Bristol-Myers Squibb | Mar 2021 |
| NCT03496168 | PIONEER-OLE | Extension Study of Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Previously Enrolled in PIONEER | P2 | completed | 13 | Bristol-Myers Squibb | Apr 2018 |
| NCT05719805 | A Study to Evaluate the Effects of Mavacamten in Healthy Participants | P1 | completed | 84 | Bristol-Myers Squibb | Feb 2023 | |
| NCT05658146 | A Study to Assess the Effects on the Single-Dose Drug Levels of Mavacamten in Healthy Participants | P1 | completed | 95 | Bristol-Myers Squibb | Jan 2023 | |
| NCT05320094 | A Study to Evaluate the Effect of Activated Charcoal With Sorbitol on the Single-dose of Mavacamten in Healthy Participants | P1 | completed | 45 | Bristol-Myers Squibb | Apr 2022 | |
| NCT05362045 | A Study to Evaluate the Effects on the Single-Dose Drug Levels of Mavacamten in Healthy Participants | P1 | completed | 158 | Bristol-Myers Squibb | May 2022 | |
| NCT05135871 | Study Evaluating the Pharmacokinetics of Mavacamten in Healthy Adult Chinese Subjects | P1 | completed | 45 | LianBio LLC | Oct 2021 | |
| NCT03470545 | EXPLORER-HCM | Clinical Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy | P3 | completed | 251 | MyoKardia, Inc. | May 2018 |
| NCT03442764 | MAVERICK-HCM | A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM) | P2 | completed | 59 | MyoKardia, Inc. | Mar 2018 |
Mavacamten clinical trials: frequently asked questions
- How many Mavacamten clinical trials are there?
- 36 Mavacamten clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 9 are actively recruiting participants. 19 are marked completed.
- Are Mavacamten clinical trials recruiting in 2026?
- Yes — 9 Mavacamten trials are actively recruiting in 2026, with 65 U.S. sites across 32 states. See the recruiting trials and the per-state site list further down this page.
- What conditions is Mavacamten being studied for?
- Mavacamten is being studied for Obstructive Hypertrophic Cardiomyopathy, Hypertrophic Cardiomyopathy, Obstructive Hypertrophic Cardiomyopathy (oHCM), Healthy Participants, Cardiomyopathy, Hypertrophic and 15 more. The trials are grouped by indication on this page.
- What phase is Mavacamten in?
- Mavacamten clinical trials span 3 Phase 4, 6 Phase 3, 3 Phase 2, 6 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
- Who sponsors Mavacamten clinical trials?
- The lead sponsor across the most Mavacamten trials is Bristol-Myers Squibb, with 9 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.
Sources and methodology
Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Mavacamtenas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.
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Related pages on Hipa.ai: