Trial results for the CAPABLE intervention, targeting conditions including Depression in formerly homeless adults, were posted on ClinicalTrials.gov on 2025-06-15. The intervention group showed a reduction in mean depression scores from 11.78 to 9.23.
Background
Formerly homeless adults living in permanent supportive housing often face complex health challenges, including depression, frailty, and an increased risk of accidental falls. This population tends to age prematurely, leading to difficulties with activities of daily living and instrumental activities of daily living. Addressing these interconnected issues is crucial for improving their overall well-being and maintaining independence. The CAPABLE (Community Aging in Place-Advancing Better Living for Elders) intervention is designed as a home-based service to enhance functioning and reduce fall risks in this vulnerable group.
Trial design
This completed pilot project, designated as Phase NA, enrolled 60 participants. The study investigated the implementation of the CAPABLE intervention for formerly homeless adults residing in permanent supportive housing, addressing conditions such as Accidental Fall, Frailty, Depression, Activities of Daily Living, and Housing Problems. The intervention involved time-limited services from an occupational therapist, a nurse, and a handyman. Participants were assigned to either an 'Immediate CAPABLE' group or a 'CAPABLE Wait-list Control Group'.
Key results
The trial reported several key measurements across the Immediate CAPABLE and CAPABLE Wait-list Control groups:
- Activities of Daily Living Limitations Score (score on a scale):
- In the Immediate CAPABLE group, the mean score changed from 17.07 to 14.67.
- In the CAPABLE Wait-list Control Group, the mean score changed from 14.47 to 13.17.
- Instrumental Activities of Daily Living Score (score on a scale):
- In the Immediate CAPABLE group, the mean score changed from 18.44 to 15.96.
- In the CAPABLE Wait-list Control Group, the mean score changed from 15.07 to 15.17.
- Depression (score on a scale):
- In the Immediate CAPABLE group, the mean score changed from 11.78 to 9.23.
- In the CAPABLE Wait-list Control Group, the mean score changed from 8.93 to 9.47.
What this means
The posted results suggest that the CAPABLE intervention may be associated with improvements in several functional and mental health outcomes for formerly homeless adults. Specifically, the Immediate CAPABLE group showed reductions in mean scores for Activities of Daily Living Limitations, Instrumental Activities of Daily Living, and Depression. In contrast, the wait-list control group also showed a reduction in Activities of Daily Living Limitations, but a slight increase in Instrumental Activities of Daily Living and Depression scores. These preliminary findings indicate potential benefits of the CAPABLE intervention in supporting the well-being and independence of this vulnerable population.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT04076319, titled 'Implementing CAPABLE in PSH', were posted on 2025-06-15 on clinicaltrials.gov.