RecruitingPhase 2Drug trialResponse-Adaptive Treatment in Untreated Locoregional HPV-Negative Head and Neck CancerThe purpose of this study is to assess the objective response rate following neoadjuvant therapy with volrustomig, paclitaxel, and carboplatin in previously untreated human papillomavirus (HPV)-negative locally advanced head and neck squamous cell carcinoma .