Lecanemab Clinical Trials (2026): 18 Studies for Alzheimer's Disease & Dementia

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

18 Lecanemab clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 9 indications (including Alzheimer's Disease & Dementia) and 6,369 total planned enrollment. 4 Phase 3 Lecanemab trials and 3 Phase 2 are listed. 8 Lecanemab clinical trials are actively recruiting at 1 U.S. site across 1 state. Most recent activity: NCT04468659 (Jan 2031).

Where to Participate: All Lecanemab Trial Sites in the U.S. (1 site across 1 state)

Every actively recruiting Lecanemabtrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
MABeth Israel Deaconess Medical CenterBoston02215NCT05925621Map

Lecanemab clinical trials at a glance: phase × recruitment status

Phaserecruitingactive not recruitingenrolling by invitationcompletednot yet recruitingTotal
Early P111
P122
P21113
P2/P322
P3134
N/A3126

Recruiting Lecanemab clinical trials (8)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT07212062The Purpose of This Study is to Evaluate the Safety and Tolerability of X/T+X-EC in Participants With Alzheimer's Disease Who Are Currently Treated With Lecanemab.P2Alzheimers Disease60Dec 2025
NCT07152418Therapeutic Efficacy of Monoclonal Antibody Drugs for Alzheimer's Disease Based on PET ResearchAlzheimer Disease (AD)120Sep 2025
NCT06285448Feasibility of Lecanemab Registry and Clinical Outcome MeasuresAlzheimer Disease20Jan 2024
NCT05925621Cognitive Neurology Unit Clinical RegistryAlzheimer Disease500Jul 2023
NCT07505095ADEfficacy of Lecanemab at Different Therapeutic Doses for Alzheimer's Disease (AD) in Real-World PracticeAlzheimer Disease (AD)140Apr 2026
NCT06741553Prospective Cohort Study of Patients With Early Alzheimer's Disease Treated With LecanemabAlzheimer Disease120Jun 2024
NCT06871839The Clinical Study of Synaptic Plasticity-based Lencanumab for the Treatment of Early Alzheimer's DiseaseAlzheimer's Disease120Mar 2025
NCT06530732Deep Cervical Lymphatlc-Venous Anastomosis Surgery for the Treatment of Alzheimer's Disease: A Pilot Study (DIVA Study)P3Alzheimer's Disease60Jul 2024

Lecanemab clinical trials by indication

Alzheimer's Disease (4)

NCTAcronymPhaseStatusTitle
NCT06384573DIAN-TUP3active not recruitingDIAN-TU Amyloid Removal Trial (ART) in Dominantly Inherited Alzheimer's Disease
NCT06602258P2active not recruitingA Study of E2814 With Concurrent Lecanemab Treatment in Participants With Early Alzheimer's Disease
NCT06530732P3recruitingDeep Cervical Lymphatlc-Venous Anastomosis Surgery for the Treatment of Alzheimer's Disease: A Pilot Study (DIVA Study)
NCT01767311P2completedA Study to Evaluate Safety, Tolerability, and Efficacy of Lecanemab in Subjects With Early Alzheimer's Disease

Alzheimers Disease (3)

NCTAcronymPhaseStatusTitle
NCT07212062P2not yet recruitingThe Purpose of This Study is to Evaluate the Safety and Tolerability of X/T+X-EC in Participants With Alzheimer's Disease Who Are Currently Treated With Lecanemab.
NCT05269394DIAN-TUP2/P3active not recruitingDominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)
NCT01760005DIAN-TUP2/P3active not recruitingDominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001

Alzheimer Disease (3)

NCTAcronymPhaseStatusTitle
NCT06285448N/Aenrolling by invitationFeasibility of Lecanemab Registry and Clinical Outcome Measures
NCT05925621N/ArecruitingCognitive Neurology Unit Clinical Registry
NCT06741553N/ArecruitingProspective Cohort Study of Patients With Early Alzheimer's Disease Treated With Lecanemab

Alzheimer Disease (AD) (2)

NCTAcronymPhaseStatusTitle
NCT07152418N/Anot yet recruitingTherapeutic Efficacy of Monoclonal Antibody Drugs for Alzheimer's Disease Based on PET Research
NCT07505095ADN/Anot yet recruitingEfficacy of Lecanemab at Different Therapeutic Doses for Alzheimer's Disease (AD) in Real-World Practice

Healthy Volunteers (2)

NCTAcronymPhaseStatusTitle
NCT05533801AIP1completedA Study to Demonstrate the Bioequivalence of Lecanemab Supplied in Vials and a Single-Use Auto-Injector (AI) in Healthy Participants
NCT05045716P1completedA Study of Subcutaneous Lecanemab in Healthy Participants

Alzheimer's Disease (1)

NCTAcronymPhaseStatusTitle
NCT06871839N/ArecruitingThe Clinical Study of Synaptic Plasticity-based Lencanumab for the Treatment of Early Alzheimer's Disease

Mild Cognitive Impairment (1)

NCTAcronymPhaseStatusTitle
NCT05469009Early P1active not recruitingSafety and Feasibility of Exablate Blood-Brain Barrier Disruption for Mild Cognitive Impairment or Mild Alzheimer's Disease Undergoing Standard of Care Monoclonal Antibody (mAb) Therapy

Preclinical Alzheimer's Disease (1)

NCTAcronymPhaseStatusTitle
NCT04468659P3active not recruitingAHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid

Early Alzheimer's Disease (1)

NCTAcronymPhaseStatusTitle
NCT03887455Clarity ADP3active not recruitingA Study to Confirm Safety and Efficacy of Lecanemab in Participants With Early Alzheimer's Disease

Lecanemab pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
DIAN-TUNCT06384573P3active not recruitingAlzheimer's Disease40
Clarity ADNCT03887455P3active not recruitingEarly Alzheimer's Disease1,906

All Lecanemab trials (18)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT04468659AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate AmyloidP3active not recruiting1,400Eisai Inc.Jul 2020
NCT06384573DIAN-TUDIAN-TU Amyloid Removal Trial (ART) in Dominantly Inherited Alzheimer's DiseaseP3active not recruiting40Washington University School of MedicineJun 2024
NCT05469009Safety and Feasibility of Exablate Blood-Brain Barrier Disruption for Mild Cognitive Impairment or Mild Alzheimer's Disease Undergoing Standard of Care Monoclonal Antibody (mAb) TherapyEarly P1active not recruiting15Ali RezaiJul 2022
NCT03887455Clarity ADA Study to Confirm Safety and Efficacy of Lecanemab in Participants With Early Alzheimer's DiseaseP3active not recruiting1,906Eisai Inc.Mar 2019
NCT07212062The Purpose of This Study is to Evaluate the Safety and Tolerability of X/T+X-EC in Participants With Alzheimer's Disease Who Are Currently Treated With Lecanemab.P2not yet recruiting60Neurology Office of South FloridaDec 2025
NCT07152418Therapeutic Efficacy of Monoclonal Antibody Drugs for Alzheimer's Disease Based on PET Researchnot yet recruiting120Second Affiliated Hospital, School of Medicine, Zhejiang UniversitySep 2025
NCT05269394DIAN-TUDominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)P2/P3active not recruiting197Washington University School of MedicineDec 2021
NCT01760005DIAN-TUDominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001P2/P3active not recruiting490Washington University School of MedicineDec 2012
NCT06285448Feasibility of Lecanemab Registry and Clinical Outcome Measuresenrolling by invitation20HealthPartners InstituteJan 2024
NCT05925621Cognitive Neurology Unit Clinical Registryrecruiting500Beth Israel Deaconess Medical CenterJul 2023
NCT07505095ADEfficacy of Lecanemab at Different Therapeutic Doses for Alzheimer's Disease (AD) in Real-World Practicenot yet recruiting140Second Affiliated Hospital, School of Medicine, Zhejiang UniversityApr 2026
NCT06602258A Study of E2814 With Concurrent Lecanemab Treatment in Participants With Early Alzheimer's DiseaseP2active not recruiting105Eisai Inc.Sep 2024
NCT06741553Prospective Cohort Study of Patients With Early Alzheimer's Disease Treated With Lecanemabrecruiting120Second Affiliated Hospital, School of Medicine, Zhejiang UniversityJun 2024
NCT06871839The Clinical Study of Synaptic Plasticity-based Lencanumab for the Treatment of Early Alzheimer's Diseaserecruiting120Cuibai Wei,Clinical ProfessorMar 2025
NCT06530732Deep Cervical Lymphatlc-Venous Anastomosis Surgery for the Treatment of Alzheimer's Disease: A Pilot Study (DIVA Study)P3recruiting60Zhejiang Provincial People's HospitalJul 2024
NCT01767311A Study to Evaluate Safety, Tolerability, and Efficacy of Lecanemab in Subjects With Early Alzheimer's DiseaseP2completed856Eisai Inc.Dec 2012
NCT05533801AIA Study to Demonstrate the Bioequivalence of Lecanemab Supplied in Vials and a Single-Use Auto-Injector (AI) in Healthy ParticipantsP1completed160Eisai Inc.Sep 2022
NCT05045716A Study of Subcutaneous Lecanemab in Healthy ParticipantsP1completed60Eisai Inc.Sep 2021

Lecanemab clinical trials: frequently asked questions

How many Lecanemab clinical trials are there?
18 Lecanemab clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 5 are actively recruiting participants. 3 are marked completed.
Are Lecanemab clinical trials recruiting in 2026?
Yes — 5 Lecanemab trials are actively recruiting in 2026, with 1 U.S. site across 1 state. See the recruiting trials and the per-state site list further down this page.
What conditions is Lecanemab being studied for?
Lecanemab is being studied for Alzheimer's Disease, Dementia, Alzheimer Disease, Alzheimers Disease, Alzheimer Disease (AD) and 14 more. The trials are grouped by indication on this page.
What phase is Lecanemab in?
Lecanemab clinical trials span 4 Phase 3, 3 Phase 2, 2 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Lecanemab clinical trials?
The lead sponsor across the most Lecanemab trials is Eisai Inc., with 8 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Lecanemabas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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Related pages on Hipa.ai:

Lecanemab Clinical Trials (2026): 18 Studies | Hipa.ai