Trial results for Personalized Integrated Chronotherapy for Perinatal Depression were posted on ClinicalTrials.gov on 2025-12-09, involving 120 participants.

Background

Perinatal depression and anxiety are common, serious, and frequently overlapping disorders that increase morbidity and mortality in new mothers, including suicide, and result in poor infant/child outcomes. Current therapies often fail to produce recovery or are poorly tolerated. Many pregnant women seek non-pharmacologic therapy or forgo treatment when non-pharmacologic options are not available. Expectant and new mothers who experience circadian rhythm dysregulation are at increased risk for perinatal depression.

Trial design

This completed study, designated as Phase NA, enrolled 120 participants. The trial investigated conditions including Depression, Postpartum Depression, Prenatal Disorder, Circadian Dysregulation, and Pregnancy Related. The intervention studied was Personalized Integrated Chronotherapy, compared against usual care.

Key results

The trial reported multiple measurements for "Change in Depressive Symptoms" on a scale:

What this means

The posted results indicate that Personalized Integrated Chronotherapy generally led to higher mean changes in depressive symptoms compared to usual care across various measurements. While these mean changes suggest a potential benefit, the data does not include statistical analyses such as p-values or confidence intervals, which would be necessary to determine the statistical significance of these differences. These findings contribute to the understanding of non-pharmacologic approaches for perinatal depression, particularly those addressing circadian rhythm dysregulation.

Source

The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT04364646, titled "Personalized Integrated Chronotherapy for Perinatal Depression", were posted on 2025-12-09 on clinicaltrials.gov.