Trial results for a study comparing different exercise approaches for women with Type 2 Diabetes were posted on ClinicalTrials.gov on 2025-06-12, with 60 participants enrolled.
Background
Type 2 Diabetes Mellitus (T2DM) is one of the most common metabolic diseases with a complex, multifactorial etiology, and is a chronic disease with various clinical and biochemical manifestations. It has been known for a long time that T2DM treatments include medication, diet, and exercise. Exercise can improve blood glucose control, increase insulin sensitivity, respiratory capacity, well-being and cognitive functions, regulate lipid profile, blood pressure, reduce cardiovascular disease risk, abdominal obesity, and weight. Understanding the comparative effectiveness of different exercise delivery methods is crucial for optimizing patient care.
Trial design
This completed study, designated as Phase NA, enrolled 60 participants to investigate different exercise approaches in women with Type 2 Diabetes. The trial compared a 'Blue Prescription Group', a 'Video Based Home Exercise Group', and a 'Supervised Exercise Group' to assess their effects on various health parameters.
Key results
The trial reported measurements for glycosylated hemoglobin and physical activity levels across the three exercise groups. For glycosylated hemoglobin, initial mean values were 6.82% (Standard Deviation 1.21%) for the Blue Prescription Group, 7.17% (Standard Deviation 2.37%) for the Video Based Home Exercise Group, and 6.80% (Standard Deviation 0.94%) for the Supervised Exercise Group. Later measurements showed mean values of 6.33% (Standard Deviation 0.94%) for the Blue Prescription Group, 6.69% (Standard Deviation 2.08%) for the Video Based Home Exercise Group, and 6.32% (Standard Deviation 0.91%) for the Supervised Exercise Group.
Regarding physical activity levels, initial mean values were 846.45 MET-min / week (Standard Deviation 615.04 MET-min / week) for the Blue Prescription Group, 797.20 MET-min / week (Standard Deviation 635.14 MET-min / week) for the Video Based Home Exercise Group, and 909.64 MET-min / week (Standard Deviation 699.90 MET-min / week) for the Supervised Exercise Group. Later measurements showed mean values of 1960.89 MET-min / week (Standard Deviation 735.78 MET-min / week) for the Blue Prescription Group, 1654.05 MET-min / week (Standard Deviation 770.22 MET-min / week) for the Video Based Home Exercise Group, and 2370.11 MET-min / week (Standard Deviation 772.45 MET-min / week) for the Supervised Exercise Group.
Statistical analyses comparing the groups yielded p-values including 0.83 (Kruskal-Wallis), 0.654 (ANCOVA), 0.803 (ANCOVA), 0.398 (ANCOVA), 0.132 (Kruskal-Wallis), and 0.991 (Kruskal-Wallis), indicating no statistically significant differences between the groups for the measured outcomes.
What this means
The results suggest that, in this study of women with Type 2 Diabetes, the different exercise approaches—blue prescription, video-based home exercise, and supervised exercise—did not lead to statistically significant differences in glycosylated hemoglobin levels or physical activity levels. This indicates that various methods of delivering exercise interventions may yield comparable outcomes for managing Type 2 Diabetes, though the specific context and intensity of each approach would warrant further investigation. The findings could inform patient education and treatment planning, suggesting flexibility in exercise modality.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT05479435, titled 'Comparison Effects Of Different Exercise Approaches On Type 2 DM Women', were posted on 2025-06-12 on clinicaltrials.gov.