RecruitingPhase 2Drug trialTo Evaluate the Safety and Efficacy of MANP in Subjects With Difficult to Control/ Resistant HypertensionThis is a Phase 2 dose-titration study designed to evaluate the safety and efficacy of MANP subcutaneous injection compared to placebo in reducing baseline daytime systolic blood pressure (SBP), derived from 24-hour ambulatory blood pressure monitoring (ABPM), in subjects with hypertension who are taking 3 or more antihypertensive medications with different mechanisms of action.