Trial results for the Sleep IntervEntion as Symptom Treatment for ADHD (SIESTA) study were posted on ClinicalTrials.gov on 2026-02-13, with 92 participants enrolled. The study investigated the impact of SIESTA Training on sleep architecture in adolescents with ADHD.
Background
Sleep problems are common among adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD), affecting up to 72% of this population. These difficulties often include initial insomnia, nocturnal awakenings, and non-restorative or restless sleep. Such sleep disturbances are thought to contribute to increased ADHD symptom impairment, as well as oppositional and depressive symptoms, leading to functional impairments in daily life. Addressing sleep problems is therefore considered an important intervention target. However, at the time of the study, there was no established evidence-based cognitive behavioral sleep treatment specifically available for adolescents with ADHD.
Trial design
This completed study, designated as Phase NA, enrolled 92 participants. The trial focused on conditions including ADHD, Sleep, and involved Adolescents and CBT (Cognitive Behavioral Therapy). The intervention arm received SIESTA Training in addition to Treatment as Usual for ADHD, while the comparator arm received Treatment as Usual for ADHD Only.
Key results
The trial reported several objective sleep architecture measurements for participants from pre-test to post-test:
- Sleep Architecture Objective TST [Total Sleep Time] Pre-test to Post-test:
- For the SIESTA Training + Treatment as Usual for ADHD group, mean Total Sleep Time was 8.11 hours (Standard Deviation 0.76) and 8.03 hours (Standard Deviation 0.64).
- For the Treatment as Usual for ADHD Only group, mean Total Sleep Time was 7.94 hours (Standard Deviation 0.95) and 8.07 hours (Standard Deviation 0.65).
- Sleep Architecture Objective SOL [Sleep Onset Latency] Pre-test to Post-test:
- For the SIESTA Training + Treatment as Usual for ADHD group, mean Sleep Onset Latency was 0.56 hours (Standard Deviation 0.45) and 0.54 hours (Standard Deviation 0.37).
- For the Treatment as Usual for ADHD Only group, mean Sleep Onset Latency was 0.74 hours (Standard Deviation 0.66) and 0.51 hours (Standard Deviation 0.38).
- Sleep Architecture Objective SE [Sleep Efficiency] Pre-test to Post-test:
- For the SIESTA Training + Treatment as Usual for ADHD group, mean Sleep Efficiency was 92 percentage (Standard Deviation 5) and 92 percentage (Standard Deviation 4).
- For the Treatment as Usual for ADHD Only group, mean Sleep Efficiency was 90 percentage (Standard Deviation 8) and 92 percentage (Standard Deviation 4).
Mixed Models Analysis was conducted, yielding the following p-values for fixed-effects coefficients:
- 0.17 (Fixed-effects coefficients: -0.17)
- 0.3 (Fixed-effects coefficients: 0.09)
- 0.33 (Fixed-effects coefficients: -0.01)
- 0.92 (Fixed-effects coefficients: -0.17)
- 0.74 (Fixed-effects coefficients: 0.05)
- 0.65 (Fixed-effects coefficients: -0.06)
What this means
The posted results indicate that the SIESTA Training intervention, when combined with usual ADHD treatment, did not demonstrate a statistically significant improvement in objective sleep architecture parameters, including Total Sleep Time, Sleep Onset Latency, and Sleep Efficiency, when compared to usual care alone. The p-values from the Mixed Models Analysis were all above the conventional threshold for statistical significance (e.g., p < 0.05). This suggests that the observed differences in sleep parameters between the groups could be due to chance, and the intervention, as studied, did not show a clear benefit in these objective measures for adolescents with ADHD.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT04723719, titled "Sleep IntervEntion as Symptom Treatment for ADHD", were posted on 2026-02-13 on clinicaltrials.gov.