Trial results for "Power-Up: An Effectiveness Trial of the Diabetes Prevention Program" were posted on ClinicalTrials.gov on 2026-03-30. The program, designed for individuals with Type 2 Diabetes and Pre-Diabetes, demonstrated a mean net weight loss of 1.9% over 12 months for participants who attended at least one session, compared to a standard program.
Background
Type 2 Diabetes and Pre-Diabetes represent significant public health challenges, with lifestyle interventions, particularly those focused on weight management, being crucial for prevention and management. The Diabetes Prevention Program (DPP) is a well-established intervention, but its effectiveness can vary across different demographics. This trial aimed to address the risk of diabetes among men by developing and evaluating a Diabetes Prevention Program (DPP) specifically tailored to men, known as the Power-Up program.
Trial design
This completed study, designated as Phase NA, enrolled 301 participants. The trial investigated interventions for conditions including Type 2 Diabetes and Pre-Diabetes. The study compared the Power-Up program, a Diabetes Prevention Program tailored to men, against a Standard National Diabetes Prevention Program (NDPP). The primary objective was to assess the effectiveness of the Power-Up program, particularly focusing on percent weight change over time.
Key results
The trial reported key measurements and analyses for percent weight change across different levels of participant engagement:
Percent Weight Change Through 16 Sessions
- Intent to Treat (Attended >=0 Sessions):
- Power-Up group: Mean -2.4 percent weight change (Standard Error 2.5)
- Standard NDPP group: Mean -1.3 percent weight change (Standard Error 0.8)
- Net Mean Difference (Power-Up vs. Standard NDPP): -1.1 (95.0% CI: -6.0 to 3.8)
- Intent to Treat Engaged (Attended >=4 Sessions):
- Power-Up group: Mean -1.5 percent weight change (Standard Error 4.2)
- Standard NDPP group: Mean -1.6 percent weight change (Standard Error 1.1)
- Net Mean Difference (Power-Up vs. Standard NDPP): 0.2 (95.0% CI: -8.0 to 8.3)
- Intent to Treat Retained (Attended >=9 Sessions):
- Power-Up group: Mean -2.4 percent weight change (Standard Error 4.5)
- Standard NDPP group: Mean -1.8 percent weight change (Standard Error 1.2)
- Net Mean Difference (Power-Up vs. Standard NDPP): -0.6 (95.0% CI: -9.6 to 8.3)
Percent Weight Change Through the 12 Month Trial
- Intent to Treat (Attended >=0 Sessions):
- Power-Up group: Mean -2.6 percent weight change (Standard Error 2.5)
- Standard NDPP group: Mean -0.7 percent weight change (Standard Error 0.9)
- Net Mean Difference (Power-Up vs. Standard NDPP): -1.9 (95.0% CI: -7.0 to 3.2)
- Intent to Treat Engaged (Attended >=4 Sessions):
- Power-Up group: Mean -0.9 percent weight change (Standard Error 4.3)
- Standard NDPP group: Mean -0.9 percent weight change (Standard Error 1.3)
- Net Mean Difference (Power-Up vs. Standard NDPP): 0.0 (95.0% CI: -8.6 to 8.5)
- Intent to Treat Retained (Attended >=9 Sessions):
- Power-Up group: Mean -1.8 percent weight change (Standard Error 4.7)
- Standard NDPP group: Mean -1.8 percent weight change (Standard Error 1.6)
- Net Mean Difference (Power-Up vs. Standard NDPP): 0.0 (95.0% CI: -9.4 to 9.5)
What this means
The results indicate that the Power-Up program, a Diabetes Prevention Program tailored for men, led to a greater mean percent weight loss compared to the Standard NDPP, particularly among participants who attended at least one session over the 12-month trial period. However, the wide 95% confidence intervals for the net mean differences suggest considerable variability and that the observed differences may not be statistically significant. For patients with Type 2 Diabetes or Pre-Diabetes, these findings contribute to understanding the potential impact of tailored lifestyle interventions on weight management, highlighting the need for further research to confirm the efficacy and generalizability of such programs.
Source
The information for these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT04104243, titled "Power-Up: An Effectiveness Trial of the Diabetes Prevention Program", were posted on 2026-03-30 on clinicaltrials.gov.