Synced daily from ClinicalTrials.gov via AACT. Last sync: .
11 Brexanolone clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 9 indications (including Postpartum Depression & Alcohol Use Disorder) and 164 total planned enrollment. 2 Phase 3 Brexanolone trials and 2 Phase 2, 3 Phase 4 are listed. 1 Brexanolone clinical trial is actively recruiting. Most recent activity: NCT06580444 (Mar 2027).
Brexanolone clinical trials at a glance: phase × recruitment status
Phase
active not recruiting
completed
terminated
withdrawn
not yet recruiting
approved for marketing
Total
Early P1
1
1
P1
1
1
P2
1
1
2
P3
1
1
2
P4
2
1
3
N/A
1
1
2
Recruiting Brexanolone clinical trials (1)
Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).
Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.
NCT05254405terminatedAn Open Label Pilot Study of IV Brexanolone for the Treatment of Post-Traumatic Stress Disorder
NCT05329779terminatedStudy on Allopregnanolone and Depression in Perimenopausal Women
NCT04273191withdrawnA Study to Evaluate Multimodal Neuroimaging Parameters in Women With Postpartum Depression Who Are Receiving ZULRESSO™ (Brexanolone)
NCT04537806terminatedA Study of Brexanolone for Acute Respiratory Distress Syndrome (ARDS) Due to Coronavirus Disease 2019 (COVID-19)
All Brexanolone trials (11)
Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.
11 Brexanolone clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 4 are marked completed.
Are Brexanolone clinical trials recruiting in 2026?
No active Brexanolone trials are recruiting on ClinicalTrials.gov as of the current AACT refresh. Trials may resume; this page is updated daily.
What conditions is Brexanolone being studied for?
Brexanolone is being studied for Postpartum Depression, Alcohol Use Disorder, Alcohol Use Disorder (AUD), COVID-19, Depression and 7 more. The trials are grouped by indication on this page.
What phase is Brexanolone in?
Brexanolone clinical trials span 3 Phase 4, 2 Phase 3, 2 Phase 2, 1 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Brexanolone clinical trials?
The lead sponsor across the most Brexanolone trials is Supernus Pharmaceuticals, Inc., with 6 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.
Sources and methodology
Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Brexanoloneas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.