Trial results for a computer training program for younger patients with brain tumors who underwent radiation therapy were posted on 2025-12-05. The study, which enrolled 45 participants, investigated intervention compliance for adaptive versus non-adaptive computerized cognitive training.
Background
Brain tumors and their treatments, particularly radiation therapy, can lead to significant cognitive difficulties in younger patients. These challenges can impact their overall well-being and quality of life. Interventions aimed at improving cognitive function are therefore important for patient care. Computerized cognitive training programs are being explored as potential tools to address these post-treatment cognitive impairments.
Trial design
This completed randomized clinical trial (Phase NA) enrolled 45 participants. The study focused on patients with Brain Neoplasm and Recurrent Brain Neoplasm who had previously undergone radiation therapy. The trial compared an adaptive computerized cognitive training program (Arm I) against a non-adaptive computerized cognitive training program (Arm II).
Key results
The trial assessed intervention compliance as a key measurement:
- For Arm I (Interactive Training Program), the proportion of participants demonstrating compliance was 0.39.
- For Arm II (Non-adaptive Training Program), the proportion of participants demonstrating compliance was 0.50.
What this means
These results indicate the observed compliance rates for two different types of computerized cognitive training programs in younger brain cancer patients post-radiation. The non-adaptive training program showed a higher proportion of participant compliance (0.50) compared to the interactive training program (0.39). This difference in compliance could be a factor in the effectiveness of such interventions, suggesting that the design or demands of a training program can influence patient adherence. Understanding compliance is crucial for implementing cognitive rehabilitation strategies effectively in this patient population.
Source
The information for these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for study NCT01503086, titled "Computer Training Program for Younger Patients With a Brain Tumor Who Underwent Radiation Therapy", were posted on 2025-12-05 on clinicaltrials.gov.