Aficamten Clinical Trials (2026): 7 Studies for Obstructive Hypertrophic Cardiomyopathy (oHCM) & Obstructive Hypertrophic Cardiomyopathy

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

7 Aficamten clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 6 indications (including Obstructive Hypertrophic Cardiomyopathy (oHCM) & Obstructive Hypertrophic Cardiomyopathy) and 1,996 total planned enrollment. 4 Phase 3 Aficamten trials are listed. 2 Aficamten clinical trials are actively recruiting at 23 U.S. sites across 18 states. Most recent activity: NCT06412666 (Jan 2030).

Where to Participate: All Aficamten Trial Sites in the U.S. (23 sites across 18 states)

Every actively recruiting Aficamtentrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
AZPhoenix Children's HospitalPhoenix85016NCT06412666Map
CAChildren's Hospital Los AngelesLos Angeles90027NCT06412666Map
CAUniversity of California, Los Angeles (UCLA)Los Angeles90095NCT06412666Map
COChildren's Hospital ColoradoAurora80045NCT06412666Map
DCChildren's National HospitalWashington D.C.20010NCT06412666Map
FLNicklaus Children's HospitalMiami33155NCT06412666Map
ILAnn & Robert H. Lurie Children's HospitalChicago60611NCT06412666Map
LAChildren's Hospital New OrleansNew Orleans70018NCT06412666Map
MIUniversity of MichiganAnn Arbor48109NCT06412666Map
MIChildren's Hospital of MichiganDetroit48201NCT06412666Map
MNMayo ClinicRochester55905NCT06412666Map
MOChildren's Mercy HospitalKansas City64108NCT06412666Map
NEUniversity of Nebraska Medical CenterOmaha68198NCT06412666Map
NJMorristown Medical CenterMorristown07960NCT06412666Map
NYNYP/Columbia University Medical CenterNew York10027NCT06412666Map
NYChildren's Hospital at MontefioreThe Bronx10467NCT06412666Map
NCDuke Clinical Research InstituteDurham27701NCT06412666Map
OROregon Health & Science UniversityPortland97239NCT06412666Map
PAChildren's Hospital of PhiladelphiaPhiladelphia19104NCT06412666Map
TNLeBonheur Children's HospitalMemphis38103NCT06412666Map
TNVanderbilt University Medical CenterNashville37235NCT06412666Map
TXDell Children's HospitalAustin78723NCT06412666Map
TXUT SouthwesternDallas75390NCT06412666Map

Aficamten clinical trials at a glance: phase × recruitment status

Phaserecruitingactive not recruitingenrolling by invitationcompletedTotal
P111
P2/P3112
P3134

Recruiting Aficamten clinical trials (2)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT06412666CEDAR-HCMA Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM).P2/P3Pediatric55May 2024
NCT04848506FOREST-HCMOpen-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCMP2/P3Symptomatic Hypertrophic Cardiomyopathy (HCM)900May 2021

Aficamten clinical trials by indication

Obstructive Hypertrophic Cardiomyopathy (oHCM) (2)

NCTAcronymPhaseStatusTitle
NCT05767346MAPLE-HCMP3completedPhase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Symptomatic oHCM
NCT05186818SEQUOIA-HCMP3completedPhase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic oHCM

Pediatric (1)

NCTAcronymPhaseStatusTitle
NCT06412666CEDAR-HCMP2/P3recruitingA Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM).

Obstructive Hypertrophic Cardiomyopathy (1)

NCTAcronymPhaseStatusTitle
NCT06116968P3completedAn Open-Label Study of Aficamten for Chinese Patients With Symptomatic oHCM

Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (1)

NCTAcronymPhaseStatusTitle
NCT06081894ACACIA-HCMP3active not recruitingPhase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic nHCM

Healthy Participants (1)

NCTAcronymPhaseStatusTitle
NCT05924815P1completedStudy to Evaluate the Effect of Aficamten Administration on QT/QTc Interval

Symptomatic Hypertrophic Cardiomyopathy (HCM) (1)

NCTAcronymPhaseStatusTitle
NCT04848506FOREST-HCMP2/P3enrolling by invitationOpen-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM

Aficamten pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
ACACIA-HCMNCT06081894P3active not recruitingSymptomatic Non-Obstructive Hypertrophic Cardiomyopathy500
MAPLE-HCMNCT05767346P3completedObstructive Hypertrophic Cardiomyopathy (oHCM)175
SEQUOIA-HCMNCT05186818P3completedObstructive Hypertrophic Cardiomyopathy (oHCM)282

All Aficamten trials (7)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT06412666CEDAR-HCMA Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM).P2/P3recruiting55CytokineticsMay 2024
NCT04848506FOREST-HCMOpen-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCMP2/P3enrolling by invitation900CytokineticsMay 2021
NCT06081894ACACIA-HCMPhase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic nHCMP3active not recruiting500CytokineticsAug 2023
NCT06116968An Open-Label Study of Aficamten for Chinese Patients With Symptomatic oHCMP3completed40Corxel PharmaceuticalsNov 2023
NCT05767346MAPLE-HCMPhase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Symptomatic oHCMP3completed175CytokineticsJun 2023
NCT05186818SEQUOIA-HCMPhase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic oHCMP3completed282CytokineticsFeb 2022
NCT05924815Study to Evaluate the Effect of Aficamten Administration on QT/QTc IntervalP1completed44CytokineticsMay 2023

Aficamten clinical trials: frequently asked questions

How many Aficamten clinical trials are there?
7 Aficamten clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 2 are actively recruiting participants. 4 are marked completed.
Are Aficamten clinical trials recruiting in 2026?
Yes — 2 Aficamten trials are actively recruiting in 2026, with 23 U.S. sites across 18 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Aficamten being studied for?
Aficamten is being studied for Obstructive Hypertrophic Cardiomyopathy (oHCM), Obstructive Hypertrophic Cardiomyopathy, Healthy Participants, Symptomatic Hypertrophic Cardiomyopathy (HCM), Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy and 2 more. The trials are grouped by indication on this page.
What phase is Aficamten in?
Aficamten clinical trials span 4 Phase 3, 1 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Aficamten clinical trials?
The lead sponsor across the most Aficamten trials is Cytokinetics, with 1 additional lead sponsor listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Aficamtenas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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