Ataciguat Clinical Trials (2026): 5 Studies for Aortic Valve Stenosis & Intermittent Claudication
Hipa.ai Research · Source: ClinicalTrials.gov / AACT
Synced daily from ClinicalTrials.gov via AACT. Last sync: .
5 Ataciguat clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 4 indications (including Aortic Valve Stenosis & Intermittent Claudication) and 1,970 total planned enrollment. 1 Ataciguat clinical trial is actively recruiting at 42 U.S. sites across 19 states. Most recent activity: NCT07001800 (Sep 2030).
Where to Participate: All Ataciguat Trial Sites in the U.S. (42 sites across 19 states)
Every actively recruiting Ataciguattrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.
| State | Facility | City | Trial | Map |
|---|---|---|---|---|
| AL | University of Alabama at Birmingham (UAB) - Medical Center | Birmingham35233 | NCT07001800 | Map |
| AL | Heart Center Research LLC | Huntsville35801 | NCT07001800 | Map |
| CA | National Heart Institute | Beverly Hills90211 | NCT07001800 | Map |
| CA | Hoag Memorial Hospital Presbyterian | Newport Beach92663 | NCT07001800 | Map |
| CA | Profound Research LLC at Southern California Heart Specialists | Pasadena91105 | NCT07001800 | Map |
| CA | University of California, San Francisco (UCSF) - Medical Center | San Francisco94143 | NCT07001800 | Map |
| CA | Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center | Torrance90502 | NCT07001800 | Map |
| FL | HCA Florida - JFK Hospital | Atlantis33462 | NCT07001800 | Map |
| FL | New Generation of Medical Research | Hialeah33016 | NCT07001800 | Map |
| FL | Jacksonville Center for Clinical Research | Jacksonville32216 | NCT07001800 | Map |
| FL | New Generation of Medical Research - Naples | Naples34116 | NCT07001800 | Map |
| FL | Flourish Research - St. Augustine | Saint Augustine32086 | NCT07001800 | Map |
| FL | Sarasota Memorial Hospital | Sarasota34239 | NCT07001800 | Map |
| FL | University of South Florida | Tampa33606 | NCT07001800 | Map |
| IL | Northwestern University The Feinberg School of Medicine | Chicago60611 | NCT07001800 | Map |
| IL | NorthShore University Health System | Glenview60026 | NCT07001800 | Map |
| IL | Midwest Cardiovascular Institute | Naperville60540 | NCT07001800 | Map |
| KY | University of Louisville Health | Louisville40202 | NCT07001800 | Map |
| MA | Brigham and Women's Hospital | Boston02115 | NCT07001800 | Map |
| MA | Massachusetts General Hospital | Boston02114 | NCT07001800 | Map |
| MI | Corewell Health | Royal Oak48073 | NCT07001800 | Map |
| MI | Henry Ford Hospital | West Bloomfield48322 | NCT07001800 | Map |
| MN | Mayo Clinic - Rochester | Rochester55905 | NCT07001800 | Map |
| MO | Washington University | St Louis63110 | NCT07001800 | Map |
| NY | Albany Medical Center | Albany12208 | NCT07001800 | Map |
| NY | University of Buffalo | Buffalo14203 | NCT07001800 | Map |
| NY | Montefiore Medical Center | The Bronx10467 | NCT07001800 | Map |
| NC | Duke University School of Medicine | Durham27710 | NCT07001800 | Map |
| NC | Moses H. Cone Memorial Hospital Operating Corporation d/b/a Cone Health | Greensboro27401 | NCT07001800 | Map |
| ND | Sanford Fargo | Fargo58122 | NCT07001800 | Map |
| OH | The Lindner Center for Research and Education at The Christ Hospital | Cincinnati45219 | NCT07001800 | Map |
| OH | Cleveland Clinic | Cleveland44195 | NCT07001800 | Map |
| OK | Ascension St. John Hospital | Tulsa74104 | NCT07001800 | Map |
| PA | University of Pennsylvania | Philadelphia19104 | NCT07001800 | Map |
| SC | OnSite Clinical Solutions, LLC - Rock Hill | Rock Hill29732 | NCT07001800 | Map |
| TN | TriStar Centennial Medical Center | Nashville37203 | NCT07001800 | Map |
| TN | Vanderbilt University Medical Center | Nashville37232 | NCT07001800 | Map |
| TX | St. David's Heart and Vascular dba Austin Heart - Main Office | Austin78705 | NCT07001800 | Map |
| TX | Houston Methodist Hospital | Houston77030 | NCT07001800 | Map |
| TX | Baylor Scott and White - The Heart Hospital Baylor Plano | Plano75093 | NCT07001800 | Map |
| TX | Methodist Hospital - San Antonio | San Antonio78229 | NCT07001800 | Map |
| UT | University of Utah Hospital & Clinics | Salt Lake City84112 | NCT07001800 | Map |
Ataciguat clinical trials at a glance: phase × recruitment status
| Phase | recruiting | completed | Total |
|---|---|---|---|
| P1 | 1 | 1 | |
| P2 | 3 | 3 | |
| P2/P3 | 1 | 1 |
Recruiting Ataciguat clinical trials (1)
Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).
| NCT ID | Title | Phase | Indication | Enrollment | Started |
|---|---|---|---|---|---|
| NCT07001800 | KATALYST-AVAtaciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study | P2/P3 | Moderate Aortic Valve Stenosis | 1,276 | Jun 2025 |
Ataciguat clinical trials by indication
Aortic Valve Stenosis (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT02481258 | CAVS | P2 | completed | A Study Evaluating the Effects of Ataciguat (HMR1766) on Aortic Valve Calcification |
| NCT02049203 | — | P1 | completed | Safety of Ataciguat in Patients With Moderate Calcific Aortic Valve Stenosis |
Moderate Aortic Valve Stenosis (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07001800 | KATALYST-AV | P2/P3 | recruiting | Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study |
Pain (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT00799656 | SERENEATI | P2 | completed | Efficacy and Safety Study of Ataciguat Versus Placebo in Patients With Neuropathic Pain |
Intermittent Claudication (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT00443287 | ACCELA | P2 | completed | Efficacy and Safety of HMR1766 in Patients With Fontaine Stage II Peripheral Arterial Disease |
Ataciguat pivotal trial highlights (Phase 2/3/4)
Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.
| Acronym | NCT | Phase | Status | Indication | Enrollment | PubMed |
|---|---|---|---|---|---|---|
| CAVS | NCT02481258 | P2 | completed | Aortic Valve Stenosis | 35 | — |
| SERENEATI | NCT00799656 | P2 | completed | Pain | 62 | — |
| ACCELA | NCT00443287 | P2 | completed | Intermittent Claudication | 553 | — |
All Ataciguat trials (5)
Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.
| NCT ID | Acronym | Title | Phase | Status | Enrollment | Sponsor | Started |
|---|---|---|---|---|---|---|---|
| NCT07001800 | KATALYST-AV | Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study | P2/P3 | recruiting | 1,276 | Kardigan, Inc. | Jun 2025 |
| NCT02481258 | CAVS | A Study Evaluating the Effects of Ataciguat (HMR1766) on Aortic Valve Calcification | P2 | completed | 35 | Mayo Clinic | Jun 2015 |
| NCT02049203 | Safety of Ataciguat in Patients With Moderate Calcific Aortic Valve Stenosis | P1 | completed | 44 | Jordan D. Miller, Ph.D. | Jan 2014 | |
| NCT00799656 | SERENEATI | Efficacy and Safety Study of Ataciguat Versus Placebo in Patients With Neuropathic Pain | P2 | completed | 62 | Sanofi | Nov 2008 |
| NCT00443287 | ACCELA | Efficacy and Safety of HMR1766 in Patients With Fontaine Stage II Peripheral Arterial Disease | P2 | completed | 553 | Sanofi | Feb 2007 |
Ataciguat clinical trials: frequently asked questions
- How many Ataciguat clinical trials are there?
- 5 Ataciguat clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 1 is actively recruiting participants. 4 are marked completed.
- Are Ataciguat clinical trials recruiting in 2026?
- Yes — 1 Ataciguat trial is actively recruiting in 2026, with 42 U.S. sites across 19 states. See the recruiting trials and the per-state site list further down this page.
- What conditions is Ataciguat being studied for?
- Ataciguat is being studied for Aortic Valve Stenosis, Intermittent Claudication, Moderate Aortic Valve Stenosis, Pain. The trials are grouped by indication on this page.
- What phase is Ataciguat in?
- Ataciguat clinical trials span 3 Phase 2, 1 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
- Who sponsors Ataciguat clinical trials?
- The lead sponsor across the most Ataciguat trials is Sanofi, with 3 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.
Sources and methodology
Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Ataciguatas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.
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