Trial results for the Family Diabetes Prevention Program Pilot Study, investigating interventions for conditions including Obesity and PreDiabetes, were posted on ClinicalTrials.gov on 2025-07-08. The study, which enrolled 34 participants, reported various attendance metrics, with the standard Diabetes Prevention Program (DPP) showing a higher mean core session attendance percentage of 97.8% compared to 74.1% and 74.7% for the Family DPP.
Background
Obesity, overweight, prediabetes, and type 2 diabetes are significant public health concerns, often linked and requiring comprehensive management strategies. Lifestyle interventions, such as the Diabetes Prevention Program (DPP), are evidence-based approaches designed to help adults at high risk for type 2 diabetes achieve weight loss and increased physical activity. This pilot study aimed to explore the feasibility and acceptability of augmenting the standard DPP with a family-oriented component, known as the Family DPP, to potentially enhance its reach and impact, particularly given the involvement of childhood overweight and obesity in the study's scope.
Trial design
This completed study, designated as Phase NA, enrolled 34 participants. It investigated conditions including PreDiabetes, Overweight and Obesity, Type 2 Diabetes, Overweight, Childhood, and Obesity, Childhood. The trial examined the feasibility and acceptability of a family-oriented augmentation of the Diabetes Prevention Program lifestyle intervention (Family DPP), comparing it against the standard Diabetes Prevention Program (DPP). The study also preliminarily examined adult and child health and health behavior outcomes.
Key results
The trial reported several key measurements related to adult participant attendance in the program:
- Adult Participant Attendance in Program as Assessed by Total Number of Required Program Sessions Attended, Core:
- For the Diabetes Prevention Program (DPP) group, the mean attendance was 17.6 sessions (Standard Error 0.22).
- For the Family Diabetes Prevention Program (Family DPP) group, mean attendance figures were 14.8 sessions (Standard Error 1.8), 13.5 sessions (Standard Error 1.6), and 1.4 sessions (Standard Error 0.24) across different measurements or subgroups.
- Adult Participant Attendance in Program as Assessed by Total Number of Program Sessions Attended, Full Program:
- For the Diabetes Prevention Program (DPP) group, the mean attendance was 25.2 sessions (Standard Error 0.99).
- For the Family Diabetes Prevention Program (Family DPP) group, mean attendance figures were 25.1 sessions (Standard Error 3.9), 18.8 sessions (Standard Error 2.8), 6.3 sessions (Standard Error 1.2), and 4.9 sessions (Standard Error 1.0) across different measurements or subgroups.
- Adult Participant Attendance in Program as Assessed by Percentage of Program Sessions Attended, Core:
- For the Diabetes Prevention Program (DPP) group, the mean attendance was 97.8 percentage of sessions (95% Confidence Interval null).
- For the Family Diabetes Prevention Program (Family DPP) group, mean attendance percentages were 74.1 percentage of sessions (95% Confidence Interval null) and 74.7 percentage of sessions (95% Confidence Interval null).
What this means
The posted results offer preliminary insights into the feasibility and acceptability of the Family Diabetes Prevention Program, particularly concerning adult participant engagement. While the study is a pilot with a small enrollment of 34 participants, the attendance data suggests that the standard DPP achieved a higher mean percentage of core session attendance (97.8%) compared to the Family DPP (74.1% and 74.7%). These findings indicate that while a family-oriented approach may hold promise, strategies to maintain adult participant attendance in core sessions within the Family DPP model may warrant further investigation and refinement in future studies. The data contributes to understanding the operational aspects of implementing such lifestyle interventions for obesity and prediabetes.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT05358444, titled "Family Diabetes Prevention Program Pilot Study", were posted on 2025-07-08 on clinicaltrials.gov.