Cenobamate Evidence: Trial Results and Peer-Reviewed Publications

Top peer-reviewed publications

Curated set of pivotal-trial result papers and recent publications in high-tier journals.

1. Efficacy of adjunctive cenobamate by focal seizure subtypes: a randomized, double-blind, placebo-controlled, multicenter study in a multinational Asian population.
   Wu X, Chen L, Choe E, et al. · Seizure · 2025
   PubMed: PMID 41101116 · NCT04557085 · Seizures
2. Efficacy of cenobamate by focal seizure subtypes: Post-hoc analysis of a phase 3, multicenter, open-label study.
   Rosenfeld WE, Ferrari L, Kamin M, et al. · Epilepsy Res · 2022
   PubMed: PMID 35605481 · NCT03678753 · Seizures
3. Cenobamate add-on therapy for drug-resistant focal epilepsy.
   Brigo F, Lattanzi S · Cochrane Database Syst Rev · 2024
   PubMed: PMID 39087564 · NCT03678753 · Seizures
4. Safe Use of Cenobamate in Super Refractory Status Epilepticus: A Case Series.
   Carlson JM, Molyneaux BJ, Lee JW, et al. · Neurohospitalist · 2024
   PubMed: PMID 37064924 · NCT06352723 (CENOBITE) · Epilepsy

Publications by year

2022–2025: 4 publications.

Publications by indication

Publications by journal

• Seizure1 paper
• Epilepsy Res1 paper
• Cochrane Database Syst Rev1 paper
• Neurohospitalist1 paper

All Cenobamate publications (4)

Sources and methodology

• Publications: ctgov.study_references (PubMed PMIDs auto-attached by ClinicalTrials.gov to each trial), reference types RESULT, DERIVED, and BACKGROUND.
• Per-arm outcome values: ctgov.outcome_measurements joined to ctgov.design_outcomes where outcome_type = 'PRIMARY', restricted to phase PHASE3 and PHASE2/PHASE3.
• Publication metadata (title, journal, year, authors): PubMed E-utilities efetch.fcgi
• Data freshness: Tue, 26 May 2026 18:05:39 GMT.