Trial results for the Cardiovascular Risk Reduction Among People Experiencing Homelessness (CV-Homes) intervention, which addresses conditions including Type 2 Diabetes, were posted on ClinicalTrials.gov on 2025-08-08. The results indicate a mean acceptability score of 31 on a scale for the intervention.
Background
People experiencing homelessness often face significant health disparities, including a higher prevalence and poorer management of chronic conditions such as heart diseases, Type 2 Diabetes, pre-diabetes, hypertension, and hyperlipidemias. These conditions contribute to increased cardiovascular risk. Access to consistent healthcare, adherence to treatment plans, and engagement in health-promoting behaviors are challenging in this population due to various socioeconomic and systemic barriers. Interventions designed to reduce cardiovascular risk must consider the unique circumstances and needs of individuals experiencing homelessness, focusing on feasibility, acceptability, and engagement to be effective.
Trial design
This completed study (NCT06025721), identified as Phase NA, enrolled 9 participants. The trial was a single-arm study designed to test the perception and feasibility of the CV-Homes intervention and its anticipated study procedures. The intervention focused on behavior change for cardiovascular risk reduction among people experiencing homelessness. The conditions addressed in the trial included Heart Diseases, Diabetes Mellitus, Type 2, Pre-diabetes, Hypertension, and Hyperlipidemias.
Key results
The trial measured several outcomes related to the intervention's acceptability, engagement, and impact on health-related quality of life and cardiovascular health:
- Acceptability Measured by the Client Satisfaction Questionnaire: The mean score for the CV-Homes Intervention group was 31 on a scale.
- Treatment Engagement Measured by Sessions Attended: Participants in the CV-Homes Intervention group attended a mean of 6.8 sessions.
- Health-related Quality of Life: Mean scores for the CV-Homes Intervention group were 11.7, 10.2, 58.6, and 65 units on a scale across different measurements.
- Cardiovascular Health (AHA Life's Essential 8): Mean scores for the CV-Homes Intervention group were 52.92 with a standard deviation of 10.73, and 55.52 with a standard deviation of 9.74, both measured on a scale.
What this means
The posted results suggest that the CV-Homes behavior change intervention demonstrates promising levels of acceptability and engagement among people experiencing homelessness. A mean acceptability score of 31 and an average of 6.8 sessions attended indicate that participants found the intervention satisfactory and were able to engage with it. These findings are crucial for the development of future, larger-scale studies, as they address the critical aspects of feasibility and participant perception in a vulnerable population. The data on health-related quality of life and cardiovascular health provide initial insights into potential areas of impact, further supporting the relevance of such interventions in addressing chronic conditions like Type 2 Diabetes and heart diseases in this population.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT06025721, titled "Behavior Change Intervention for Cardiovascular Risk Reduction Among People Experiencing Homelessness", were posted on 2025-08-08 on clinicaltrials.gov.