LY4268989 Clinical Trials (2026): 3 Studies for Healthy & Ulcerative Colitis
Hipa.ai Research · Source: ClinicalTrials.gov / AACT
Synced daily from ClinicalTrials.gov via AACT. Last sync: .
3 LY4268989 clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 3 indications (including Healthy & Ulcerative Colitis) and 1,827 total planned enrollment. 2 LY4268989 clinical trials are actively recruiting at 63 U.S. sites across 21 states. Most recent activity: NCT07415044 (Jul 2031).
Where to Participate: All LY4268989 Trial Sites in the U.S. (63 sites across 21 states)
Every actively recruiting LY4268989trial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.
| State | Facility | City | Trial | Map |
|---|---|---|---|---|
| CA | Clinnova Research | Anaheim92805 | NCT07415044 | Map |
| CA | Clinnova Research - Anaheim | Anaheim92805 | NCT07186101 | Map |
| CA | GMC Clinical Research | Folsom95630 | NCT07415044 | Map |
| CA | Om Research LLC | Lancaster93534 | NCT07186101 | Map |
| CA | Biopharma Informatic, LLC | Los Angeles90035 | NCT07186101 | Map |
| CA | Om Research LLC | Temple City91780 | NCT07415044 | Map |
| CA | Om Research LLC | Victorville92395 | NCT07415044 | Map |
| CO | Peak Gastroenterology Associates | Colorado Springs80907 | NCT07186101 | Map |
| CO | Peak Gastroenterology Associates | Colorado Springs80907 | NCT07415044 | Map |
| CO | Rocky Mountain Gastroenterology Associates - Lakewood | Lakewood80228 | NCT07415044 | Map |
| FL | K2 Medical Research - Daytona Beach | Daytona Beach32114 | NCT07415044 | Map |
| FL | NeoClinical Research | Hialeah33016 | NCT07186101 | Map |
| FL | Encore Borland-Groover Clinical Research | Jacksonville32256 | NCT07186101 | Map |
| FL | Clinical Research of Osceola | Kissimmee34741 | NCT07186101 | Map |
| FL | Clinical Research of Osceola | Kissimmee34741 | NCT07415044 | Map |
| FL | Florida Research Institute | Lakewood Rch34211 | NCT07186101 | Map |
| FL | Florida Research Institute | Lakewood Rch34211 | NCT07415044 | Map |
| FL | Alliance Medical Research | Lighthouse PT33064 | NCT07186101 | Map |
| FL | Atlantic Medical Research | Margate33063 | NCT07186101 | Map |
| FL | Digestive and Liver Center of Florida | Orlando32825 | NCT07186101 | Map |
| ID | Grand Teton Research Group | Idaho Falls83404 | NCT07415044 | Map |
| IL | Midtown Gastroenterology and Liver Disease | Des Plaines60016 | NCT07186101 | Map |
| IL | Midwest Digestive Health & Nutrition | Des Plaines60016 | NCT07415044 | Map |
| IL | GI Alliance - Glenview | Glenview60026 | NCT07186101 | Map |
| IL | Gi Alliance - Gurnee | Gurnee60031 | NCT07186101 | Map |
| IL | Springfield Clinic - First | Springfield62702 | NCT07415044 | Map |
| IN | Gastroenterology Health Partners | New Albany47150 | NCT07186101 | Map |
| IN | Gastroenterology Health Partners | New Albany47150 | NCT07415044 | Map |
| KY | Gastroenterology Health Partners | Louisville40218 | NCT07186101 | Map |
| KY | Gastroenterology Health Partners | Louisville40218 | NCT07415044 | Map |
| MA | Brigham and Women's Hospital | Boston02215 | NCT07186101 | Map |
| MI | Clinical Research Institute of Michigan, LLC | Clinton Township48038 | NCT07186101 | Map |
| MI | Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research Center | Wyoming49519 | NCT07415044 | Map |
| MS | GI Associates - GIA and Endoscopy Center - Flowood | Flowood39232 | NCT07186101 | Map |
| NV | Digestive Disease Specialists - Las Vegas - Crimson Canyon Drive | Las Vegas89128 | NCT07415044 | Map |
| NY | Digestive Disease Medicine of Central New York | Utica13502 | NCT07186101 | Map |
| NC | Carolina Digestive Diseases and Endoscopy Center | Greenville27834 | NCT07415044 | Map |
| NC | Wilmington Health, PLLC | Wilmington28401 | NCT07415044 | Map |
| OH | Gastroenterology & Hepatology Specialists | Canton44718 | NCT07186101 | Map |
| OH | Dayton Gastroenterology, LLC | Dayton45415 | NCT07186101 | Map |
| RI | University Gastroenterology - Providence - West River Street | Providence02904 | NCT07186101 | Map |
| SC | Gastroenterology Associates, P.A. of Greenville | Greenville29607 | NCT07186101 | Map |
| TN | Gastro One - Walnut Run Road | Cordova38018 | NCT07186101 | Map |
| TX | Texas Digestive Disease Consultants - Cedar Park | Cedar Park78613 | NCT07186101 | Map |
| TX | GI Alliance - Fort Worth | Fort Worth76104 | NCT07186101 | Map |
| TX | GI Alliance - Fort Worth | Fort Worth76104 | NCT07415044 | Map |
| TX | GI Alliance - Garland | Garland75044 | NCT07186101 | Map |
| TX | GI Alliance - Garland | Garland75044 | NCT07415044 | Map |
| TX | Integrity Advanced Therapeutics | Houston77090 | NCT07415044 | Map |
| TX | GI Alliance - Lubbock | Lubbock79410 | NCT07186101 | Map |
| TX | GI Alliance: Mansfield | Mansfield76063 | NCT07415044 | Map |
| TX | Southern Star Research Institute | San Antonio78229 | NCT07186101 | Map |
| TX | Southern Star Research Institute | San Antonio78229 | NCT07415044 | Map |
| TX | GI Alliance - San Marcos | San Marcos78666 | NCT07415044 | Map |
| TX | Tyler Research Institute | Tyler75701 | NCT07186101 | Map |
| TX | Tyler Research Institute | Tyler75701 | NCT07415044 | Map |
| TX | GI Alliance-Webster | Webster77598 | NCT07186101 | Map |
| UT | Care Access - Ogden | Ogden84403 | NCT07186101 | Map |
| VA | Eximia Research-VA, LLC | Norfolk23502 | NCT07415044 | Map |
| VA | Clinical Research Partners, LLC | Richmond23226 | NCT07186101 | Map |
| VA | GI Alliance - Richmond | Richmond23229 | NCT07186101 | Map |
| WA | Washington Gastroenterology - Bellevue | Bellevue98004 | NCT07186101 | Map |
| WA | Washington Gastroenterology - Tacoma | Tacoma98405 | NCT07415044 | Map |
LY4268989 clinical trials at a glance: phase × recruitment status
| Phase | recruiting | completed | Total |
|---|---|---|---|
| P1 | 1 | 1 | |
| P2 | 2 | 2 |
Recruiting LY4268989 clinical trials (2)
Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).
| NCT ID | Title | Phase | Indication | Enrollment | Started |
|---|---|---|---|---|---|
| NCT07415044 | EMERALD-3LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis | P2 | Ulcerative Colitis (UC) | 1,431 | Mar 2026 |
| NCT07186101 | TOPAZ-UCLY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis: | P2 | Ulcerative Colitis | 252 | Nov 2025 |
LY4268989 clinical trials by indication
Ulcerative Colitis (UC) (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07415044 | EMERALD-3 | P2 | recruiting | LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis |
Ulcerative Colitis (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07186101 | TOPAZ-UC | P2 | recruiting | LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis: |
Healthy (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06964776 | MORF-057 | P1 | completed | A Study of LY4268989 (MORF-057) in Healthy Participants |
LY4268989 pivotal trial highlights (Phase 2/3/4)
Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.
| Acronym | NCT | Phase | Status | Indication | Enrollment | PubMed |
|---|---|---|---|---|---|---|
| EMERALD-3 | NCT07415044 | P2 | recruiting | Ulcerative Colitis (UC) | 1,431 | — |
| TOPAZ-UC | NCT07186101 | P2 | recruiting | Ulcerative Colitis | 252 | — |
All LY4268989 trials (3)
Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.
| NCT ID | Acronym | Title | Phase | Status | Enrollment | Sponsor | Started |
|---|---|---|---|---|---|---|---|
| NCT07415044 | EMERALD-3 | LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis | P2 | recruiting | 1,431 | Eli Lilly and Company | Mar 2026 |
| NCT07186101 | TOPAZ-UC | LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis: | P2 | recruiting | 252 | Eli Lilly and Company | Nov 2025 |
| NCT06964776 | MORF-057 | A Study of LY4268989 (MORF-057) in Healthy Participants | P1 | completed | 144 | Eli Lilly and Company | May 2025 |
LY4268989 clinical trials: frequently asked questions
- How many LY4268989 clinical trials are there?
- 3 LY4268989 clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 2 are actively recruiting participants. 1 is marked completed.
- Are LY4268989 clinical trials recruiting in 2026?
- Yes — 2 LY4268989 trials are actively recruiting in 2026, with 63 U.S. sites across 21 states. See the recruiting trials and the per-state site list further down this page.
- What conditions is LY4268989 being studied for?
- LY4268989 is being studied for Healthy, Ulcerative Colitis, Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate, Ulcerative Colitis, Active Severe. The trials are grouped by indication on this page.
- What phase is LY4268989 in?
- LY4268989 clinical trials span 2 Phase 2, 1 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
- Who sponsors LY4268989 clinical trials?
- The lead sponsor across the most LY4268989 trials is Eli Lilly and Company. Each trial row links to the full study detail page including sponsor information.
Sources and methodology
Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming LY4268989as an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.
Last refreshed .
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