Trial results for the Positive Minds-Strong Bodies Enhanced intervention, targeting Depression, Anxiety, and Physical Disability, were posted on ClinicalTrials.gov on 2026-03-30, with 427 participants enrolled.
Background
Depression and anxiety are prevalent mental health conditions that can significantly impact quality of life, particularly among racial/ethnic and linguistic minority elders who often face treatment and service disparities. These conditions can also exacerbate or be compounded by physical disabilities. Interventions that integrate both mental and physical health support are crucial for this population, especially when designed for implementation in low-resource community settings, to prevent disability and improve overall well-being.
Trial design
This completed study, designated as Phase NA, enrolled 427 participants to address treatment and service disparities and prevent disability among racial/ethnic and linguistic minority elders. The trial investigated the effectiveness and implementation readiness of the Positive Minds-Strong Bodies Enhanced (PMSB-E) intervention, a combined mental and physical health program. The study focused on participants with Depression, Anxiety, and Physical Disability. The PMSB-E intervention was compared against Enhanced Usual Care.
Key results
The trial reported key measurements for acceptability, depression and anxiety symptoms, and physical functioning:
- Acceptability (Count of Participants in Positive Minds Strong Bodies Enhanced group):
- 167 participants
- 132 participants
- 80 participants
- 82 participants
- Depression and Anxiety Symptoms as Assessed by Hopkins Symptom Checklist-25 (score on a scale, Least Squares Mean with Standard Error):
- Positive Minds Strong Bodies Enhanced: 1.45 (Standard Error 0.03)
- Enhanced Usual Care: 1.52 (Standard Error 0.03)
- Positive Minds Strong Bodies Enhanced: 1.49 (Standard Error 0.03)
- Enhanced Usual Care: 1.50 (Standard Error 0.03)
- Positive Minds Strong Bodies Enhanced: 1.51 (Standard Error 0.03)
- Enhanced Usual Care: 1.50 (Standard Error 0.03)
- Physical Functioning as Assessed by Short Physical Performance Battery (score on a scale, Least Squares Mean with Standard Error):
- Positive Minds Strong Bodies Enhanced: 8.78 (Standard Error 0.17)
- Enhanced Usual Care: 8.03 (Standard Error 0.15)
What this means
The posted results suggest that the Positive Minds-Strong Bodies Enhanced (PMSB-E) intervention may offer benefits for individuals with depression, anxiety, and physical disability, particularly among racial/ethnic and linguistic minority elders. The PMSB-E group consistently demonstrated lower least squares mean scores for depression and anxiety symptoms (e.g., 1.45 vs. 1.52) and higher least squares mean scores for physical functioning (8.78 vs. 8.03) compared to Enhanced Usual Care. These findings indicate a potential positive impact of the combined mental and physical health intervention in improving both psychological well-being and physical capabilities in this population.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT04545593, titled "Positive Minds Strong Bodies Implementation", were posted on 2026-03-30 on clinicaltrials.gov.