RecruitingPhase 3Drug trialPalazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast CancerThis phase 3 clinical trial compares the efficacy and safety of palazestrant with ribociclib to letrozole and ribociclib in women and men who have not received prior systemic anti-cancer treatment for advanced breast cancer.