RecruitingPhase 2Drug trialNeoadjuvant and Adjuvant Anti-PD1 or Combinations for Locoregionally Advanced MelanomaThe purpose of this study is to determine if neoadjuvant (treatment before surgery) immunotherapy treatment based on tumor biomarkers results in better participant outcomes. Immunotherapy is the treatment of disease by using a person's own immune system. This study is divided into 2 sub-studies/parts designated Part 1 and Part 2 that will enroll in sequence starting with Part 1 followed by Part 2.