Icalcaprant Clinical Trials (2026): 4 Studies for Healthy Volunteer & Bipolar I Disorder
Hipa.ai Research · Source: ClinicalTrials.gov / AACT
Synced daily from ClinicalTrials.gov via AACT. Last sync: .
4 Icalcaprant clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 3 indications (including Healthy Volunteer & Bipolar I Disorder) and 418 total planned enrollment. 2 Icalcaprant clinical trials are actively recruiting at 64 U.S. sites across 15 states. Most recent activity: NCT06696755 (Nov 2027).
Where to Participate: All Icalcaprant Trial Sites in the U.S. (64 sites across 15 states)
Every actively recruiting Icalcapranttrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.
| State | Facility | City | Trial | Map |
|---|---|---|---|---|
| AL | Harmonex /ID# 277517 | Dothan36303 | NCT07276997 | Map |
| AL | University of Alabama - Huntsville Regional Medical Campus /ID# 272951 | Huntsville35801 | NCT06696755 | Map |
| AZ | Chandler Clinical Research Trials /ID# 274500 | Chandler85224 | NCT06696755 | Map |
| AZ | Ima Clinical Research Phoenix (Alea) /ID# 277516 | Phoenix85012 | NCT07276997 | Map |
| AR | Sanro Clinical Research Group /ID# 279462 | Bryant72022 | NCT06696755 | Map |
| AR | Preferred Research Partner, Inc /ID# 279206 | Little Rock72211 | NCT07276997 | Map |
| AR | Woodland International Research Group /ID# 277605 | Little Rock72211 | NCT07276997 | Map |
| CA | Advanced Research Center /ID# 272828 | Anaheim92805 | NCT06696755 | Map |
| CA | Advanced Research Center /ID# 277537 | Anaheim92805 | NCT07276997 | Map |
| CA | Collaborative Neuroscience Research - Garden Grove /ID# 271917 | Garden Grove92845 | NCT06696755 | Map |
| CA | Sun Valley Research Center /ID# 277513 | Imperial92251 | NCT07276997 | Map |
| CA | Synergy San Diego /ID# 277553 | Lemon Grove91945 | NCT07276997 | Map |
| CA | Accellacare - Long Beach /ID# 279181 | Long Beach90807 | NCT07276997 | Map |
| CA | Catalina Research Institute, LLC /ID# 272831 | Montclair91763 | NCT06696755 | Map |
| CA | Excell Research /ID# 272854 | Oceanside92056 | NCT06696755 | Map |
| CA | Pacific Neuropsychiatric Specialists - Orange /ID# 273118 | Orange92868 | NCT06696755 | Map |
| CA | CenExel CNR /ID# 277533 | Sherman Oaks91403 | NCT07276997 | Map |
| CA | Schuster Medical Research Institute /ID# 272848 | Sherman Oaks91403 | NCT06696755 | Map |
| CA | Inland Psychiatric Medical Group Inc. /ID# 279275 | Temecula92591 | NCT07276997 | Map |
| CA | Sunwise Clinical Research /ID# 277555 | Walnut Creek94596 | NCT07276997 | Map |
| FL | CenExel Hollywood FL /ID# 273101 | Hollywood33024 | NCT06696755 | Map |
| FL | CenExel Hollywood FL /ID# 278200 | Hollywood33024 | NCT07276997 | Map |
| FL | Cns Healthcare - Jacksonville /ID# 277658 | Jacksonville32256 | NCT07276997 | Map |
| FL | Accel Research Sites Network - St. Pete /ID# 272962 | Largo33777 | NCT06696755 | Map |
| FL | GMI Florida - Central Miami Medical Institute /ID# 278218 | Miami33125 | NCT07276997 | Map |
| FL | Apg Research /ID# 272925 | Orlando32803 | NCT06696755 | Map |
| FL | Clinical Neuroscience Solutions - Orlando - East South Street /ID# 277558 | Orlando32801 | NCT07276997 | Map |
| FL | Combined Research Orlando Phase I-IV /ID# 279458 | Orlando32814 | NCT06696755 | Map |
| FL | Clinical Research Center Of Florida /ID# 278790 | Pompano Beach33060 | NCT06696755 | Map |
| FL | EquiPath Health & Research Tampa Bay, LLC /ID# 279128 | Riverview33578 | NCT07276997 | Map |
| FL | St. Johns Center for Clinical Research - Saint Augustine Location /ID# 279465 | Saint Augustine32086 | NCT06696755 | Map |
| FL | Neuroscience Institute - West Palm Beach /ID# 272922 | West Palm Beach33407 | NCT06696755 | Map |
| GA | Georgia Psychiatric Consultants & Advanced Discovery Research /ID# 279438 | Atlanta30318 | NCT06696755 | Map |
| GA | Trialmed /ID# 277601 | Atlanta30328 | NCT07276997 | Map |
| GA | Evergreen Clinical Trials - Norcross /ID# 279421 | Norcross30092 | NCT07276997 | Map |
| IL | Flourish Research - Great Lakes Clinical Trials /ID# 278201 | Chicago60640 | NCT07276997 | Map |
| IL | Pillar Clinical Research - Chicago /ID# 272823 | Chicago60641 | NCT06696755 | Map |
| IL | Amr Conventions Research /ID# 272867 | Warrenville60555 | NCT06696755 | Map |
| IL | Amr Conventions Research /ID# 277547 | Warrenville60555 | NCT07276997 | Map |
| MO | St. Charles Psychiatric Associates /ID# 279239 | Saint Charles63304 | NCT06696755 | Map |
| NV | Redbird Research /ID# 277485 | Las Vegas89119 | NCT07276997 | Map |
| NY | Ima Clinical Research - Manhattan /ID# 278212 | New York10036 | NCT07276997 | Map |
| NY | Manhattan Behavioral Medicine /ID# 277910 | New York10036 | NCT07276997 | Map |
| NY | Manhattan Behavioral Medicine /ID# 279769 | New York10036 | NCT06696755 | Map |
| OH | Quest Therapeutics of Avon /ID# 277550 | Avon Lake44012-1004 | NCT07276997 | Map |
| OH | University Of Cincinnati Medical Center /ID# 274160 | Cincinnati45219 | NCT06696755 | Map |
| OH | OSU Psychiatry Department /ID# 277529 | Columbus43210-1250 | NCT07276997 | Map |
| OH | The Ohio State University /ID# 272954 | Columbus43210 | NCT06696755 | Map |
| OK | Sooner Clinical Research /ID# 272856 | Oklahoma City73116 | NCT06696755 | Map |
| OK | Sooner Clinical Research /ID# 277659 | Oklahoma City73116 | NCT07276997 | Map |
| TN | CNS Healthcare - Memphis /ID# 278192 | Memphis38119 | NCT07276997 | Map |
| TX | Austin Clinical Trial Partners /ID# 279321 | Austin78737 | NCT07276997 | Map |
| TX | Community Clinical Research - Austin - Cross Park Drive /ID# 272940 | Austin78754 | NCT06696755 | Map |
| TX | Community Clinical Research - Austin - Cross Park Drive /ID# 277935 | Austin78754 | NCT07276997 | Map |
| TX | Houston Clinical Trials - Bellaire /ID# 277551 | Bellaire77401 | NCT07276997 | Map |
| TX | Elixia - Houston /ID# 279200 | Houston77007 | NCT06696755 | Map |
| TX | Mind Matters Psychiatry /ID# 273536 | Missouri City77459-5204 | NCT06696755 | Map |
| TX | Pillar Clinical Research - Richardson /ID# 272821 | Richardson75080 | NCT06696755 | Map |
| TX | Pillar Clinical Research - Richardson /ID# 276764 | Richardson75080 | NCT07276997 | Map |
| TX | Family Psychiatry Of The Woodlands /ID# 275177 | The Woodlands77381 | NCT06696755 | Map |
| WA | Northwest Clinical Research Center /ID# 272847 | Bellevue98007 | NCT06696755 | Map |
| WA | Northwest Clinical Research Center /ID# 277484 | Bellevue98007 | NCT07276997 | Map |
| WA | Core Clinical Research /ID# 272955 | Everett98201 | NCT06696755 | Map |
| WA | Core Clinical Research /ID# 277518 | Everett98201 | NCT07276997 | Map |
Icalcaprant clinical trials at a glance: phase × recruitment status
| Phase | recruiting | completed | Total |
|---|---|---|---|
| P1 | 2 | 2 | |
| P2 | 2 | 2 |
Recruiting Icalcaprant clinical trials (2)
Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).
| NCT ID | Title | Phase | Indication | Enrollment | Started |
|---|---|---|---|---|---|
| NCT06696755 | A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder | P2 | Bipolar I Disorder | 195 | Feb 2026 |
| NCT07276997 | A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder | P2 | Major Depressive Disorder | 195 | Dec 2025 |
Icalcaprant clinical trials by indication
Healthy Volunteer (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06722417 | 528 Asian PK | P1 | completed | A Single Dose Study to Assess Adverse Events and How Oral Icalcaprant Moves Through the Body in Healthy Adult Japanese and Han Chinese Participants |
| NCT06722430 | 529 DDI ITZ | P1 | completed | A Study to Assess Change in How Oral Icalcaprant With Itraconazole Moves Through the Body in Healthy Adult Participants |
Bipolar I Disorder (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06696755 | — | P2 | recruiting | A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder |
Major Depressive Disorder (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07276997 | — | P2 | recruiting | A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder |
All Icalcaprant trials (4)
Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.
| NCT ID | Acronym | Title | Phase | Status | Enrollment | Sponsor | Started |
|---|---|---|---|---|---|---|---|
| NCT06696755 | A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder | P2 | recruiting | 195 | AbbVie | Feb 2026 | |
| NCT07276997 | A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder | P2 | recruiting | 195 | AbbVie | Dec 2025 | |
| NCT06722417 | 528 Asian PK | A Single Dose Study to Assess Adverse Events and How Oral Icalcaprant Moves Through the Body in Healthy Adult Japanese and Han Chinese Participants | P1 | completed | 16 | AbbVie | Nov 2024 |
| NCT06722430 | 529 DDI ITZ | A Study to Assess Change in How Oral Icalcaprant With Itraconazole Moves Through the Body in Healthy Adult Participants | P1 | completed | 12 | AbbVie | Nov 2024 |
Icalcaprant clinical trials: frequently asked questions
- How many Icalcaprant clinical trials are there?
- 4 Icalcaprant clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 2 are actively recruiting participants. 2 are marked completed.
- Are Icalcaprant clinical trials recruiting in 2026?
- Yes — 2 Icalcaprant trials are actively recruiting in 2026, with 64 U.S. sites across 15 states. See the recruiting trials and the per-state site list further down this page.
- What conditions is Icalcaprant being studied for?
- Icalcaprant is being studied for Healthy Volunteer, Bipolar I Disorder, Bipolar II Disorder, Major Depressive Disorder. The trials are grouped by indication on this page.
- What phase is Icalcaprant in?
- Icalcaprant clinical trials span 2 Phase 2, 2 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
- Who sponsors Icalcaprant clinical trials?
- The lead sponsor across the most Icalcaprant trials is AbbVie. Each trial row links to the full study detail page including sponsor information.
Sources and methodology
Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Icalcaprantas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.
Last refreshed .
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