Trial results exploring the impact of exercise training on human adipose tissue characteristics in individuals with Type 2 Diabetes, obesity, and healthy participants were posted on ClinicalTrials.gov on 2025-08-14. The study enrolled 93 participants.
Background
Type 2 Diabetes is a chronic condition characterized by insulin resistance and high blood sugar. Obesity is a major risk factor for developing Type 2 Diabetes, and both conditions are often associated with altered adipose tissue function. Exercise is a well-established intervention for managing Type 2 Diabetes and obesity, known to improve metabolic health. This study aimed to investigate how exercise training influences white adipose tissue characteristics, potentially offering insights into its beneficial effects on sugar regulation and body weight.
Trial design
This completed study, titled 'Exercise Regulation of Human Adipose Tissue', enrolled 93 participants. The trial investigated conditions including Healthy, Obese, and Diabetes Mellitus, Type 2. The purpose was to determine whether exercise training leads to changes in white adipose tissue that are beneficial to the body's regulation of sugar and body weight.
Key results
For the outcome titled 'Changes in Human Adipose Tissue Characteristics Following Exercise Training', the following mean values were reported:
- Body Fat %:
- In the Moderate Intensity Training-Healthy Lean group, body fat % was 25.45 (Standard Deviation 6.34). Another measurement for this group showed body fat % at 25.38 (Standard Deviation 7.02).
- In the Moderate Intensity Training-Healthy Overweight/Obese group, body fat % was 34.12 (Standard Deviation 7.97). Another measurement for this group showed body fat % at 33.90 (Standard Deviation 8.60).
- In the Moderate Intensity Training-Overweight/Obese Type 2 Diabetes group, body fat % was 38.06 (Standard Deviation 6.96). Another measurement for this group showed body fat % at 37.20 (Standard Deviation 7.31).
- In the High Intensity Training-Healthy Lean group, body fat % was 27.05 (Standard Deviation 7.70). Another measurement for this group showed body fat % at 25.32 (Standard Deviation 7.57).
- Adipose Tissue in Kilograms:
- In the Moderate Intensity Training-Healthy Lean group, adipose tissue measured 17.83 kilograms (Standard Deviation 4.38).
- In the Moderate Intensity Training-Healthy Overweight/Obese group, adipose tissue measured 29.96 kilograms (Standard Deviation 7.55).
- In the Moderate Intensity Training-Overweight/Obese Type 2 Diabetes group, adipose tissue measured 31.47 kilograms (Standard Deviation 6.85).
- In the High Intensity Training-Healthy Lean group, adipose tissue measured 19.76 kilograms (Standard Deviation 5.54).
What this means
This study provides descriptive data on adipose tissue characteristics in various participant groups, including those with Type 2 Diabetes, following exercise training. The reported mean body fat percentages and kilograms of adipose tissue offer insights into the physiological state of these groups. For individuals in the Moderate Intensity Training-Overweight/Obese Type 2 Diabetes group, the mean body fat percentage was observed at 38.06% (SD 6.96) and 37.20% (SD 7.31), with mean adipose tissue mass at 31.47 kilograms (SD 6.85). Without comparative baseline data or statistical analyses of changes or differences between groups, specific conclusions about the efficacy or magnitude of exercise-induced changes cannot be drawn from these posted results alone. However, the data contributes to the understanding of adipose tissue characteristics in these populations.
Source
The information for these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT03133156, titled "Exercise Regulation of Human Adipose Tissue", were posted on 2025-08-14 on clinicaltrials.gov.