Trial results for iTEST, an intervention targeting introspective accuracy in patients with Schizophrenia and other psychotic disorders, were posted on ClinicalTrials.gov on 2026-03-18, involving 69 participants.
Background
Functional disability is a significant challenge for individuals living with psychotic disorders. A primary contributor to this disability is introspective accuracy, which refers to the accuracy of judgments about one's own abilities and performance on tasks. Despite its impact, interventions specifically designed to target introspective accuracy in psychotic illnesses have been lacking. The iTEST intervention was developed to address this gap, aiming to improve introspective accuracy and, consequently, functional outcomes through the use of mobile devices.
Trial design
This completed study, identified as Phase NA, enrolled 69 participants. The trial included individuals diagnosed with Schizophrenia, Schizo Affective Disorder, and other Psychotic Disorders. The intervention, iTEST, utilized mobile devices to train participants to enhance their introspective accuracy. No specific primary outcomes were listed, and no comparator arms were explicitly detailed in the provided data.
Key results
Key analyses from the trial indicated:
- A linear regression analysis yielded a p-value of 0.001.
- An ANOVA analysis showed a p-value of 0.05, with a Mean Difference (Final Values) of 3.9.
Key measurements reported for the iTEST group included:
- Trained Introspective Accuracy: A mean of 3.70 (Standard Error: 0.91) and a mean of -0.77 (Standard Error: 0.99) on a score scale.
- Untrained Introspective Accuracy on WCST: A mean of 17.30 (Standard Error: 2.29) and a mean of 14.66 (Standard Error: 2.41) on a score scale.
- Adherence: A mean of 87.02 (Standard Deviation: 14.1) as a percentage of total prompts.
- Specific Level of Function Scale (Informant Version): A mean of 4.11 (Standard Deviation: 0.07) and a mean of 4.25 (Standard Deviation: 0.07) on a score scale.
What this means
The statistically significant p-values from the linear regression (0.001) and ANOVA (0.05) analyses suggest that the iTEST mobile device intervention may have a meaningful impact on targeted aspects of introspective accuracy in individuals with schizophrenia and other psychotic disorders. Given that the intervention aims to improve introspective accuracy to address functional disability, these findings imply a potential new avenue for non-pharmacological support. The reported adherence rate of 87.02% also suggests that a mobile-based intervention is feasible and well-engaged by this patient population, offering a practical approach to potentially enhance functional outcomes.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT05899348, titled "iTEST: Introspective Accuracy as a Novel Target for Functioning in Psychotic Disorders", were posted on 2026-03-18 on clinicaltrials.gov.