Avacopan Clinical Trials (2026): 15 Studies for Acne Inversa & ANCA-Associated Vasculitis
Hipa.ai Research · Source: ClinicalTrials.gov / AACT
Synced daily from ClinicalTrials.gov via AACT. Last sync: .
15 Avacopan clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 15 indications (including Acne Inversa & ANCA-Associated Vasculitis) and 1,862 total planned enrollment. 3 Phase 3 Avacopan trials and 3 Phase 2, 2 Phase 4 are listed. 8 Avacopan clinical trials are actively recruiting at 70 U.S. sites across 29 states. Most recent activity: NCT06072482 (Dec 2036).
Where to Participate: All Avacopan Trial Sites in the U.S. (70 sites across 29 states)
Every actively recruiting Avacopantrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.
| State | Facility | City | Trial | Map |
|---|---|---|---|---|
| AZ | Scottsdale Healthcare at Shea - HonorHealth | Scottsdale85258 | NCT06072482 | Map |
| AZ | Southwest Kidney Institute | Surprise85374 | NCT06072482 | Map |
| AR | Unity Health | Searcy72143 | NCT06072482 | Map |
| CA | Palo Alto Medical Foundation Fremont | Fremont94538 | NCT06072482 | Map |
| CA | The Nephrology Group | Fresno93720 | NCT06072482 | Map |
| CA | Providence Medical Foundation | Fullerton92835 | NCT06072482 | Map |
| CA | Southland Arthritis and Osteoarthritis Medical Center, Inc | Menifee92586 | NCT06072482 | Map |
| CA | University of California San Francisco- Zuckerburg San Francisco General | San Francisco94110 | NCT06072482 | Map |
| CA | Harbor University of California at Los Angeles Medical Center | Torrance90502 | NCT06072482 | Map |
| CO | University of Colorado | Aurora80045 | NCT06072482 | Map |
| FL | Florida Kidney Physicians | Boca Raton33431 | NCT06072482 | Map |
| FL | Malcom Randall Veterans Affairs Medical Center | Gainesville32608 | NCT06072482 | Map |
| FL | Mayo Clinic | Jacksonville32224 | NCT06072482 | Map |
| FL | Mayo Clinic in Florida | Jacksonville32224 | NCT06676579 | Map |
| FL | ClinTrial Research Oakwater, Llc | Orlando32806 | NCT06072482 | Map |
| FL | University of South Florida | Tampa33606 | NCT06072482 | Map |
| GA | Emory University | Atlanta30322 | NCT06072482 | Map |
| GA | Emory University | Atlanta30322 | NCT06321601 | Map |
| IN | Riley Hospital for Children | Indianapolis46202 | NCT06321601 | Map |
| IN | Lake Cumberland Rheumatology | New Albany47150 | NCT06072482 | Map |
| IA | University of Iowa Hospitals and Clinics | Iowa City52242 | NCT06072482 | Map |
| IA | Dunes Clinical Research LLC | Sioux City51104 | NCT06072482 | Map |
| KY | University of Kentucky | Lexington40536 | NCT06072482 | Map |
| MD | Johns Hopkins Bayview Medical Center | Baltimore21224 | NCT06072482 | Map |
| MA | Brigham and Womens Hospital | Boston02115 | NCT06072482 | Map |
| MA | Massachusetts General Hospital | Boston02114 | NCT06072482 | Map |
| MI | Henry Ford Health System | Detroit48202 | NCT06072482 | Map |
| MI | Kidney Michigan Institute | Saginaw49804 | NCT06072482 | Map |
| MI | Clinical Research Institute of Michigan | Saint Clair Shores48081 | NCT06072482 | Map |
| MI | Revive Research Institute | Sterling Heights48313 | NCT06072482 | Map |
| MN | University of Minnesota | Minneapolis55414 | NCT06072482 | Map |
| MN | University of Minnesota Masonic Childrens Hospital Discovery Clinic | Minneapolis55454 | NCT06321601 | Map |
| MN | Mayo Clinic | Rochester55905 | NCT06072482 | Map |
| MN | Mayo Clinic in Rochester | Rochester55905 | NCT06676579 | Map |
| MN | Mayo Clinic in Rochester | Rochester55905 | NCT07556484 | Map |
| NV | Renown Rheumatology | Reno89502 | NCT06072482 | Map |
| NH | Dartmouth Hitchcock Medical Center | Lebanon03766 | NCT06072482 | Map |
| NM | Renal Medicine Associates | Albuquerque87109 | NCT06072482 | Map |
| NY | New York Nephrology Vasculitis and Glomerular Center | Albany12209 | NCT06072482 | Map |
| NY | Northwell Health | Great Neck11021 | NCT06072482 | Map |
| NY | Cohen Children Medical Center | Lake Success11042 | NCT06321601 | Map |
| NY | Hospital For Special Surgery | New York10021 | NCT06072482 | Map |
| NC | University of North Carolina | Chapel Hill27599 | NCT06321601 | Map |
| NC | Wake Forest University Health Sciences | Charlotte28203 | NCT06321601 | Map |
| NC | Carolina Kidney Associates | Greensboro27405 | NCT06072482 | Map |
| NC | East Carolina University Brody Outpatient Center | Greenville27834 | NCT06072482 | Map |
| NC | Brookview Hills Research Associates Llc | Winston-Salem27103 | NCT06072482 | Map |
| OH | Akron Childrens Hospital | Akron44308 | NCT06321601 | Map |
| OH | Cleveland Clinic Foundation | Cleveland44195 | NCT06321601 | Map |
| OH | University Hospitals Cleveland Medical Center | Cleveland44106 | NCT06072482 | Map |
| OH | The Ohio State University | Columbus43201 | NCT06072482 | Map |
| OH | Stat Research | Miamisburg45342 | NCT06072482 | Map |
| OK | Hightower Clinical | Oklahoma City73114 | NCT06072482 | Map |
| OR | Oregon Health and Science University | Portland97239 | NCT06072482 | Map |
| PA | University of Pennsylvania | Philadelphia19104 | NCT06072482 | Map |
| PA | Allegheny Health Network Cancer Institute at Mellon Pavilion | Pittsburgh15224 | NCT06072482 | Map |
| PA | University of Pittsburgh Medical Center | Pittsburgh15213 | NCT06072482 | Map |
| PA | University of Pittsburgh Medical Center Childrens Hospital of Pittsburgh | Pittsburgh15224 | NCT06321601 | Map |
| RI | Nephrology Associates Inc | East Providence02914 | NCT06072482 | Map |
| SC | Medical University of South Carolina | Charleston29425 | NCT06072482 | Map |
| TN | West Tennessee Research Institute | Jackson38305 | NCT06072482 | Map |
| TN | Vanderbilt University Medical Center | Nashville37232 | NCT06072482 | Map |
| TX | Vital Rheumatology | Austin78727 | NCT06072482 | Map |
| TX | Renal Disease Research Institute - Landry Office | Dallas75204 | NCT06072482 | Map |
| TX | Texas Childrens Hospital | Houston77030 | NCT06321601 | Map |
| TX | Epic Medical Research - Red Oak | Red Oak75154 | NCT06072482 | Map |
| TX | Scott and White Memorial Hospital | Temple76502 | NCT06072482 | Map |
| VA | Nephrology Associates of Northern Virginia Inc | Fairfax22033 | NCT06072482 | Map |
| WV | Rheumatology and Pulmonary Clinic | Beckley25801 | NCT06072482 | Map |
| WI | Medical College of Wisconsin | Milwaukee53226 | NCT06072482 | Map |
Avacopan clinical trials at a glance: phase × recruitment status
| Phase | recruiting | completed | not yet recruiting | Total |
|---|---|---|---|---|
| P1 | 1 | 4 | 5 | |
| P2 | 1 | 2 | 3 | |
| P2/P3 | 1 | 1 | ||
| P3 | 1 | 1 | 1 | 3 |
| P4 | 2 | 2 | ||
| N/A | 1 | 1 |
Recruiting Avacopan clinical trials (8)
Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).
| NCT ID | Title | Phase | Indication | Enrollment | Started |
|---|---|---|---|---|---|
| NCT06072482 | A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis | P4 | Antineutrophil Cytoplasmic Antibody-associated Vasculitis | 300 | Feb 2024 |
| NCT07176546 | TAVNEOS for Otolaryngologic Manifestations of Granulomatosis With Polyangiitis | P2/P3 | Granulomatosis With Polyangiitis | 30 | Jul 2026 |
| NCT07373262 | REVERSEAvacopan Added to Standard-of-care Therapy in ANCA-associated Vasculitis With Severe Kidney Involvement | P3 | ANCA-Associated Vasculitis (AAV) | 130 | Mar 2026 |
| NCT06676579 | Avacopan in Crescentic Immunoglobulin A Nephropathy (IgAN) | P2 | IgA Nephropathy (IgAN) | 16 | Jun 2025 |
| NCT06611696 | ARRIAAvacopan vs Reduced-dose Glucocorticoids in ANCA-associated Vasculitis | P4 | ANCA Associated Vasculitis (AAV) | 160 | Nov 2024 |
| NCT06321601 | Study to Evaluate Avacopan in Combination With a Rituximab or Cyclophosphamide-containing Regimen, in Children From 6 Years to < 18 Years of Age With AAV. | P3 | Vasculitis | 20 | Oct 2024 |
| NCT06758271 | Special Drug Use-results Survey for Long-term Use（Avacopan） | — | Microscopic Polyangiitis (MPA) | 250 | Jul 2022 |
| NCT07556484 | Pharmacokinetics Of Emulsified Avacopan Applied By NG Tube | P1 | Diffuse Alveolar Hemorrhage | 6 | May 2026 |
Avacopan clinical trials by indication
Granulomatosis With Polyangiitis (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07176546 | — | P2/P3 | not yet recruiting | TAVNEOS for Otolaryngologic Manifestations of Granulomatosis With Polyangiitis |
Diffuse Alveolar Hemorrhage (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07556484 | — | P1 | recruiting | Pharmacokinetics Of Emulsified Avacopan Applied By NG Tube |
ANCA-Associated Vasculitis (AAV) (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07373262 | REVERSE | P3 | not yet recruiting | Avacopan Added to Standard-of-care Therapy in ANCA-associated Vasculitis With Severe Kidney Involvement |
IgA Nephropathy (IgAN) (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06676579 | — | P2 | recruiting | Avacopan in Crescentic Immunoglobulin A Nephropathy (IgAN) |
ANCA Associated Vasculitis (AAV) (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06611696 | ARRIA | P4 | recruiting | Avacopan vs Reduced-dose Glucocorticoids in ANCA-associated Vasculitis |
Vasculitis (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06321601 | — | P3 | recruiting | Study to Evaluate Avacopan in Combination With a Rituximab or Cyclophosphamide-containing Regimen, in Children From 6 Years to < 18 Years of Age With AAV. |
End-Stage Renal Disease (ESRD) (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06468826 | ESRD | P1 | completed | A Study of Avacopan in Participants With Normal Renal Function and Participants With End-Stage Renal Disease (ESRD) |
Antineutrophil Cytoplasmic Antibody-associated Vasculitis (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06072482 | — | P4 | recruiting | A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis |
Microscopic Polyangiitis (MPA) (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06758271 | — | N/A | recruiting | Special Drug Use-results Survey for Long-term Use（Avacopan） |
Healthy Volunteers (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06207682 | PK | P1 | completed | Effect of Repeated Oral Doses of Avacopan on the Pharmacokinetics (PK) of a Single Dose of Simvastatin |
Electrocardiography (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05988034 | — | P1 | completed | A Study to Assess the Effect of Avacopan at Therapeutic and Supratherapeutic Doses on the QT/QTc Interval in Healthy Participants |
Hidradenitis Suppurativa (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT03852472 | AURORA | P2 | completed | Evaluation of Safety and Efficacy of Avacopan in Subjects With Moderate to Severe Hidradenitis Suppurativa (AURORA) |
Hepatic Impairment (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06004934 | CCX168 | P1 | completed | A Study to Evaluate the Pharmacokinetics of Avacopan (CCX168) in Participants With Mild or Moderate Hepatic Impairment |
C3 Glomerulopathy (C3G) (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT03301467 | ACCOLADE | P2 | completed | Controlled Trial Evaluating Avacopan in C3 Glomerulopathy |
ANCA-Associated Vasculitis (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT02994927 | ADVOCATE | P3 | completed | A Phase 3 Clinical Trial of CCX168 (Avacopan) in Patients With ANCA-Associated Vasculitis |
Avacopan pivotal trial highlights (Phase 2/3/4)
Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.
| Acronym | NCT | Phase | Status | Indication | Enrollment | PubMed |
|---|---|---|---|---|---|---|
| ARRIA | NCT06611696 | P4 | recruiting | ANCA Associated Vasculitis (AAV) | 160 | PMID 35110332 |
| REVERSE | NCT07373262 | P3 | not yet recruiting | ANCA-Associated Vasculitis (AAV) | 130 | — |
| ADVOCATE | NCT02994927 | P3 | completed | ANCA-Associated Vasculitis | 331 | PMID 35167187 |
| ACCOLADE | NCT03301467 | P2 | completed | C3 Glomerulopathy (C3G) | 57 | PMID 39392695 |
| AURORA | NCT03852472 | P2 | completed | Hidradenitis Suppurativa | 435 | — |
All Avacopan trials (15)
Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.
| NCT ID | Acronym | Title | Phase | Status | Enrollment | Sponsor | Started |
|---|---|---|---|---|---|---|---|
| NCT06072482 | A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis | P4 | recruiting | 300 | Amgen | Feb 2024 | |
| NCT07176546 | TAVNEOS for Otolaryngologic Manifestations of Granulomatosis With Polyangiitis | P2/P3 | not yet recruiting | 30 | Robert Spiera, MD | Jul 2026 | |
| NCT07373262 | REVERSE | Avacopan Added to Standard-of-care Therapy in ANCA-associated Vasculitis With Severe Kidney Involvement | P3 | not yet recruiting | 130 | University Hospital, Toulouse | Mar 2026 |
| NCT06676579 | Avacopan in Crescentic Immunoglobulin A Nephropathy (IgAN) | P2 | recruiting | 16 | Mayo Clinic | Jun 2025 | |
| NCT06611696 | ARRIA | Avacopan vs Reduced-dose Glucocorticoids in ANCA-associated Vasculitis | P4 | recruiting | 160 | Chiba University | Nov 2024 |
| NCT06321601 | Study to Evaluate Avacopan in Combination With a Rituximab or Cyclophosphamide-containing Regimen, in Children From 6 Years to < 18 Years of Age With AAV. | P3 | recruiting | 20 | Amgen | Oct 2024 | |
| NCT06758271 | Special Drug Use-results Survey for Long-term Use（Avacopan） | — | recruiting | 250 | Kissei Pharmaceutical Co., Ltd. | Jul 2022 | |
| NCT07556484 | Pharmacokinetics Of Emulsified Avacopan Applied By NG Tube | P1 | recruiting | 6 | Mayo Clinic | May 2026 | |
| NCT06468826 | ESRD | A Study of Avacopan in Participants With Normal Renal Function and Participants With End-Stage Renal Disease (ESRD) | P1 | completed | 13 | Amgen | Jun 2024 |
| NCT06207682 | PK | Effect of Repeated Oral Doses of Avacopan on the Pharmacokinetics (PK) of a Single Dose of Simvastatin | P1 | completed | 32 | Amgen | Jun 2022 |
| NCT03301467 | ACCOLADE | Controlled Trial Evaluating Avacopan in C3 Glomerulopathy | P2 | completed | 57 | Amgen | Sep 2017 |
| NCT03852472 | AURORA | Evaluation of Safety and Efficacy of Avacopan in Subjects With Moderate to Severe Hidradenitis Suppurativa (AURORA) | P2 | completed | 435 | Amgen | Dec 2018 |
| NCT05988034 | A Study to Assess the Effect of Avacopan at Therapeutic and Supratherapeutic Doses on the QT/QTc Interval in Healthy Participants | P1 | completed | 58 | Amgen | Nov 2019 | |
| NCT02994927 | ADVOCATE | A Phase 3 Clinical Trial of CCX168 (Avacopan) in Patients With ANCA-Associated Vasculitis | P3 | completed | 331 | Amgen | Mar 2017 |
| NCT06004934 | CCX168 | A Study to Evaluate the Pharmacokinetics of Avacopan (CCX168) in Participants With Mild or Moderate Hepatic Impairment | P1 | completed | 24 | Amgen | Apr 2018 |
Avacopan clinical trials: frequently asked questions
- How many Avacopan clinical trials are there?
- 15 Avacopan clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 6 are actively recruiting participants. 7 are marked completed.
- Are Avacopan clinical trials recruiting in 2026?
- Yes — 6 Avacopan trials are actively recruiting in 2026, with 70 U.S. sites across 29 states. See the recruiting trials and the per-state site list further down this page.
- What conditions is Avacopan being studied for?
- Avacopan is being studied for Acne Inversa, ANCA-Associated Vasculitis, ANCA-Associated Vasculitis (AAV), ANCA Associated Vasculitis (AAV), Antineutrophil Cytoplasmic Antibody-associated Vasculitis and 15 more. The trials are grouped by indication on this page.
- What phase is Avacopan in?
- Avacopan clinical trials span 2 Phase 4, 3 Phase 3, 3 Phase 2, 5 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
- Who sponsors Avacopan clinical trials?
- The lead sponsor across the most Avacopan trials is Amgen, with 5 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.
Sources and methodology
Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Avacopanas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.
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