Trial results for a study on Compensatory Cognitive Training (CCT) for Posttraumatic Stress Disorder (PTSD) were posted on ClinicalTrials.gov on 2025-10-15. The trial enrolled 21 participants.
Background
Posttraumatic Stress Disorder (PTSD) affects approximately half a million Veterans receiving services at the VA. This condition is strongly linked to cognitive functioning deficits, impacting areas such as concentration, attention, memory, learning, verbal abilities, processing speed, and multitasking. Compensatory Cognitive Training (CCT) is an evidence-based intervention known to be effective for cognitive problems in other Veteran populations, including those with a history of traumatic brain injury (TBI). However, CCT had not been previously tested in Veterans with PTSD who do not have a history of TBI.
Trial design
This completed study, designated as Phase NA, enrolled a total of 21 participants. The trial investigated the condition of Posttraumatic Stress Disorder. Participants were assigned to either the Compensatory Cognitive Training (CCT) group or the Treatment as Usual (TAU) group.
Key results
The study reported several key measurements for cognitive function:
- Prospective-Retrospective Memory Questionnaire (PRMQ; Crawford et al., 2006):
- For the Compensatory Cognitive Training (CCT) group, the mean score was 50.38 (Standard Deviation 10.145) on a scale.
- For the Treatment as Usual (TAU) group, the mean score was 38.5 (Standard Deviation 15.875) on a scale.
- In a subsequent measurement, the Compensatory Cognitive Training (CCT) group had a mean score of 47.875 (Standard Deviation 9.96) on a scale.
- The Treatment as Usual (TAU) group's subsequent mean score was 42.5 (Standard Deviation 16.01) on a scale.
- A third measurement showed the Compensatory Cognitive Training (CCT) group with a mean score of 39.8 (Standard Deviation 13.846) on a scale.
- The Treatment as Usual (TAU) group's third mean score was 45.857 (Standard Deviation 16.406) on a scale.
- Multiple Sclerosis Neuropsychological Screening Questionnaire - Patient Version (MSNQ; Benedict et al., 2003):
- For the Compensatory Cognitive Training (CCT) group, the mean score was 33.15 (Standard Deviation 8.143) on a scale.
- For the Treatment as Usual (TAU) group, the mean score was 22.75 (Standard Deviation 12.903) on a scale.
- In a subsequent measurement, the Compensatory Cognitive Training (CCT) group had a mean score of 29.375 (Standard Deviation 7.52) on a scale.
- The Treatment as Usual (TAU) group's subsequent mean score was 26.5 (Standard Deviation 11.387) on a scale.
- A third measurement showed the Compensatory Cognitive Training (CCT) group with a mean score of 22.6 (Standard Deviation 14.117) on a scale.
- The Treatment as Usual (TAU) group's third mean score was 29.833 (Standard Deviation 14.442) on a scale.
What this means
This trial explored the impact of Compensatory Cognitive Training (CCT) in Veterans with PTSD who do not have a history of TBI, a population where CCT had not been previously tested. The posted results provide specific mean scores and standard deviations for both the CCT and Treatment as Usual (TAU) groups across multiple measurements using the Prospective-Retrospective Memory Questionnaire (PRMQ) and the Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ). Without further statistical analysis or p-values comparing the groups, definitive conclusions regarding the comparative efficacy of CCT versus TAU cannot be drawn from the provided data alone.
Source
The information for these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT03696225, titled "Assessment and Treatment of Cognitive Functioning Deficits in Veterans With PTSD", were posted on 2025-10-15 on clinicaltrials.gov.