RecruitingPhase 2Drug trialConvergent Mechanisms Underlying Reprometabolic Syndrome in WomenDr. Nanette Santoro proposes to test the specific question that obesity results in abnormal estradiol response at the level of the pituitary and hypothalamus. This will be shown in diminished pituitary sensitivity to gonadorelin releasing hormone with a reduced estradiol induced luteinizing hormone surge in obese women.