Empasiprubart IV Clinical Trials (2026): 8 Studies for AChR-Ab Seropositive Generalized Myasthenia Gravis & Chronic Inflammatory Demyelinating Polyneuropathy

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

8 Empasiprubart IV clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 6 indications (including AChR-Ab Seropositive Generalized Myasthenia Gravis & Chronic Inflammatory Demyelinating Polyneuropathy) and 865 total planned enrollment. 3 Phase 3 Empasiprubart IV trials and 2 Phase 2 are listed. 6 Empasiprubart IV clinical trials are actively recruiting at 37 U.S. sites across 12 states. Most recent activity: NCT07091630 (Jan 2031).

Where to Participate: All Empasiprubart IV Trial Sites in the U.S. (37 sites across 12 states)

Every actively recruiting Empasiprubart IVtrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
CAProfound Research LLC - CarlsbadCarlsbad92011NCT07284420Map
CAProfound Research LLC - CarlsbadCarlsbad92011NCT07294170Map
CASamir Macwan, M.D., Inc.Rancho Mirage922701NCT06920004Map
CASamir Macwan, M.D., Inc. (S corporation)Rancho Mirage92270NCT07091630Map
COColorado Springs Neurological AssociatesColorado Springs80907NCT06920004Map
COColorado Springs Neurological AssociatesColorado Springs80907NCT07091630Map
DCMedstar Health Research InstituteWashington D.C.20010NCT07091630Map
DCMedStar Washington Hospital CenterWashington D.C.20010NCT06920004Map
FLHomestead Associates in Research IncHomestead33033NCT06920004Map
FLGables NeurologyMiami33133NCT07091630Map
FLVisionary Investigators NetworkMiami33133NCT06920004Map
FLVisionary Investigators NetworkMiami33176NCT07284420Map
FLVisionary Investigators NetworkMiami33133NCT07294170Map
FLAqualane Clinical ResearchNaples34105NCT07091630Map
FLUniversity of South FloridaTampa33616NCT06920004Map
FLUniversity of South FloridaTampa33620NCT07284420Map
FLUniversity of South FloridaTampa33620NCT07294170Map
LAParadigm Health SystemSlidell70458NCT06920004Map
LAParadigm Health SystemSlidell70458NCT07091630Map
MDErlanger Health SystemColumbia21044NCT06920004Map
MDErlanger Health SystemColumbia21044NCT07294170Map
MIUniversity of Michigan HospitalAnn Arbor48109NCT06920004Map
NYDent Neurologic Institute - AmherstAmherst14226NCT07284420Map
NYDent Neurologic Institute - AmherstAmherst14226NCT07294170Map
OHOhio State Martha Morehouse Outpatient CareColumbus43221-3502NCT07284420Map
OHOhio State Martha Morehouse Outpatient CareColumbus43221-3502NCT07294170Map
PAPenn Medicine University CityPhiladelphia19104-5545NCT07091630Map
TNErlanger Health SystemChattanooga37403NCT07284420Map
TNErlanger Health SystemChattanooga37403-2136NCT07294170Map
TXNational Neuromuscular Research InstituteAustin78756NCT07091630Map
TXNational Neuromuscular Research InstituteAustin78756NCT07284420Map
TXNational Neuromuscular Research InstituteAustin78759NCT07294170Map
TXNeuroCarePlusHouston77094NCT06920004Map
TXNeuroCarePlusHouston77094NCT07091630Map
TXNational Neuromuscular Research InstituteIrving75063NCT06920004Map
TXUniversity of Texas- San Antonio - Health Science Center - PPDSSan Antonio78229NCT07284420Map
TXUniversity of Texas- San Antonio - Health Science Center - PPDSSan Antonio78229NCT07294170Map

Empasiprubart IV clinical trials at a glance: phase × recruitment status

Phaserecruitingactive not recruitingnot yet recruitingTotal
P1112
P2112
P3213
N/A11

Recruiting Empasiprubart IV clinical trials (6)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT07091630emnergizeA Study to Assess the Efficacy and Safety of Empasiprubart in Adults With CIDPP3Chronic Inflammatory Demyelinating Polyneuropathy160Sep 2025
NCT06920004emvigorateA Study to Assess Efficacy and Safety of Empasiprubart Versus IVIg in Adults With CIDPP3Chronic Inflammatory Demyelinating Polyneuropathy218Aug 2025
NCT07610564EmpaSoundA Study to Assess the Effect of Empasiprubart on Nerve Morphology by Ultrasound in Adults With Multifocal Motor NeuropathyP1Multifocal Motor Neuropathy (MMN)60Jun 2026
NCT07284420ADAPT Forward 1 - ISA1 - a Study to Evaluate Empasiprubart IV as add-on Therapy to Efgartigimod IV in Participants With AChR-Ab Seropositive Generalized Myasthenia Gravis With a Partial Clinical Response to EfgartigimodP2AChR-Ab Seropositive Generalized Myasthenia Gravis70Dec 2025
NCT07294170ADAPT Forward - Master Protocol of a Platform Study to Evaluate the Safety and Efficacy of Multiple Regimens in Participants With Myasthenia GravisMyasthenia Gravis70Dec 2025
NCT07612020IVA Study to Assess the Absolute Bioavailability of Empasiprubart SC Administered With an Autoinjector and the Pharmacokinetic Noninferiority of Empasiprubart SC Versus Intravenous (IV) in Healthy Adult ParticipantsP1Healthy Volunteers130Mar 2026

Empasiprubart IV clinical trials by indication

Multifocal Motor Neuropathy (MMN) (2)

NCTAcronymPhaseStatusTitle
NCT07610564EmpaSoundP1not yet recruitingA Study to Assess the Effect of Empasiprubart on Nerve Morphology by Ultrasound in Adults With Multifocal Motor Neuropathy
NCT06742190EmpassionP3active not recruitingA Study to Assess the Efficacy and Safety of Empasiprubart Versus IVIg in Adults With Multifocal Motor Neuropathy

Chronic Inflammatory Demyelinating Polyneuropathy (2)

NCTAcronymPhaseStatusTitle
NCT07091630emnergizeP3recruitingA Study to Assess the Efficacy and Safety of Empasiprubart in Adults With CIDP
NCT06920004emvigorateP3recruitingA Study to Assess Efficacy and Safety of Empasiprubart Versus IVIg in Adults With CIDP

Healthy Volunteers (1)

NCTAcronymPhaseStatusTitle
NCT07612020IVP1recruitingA Study to Assess the Absolute Bioavailability of Empasiprubart SC Administered With an Autoinjector and the Pharmacokinetic Noninferiority of Empasiprubart SC Versus Intravenous (IV) in Healthy Adult Participants

AChR-Ab Seropositive Generalized Myasthenia Gravis (1)

NCTAcronymPhaseStatusTitle
NCT07284420P2recruitingADAPT Forward 1 - ISA1 - a Study to Evaluate Empasiprubart IV as add-on Therapy to Efgartigimod IV in Participants With AChR-Ab Seropositive Generalized Myasthenia Gravis With a Partial Clinical Response to Efgartigimod

Myasthenia Gravis (1)

NCTAcronymPhaseStatusTitle
NCT07294170N/ArecruitingADAPT Forward - Master Protocol of a Platform Study to Evaluate the Safety and Efficacy of Multiple Regimens in Participants With Myasthenia Gravis

Dermatomyositis (1)

NCTAcronymPhaseStatusTitle
NCT06284954empacificP2active not recruitingA Study to Evaluate Safety and Efficacy of Empasiprubart in Adults With Dermatomyositis

Empasiprubart IV pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
emnergizeNCT07091630P3recruitingChronic Inflammatory Demyelinating Polyneuropathy160
emvigorateNCT06920004P3recruitingChronic Inflammatory Demyelinating Polyneuropathy218
EmpassionNCT06742190P3active not recruitingMultifocal Motor Neuropathy (MMN)154PMID 40913126
empacificNCT06284954P2active not recruitingDermatomyositis3

All Empasiprubart IV trials (8)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT07091630emnergizeA Study to Assess the Efficacy and Safety of Empasiprubart in Adults With CIDPP3recruiting160argenxSep 2025
NCT06920004emvigorateA Study to Assess Efficacy and Safety of Empasiprubart Versus IVIg in Adults With CIDPP3recruiting218argenxAug 2025
NCT07610564EmpaSoundA Study to Assess the Effect of Empasiprubart on Nerve Morphology by Ultrasound in Adults With Multifocal Motor NeuropathyP1not yet recruiting60argenxJun 2026
NCT06742190EmpassionA Study to Assess the Efficacy and Safety of Empasiprubart Versus IVIg in Adults With Multifocal Motor NeuropathyP3active not recruiting154argenxDec 2024
NCT07284420ADAPT Forward 1 - ISA1 - a Study to Evaluate Empasiprubart IV as add-on Therapy to Efgartigimod IV in Participants With AChR-Ab Seropositive Generalized Myasthenia Gravis With a Partial Clinical Response to EfgartigimodP2recruiting70argenxDec 2025
NCT07294170ADAPT Forward - Master Protocol of a Platform Study to Evaluate the Safety and Efficacy of Multiple Regimens in Participants With Myasthenia Gravisrecruiting70argenxDec 2025
NCT07612020IVA Study to Assess the Absolute Bioavailability of Empasiprubart SC Administered With an Autoinjector and the Pharmacokinetic Noninferiority of Empasiprubart SC Versus Intravenous (IV) in Healthy Adult ParticipantsP1recruiting130argenxMar 2026
NCT06284954empacificA Study to Evaluate Safety and Efficacy of Empasiprubart in Adults With DermatomyositisP2active not recruiting3argenxAug 2024

Empasiprubart IV clinical trials: frequently asked questions

How many Empasiprubart IV clinical trials are there?
8 Empasiprubart IV clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 5 are actively recruiting participants.
Are Empasiprubart IV clinical trials recruiting in 2026?
Yes — 5 Empasiprubart IV trials are actively recruiting in 2026, with 37 U.S. sites across 12 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Empasiprubart IV being studied for?
Empasiprubart IV is being studied for AChR-Ab Seropositive Generalized Myasthenia Gravis, Chronic Inflammatory Demyelinating Polyneuropathy, Generalized Myasthenia Gravis, Generalized Myasthenia Gravis (gMG), gMG and 10 more. The trials are grouped by indication on this page.
What phase is Empasiprubart IV in?
Empasiprubart IV clinical trials span 3 Phase 3, 2 Phase 2, 2 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Empasiprubart IV clinical trials?
The lead sponsor across the most Empasiprubart IV trials is argenx. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Empasiprubart IVas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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