RecruitingPhase 1Drug trialPathways, Risk Factors, and mOleculeS to Prevent Early-onset Colorectal TumorsThis research study is an open-label Phase 1 Exploratory/Pilot clinical trial to measure the effects of the incretin mimetic, tirzepatide, on tissue, urine, blood, and microbiome biomarkers associated with colorectal cancer risk and to understand the feasibility of this precision prevention trial approach for a future larger study.