Trial results for a feasibility study testing an inpatient insulin dosing calculator for Type 2 Diabetes were posted on ClinicalTrials.gov on 2026-04-15. The calculator significantly reduced clinical significant hyperglycemia events, with only 1 event in the calculator group compared to 42 in the observational cohort.
Background
Effective blood glucose management is crucial for patients with Type 2 Diabetes, particularly during hospital admissions, where hyperglycemia can lead to complications. Developing tools to optimize insulin dosing in this setting is important for improving patient safety and outcomes. This feasibility trial explored a novel insulin dosing calculator's ability to enhance glucose control upon hospital admission.
Trial design
This completed feasibility trial enrolled 38 participants with Diabetes Mellitus, Type 2. The study evaluated a novel inpatient insulin dosing calculator. Participants received initial insulin doses guided by the calculator and standard care, compared to an observational cohort receiving standard care. The trial aimed to assess if the calculator could prevent excessive hypoglycemia and decrease hyperglycemia.
Key results
The trial reported the following key measurements and analyses:
- Clinical Significant Hypoglycemia: The Insulin Dosing Calculator group had 0 participants experiencing clinical significant hypoglycemia, compared to 1 participant in the Observational Cohort. A Chi-squared test yielded a p-value of 0.6.
- Mean Blood Glucose Concentration (mg/dL): The Initial Insulin Dosing Calculator group showed a mean blood glucose concentration of 184.5 mg/dL (Standard Deviation 40.3), while the Observational Cohort had a mean of 204.0 mg/dL (Standard Deviation 63.4). A 2-sided t-test resulted in a p-value of 0.023.
- Clinical Significant Hyperglycemia: Only 1 participant in the Initial Insulin Dosing Calculator group experienced clinical significant hyperglycemia, compared to 42 participants in the Observational Cohort. A Chi-squared test for this outcome yielded a p-value of 0.0005.
- Hypoglycemia Lower Than 70 mg/dL: The Initial Insulin Dosing Calculator group reported 0 participants with hypoglycemia lower than 70 mg/dL, versus 2 participants in the Observational Cohort. A Chi-squared test resulted in a p-value of 0.5.
What this means
The trial results suggest that the inpatient insulin dosing calculator significantly improves glucose control for hospitalized Type 2 Diabetes patients. A key finding is the substantial reduction in clinical significant hyperglycemia, from 42 participants in the observational cohort to just 1 in the calculator group (p-value 0.0005). The calculator group also achieved a lower mean blood glucose concentration of 184.5 mg/dL compared to 204.0 mg/dL in the observational cohort (p-value 0.023). These benefits were observed without increasing hypoglycemia events, indicating enhanced safety and efficacy in inpatient glucose management.
Source
The information for this condition update was sourced from ClinicalTrials.gov, a public registry of clinical studies. The trial results for the study "Feasibility Trial Using an Inpatient Insulin Dosing Calculator" were posted on 2026-04-15 on clinicaltrials.gov.