LY4268989 Clinical Trials (2026): 3 Studies for Healthy & Ulcerative Colitis

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

3 LY4268989 clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 3 indications (including Healthy & Ulcerative Colitis) and 1,827 total planned enrollment. 2 LY4268989 clinical trials are actively recruiting at 63 U.S. sites across 21 states. Most recent activity: NCT07415044 (Jul 2031).

Where to Participate: All LY4268989 Trial Sites in the U.S. (63 sites across 21 states)

Every actively recruiting LY4268989trial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
CAClinnova ResearchAnaheim92805NCT07415044Map
CAClinnova Research - AnaheimAnaheim92805NCT07186101Map
CAGMC Clinical ResearchFolsom95630NCT07415044Map
CAOm Research LLCLancaster93534NCT07186101Map
CABiopharma Informatic, LLCLos Angeles90035NCT07186101Map
CAOm Research LLCTemple City91780NCT07415044Map
CAOm Research LLCVictorville92395NCT07415044Map
COPeak Gastroenterology AssociatesColorado Springs80907NCT07186101Map
COPeak Gastroenterology AssociatesColorado Springs80907NCT07415044Map
CORocky Mountain Gastroenterology Associates - LakewoodLakewood80228NCT07415044Map
FLK2 Medical Research - Daytona BeachDaytona Beach32114NCT07415044Map
FLNeoClinical ResearchHialeah33016NCT07186101Map
FLEncore Borland-Groover Clinical ResearchJacksonville32256NCT07186101Map
FLClinical Research of OsceolaKissimmee34741NCT07186101Map
FLClinical Research of OsceolaKissimmee34741NCT07415044Map
FLFlorida Research InstituteLakewood Rch34211NCT07186101Map
FLFlorida Research InstituteLakewood Rch34211NCT07415044Map
FLAlliance Medical ResearchLighthouse PT33064NCT07186101Map
FLAtlantic Medical ResearchMargate33063NCT07186101Map
FLDigestive and Liver Center of FloridaOrlando32825NCT07186101Map
IDGrand Teton Research GroupIdaho Falls83404NCT07415044Map
ILMidtown Gastroenterology and Liver DiseaseDes Plaines60016NCT07186101Map
ILMidwest Digestive Health & NutritionDes Plaines60016NCT07415044Map
ILGI Alliance - GlenviewGlenview60026NCT07186101Map
ILGi Alliance - GurneeGurnee60031NCT07186101Map
ILSpringfield Clinic - FirstSpringfield62702NCT07415044Map
INGastroenterology Health PartnersNew Albany47150NCT07186101Map
INGastroenterology Health PartnersNew Albany47150NCT07415044Map
KYGastroenterology Health PartnersLouisville40218NCT07186101Map
KYGastroenterology Health PartnersLouisville40218NCT07415044Map
MABrigham and Women's HospitalBoston02215NCT07186101Map
MIClinical Research Institute of Michigan, LLCClinton Township48038NCT07186101Map
MIGastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research CenterWyoming49519NCT07415044Map
MSGI Associates - GIA and Endoscopy Center - FlowoodFlowood39232NCT07186101Map
NVDigestive Disease Specialists - Las Vegas - Crimson Canyon DriveLas Vegas89128NCT07415044Map
NYDigestive Disease Medicine of Central New YorkUtica13502NCT07186101Map
NCCarolina Digestive Diseases and Endoscopy CenterGreenville27834NCT07415044Map
NCWilmington Health, PLLCWilmington28401NCT07415044Map
OHGastroenterology & Hepatology SpecialistsCanton44718NCT07186101Map
OHDayton Gastroenterology, LLCDayton45415NCT07186101Map
RIUniversity Gastroenterology - Providence - West River StreetProvidence02904NCT07186101Map
SCGastroenterology Associates, P.A. of GreenvilleGreenville29607NCT07186101Map
TNGastro One - Walnut Run RoadCordova38018NCT07186101Map
TXTexas Digestive Disease Consultants - Cedar ParkCedar Park78613NCT07186101Map
TXGI Alliance - Fort WorthFort Worth76104NCT07186101Map
TXGI Alliance - Fort WorthFort Worth76104NCT07415044Map
TXGI Alliance - GarlandGarland75044NCT07186101Map
TXGI Alliance - GarlandGarland75044NCT07415044Map
TXIntegrity Advanced TherapeuticsHouston77090NCT07415044Map
TXGI Alliance - LubbockLubbock79410NCT07186101Map
TXGI Alliance: MansfieldMansfield76063NCT07415044Map
TXSouthern Star Research InstituteSan Antonio78229NCT07186101Map
TXSouthern Star Research InstituteSan Antonio78229NCT07415044Map
TXGI Alliance - San MarcosSan Marcos78666NCT07415044Map
TXTyler Research InstituteTyler75701NCT07186101Map
TXTyler Research InstituteTyler75701NCT07415044Map
TXGI Alliance-WebsterWebster77598NCT07186101Map
UTCare Access - OgdenOgden84403NCT07186101Map
VAEximia Research-VA, LLCNorfolk23502NCT07415044Map
VAClinical Research Partners, LLCRichmond23226NCT07186101Map
VAGI Alliance - RichmondRichmond23229NCT07186101Map
WAWashington Gastroenterology - BellevueBellevue98004NCT07186101Map
WAWashington Gastroenterology - TacomaTacoma98405NCT07415044Map

LY4268989 clinical trials at a glance: phase × recruitment status

PhaserecruitingcompletedTotal
P111
P222

Recruiting LY4268989 clinical trials (2)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT07415044EMERALD-3LY4268989 in Adults With Moderately to Severely Active Ulcerative ColitisP2Ulcerative Colitis (UC)1,431Mar 2026
NCT07186101TOPAZ-UCLY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:P2Ulcerative Colitis252Nov 2025

LY4268989 clinical trials by indication

Ulcerative Colitis (UC) (1)

NCTAcronymPhaseStatusTitle
NCT07415044EMERALD-3P2recruitingLY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis

Ulcerative Colitis (1)

NCTAcronymPhaseStatusTitle
NCT07186101TOPAZ-UCP2recruitingLY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:

Healthy (1)

NCTAcronymPhaseStatusTitle
NCT06964776MORF-057P1completedA Study of LY4268989 (MORF-057) in Healthy Participants

LY4268989 pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
EMERALD-3NCT07415044P2recruitingUlcerative Colitis (UC)1,431
TOPAZ-UCNCT07186101P2recruitingUlcerative Colitis252

All LY4268989 trials (3)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT07415044EMERALD-3LY4268989 in Adults With Moderately to Severely Active Ulcerative ColitisP2recruiting1,431Eli Lilly and CompanyMar 2026
NCT07186101TOPAZ-UCLY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:P2recruiting252Eli Lilly and CompanyNov 2025
NCT06964776MORF-057A Study of LY4268989 (MORF-057) in Healthy ParticipantsP1completed144Eli Lilly and CompanyMay 2025

LY4268989 clinical trials: frequently asked questions

How many LY4268989 clinical trials are there?
3 LY4268989 clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 2 are actively recruiting participants. 1 is marked completed.
Are LY4268989 clinical trials recruiting in 2026?
Yes — 2 LY4268989 trials are actively recruiting in 2026, with 63 U.S. sites across 21 states. See the recruiting trials and the per-state site list further down this page.
What conditions is LY4268989 being studied for?
LY4268989 is being studied for Healthy, Ulcerative Colitis, Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate, Ulcerative Colitis, Active Severe. The trials are grouped by indication on this page.
What phase is LY4268989 in?
LY4268989 clinical trials span 2 Phase 2, 1 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors LY4268989 clinical trials?
The lead sponsor across the most LY4268989 trials is Eli Lilly and Company. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming LY4268989as an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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